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| 1 | 克罗恩病:CT小肠成像、MR小肠成像和小肠灌肠造影的比较显示文摘目的前瞻性比较CT和MR小肠成像及小肠灌肠造影3种检查方法发现克罗恩病病人活动性小肠炎症和肠外并发症的准确性。方法机构伦理审查委员会批准本研究计划,并所有参与者知情同意。对连续31例克罗恩病或疑有克罗恩病的病人行CT和MR小肠成像、小肠灌肠造影和回肠结肠镜检查。2位独立的阅片者回顾CT和MR小肠成像及小肠灌肠造影影像以确定活动性末端回肠炎和肠道外并发症的存在。以回结肠镜检查结果作为参考标准,利用受试者工作特性曲线方法来评估CT和MR小肠成像及小肠灌肠造影确定活动性末端回肠炎的准确度。 | S.S. Lee A.Y. Kim S.K. Yang J. W. Chung S.Y. Kim S.H. Park 孙东辉(译) 万业达(校) | 2009 | 国际医学放射学杂志2009，32，4： | 57 |
| 2 | Diagnostic value of PIVKA-Ⅱ and alpha-fetoprotein in hepatitis B virus-associated hepatocellular carcinoma显示文摘AIM: To determine the cutoff values and to compare the diagnostic role of alpha-fetoprotein(AFP) and prothrombin induced by vitamin K absence-Ⅱ(PIVKA-Ⅱ) in chronic hepatitis B(CHB).METHODS: A total of 1255 patients with CHB, including 157 patients with hepatocellular carcinoma(HCC), 879 with non-cirrhotic CHB and 219 with cirrhosis without HCC, were retrospectively enrolled. The areas under the receiver operating characteristic(AUROC) curves of PIVKA-Ⅱ, AFP and their combination were calculated and compared.RESULTS: The optimal cutoff values for PIVKA-Ⅱ and AFP were 40 m AU/m L and 10 ng/m L, respectively, for the differentiation of HCC from nonmalignant CHB. The sensitivity and specificity were 73.9% and 89.7%, respectively, for PIVKA-Ⅱ and 67.5% and 90.3% for AFP, respectively. The AUROC curves of both PIVKA-Ⅱ and AFP were not significantly different(0.854 vs 0.853, P = 0.965) for the differentiation of HCC from nonmalignant CHB, whereas the AUROC of PIVKA-Ⅱ was significantly better than that of AFP in patients with cirrhosis(0.870 vs 0.812, P = 0.042). When PIVKA-Ⅱ and AFP were combined, the diagnostic power improved significantly compared to either AFP or PIVKA-Ⅱ alone for the differentiation of HCC from nonmalignant CHB(P < 0.05), especially when cirrhosis was present(P < 0.05).CONCLUSION: Serum PIVKA-Ⅱ might be a better tumor marker than AFP, and its combination with AFP may enhance the early detection of HCC in patients with CHB. | Seung In Seo Hyoung Su Kim Won Jin Kim Woon Geon Shin Doo Jin Kim Kyung Ho Kim Myoung Kuk Jang Jin Heon Lee Joo Seop Kim Hak Yang Kim Dong Joon Kim Myung Seok Lee Choong Kee Park | 2015 | World Journal of Gastroenterology2015，21，13： | 60 |
| 3 | Berberine induces cell cycle arrest and apoptosis in human gastric carcinoma SNU-5 cell line显示文摘瞄准:与它行动的分子的机制调查在小檗硷和 apoptotic 小径的禁止的生长(细胞毒素的活动) 之间的关系。方法:在试管内细胞毒素的技术被房间周期分析和 sub-G1 的决心在人的胃的癌 SNU-5 房间为 apoptosis 补充。可行房间,房间周期,和 sub-G1 组(apoptosis ) 的百分比被流动 cytometric 方法检验并且决定。为房间周期拘捕和 apoptosis 的联系蛋白质被西方的弄污检验。结果:为 SNU-5 房间线, IC50 被发现是小檗硷的 48 micromol/L。在与 25-200 micromol/L 小檗硷对待的 SNU-5 房间, G2/M 房间周期拘捕被观察它与 p53, Wee1 和 CDk1 蛋白质和减少的 cyclin 的表示的显著增长被联系 B。在 G0/G1 阶段的房间和 G2/M 阶段的增加的集中依赖者减少被检测。另外,当在房间周期测量的 sub-G0 房间人口被监视 apoptotic 小径在 25-200 micromol/L 证明对待 berberine 的房间, apoptosis 检测了。 Apoptosis 被 sub-G0 房间人口识别,并且在 Bcl-2 的规定下面,Ca2+在 Bax 的规定上面释放,减少 mitochondrial 膜电位然后导致了 mitochondrial 细胞色素 C 的版本进细胞质并且引起了 caspase-3 的激活,并且最后导致了 apoptosis 的出现。结论:小檗硷导致 p53 表示并且为 apoptosis 的正式就职导致 mitochondrial 膜电位,细胞色素 C 版本和 caspase-3 的激活的减少。 | Jing-Pin Lin Jai-Sing Yang Jau-Hong Lee Wen-Tsong Hsieh Jing-Gung Chung | 2006 | World Journal of Gastroenterology2006，12，1： | 34 |
| 4 | Pancreatic fistula after pancreaticoduodenectomy:A comparison between the two pancreaticojejunostomy methods for approximating the pancreatic parenchyma to the jejunal seromuscular layer:Interrupted vs continuous stitches显示文摘瞄准:学习是由比较发现一种更好起作用的技术的这的目的为胰管空肠吻合术的外部层与连续的针打断了针,即在胰和空肠浆膜肌膜层的树桩实质之间的针,和其它为胰腺的漏的发生冒因素的风险。方法:在到 2004 年 10 月的时期 1997 年 1 月期间, 133 个病人与连续缝术为胰管空肠吻合术和 170 个病人的外部层与间断缝术在 pancreaticoduodenectomy 以后经历了 end-to-side 和 duct-to-mucosa 胰管空肠吻合术重建在我们由一位外科医生的机构。结果:在在诊断,胰的质地, octreotide 的使用和病理学的舞台的二个组之间没有有效差量。胰腺的管在间断缝术盒子之中并且在 10 发生在 14 个病人(11%)(6%) 在连续缝术盒子之中(P = 0.102 ) 。主要的胰腺的漏在三个间断缝术病人(2%) 和零个连续缝术病人发展了(P = 0.026 ) 。在里面多变量分析,软胰腺的一致性(机会比率, 5.5;95% 信心间隔 2.3-13.1 ) 并且胆总管癌症(机会比率, 3.7;95% CI 1.6-8.5 ) 胰腺的漏是预兆的。结论:胰腺的质地和病理是在决定 pancreaticojejunal 吻合和我们的连续缝术方法的命运与主要的胰腺的管的显著地减少的出现被执行的最重要的因素。在结论,连续缝术方法在执行 duct-to-mucosa 胰管空肠吻合术更可行、更安全。 | Seung Eun Lee Sung Hoon Yang Jin-Young Jang Sun-Whe Kim | 2007 | World Journal of Gastroenterology2007，13，40： | 31 |
| 5 | Pt/CNT纳米催化剂的微波快速合成及其对甲醇电化学氧化的电催化性能显示文摘As a rapid uniform and efficient heating method, microwave irradiation has been widely used in chemical reaction and preparing nanomaterials. Here Pt/carbon nanotube(CNT) catalysts with w(Pt)=18.1% and 9.4 % were rapidly synthesized by microwave irradiation heating polyol process and employing the ethylene glycol solution of H 2PtCl 6 as the precursors in the presence of CNT support. TEM imaging showed that microwave-prepared Pt nanoparticles were very uniform in size, with an average size of 3.1 nm, and uniformly dispersed on the CNT surface. Electrochemical experiments demonstrated that microwave-synthesized Pt/CNT catalysts exhibited a higher catalytic activity for electrooxidation of liquid methanol than E-TEK Pt/C. The significant improvement in catalyst performance derives from that microwave-synthesized Pt nanoparticles have a uniform small particle size and uniforml dispersion on the CNT surface. | 陈卫祥 韩贵 LEE Jim Yang 刘昭林 | 2003 | 高等学校化学学报2003，24，12： | 31 |
| 6 | REE geochemistry of suspended sediments from the rivers around the Yellow Sea and provenance indicators显示文摘Rare earth element (REE) compositions of the suspended sediments from the rivers around the Yellow Sea were different in that Korean river sediments (Han, Keum and Yeongsan Rivers) yield stronger fractionations than Chinese river sediments (Changjiang, Huanghe and Yalujiang), shown by obvious enrichments of LREE (light rare earth element) relative to UCC (upper continental crust). Variations of source rock compositions in the drainage basins are responsible for the differences of REE compositions between the river sediments. REE fractionation parameters including (La/Yb)UCC and (Gd/Yb)UCC as well as the ratios of La/Sc and Th/Sc can be treated as proper proxies for identifying the Chinese river sediments from those Korean river matters, and furthermore, for studying the provenances and paleoenvironmental changes of the marginal seas of China. | YANG Shouye LI Congxian C. B. Lee T. K. Na | 2003 | Chinese Science Bulletin2003，48，11： | 30 |
| 7 | Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function显示文摘在肿瘤和免疫系统之间的相互作用仍然糟糕被理解。重要临床的回答在对 CTLA4 和 PD-1/PD-L1 检查点与抗体对待的癌症病人被完成了;然而,仅仅病人的小部分对治疗作出回应,显示需要探索为癌症治疗的另外的 co 禁止的分子。B7-H3, B7 总科的一个成员,被我们以前显示出禁止 T 房间激活和 autoimmunity。在这研究,我们在肿瘤免疫分析了 B7-H3 的功能。B7-H3 的表示在多重肿瘤线,渗入肿瘤的树枝状的房间,和巨噬细胞被发现。与对抗抗体对待到 B7-H3 的 B7-H3-deficient 老鼠或老鼠显示出多重肿瘤的减少的生长,它取决于 NK 和 CD8 + T 房间。与细胞毒素的淋巴细胞表示的通常认为的受体, B7-H3 禁止了他们的激活,并且它的缺乏在忍受肿瘤的鼠标导致了增加的细胞毒素的淋巴细胞功能。B7-H3 和 PD-1 的联合封锁导致了迟了阶段的肿瘤的进一步提高的治疗学的控制。一起拿,我们的结果显示 B7-H3 检查点可以对癌症为免疫疗法用作一个新奇目标。 | Young-hee Lee Natalia Martin-Orozco Peilin Zheng Jing Li Peng Zhang Haidong Tan Hyun Jung Park Mira Jeong Seon Hee Chang Byung-Seok Kim Wei Xiong Wenjuan Zang Li Guo Yang Liu Zhong-jun Dong Willem W Overwijk Patrick Hwu Qing Yi Larry Kwak Zhiying Yang Tak W Mak Wei-Li Laszlo G Radvanyi Ling Ni Dongfang Liu Chen Dong | 2017 | Cell Research2017，27，8： | 29 |
| 8 | Lymph node metastasis in early gastric cancer with submucosal invasion:Feasibility of minimally invasive surgery显示文摘AIM:To explore the feasibility of performing minimally invasive surgery(MIS) on subsets of submucosal gastric cancers that are unlikely to have regional lymph node metastasis.METHOPS:A total of 105 patients underwent radical gastrectomy with lymph node dissection for submucosal gastric cancer at our hospital from January 1995 to December 1995,Besides investigating many clinicopathological features such as tumor size,gross appearance,and differentiation,we measured the depth of invasion into submucosa minutely and analyzed the clinicopathologic features of these patients regarding lymph node metastasis.RESULTS:the rate of lymph node metastasis in cases where the depth of invasion was<500μm,500-200μm,or>2000μm was 9% (2/23),19%(7/36),and 33%(15/46),respectively(P<0.05).In univariate analysis,no significant correlation was found between lymph node metastasis and clinicopathological characteristics such as age,sex,tumor location,gross appearance,tumor differentiation,Lauren's classification,and lymphatic invasion,In multivariate analysis,tumor size(>4cm vs≤2cm,odds ratio=4。80,P=0.04)and depth of invasion(>2000μm vs ≤500μm,odds ratio=6.81,P=0.02)were significantly correlated with lymph node metastasis,Combining the depth and size in cases where the depth of invasion was less than 500μm,we found that lymph node metastasis occurred where the tumor size was greater than 4 cm.In cases where the tumor size was less than 2 cm,lymph node metastasis was found only where the depth of tumor invasion was more than 2000μm.CONCLUSION:MIS can be applied to submucosal gastric cancer that is less than 2 cm in size and 500μm in depth. | Do-Joong Park Hyeon-Kook Lee Hyuk-Joon Lee Hye-SeungLee Woo-HoKim Han-Kwang Yang Kuhn-UkLee Kuk-JinChoe | 2004 | World Journal of Gastroenterology2004，10，24： | 22 |
| 9 | Alteration of p53 and p21 during hepatocarcinogenesis in tree shrews显示文摘AIM: To investigate p53 mutation and p21 expression in hepatocarcinogenesis induced by hepatitis B virus (HBV) and aflatoxin B1 (AFB1) in tree shrews, and to reveal the role of these genes in hepatocarcinogenesis.METHODS: Tree shrews were divided into four groups:group A, those infected with HBV and fed with AFB1 (n = 39);group B, those infected with HBV alone (n = 28); group C,those fed with AFB1 alone (n = 29); and group D, normal controls (n = 20). The tree shrews underwent liver biopsies once every 15 wk. Expression of p53 and p21 proteins and genes in the biopsies and tumor tissues of the experimental tree shrews was detected, respectively, by immunohistochemistry,and by Southem blotting and reverse transcription-polymerase chain reaction and sequencing.RESULTS: The incidence of hepatocellular carcinomas (HCC) was higher in group A (66.7%) than that in group B (3.57%) and C (30%). The time of HCC occurrence was also earlier in group A than that in group C (120.0±16.6 wk vs 153.3±5.8 wk, respectively, P<0.01). p53 protein was not detected by immunohistochemistry in all groups before the 75^th wk of the experiment. At the 105^th wk, the positive rates fo p53 were 78.6%, 60% and 71.4% in groups A, B and C, respectively, which were significantly higher than that in group D (10%) (all P<0.05). An abnormal band of p53 gene was observed in groups A and C. The mutation points of p53gene in tree shrews with HCC were at codons 275, 78 and 13. The nucleotide sequence and amino acid sequence of tree shrew's wild-type p53 showed 91.7% and 93.4% homologies with those of human p53,respectively. The immunopositivity for p21 was found before HCC development. The incidence of HCC was significantly higher in tree shrews that were positive for p21 than those negative for p21 (80.0% vs 11.0%, P<0.001).The incidence of HCC in p21 positive animals in group A was significantly higher than those positive for p21 in group C (P | Jian-Jia Su Yuan Li Ke-Chen Ban Liu-Liang Qin Chun Yang Chao Ou Xiao-Xian Duan Hui-Yun Wang Rui-Qi Yang Young-Lk Lee | 2004 | World Journal of Gastroenterology2004，10，24： | 21 |
| 10 | Ten-year survival of hepatocellular carcinoma patients undergoing radiofrequency ablation as a first-line treatment显示文摘AIM: To investigate the long-term survival and prognostic factors in hepatocellular carcinoma(HCC) patients undergoing radiofrequency ablation(RFA) as a first-line treatment.METHODS: From 2000 to 2013, 316 consecutivepatients with 404 HCC(1.0-5.0 cm; mean: 3.2 ± 1.1 cm) underwent ultrasonography-guided percutaneous RFA as a first-line treatment. There were 250 males and 66 females with an average age of 60.1 ± 10.8 years(24-87 years). Patients were followed for 1 year to > 10 years after RFA(234, 181, 136, and 71 for 3, 5, 7, and 10 years, respectively). Overall local response rates and long-term survival rates were assessed. Survival results were generated using Kaplan-Meier estimates, and multivariate analysis was performed using the Cox regression model. RESULTS: In total, 548 RFA sessions were performed and major complications occurred in 10 sessions(1.8%). Local tumor progression and/or new tumor development were observed in 43.3%(132/305) of the patients during the follow-up period. Overall 5-and 10-year survival rates were 49.7% and 28.4%, respectively. Based on multivariate analysis, three factors were identified as independent prognostic factors for overall survival: Child-Pugh classification(HR = 4.054, P < 0.001), portal vein hypertension(HR = 2.743, P = 0.002), and tumor number(HR = 2.693, P = 0.003). The local progression-free 5- and 10-year survival rates were 42.7% and 19.5%. In addition to the Child-Pugh classification and the number of tumors, the number of RFA sessions(HR = 1.550, P = 0.002) was associated with local progression-free survival.CONCLUSION: RFA can achieve acceptable outcomes for HCC patients as a first-line treatment, especially for patients with Child-Pugh class A, patients with a single tumor and patients without portal vein hypertension. | Wei Yang Kun Yan S Nahum Goldberg Muneeb Ahmed Jung-Chieh Lee Wei Wu Zhong-Yi Zhang Song Wang Min-Hua Chen | 2016 | World Journal of Gastroenterology2016，22，10： | 20 |
| 11 | Synergistic Effects of Chuanxiong-Chishao Herb-Pair on Promoting Angiogenesis at Network Pharmacological and Pharmacodynamic Levels显示文摘Objective: To investigate the synergistic effects of Chuanxiong-Chishao herb-pair(CCHP) on promoting angiogenesis in silico and in vivo. Methods: The mechanisms of action of an herb-pair, ChuanxiongChishao, were investigated using the network pharmacological and pharmacodynamic strategies involving computational drug target prediction and network analysis, and experimental validation. A set of network pharmacology methods were created to study the herbs in the context of targets and diseases networks, including prediction of target profiles and pharmacological actions of main active compounds in Chuanxiong and Chishao. Furthermore, the therapeutic effects and putative molecular mechanisms of Chuanxiong-Chishao actions were experimentally validated in a chemical-induced vascular insufficiency model of transgenic zebrafish in vivo. The m RNA expression of the predicted targets were further analyzed by real-time polymerase chain reaction(RT-PCR). Results: The computational prediction results found that the compounds in Chuanxiong have antithrombotic, antihypertensive, antiarrhythmic, and antiatherosclerotic activities, which were closely related to protecting against hypoxic-ischemic encephalopathy, ischemic stroke, myocardial infarction and heart failure. In addition, compounds in Chishao were found to participate in anti-inflammatory effect and analgesics. Particularly, estrogen receptor α(ESRα) and hypoxia-inducible factor 1-α(HIF-1α) were the most important potential protein targets in the predicted results. In vivo experimental validation showed that post-treatment of tetramethylpyrazine hydrochloride(TMP·HCl) and paeoniflorin(PF) promoted the regeneration of new blood vessels in zebrafish involving up-regulating ESRα m RNA expression. Co-treatment of TMP·HCl and PF could enhance the vessel sprouting in chemical-induced vascular insufficiency zebrafish at the optimal compatibility proportion of PF 10 μmol/L with TMP·HCl 1 μmol/L. Conclusions: The network pharmacological strategies combining drug target prediction and network analysis identified some putative targets of CCHP. Moreover, the transgenic zebrafish experiments demonstrated that the Chuanxiong-Chishao combination synergistically promoted angiogenic activity, probably involving ESRα signaling pathway. | WANG Yan GUO Gang YANG Bin-rui XIN Qi-qi LIAO Qi-wen LEE Simon Ming-Yuen HU Yuan-jia CHEN Ke-ji CONG Wei-hong | 2017 | Chinese Journal of Integrative Medicine2017，23，9： | 19 |
| 12 | Endoscopic treatment for early gastric cancer显示文摘Gastric cancer remains one of the most common causes of cancer death.However the proportion of early gastric cancer(EGC)at diagnosis is increasing.Endoscopic treatment for EGC is actively performed worldwide in cases meeting specific criteria.Endoscopic mucosal resection can treat EGC with comparable results to surgery for selected cases.Endoscopic submucosal dissection(ESD)increases the en bloc and complete resection rates and reduces the local recurrence rate.ESD has been performed with expanded indication and is expected to be more widely used in the treatment of EGC through the technological advances in the near future.This review will describe the techniques,indications and outcomes of endoscopic treatment for EGC. | Yang Won Min Byung-Hoon Min Jun Haeng Lee Jae J. Kim | 2014 | World Journal of Gastroenterology2014，20，16： | 18 |
| 13 | CPS Modeling of CNC Machine Tool Work Processes Using an Instruction-Domain Based Approach显示文摘Building cyber-physical system(CPS) models of machine tools is a key technology for intelligent manufacturing. The massive electronic data from a computer numerical control(CNC) system during the work processes of a CNC machine tool is the main source of the big data on which a CPS model is established. In this work-process model, a method based on instruction domain is applied to analyze the electronic big data, and a quantitative description of the numerical control(NC) processes is built according to the G code of the processes. Utilizing the instruction domain, a work-process CPS model is established on the basis of the accurate, real-time mapping of the manufacturing tasks, resources, and status of the CNC machine tool. Using such models, case studies are conducted on intelligent-machining applications, such as the optimization of NC processing parameters and the health assurance of CNC machine tools. | Jihong Chen Jianzhong Yang Huicheng Zhou Hua Xiang Zhihong Zhu Yesong Li Chen-Han Lee Guangda Xu | 2015 | Engineering2015，1，2： | 17 |
| 14 | Progressive Muscle Relaxation Combined with Chinese Medicine Five-Element Music on Depression for Cancer Patients: A Randomized Controlled Trial显示文摘Objectives: To evaluate the effects of progressive muscle relaxation training(PMRT) combined with five elements music therapy of Chinese medicine(CM) for improving anxiety and depression of cancer patients. Methods: From June 2015 to March 2016, 60 cancer patients were included into the study. The patients were randomly assigned to a control group and a treatment group by envelope randomization, receiving PMRT and PMRT plus CM five elements music therapy, respectively, for 8 weeks. Hospital Anxiety and Depression Scale(HADS), Benefit Finding Scales(BFS), Functional Assessment of Chronic Illness Therapy-Spiritual(FACIT-Sp), and Intervention Expectations Questionnaire(IEQU) were adopted to assess the depression of the two groups before and after the treatment. Results: Four cases dropped out during the study, and 29 cases in the treatment group and 27 in the control group were included in the final analysis. Prior to the treatments, the baselines of the 4 questionnaires in the two groups showed no difference. After the 8-week treatment, the treatment group presented better levels of HADS, BFS and FACIT-Sp scores compared with the control group(P<0.05). Among the single items of HADS, 4 items involving vexation, feeling fidgeted, pleasure and prospecting the future in the treatment group were improved compared with the control group(P<0.05). Conclusions: As a simple and reliable and effective intervention, PMRT combined with five elements music therapy mitigated anxiety and depression of cancer patients. Cancer patients have been found to respond well to psychological intervention in areas regarding stabilisation of emotions, disease awareness, and therapeutic compliance. This brings about a great difference in improving their quality of life and psychological state, offers an effective approach to better self-management in cancer treatment. | LIAO Juan WU Yu ZHAO Yang ZHAO Yuan-chen ZHANG Xu ZHAO Nan LEE Chun-ging YANG Yu-fei | 2018 | Chinese Journal of Integrative Medicine2018，24，5： | 17 |
| 15 | Highly-Sensitive Multiplexed in vivo Imaging Using PEGylated Upconversion Nanoparticles显示文摘Lanthanide-based upconversion nanoparticles(UCNPs)have been widely explored in various fields,including optical imaging,in recent years.Although earlier work has shown that UCNPs with different lanthanide(Ln3+)dopants exhibit various colors,multicolor-especially in vivo multiplexed biomedical imaging-using UCNPs has rarely been reported.In this work,we synthesize a series of UCNPs with different emission colors and functionalize them with an amphiphilic polymer to confer water solubility.Multicolor in vivo upconversion luminescence(UCL)imaging is demonstrated by imaging subcutaneously injected UCNPs and applied in multiplexed in vivo lymph node mapping.We also use UCNPs for multicolor cancer cell labeling and realize in vivo cell tracking by UCL imaging.Moreover,for the first time we compare the in vivo imaging sensitivity of quantum dot(QD)-based fluorescence imaging and UCNP-based UCL imaging side by side,and find the in vivo detection limit of UCNPs to be at least one order of magnitude lower than that of QDs in our current non-optimized imaging system.Our data suggest that,by virtue of their unique optical properties,UCNPs have great potential for use in highly-sensitive multiplexed biomedical imaging. | Liang Cheng Kai Yang Shuai Zhang Mingwang Shao Shuittong Lee Zhuang Liu | 2010 | Nano Research2010，3，10： | 17 |
| 16 | Density of Helicobacterpylorimay affect the efficacy of eradication therapy and ulcer healing in patients with active duodenal ulcers显示文摘AIM: To evaluate the association of pre-treatment Helicobacter pylon(H, pylon) density with bacterial eradication and ulcer healing rates in patients with active duodenal ulcer. METHODS: One hundred and four consecutive duodenal ulcer outpatients with H. py/ori infection ascertained by gastric histopathology and 13C-urea breath test (UBT) were enrolled in this study. H. py/ori density was graded histologically according to the Sydney system (normal, mild, moderate, and marked). In each patient, lansoprazole (30mg b.i.d.), clarithromycin (500 mg b.i.d.) and amoxicillin (1g b.i.d.) were used for i week, then 30 mg lansoprazole once daily was continued for an additional 3 weeks. Followup endoscopy was performed at 4 weeks after completion of the therapy, and UBT was done at 4 and 8 weeks after completion of the therapy. RESULTS: The H. pylori eradication rates were 88.9 %/100.0 %, 94.3 %/100.0 %, and 69.7 %/85.2 %; and the ulcer healing rates were 88.9 %/100.0 %, 94.3 %/100.0 %,and 63.6 %/77.8 % (intention-to-treat/per protocol analysis) in the mild, moderate, and marked H. pyloridensity groups, respectively. The association of pretreatment H. pyloriderisity with the eradication rate and ulcer healing rate was both statistically significant (P=-0.013/0.006 and 0.002/<0.001, respectively; using results of intention-to-treat/per protocol analysis).CONCLUSION: Intragastric bacterial load may affect both the outcome of eradication treatment and ulcer healing in patients with active duodenal ulcer disease. | Yung-Chih Lai Teh-Hong Wang Shih-Hung Huang Sien-Sing Yang Chi-Hwa Wu Tzen-Kwan Chen Chia-Long Lee | 2003 | World Journal of Gastroenterology2003，9，7： | 15 |
| 17 | Solving traveling salesman problems using generalized chromosome genetic algorithm显示文摘Generalized chromosome genetic algorithm (GCGA) was proposed for solving generalized traveling salesman problems (GTSP) as reported in the authors’ earlier work. Theoretically, the GCGA could also be used to solve the classical traveling salesman problem (CTSP), which has not been reported by others. In this paper, the generalized chromosome characteristics are analyzed and the feasibility for consistently solving the GTSP and CTSP is verified. Numerical experiments show the advantages of the GCGA for solving a large- scale CTSP. | Jinhui Yang Chunguo Wu Heow Pueh Lee Yanchun Liang | 2008 | Progress in Natural Science:Materials International2008，18，7： | 15 |
| 18 | Prevalence of clonorchiasis in patients with gastrointestinal disease: A Korean nationwide multicenter survey显示文摘AIM: To investigate prevalence of Clonorchis sinensis in patients with gastrointestinal symptoms, and the relation of the infection to hepatobiliary diseases in 26 hospitals in Korea.METHODS: Consecutive patients who had been admitted to the Division of Gastroenterology with gastrointestinal symptoms were enrolled from March to April 2005. Of those who had been diagnosed with clonorchiasis, epidemiology and correlation between infection and hepatobiliary diseases were surveyed by questionnaire.RESULTS: Of 3080 patients with gastrointestinal diseases, 396 (12.9%) had clonorchiasis and 1140 patients (37.2%) had a history of eating raw freshwater fish. Of those with a history of raw freshwater fish ingestion, 238 (20.9%) patients had clonorchiasis. Cholangiocarcinoma was more prevalent in C. sinensis-infected patients than non-infected patients [34/396 (8.6%) vs 145/2684 (5.4%), P = 0.015]. Cholangiocarcinoma and clonorchiasis showed statistically significant positive cross-relation (P = 0.008). Choledocholithiasis, cholecystolithiasis, cholangitis, hepatocellular carcinoma, and biliary pancreatitis did not correlate with clonorchiasis.CONCLUSION: Infection rate of clonorchiasis was still high in patients with gastrointestinal diseases in Korea, and has not decreased very much during the last two decades. Cholangiocarcinoma was related to clonorchiasis, which suggested an etiological role for the parasite. | Ho Gak Kim Jimin Han Myung-Hwan Kim Kyu Hyun Cho Im Hee Shin Gwang Ha Kim Jae Seon Kim Jin Bong Kim Tae Nyeun Kim Tae Hyeon Kim Tae Hyo Kim Jae Woo Kim Ji Kon Ryu Young-Soo Moon Jong Ho Moon Sung Jae Park Chan Guk Park Sung-Jo Bang Chang Heon Yang Kyo-Sang Yoo Byung Moo Yoo Kyu Taek Lee Dong Ki Lee Byung Seok Lee Sang Soo Lee Seung Ok Lee Woo Jin Lee Chang Min Cho Young-Eun Joo Gab Jin Cheon Young Woo Choi Jae Bok Chung Yong Bum Yoon | 2009 | World Journal of Gastroenterology2009，15，1： | 15 |
| 19 | p53-dependent Fas expression is critical for Ginsenoside Rh2 triggered caspase-8 activation in HeLa cells显示文摘我们最近报导了人参皂甙 Rh2 (G-Rh2 ) 在人的癌症房间导致二开始者 caspases, caspase-8 和 caspase-9 的激活。然而,它的导致死亡的功能的分子的机制仍然保持不清楚。这里,我们证明 G-Rh2 在 HeLa 房间同时刺激了 caspase-8 和 caspase-9 的激活。在 G-Rh2 治疗下面,膜死亡受体船边交货和 TNFR1 是显著地 upregulated。然而,船边交货然而并非 TNFR1 的导致的表示被贡献 apoptosis 过程。而且,船边交货表示的重要增加和 caspase-8 活动时间地在 G-Rh2 治疗之上随 p53-non-mutated HeLa 和 SK-HEP-1 房间的 p53 表示的增加与一致。相反,船边交货表示和 caspase-8 活动在变异 p53 的 SW480 和 PC-3 房间与 G-Rh2 治疗仍然保持不变。另外,调停 siRNA p53 击倒减少的 G-Rh2-induced 船边交货表示和 caspase-8 激活。这些结果显示 G-Rh2-triggered 外来的 apoptosis 依靠调停 p53 的船边交货在表示上。在内在的 apoptotic 小径, G-Rh2 在 HeLa 并且在 SW480 房间导致了 cytosolic BAK 和 BAX 的强壮、立即的 translocation 到线粒体, mitochondrial 细胞色素 c 版本,和随后的 caspase-9 激活。象 p53 独立的 caspase-9 激活一样的调停 p53 的船边交货表示和随后的下游的 caspase-8 激活都贡献下游的受动器 caspase-3/-7 的激活,导致肿瘤房间死亡。一起拿,我们建议 G-Rh2 以一种多路径方式导致癌症房间 apoptosis 并且因此是反肿瘤药开发的一个有希望的候选人。 | Xiao-Xi Guo Yang Li Chao Sun Dan Jiang Ying-Jia Lin Feng-Xie Jin Seung-Ki Lee Ying-Hua Jin | 2014 | Protein & Cell2014，5，3： | 14 |
| 20 | Epidemiology and natural history of hepatitis C virus infection显示文摘Hepatitis C virus(HCV)affects 130-210 million people worldwide and is one of the major risk factors for hepatocellular carcinoma.Globally,at least one third of hepatocellular carcinoma cases are attributed to HCV infection,and 350000 people died from HCV related diseases per year.There is a great geographical variation of HCV infection globally,with risk factors for the HCV infection differing in various countries.The progression of chronic hepatitis C to end-stage liver disease also varies in different study populations.A long-term follow-up cohort enrolling participants with asymptomatic HCV infection is essential for elucidating the natural history of HCV-caused hepatocellular carcinoma,and for exploring potential seromarkers that have high predictability for risk of hepatocellular carcinoma.However,prospective cohorts comprising individuals with HCV infection are still uncommon.The risk evaluation of viral load elevation and associated liver disease/cancer in HCV(REVEAL-HCV)study has followed a cohort of 1095 residents seropositive for antibodies against hepatitis C virus living in seven townships in Taiwan for more than fifteen years.Most of them have acquired HCV infection through iatrogenic transmission routes.As the participants in the REVEALHCV study rarely receive antiviral therapies,it provides a unique opportunity to study the natural history of chronic HCV infection.In this review,the prevalence,risk factors and natural history of HCV infection are comprehensively reviewed.The study cohort,data collection,and findings on liver disease progression of the REVEAL-HCV study are described. | Mei-Hsuan Lee Hwai-I Yang Yong Yuan Gilbert L’Italien Chien-Jen Chen | 2014 | World Journal of Gastroenterology2014，20，28： | 14 |
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