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| 1 | Cancer nanotechnology: Enhancing tumor cell response to chemotherapy for hepatocellular carcinoma therapy显示文摘Hepatocellular carcinoma(HCC)is one of the deadliest cancers due to its complexities,reoccurrence after surgical resection,metastasis and heterogeneity.In addition to sorafenib and lenvatinib for the treatment of HCC approved by FDA,various strategies including transarterial chemoembolization,radiotherapy,locoregional therapy and chemotherapy have been investigated in clinics.Recently,cancer nanotechnology has got great attention for the treatment of various cancers including HCC.Both passive and active targetings are progressing at a steady rate.Herein,we describe the lessons learned from pathogenesis of HCC and the understanding of targeted and non-targeted nanoparticles used for the delivery of small molecules,monoclonal antibodies,miRNAs and peptides.Exploring current efficacy is to enhance tumor cell response of chemotherapy.It highlights the opportunities and challenges faced by nanotechnologies in contemporary hepatocellular carcinoma therapy,where personalized medicine is increasingly becoming the mainstay.Overall objective of this review is to enhance our understanding in the design and development of nanotechnology for treatment of HCC. | Yongbing Sun Wen Ma Yuanyuan Yang Mengxue He Aimin Li Lei Bai Bin Yu Zhiqiang Yu | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，6： | 8 |
| 2 | Delivery of triptolide with reduction-sensitive polymer nanoparticles for liver cancer therapy on patient-derived xenografts models显示文摘Hepatocellular carcinoma(HCC)has become the fourth predominant cause of cancer-related deaths worldwide,and HCC is still one of the worst prognoses for survival as it is poorly responsive to both chemotherapy and surgical treatment due to drug resista nce and great toxic effects.Triptolide(TP),a key ingredient from the traditional Chinese medical herb,has been utilized to treat inflammation and antitumor for centuries.However,investigations of this potent agent have been met with only limited success due to the severe systemic toxicities in patients and low water solubility as well as its high toxicity over the past two decades.Herein,we reported the development of a reduction-responsive drug delive ry system loaded with TP fo r glutathione(GSH)-trigge red drug release for cancer therapy.With the GSH-sensitive TP loaded nanoparticles,the remarkable increases in tumor accumulation and amelioration of drug toxicity in animals are demonstrated,which is likely due to sustained stepwise release of active TP within cancer cells.Moreover,in a patient-derived tumor xenograft model of liver cancer,administration of tritolide nanoparticles enhances the antitumor efficacy relative to administration of free TP.These findings indicate that GSH-sensitive release of TP may be a promising strategy for cancer treatment. | Mengxue He Ling Yu Yuanyuan Yang Binhua Zou Wen Ma Meng Yu Jiandong Lu Guoliang Xiong Zhiqiang Yu Aimin Li | 2020 | Chinese Chemical Letters2020，31，12： | 5 |
| 3 | Expression of human FUS protein in Drosophila leads to progressive neurodegeneration显示文摘Mutations in the Fused in sarcoma/Translated in liposarcoma gene(FUS/TLS,FUS)have been identified among patients with amyotrophic lateral sclerosis(ALS).FUS protein aggregation is a major pathological hallmark of FUS proteinopathy,a group of neurodegenerative diseases characterized by FUS-immunoreactive inclusion bodies.We prepared transgenic Drosophila expressing either the wild type(Wt)or ALS-mutant human FUS protein(hFUS)using the UAS-Gal4 system.When expressing Wt,R524S or P525L mutant FUS in photoreceptors,mushroom bodies(MBs)or motor neurons(MNs),transgenic flies show age-dependent progressive neural damages,including axonal loss in MB neurons,morphological changes and functional impairment in MNs.The transgenic flies expressing the hFUS gene recapitulate key features of FUS proteinopathy,representing the first stable animal model for this group of devastating diseases. | Yanbo Chen Mengxue Yang Jianwen Deng Xiaoping Chen Ye Ye Li Zhu Jianghong Liu Haihong Ye Yan Shen Yan Li Elizabeth J.Rao Kazuo Fushimi Xiaohong Zhou Eileen H.Bigio Marsel Mesulam Qi Xu Jane Y.Wu | 2011 | Protein & Cell2011，2，6： | 1 |
| 4 | Comparison between forced-air and air-free warming on perioperative hypothermia in patients undergoing elective surgery显示文摘To the Editor:Hypothermia is described as a state in which the core temperature of a patient is decreased to equal to or<36,which is a common and severe complication among patients_undergoing elective sur-gery,.il Studies reported that hypothermia is associated withan increased riskof severaladverse events including postoperative shivering,surgical site infection,increased blood loss,and a longerlength of hospitalization.21Active warming for>30 min during the surgical procedure has been found to reduce the risk of perioperative hypothermia.Thus,more and more attention has been paid to how effectively prevent perioperative hypothermia,and many intraoperative active warming strategies have therefore been applied in,clinical practice,such as forced-air warming technology,_prewarming technology before anesthesia,resistive-polymer system,circulating water mattresses,and self-warming blanket. | Bin Ji Mengxue He Hang Chen Yu Chen Siyuan Wang Lyucheng Yang Weihong Xu Nanping Shen | 2022 | Chinese Medical Journal2022，135，19： | 1 |
| 5 | Improving RhoA-mediatedintestinal epithelial permeability by continuous bloodpurification in patients with severe acute pancreatitis显示文摘 | Qing Shen Hua Gan Mengxue Yang | 2013 | Theinternational journal of artificial organs2013，36，11： | 1 |
| 6 | Anti - inflammatory effects of 1, 25 -dihydroxyvitamin D3 in monocytes cultured in serum from patients with type 2 diabetes mellitus and diabetic nephropathy with uremia via Toll - like receptor 4 and nuclear factor - KB p65 显示文摘 | Yang Mengxue Xu Jie Yu Jie | 2015 | Molecular medicine reports2015，20，9： | 1 |
| 7 | Proinflammatory CD~4 CD1+6 monocytes are associated with microinflammation in patients with type 2 diabetes mellitus and diabetic nephropathy uremia 显示文摘 | MENGXUE YANG HUA GANG | 2012 | Inflammation2012，35，10： | 1 |
| 8 | Anti-inflammatory effects of 1,25-dihydroxyvitamin D3 in monocytes culturedin serum from patients with type 2 diabetes mellitus and diabetic nephropathywith uremia via Toll-like receptor 4 and nuclear factor-κB p65显示文摘 | Mengxue Yang Jie Xu Jie Yu Bo Yang Hua Gan Sicheng Li Xianwen Li | 2015 | Molecular Medicine Reports2015，，： | 1 |
| 9 | Improving RhoA - mediated in-testinal epithelial peimeability by continuous blood purification in patients with se-vere acute pancreatitis 显示文摘 | Qing Shen Hua Gan Mengxue Yang | 2013 | The international journal of artificial oi^ans2013，36，11： | 1 |
| 10 | 家庭因素对前青春期儿童问题行为的影响及作用机制显示文摘前青春期(preadolescence)是指从童年晚期到青春期早期的过渡时期,这一时期出现的不良表现是个体后期问题行为的重要风险因素,因此也被认为是实施干预的关键时期。研究发现,许多患有行为障碍、多动症、冲动控制障碍和焦虑症等问题行为的人在前青春期首次发作,其中家庭环境因素有重要影响。 | 邵晨冉(编译) 邢淑芬(编译) Wang Juan Yang Ying Tang Yulong Wu Mengxue Jiang Suo Zou Hong | 2021 | 基础教育参考2021，，4： | 1 |
| 11 | Recent progress of unconventional and multifunctional integrated supercapacitors显示文摘Integration can diversify the function of a device with the same volume, therefore it facilitates the development of portable, wearable and flexible electronics. In this review, we described several kinds of novel and unconventional multifunctional integrated supercapacitors which can not only be used to storage energy but also be applied to other fields such as photodetecting, electrochromics, monitoring physiological/mechanical activities, gas sensor, and so on. First, a brief introduction of the significance and advantages of multifunctional integrated supercapacitors was presented. Then we outlined the enormous progress which has been made in the area of multifunctional integrated supercapacitors. In the end, the prospects and further developments in this exciting field were also suggested. | Mengxue Chen Yun Yang Dezhi Chen Hua Wang | 2018 | Chinese Chemical Letters2018，29，4： | 1 |
| 12 | Optical properties of Zn-diffused InP layers for the planar-type InGaAs/InP photodetectors显示文摘Zn diffusion into InP was carried out ex-situ using a new Zn diffusion technique with zinc phosphorus particles placed around InP materials as zinc source in a semi-closed chamber formed by a modified diffusion furnace.The optical characteristics of the Zn-diffused InP layer for the planar-type InGaAs/InP PIN photodetectors grown by molecular beam epitaxy(MBE) has been investigated by photoluminescence(PL) measurements. The temperature-dependent PL spectrum of Zn-diffused InP samples at different diffusion temperatures showed that band-to-acceptor transition dominates the PL emission, which indicates that Zn was commendably diffused into InP layer as the acceptor. High quality Zn-diffused InP layer with typically smooth surface was obtained at 580 °C for 10 min. Furthermore, more interstitial Zn atoms were activated to act as acceptors after a rapid annealing process.Based on the above Zn-diffusion technique, a 50 μm planar-type InGaAs/InP PIN photodector device was fabricated and exhibited a low dark current of 7.73 pA under a reverse bias potential of.5 V and a high breakdown voltage of larger than 41 V(I < 10 μA). In addition, a high responsivity of 0.81 A/W at 1.31 μm and 0.97 A/W at 1.55 μm was obtained in the developed PIN photodetector. | Guifeng Chen Mengxue Wang Wenxian Yang Ming Tan Yuanyuan Wu Pan Dai Yuyang Huang Shulong Lu | 2017 | Journal of Semiconductors2017，38，12： | 0 |
| 13 | Efficient TurboID-based proximity labelling method for identifying terminal sialic acid glycosylation in living cells显示文摘TurboID,a proximity labelling method based on mutant biotin ligase,is an efficient new technique for recognizing protein-protein interactions and has been successfully applied to living cells.Sialic acid is typically the terminal monosaccharide attached to many glycoproteins and plays many important roles in many biological processes.However,the lack of enrichment methods for terminal sialic acid glycosylation in vivo hinders the identification and analysis of this glycosylation.Here,we introduce TurboID to identify terminal sialic acid glycosylation in living cells.SpCBM,the carbohydrate-binding domain of sialidase from Streptococcus pneumoniae,is fused with TurboID and overexpressed in HeLa cells.After streptavidin-based purification and detection by mass spectrometry,31 terminal sialic acid N-glycosylated sites and 1359 putative terminal sialic acid glycosylated proteins are identified,many of which are located in the cytoplasm and nucleus. | Wu Liu Yunfeng Long Yongfen Bao Yang Li Mengxue Deng Xiuyi Yang He Zhu Yanting Su | 2022 | Acta Biochimica et Biophysica Sinica2022，54，12： | 0 |
| 14 | Noise attenuation of frequency-modulated multi-rotor using sound field reproduction显示文摘Multi-rotor aircraft has great potential in urban traffic and military use and its noise problem has attracted more attention recently.Multi-rotor aircrafts are typically controlled by changing the rotation speeds of the rotors.To reduce the noise of multiple frequency-modulated rotors,a global noise attenuation method is proposed in this study.First,the fast prediction method is used to estimate the global noise of the multirotor with different configurations online.Meanwhile,the sound field reproduction method is used to obtain the control signal of the loudspeaker array to achieve global noise attenuation.Then,the influence of array arrangement on noise reduction is analyzed in the acoustic modal domain,which reveals that different optimization models are needed to minimize the noise power or/and the noise pressure in some directions when the scale of the array is limited.Next,to improve the real-time performance of the system,the online calculation of the optimal control signal is transformed into the offline design of the optimal filter,which satisfies the target frequency-domain characteristics.Finally,the experimental results of the noise of a model quadrotor in the anechoic chamber were consistent with the predicted results.The simulation results of noise attenuation for the quadrotor show that the method proposed reduced the global noise power by about 13 dB.Moreover,the noise region radiated from the quadrotor to the ground with the boundary of 40 dB was reduced to 8.4%of that before control. | Xice XU Yang LU Mengxue SHAO Jiaxin LU | 2023 | Chinese Journal of Aeronautics2023，36，11： | 0 |
| 15 | Haem Oxygenase 1 is a potential target for creating etiolated/albino tea plants (Camellia sinensis) with high theanine accumulation显示文摘Theanine content is highly correlated with sensory quality and health benefits of tea infusion.The tender shoots of etiolated and albino tea plants contain higher theanine than the normal green tea plants and are valuable materials for high quality green tea processing.However,why these etiolated or albino tea plants can highly accumulate theanine is largely unknown.In this study,we observed an Arabidopsis etiolated mutant hy1–100(mutation in Haem Oxygenase 1,HO1)that accumulated higher levels of glutamine(an analog of theanine).We therefore identified CsHO1 in tea plants and found CsHO1 is conserved in amino acid sequences and subcellular localization with its homologs in other plants.Importantly,CsHO1 expression in the new shoots was much lower in an etiolated tea plants‘Huangkui’and an albino tea plant‘Huangshan Baicha’than that in normal green tea plants.The expression levels of CsHO1 were negatively correlated with theanine contents in these green,etiolated and albino shoots.Moreover,CsHO1 expression levels in various organs and different time points were also negatively correlated with theanine accumulation.The hy1–100 was hypersensitive to high levels of theanine and accumulated more theanine under theanine feeding,and these phenotypes were rescued by the expression of CsHO1 in this mutant.Transient knockdown CsHO1 expression in the new shoots of tea plant using antisense oligonucleotides(asODN)increased theanine accumulation.Collectively,these results demonstrated CsHO1 negatively regulates theanine accumulation in tea plants,and that low expression CsHO1 likely contributes to the theanine accumulation in etiolated/albino tea plants. | Ziping Chen Shijia Lin Tingting Chen Mengxue Han Tianyuan Yang Yan Wang Shilai Bao Zhougao Shen Xiaochun Wan Zhaoliang Zhang | 2023 | Horticulture Research2023，10，2： | 0 |
| 16 | Hybridization chain reaction-based DNA nanomaterials for biosensing,bioimaging and therapeutics显示文摘DNA nanomaterials hold great promise in biomedical fields due to its excellent sequence programmability,molecular recognition ability and biocompatibility.Hybridization chain reaction(HCR)is a simple and efficient isothermal enzyme-free amplification strategy of DNA,generating nicked double helices with repeated units.Through the design of HCR hairpins,multiple nanomaterials with desired functions are assembled by DNA,exhibiting great potential in biomedical applications.Herein,the recent progress of HCR-based DNA nanomaterials for biosensing,bioimaging and therapeutics are summarized.Representative works are exemplified to demonstrate how HCR-based DNA nanomaterials are designed and constructed.The challenges and prospects of the development of HCR-based DNA nanomaterials are discussed.We envision that rationally designing HCR-based DNA nanomaterials will facilitate the development of biomedical applications. | Zhaoyue Lv Mengxue Huang Peiran Li Mengdi Xu Chi Yao Dayong Yang | 2024 | Chinese Chemical Letters2024，35，2： | 0 |
| 17 | Effects of Application of Iron Ore tailing in Soil on the Content and Allocation of Some Nutrient Elements in Gardenia jasminoides Ellis显示文摘 | Rui Li Lanfang Yang Haibo Li Mengxue Wan | 2014 | 环境科学前沿(中英文版)2014，3，2： | 0 |
| 18 | Chromosome-scale genome assembly of Cucumis hystrix-a wild species interspecifically cross-compatible with cultivated cucumber显示文摘Cucumis hystrix Chakr.(2n=2x=24)is a wild species that can hybridize with cultivated cucumber(C.sativus L.,2n=2x=14),a globally important vegetable crop.However,cucumber breeding is hindered by its narrow genetic base.Therefore,introgression from C.hystrix has been anticipated to bring a breakthrough in cucumber improvement.Here,we report the chromosome-scale assembly of C.hystrix genome(289 Mb).Scaffold N50 reached 14.1 Mb.Over 90%of the sequences were anchored onto 12 chromosomes.A total of 23,864 genes were annotated using a hybrid method.Further,we conducted a comprehensive comparative genomic analysis of cucumber,C.hystrix,and melon(C.melo L.,2n=2x=24).Whole-genome comparisons revealed that C.hystrix is phylogenetically closer to cucumber than to melon,providing a molecular basis for the success of its hybridization with cucumber.Moreover,expanded gene families of C.hystrix were significantly enriched in“defense response,”and C.hystrix harbored 104 nucleotide-binding site-encoding disease resistance gene analogs.Furthermore,121 genes were positively selected,and 12(9.9%)of these were involved in responses to biotic stimuli,which might explain the high disease resistance of C.hystrix.The alignment of whole C.hystrix genome with cucumber genome and self-alignment revealed 45,417 chromosome-specific sequences evenly distributed on C.hystrix chromosomes.Finally,we developed four cucumber-C.hystrix alien addition lines and identified the exact introgressed chromosome using molecular and cytological methods.The assembled C.hystrix genome can serve as a valuable resource for studies on Cucumis evolution and interspecific introgression breeding of cucumber. | Xiaodong Qin Zhonghua Zhang Qunfeng Lou Lei Xia Ji Li Mengxue Li Junguo Zhou Xiaokun Zhao Yuanchao Xu Qing Li Shuqiong Yang Xiaqing Yu Chunyan Cheng Sanwen Huang Jinfeng Chen | 2021 | Horticulture Research2021，8，1： | 0 |
| 19 | A new method for quantifying mitochondrial axonal transport显示文摘线粒体的 Axonal 运输为 neuronal 幸存和功能是批评的。自动地确定并且在质问的一个大数量遗体分析 mitochondrial 运动。这里,我们和一个最新发达的分析包裹用 microfluidic-chamber-cultured 神经原为成像和确定的 axonal mitochondrial 运输报导一个有效方法命名 MitoQuant。这个工具箱为为分析线粒体的动态运动模式在实时 neuronal 轴突和一个短暂速度的分析节目内追踪 mitochondrial 运动由一个自动化节目组成。用这个方法,我们在 vivo 在有教养的哺乳动物的神经原并且在果蝇的马达神经原轴突检验了 axonal mitochondrial 运动。在影响线粒体的 3 个不同范例(温度变化,药处理和基因操作) ,我们证明了这个新方法为在 mitochondrial 运动检测变化高度有效、敏感。方法显著地提高了我们的能力到份量上分析 axonal mitochondrial 运动并且允许我们在没被传统的 kymographic 分析检测的 axonal mitochondrial 运输检测动态变化。 | Mengmeng Chen Yang Li Mengxue Yang Xiaoping Chen Yemeng Chen Fan Yang Sheng Lu Shengyu Yao Timothy Zhou Jianghong Liu Li Zhu Sidan Du Jane Y. Wu | 2016 | Protein & Cell2016，7，11： | 0 |
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