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| 1 | Enhanced pyrocatalysis of the pyroelectric BiFeO_(3)/g-C_(3)N_(4) heterostructure for dye decomposition driven by cold–hot temperature alternation显示文摘The BiFeO_(3)/g-C_(3)N_(4) heterostructure,which is fabricated via a simple mixing–calcining method,benefits the significant enhancement of the pyrocatalytic performance.With the growth of g-C_(3)N_(4) content in the heterostructure pyrocatalysts from 0 to 25%,the decomposition ratio of Rhodamine B(RhB)dye after 18 cold-hot temperature fluctuation(25-65℃)cycles increases at first and then decreases,reaching a maximum value of~94.2%at 10%while that of the pure BiFeO_(3) is~67.7%.The enhanced dye decomposition may be due to the generation of the internal electric field which strengthens the separation of the positive and negative carriers and further accelerates their migrations.The intermediate products in the pyrocatalytic reaction also have been detected and confirmed,which proves the key role of the pyroelectric effect in realizing the dye decomposition using BiFeO_(3)/g-C_(3)N_(4) heterostructure catalyst.The pyroelectric BiFeO_(3)/g-C_(3)N_(4) heterostructure shows the potential application in pyrocatalytically degrading dye wastewater. | Mingzi Chen Yanmin Jia Huamei Li Zheng Wu Tianyin Huang Hongfang Zhang | 2021 | Journal of Advanced Ceramics2021，10，2： | 6 |
| 2 | Magnetic properties of Jiaxian red clay sequences from northern Chinese Loess Plateau and its paleoclimatic significance显示文摘Detailed rock magnetism investigation of the Jiaxian red clay sequences indicated that there are common magnetic mineralogy properties in red clay and loess-paleosol sequences from the Chinese Loess Plateau as well as the marked properties of themselves, magnetic min-erals mainly with magnetite, maghemite, hematite, and possibly limonite/goethite contributing to the magnetic behavior. Meanwhile, it is found that the strong paleosol in red clay sequences has a lower coercivity and higher content of ultra-fine ferrimagnetic grains than that of the weak pa-leosol, which is similar to loess and paleosol in upper Wucheng Loess sequences, and indicates that humid conditions and relatively strong pedogenesis play a significant role in the increase of ultra-fine magnetic minerals and transformation of the magnetic minerals. This suggests that, like Quaternary loess-paleosols, the change of characteristics of paleoclimatic conditions of the late Tertiary red clay deposits is fluctuant. In addition, the results of magnetic hysteresis properties show that the applied saturated field for samples from the Jiaxian red clay sequences is higher than that of the samples from eastern and southern Chinese Loess Plateau. It is obviously shown that there exist more hard magnetic minerals and relatively weak biochemical processes in the Jiaxian red clay sequences on northern Chinese Loess Plateau. We conclude that the paleocli-matic environment is different between northern and eastern/southern Chinese Loess Plateau, and it should be more arid in northern Chinese Loess Plateau. | QIANG Xiaoke, AN Zhisheng, LI Huamei, CHANG Hong & SONG Yougui 1. SKLLQG, Institute of Earth Environment, Chinese Academy of Sciences, Xi’an 710075, China 2. Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China | 2005 | Science China Earth Sciences2005，48，8： | 4 |
| 3 | Rock magnetic properties and palaeomagnetic results of sediments from a stone implement layer in the Bose Basin, Guangxi显示文摘Directional samples were taken to study rock magnetism and palaeomagnetic records from the Dong- sheng profile, which is 5 m thick and on the northwest edge of the Bose Basin. Mineralogy and rock magnetism of typical samples indicate that coarse granular titanomagnetite, and fine-grained hematite, superparamagnetic maghemite formed by pedogenesis are in the sediment, which has undergone many transformative processes during different stages of pedogenesis. Parallel samples were taken for thermal demagnetization (TH) (0 to 680℃) and alternating field (AF) demagnetization (0 to 80 mT) respectively. Experimental results of these two kinds of demagnetization illustrate that there are two or more magnetic components in the samples. Intensity of NRM decreases by almost 60% to 90% rapidly when the temperature ranges from 100℃ to 350℃, with a steady magnetic component. It is impossible to analyze the magnetic components at high temperature because those fluctuate widely when the temperature is higher than 400℃. Steady magnetic components from 100℃ to 350℃ indicate that the remanence was mainly carried by fine-grained hematite formed by pedogenesis, reflecting a change in the geomagnetic field while the magnetite was being oxidized into hematite by chemical weathering after deposition. The formative age of the sediments cannot be obtained by magnetic methods in this profile. | YANG XiaoQiang ZHU ZhaoYu ZHANG YiNan LI HuaMei ZHOU WenJuan YANG Jie | 2008 | Science China Earth Sciences2008，51，3： | 2 |
| 4 | Estrogen and pure antiestrogen fulvestrant (ICI 182 780) augment cell–matrigel adhesion of MCF-7 breast cancer cells through a novel G protein coupled estrogen receptor (GPR30)-to-calpain signaling axis显示文摘 | Yan Chen Zheng Li Yan He Dandan Shang Jigang Pan Hongmei Wang Huamei Chen Zhuxia Zhu Lei Wan Xudong Wang | 2014 | Toxicology and Applied Pharmacology2014，，： | 1 |
| 5 | Localized nonlinear waves in combined time-dependent magnetic-optical potentials with spatiotemporally modu- lated nonlinearities 显示文摘 | He Junrong Yi Lin Li Huamei | 2013 | Physics Letters A2013，377，34： | 1 |
| 6 | Greater enhance- ment of Bacillus subtilis spore yields in submerged cultures by optimization of medium composition through statistical experi- mental designs 显示文摘 | Chen Zhenmin Li Qing Liu Huamei | 2010 | Applied Microbiology and Biotechnology2010，85，5： | 1 |
| 7 | Advancements in understanding mechanisms of hepatocellular carcinoma radiosensitivity:A comprehensive review显示文摘Primary liver cancer is a significant health problem worldwide.Hepatocellular carcinoma(HCC)is the main pathological type of primary liver cancer,accounting for 75%-85%of cases.In recent years,radiotherapy has become an emerging treatment for HCC and is effective for various stages of HCC.However,radiosensitivity of liver cancer cells has a significant effect on the efficacy of radiotherapy and is regulated by various factors.How to increase radiosensitivity and improve the therapeutic effects of radiotherapy require further exploration.This review summarizes the recent research progress on the mechanisms affecting sensitivity to radiotherapy,including epigenetics,transportation and metabolism,regulated cell death pathways,the microenvironment,and redox status,as well as the effect of nanoparticles on the radiosensitivity of liver cancer.It is expected to provide more effective strategies and methods for clinical treatment of liver cancer by radiotherapy. | Gaoyuan Yang Huamei Yan Yongchang Tang Feng Yuan Mingbo Cao Yupeng Ren Yuxuan Li Zhiwei He Xiaorui Su Zhicheng Yao Meihai Deng | 2023 | Chinese Journal of Cancer Research2023，35，3： | 1 |
| 8 | Soliton solutions for two nonlinear partial differential equations using a Darboux transformation of the Lax pairs显示文摘 | Lin Ji Ren Bo Li Huamei et at | 2008 | Phys Rev E2008，77，03： | 1 |
| 9 | Generation of low-cadmium rice germplasms via knockout of OsLCD using CRISPR/Cas9显示文摘The OsLCD gene,which has been implicated in cadmium (Cd) accumulation in rice,might be a useful target for CRISPR/Cas9 editing.However,the effects of Os LCD gene editing on Cd accumulation,plant growth,and yield traits remain unknown.Here,we used CRISPR/Cas9to generate oslcd single mutants from indica and japonica rice cultivars.We also generated osnramp5 single mutants and oslcd osnramp5 double mutants in the indica background.When grown in Cd-contaminated paddy soils,all oslcd single mutants accumulated less Cd than the wild types (WTs).Consistent with this,oslcd single mutants grown in Cd-contaminated hydroponic culture accumulated significantly less Cd in the shoots as compared to WTs.This decrease in accumulation probably resulted from the reduction of Cd translocation under Cd stress.Oxidative damage also decreased,and plant growth increased in all oslcd single mutant seedlings as compared to WTs in the presence of Cd.Plant growth and most yield traits,as well essential element concentrations in rice seedling shoots,brown rice,and rice straw,were similar between oslcd single mutants and WTs.In the presence of Cd,Cd concentrations in the brown rice and shoots of oslcd osnramp5 double mutants were significantly decreased compared with WTs as well as osnramp single mutants.Our results suggested that OsL CD knockout may reduce Cd accumulation alone or in combination with other knockout mutations in a variety of rice genotypes;unlike Os Nramp5 mutations,Os LCD knockout did not reduce essential element contents.Therefore,Os LCD knockout might be used to generate low-Cd rice germplasms. | Huamei Chen Rong Ye Ying Liang Shuchang Zhang Xiulian Liu Chongjun Sun Fangbai Li Jicai Yi | 2023 | Journal of Environmental Sciences2023，，4： | 1 |
| 10 | High resolution magnetostratigraphy and deposition cycles in the Nihewan Basin (North China) and their significance for stone artifact dating显示文摘 | Li Huamei Yang Xiaoqiang Friedrich Heller Li Haitao | 2008 | Quaternary Research2008，，2： | 1 |
| 11 | Insecticidal action of Quinomycin A from Streptomyces sp. KN-0647, isolated from a forest soil显示文摘 | Huamei Liu Sheng Qin Yongxia Wang Wenjun Li Jie Zhang | 2008 | World Journal of Microbiology and Biotechnology2008，，10： | 1 |
| 12 | Paleomagnetism of Cretaceous to Tertiary sediments from southern Tibet: evidence for the extent of the northern margin of India prior to the collision with Eurasia 显示文摘 | Patzelt A Li Huamei Wang Junda | 1996 | Tectonophysics1996，259，： | 1 |
| 13 | Comparative transcriptomics provide new insights into the mechanisms by which foliar silicon alleviates the effects of cadmium exposure in rice显示文摘Silicon(Si)has been shown to alleviate Cd stress in rice.Here,we investigated the beneficial effects of foliar Si in an indica rice Huanghuazhan(HHZ).Our results showed that foliar Si in-creases the dry weight and decreases Cd translocation in Cd-exposed rice at the grain-filling stage only,implying that the filling stage is critical for foliar Si to reduce Cd accumulation.We also investigated the transcriptomics in flag leaves(FLs),spikelets(SPs),and node Is(NIs)of Cd-exposed HHZ after foliar Si application at the filling stage.Importantly,the gene expression profiles associated with the Si-mediated alleviation of Cd stress were tissue spe-cific,while shared pathways were mediated by Si in Cd-exposed rice tissues.Furthermore,after the Si treatment of Cd-exposed rice,the ATP-binding cassette(ABC)-transporters were mostly upregulated in FL and SP,while the bivalent cation transporters were mostly down-regulated in FL and NI,possibly helping to reduce Cd accumulation.The genes associated with essential nutrient transporters,carbohydrate and secondary metabolite biosynthesis,and cytochrome oxidase activity were mostly upregulated in Cd-exposed FL and SP,which may help to alleviate oxidative stress and improve plant growth under Cd exposure.Inter-estingly,genes responsible for signal transduction were negatively regulated in FL,but pos-itively regulated in SP,by foliar Si.Our results provide transcriptomic evidence that foliar Si plays an active role in alleviating the effects of Cd exposure in rice.In particular,foliar Si may alter the expression pattern of genes associated with transport,biosynthesis and metabolism,and oxidation reduction. | Chongjun Sun Xiaoyu Liang Xiaomei Gong Huamei Chen Xiulian Liu Shuchang Zhang Fangbai Li Junliang Zhao Jicai Yi | 2022 | Journal of Environmental Sciences2022，34，5： | 0 |
| 14 | Clinical evaluation of recombinant human growth hormone injection in children with growth hormone deficiency显示文摘Recombinant human growth hormone(rhGH)has been widely used in the clinical treatment of growth hormone deficiency.To simplify the injection process and increase drug compliance,application of the GH injection has become a new treatment plan in recent years.The purpose of the current study was to evaluate the efficacy and safety of rhGH injection for the treatment of growth hormone deficiency(GHD)in children in China.In a nationwide,noncomparative,prospective,randomized,open trial,31 children with confirmed complete GHD received subcutaneous injection of rhGH at 0.25 mg/kg$wk(0.107 IU/kg$d).The injection was given daily and the total weekly amount was separated into 6–7 injections.The patients were followed up at 3-month intervals and the treatment duration was 12 months.The height(HT),annual growth velocity(GV),mean height standard deviation score(HT SDS),blood serum insulin-like growth factor I(IGF-I),insulin-like growth factor binding protein 3(IGFBP-3),and bone maturity before and after treatment were compared,and the safety of the treatment was analyzed.The mean HT,GV,and HT SDS were increased from 109.0�14 cm,2.7�0.9 cm/yr,and–4.62�1.46 at baseline to 121.8�13.4 cm,12.9�3.3 cm/yr,and–2.47�1.86 after 12 months of treatment,respectively(P<0.001).At the same time,blood IGF-I and IGFBP-3 were increased significantly[41.27�64.43μg/L vs 159.21�167.92μg/L and 1540.00�1325.11 mg/L vs 3533.93�1413.82 mg/L,respectively(P<0.001)].The bone age assessments performed 6 and 12 months after the treatment showed that no advanced bone maturation was noted.No serious adverse events occurred during the treatment,and the drug-related adverse events were mainly decreased thyroid function.We conclude that rhGH injection is a safe and effective drug for treatment of growth hormone deficiency in children. | Ling HOU Xiaoping LUO Minlian DU Huamei MA Chunxiu GONG Yuchuan LI Shuixian SHEN Zhuhui ZHAO Li LIANG Guanping DONG Chaoying YAN Hongwei DU | 2009 | Frontiers of Medicine2009，3，2： | 0 |
| 15 | Comparative physiological and transcriptomic analyses illuminate common mechanisms by which silicon alleviates cadmium and arsenic toxicity in rice seedlings显示文摘The inessential heavy metal/loids cadmium(Cd)and arsenic(As),which often co-occur in polluted paddy soils,are toxic to rice.Silicon(Si)treatment is known to reduce Cd and As toxicity in rice plants.To better understand the shared mechanisms by which Si alleviates Cd and As stress,rice seedlings were hydroponically exposed to Cd or As,then treated with Si.The addition of Si significantly ameliorated the inhibitory effects of Cd and As on rice seedling growth.Si supplementation decreased Cd and As translocation from roots to shoots,and significantly reduced Cd-and As-induced reactive oxygen species generation in rice seedlings.Transcriptomics analyses were conducted to elucidate molecular mechanisms underlying the Si-mediated response to Cd or As stress in rice.The expression patterns of the differentially expressed genes in Cd-or As-stressed rice roots with and without Si application were compared.The transcriptomes of the Cd-and As-stressed rice roots were similarly and profoundly reshaped by Si application,suggesting that Si may play a fundamental,active role in plant defense against heavy metal/loid stresses by modulating whole genome expression.We also identified two novel genes,0s01g0524500 and 0s06g0514800,encoding a myeloblastosis(MYB)transcription factor and a thionin,respectively,which may be candidate targets for Si to alleviate Cd and As stress in rice,as well as for the generation of Cd-and/or As-resistant plants.This study provides valuable resources for further clarification of the shared molecular mechanisms underlying the Si-mediated alleviation of Cd and As toxicity in rice. | Huiqiong Chen Xiaoyu Liang Xiaomei Gong John R.Reinfelder Huamei Chen Chongjun Sun Xiulian Liu Shuchang Zhang Fangbai Li Chuanping Liu Junliang Zhao Jicai Yi | 2021 | Journal of Environmental Sciences2021，33，11： | 0 |
| 16 | Click CAR-T cell engineering for robustly boosting cell immunotherapy in blood and subcutaneous xenograft tumor显示文摘The adoptive transfer of chimeric antigen receptor-T(CAR-T)cells has shown remarkable clinical responses in hematologic malignancies.However,unsatisfactory curative results and side effects for tumor treatment are still unsolved problems.Herein we develop a click CAR-T cell engineering strategy via cell glycometabolic labeling for robustly boosting their antitumor effects and safety in vivo.Briefly,paired chemical groups(N3/BCN)are separately incorporated into CAR-T cell and tumor via nondestructive intrinsic glycometabolism of exogenous Ac4GalNAz and Ac4ManNBCN,serving as an artificial ligand-receptor.Functional groups anchored on cell surface strengthen the interaction of CAR-T cell and tumor via bioorthogonal click chemistry,further enhancing specific recognition,migration and selective antitumor effects of CAR-T cells.In vivo,click CAR-T cell completely removes lymphoma cells and minimizes off-target toxicity via selective and efficient bioorthogonal targeting in blood cancer.Surprisingly,compared to unlabeled cells,artificial bioorthogonal targeting significantly promotes the accumulation,deep penetration and homing of CAR-T cells into tumor tissues,ultimately improving its curative effect for solid tumor.Click CAR-T cell engineering robustly boosts selective recognition and antitumor capabilities of CAR T cells in vitro and in vivo,thereby holding a great potential for effective clinical cell immunotherapy with avoiding adverse events in patients. | Hong Pan Wenjun Li Ze Chen Yingmei Luo Wei He Mengmeng Wang Xiaofan Tang Huamei He Lanlan Liu Mingbin Zheng Xin Jiang Ting Yin Ruijing Liang Yifan Ma Lintao Cai | 2021 | Bioactive Materials2021，6，4： | 0 |
| 17 | Plasma-induced Mo-doped Co_(3)O_(4)with enriched oxygen vacancies for electrocatalytic oxygen evolution in water splitting显示文摘Heteroatomic substitution and vacancy engineering of spinel oxides can theoretically optimize the oxygen evolution reaction(OER)through charge redistribution and d-band center modification but still remain a great challenge in both the preparation and catalytic mechanism.Herein,we proposed a novel and efficient Ar-plasma(P)-assisted strategy to construct heteroatom Mo-substituted and oxygen vacancies enriched hierarchical spinel Co_(3)O_(4)porous nanoneedle arrays in situ grown on carbon cloth(denoted P-Mo-Co_(3)O_(4)@CC)to improve the OER performance.Ar-plasma technology can efficiently generate vacancy sites at the surface of hydroxide,which induces the anchoring of Mo anion salts through electrostatic interaction,finally facilitating the substitution of Mo atoms and the formation of oxygen vacancies on the Co_(3)O_(4)surface.The P-Mo-Co_(3)O_(4)@CC affords a low overpotential of only 276 mV at 10 mA cm^(−2)for the OER,which is 58 mV superior to that of Mo-free Co_(3)O_(4)@CC and surpasses commercial RuO_(2)catalyst.The robust stability and satisfactory selectivity(nearly 100%Faradic efficiency)of P-Mo-Co_(3)O_(4)@CC for the OER are also demonstrated.Theoreti-cal studies demonstrate that Mo with variable valance states can efficiently regulates the atomic ratio of Co^(3+)/Co^(2+)and increases the number of oxygen vacancies,thereby inducing charge redistribution and tuning the d-band center of Co_(3)O_(4),which improve the adsorption energy of oxygen intermediates(e.g.,*OOH)on P-Mo-Co_(3)O_(4)@CC during OER.Furthermore,the two-electrode OER//HER electrolyzer equipped with P-Mo-Co_(3)O_(4)@CC as anode displays a low operation potential of 1.54 V to deliver a current density of 10 mA cm^(−2),and also exhibits good reversibility and anticurrent fluctuation ability under simulated real energy supply conditions,demonstrating the great potential of P-Mo-Co_(3)O_(4)@CC in water electrolysis. | Yujie Huang Meng Li Fei Pan Zhuoya Zhu Huamei Sun Yawen Tang Gengtao Fu | 2023 | Carbon Energy2023，5，3： | 0 |
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