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| 1 | Transcriptional Repression by Histone Deacetylases in Plants显示文摘在 histone 尾巴的 N 终点的可逆 histone acetylation 和 deacetylation 在 eukaryoticgene 活动的规定起关键作用。核心 histones 的 Acetylation 通常导致开的染色质结构并且与基因激活被联系,而 histone 的 deacetylation 经常与关上的染色质和基因压抑被相关。由 histone deacetylases (HDAC ) 的 Histone deacetylation iscatalyzed。越来越多的研究在植物表明了 histone deacetylation/acetylationon 染色体稳定性, transcriptional 规定,和开发的重要性。而且, HDAC 被显示交往在多重 developmentalprocesses 涉及 transcriptional 压抑的 withvarious 染色质 remolding 因素和抄写因素。在这评论,我们在 transcriptional 压抑上总结了最近的调查结果在 plants.Key 词由 HDAC 调停了: | Xuncheng Liua Songguang Yang Minglei Zhaoa Ming Luo Chun-Wei Yu Chia-Yang Chen Ready Tai Keqiang Wu | 2014 | Molecular Plant2014，7，5： | 16 |
| 2 | PepperHub, an Informatics Hub for the Chili Pepper Research Community显示文摘 | Feng Liu Huiyang Vu Yingtian Deng Jingyuan Zheng Minglei Liu Lijun Ou Bozhi Yang Xiongze Dai Yanqing Ma Shengyu Feng Shuang He Xuefeng Li Zhuqing Zhang Wenchao Chen Shudong Zhou Rong Chen Minmin Liu Sha Yang Ruimin Wei Huadong Li Feng Li Bo Ouyang Xuexiao Zou | 2017 | Molecular Plant2017，10，8： | 13 |
| 3 | Warming moxibustion attenuates inflammation and cartilage degradation in experimental rabbit knee osteoarthritis显示文摘OBJECTIVE:To explore the molecular mechanism of warming moxibustion(WM)in knee osteoarthritis(KOA).METHODS:The knee joints of 40 New Zealand rabbits were placed in a plaster cast in an extended position to establish a KOA model.The animals were randomly divided into four groups:the control group,model group,WM group,and diclofenac(DF)group.Hematoxylin-eosin staining and the modified Mankin score were applied to evaluate the histopathological changes.Chondrocyte apoptosis was determined by the terminal deoxynucleotidyl transferase dUTP nick end labeling(TUNEL)assay.Western blotting and real-time quantitative polymerase chain reaction were performed to measure the expression of interleukin-1β(IL-1β),prostaglandin E receptor 3(PTGER3),a disintegrin-like and metalloproteinase with thrombospondin type-1 motifs-5(ADAMTS-5),matrix metalloproteinase-13(MMP-13),and C-terminal telopeptides of collagen typeⅡ(CTX-Ⅱ)in cartilage tissues of the different groups.The concentrations of IL-1β,PTGER3,and CTX-Ⅱin serum were detected by the enzyme-linked immunosorbent assay.RESULTS:Rabbits with KOA in the WM and DF groups showed significantly reduced cartilage erosion and Mankin scores,compared with the untreated rabbits.The number of TUNEL-positive cells observed in the WM group was much fewer than that in the model group.The expression of PTGER3,MMP-13,CTX-Ⅱ,IL-1β,and ADAMTS-5 in cartilage tissues was remarkably downregulated following therapy with WM and DF.Moreover,a marked reduction was observed in the serum levels of IL-1β,PTGER3,and CTX-Ⅱin the WM and DF groups.CONCLUSION:WM exerts favorable therapeutic effects on articular injuries of KOA by regulating the expression of inflammatory and cartilage degradation-related cytokines. | LIU Di WU Yongli LI Chun WANG Minglei MA Xiaoxiu LIU Junwei ZHANG Yanling YANG Lei | 2021 | Journal of Traditional Chinese Medicine2021，41，6： | 9 |
| 4 | In situ construction of porous hierarchical(Ni3-xFex)FeN/Ni heterojunctions toward efficient electrocatalytic oxygen evolution显示文摘As a choke point in water electrolysis,the oxygen evolution reaction(OER)suffers from the severe electrode polarization and large overpotential.Herein,the porous hierarchical hetero-(Nis Fe)FeN/Ni catalysts are in situ constructed for the eficient electrocatalytic OER.X-ray absorption fine structure characterizations reveal the strong Ni-Fe bimetallic interaction in(Niz Fex)FeN/Ni.Theoretical study indicates the heterojunction and bimetallic interaction decrease the free-energy change for the rate-limiting step of the OER and the overpotential thereof.In addition,the high conductivity and porous hierarchical morphology favor the electron transfer,electrolyte access and O2 release.Consequently,the optimized catalyst achieves a low overpotential of 223 mV at 10 mA.cm^-2,a small Tafel slope of 68 mV:dec^-1,and a high stability.The excellent performance of the optimized catalyst is also demonstrated by the overall water electrolysis with a low working voltage and high Faradaic efficiency.Moreover,the correlation between the structure and performance is well established by the experimental characterizations and theoretical calculations,which confirms the origin of the OER activity from the surface metal oxyhydroxide in situ generated upon applying the current.This study suggests a promising approach to the advanced OER electrocatalysts for practical applications by constructing the porous hierarchical metal-compound/metal heterojunctions. | Minglei Yan Kun Mao Peixin Cui Chi Chen Jie Zhao Xizhang Wang Lijun Yang Hui Yang Qiang Wu Zheng Hu | 2020 | Nano Research2020，13，2： | 8 |
| 5 | Survival difference between EGFR Del19 and L858R mutant advanced non-small cell lung cancer patients receiving gefitinib:a propensity score matching analysis显示文摘Objective: Although superior clinical benefits of epidermal growth factor receptor(EGFR) tyrosine kinase inhibitors(TKIs) in the treatment of advanced non-small-cell lung cancer(NSCLC) had been reported,the survival difference between exon 19 deletion(Del19) and exon 21 Leu858 Arg substitution(L858 R) remains controversial.The purpose of this study is to investigate the differences in progression-free survival(PFS) and overall survival(OS) between different EGFR mutant subtypes among advanced NSCLC patients receiving gefitinib.Methods: There were 204 advanced NSCLC patients with EGFR mutations treated with gefitinib were enrolled in this retrospective cohort study.Patients were divided into the EGFR Del19 group and the L858 R mutated group according to their mutant subtype.Propensity score matching(PSM) was conducted by using a nearest-neighbor algorithm(1:1) to adjust for demographical and clinical covariates.Survival curves were constructed with the Kaplan-Meier method and compared by using the log-rank test.Results: The PFS in Del19 group was similar to that in the L858 R group [before PSM 8.6 vs.7.2 months,P=0.072; after PSM 7.3 vs.7.2 months,P=0.155].No differences were detected in OS between the L858 R and the Del19 group(before PSM 17.8 vs.13.1 months,P=0.253; after PSM 16.9 vs.13.1 months,P=0.339).The Del19 group was significantly younger compared with the L858 R mutation group in age(P=0.015).Conclusions: No significant difference was found in the PFS or OS between the Del19 and L858 R mutant NSCLC patients receiving gefitinib.The age gap might contribute to the survival differences between Del19 and L858 R groups.PSM is of important value to the elimination of potential bias. | Minglei Zhuo Qiwen Zheng Jun Zhao Meina Wu Tongtong An Yuyan Wang Jianjie Li Shuhang Wang Jia Zhong Xue Yang Hanxiao Chen Bo Jia Zhi Dong Emei Gao JingjingWang Ziping Wang | 2017 | Chinese Journal of Cancer Research2017，29，6： | 4 |
| 6 | Frequency steering of spaceborne clocks based on XPNAV-1 observations显示文摘Due to high stable rotations, timing of pulsars provides a natural tool to correct the frequency deviation of spaceborne atomic clocks. Based on processing the observational data about a year of Crab pulsar given by XPNAV-1 satellite, we study the possibility of correcting the frequency deviation of spaceborne atomic clocks using pulsar timing. According to the observational data in X-ray band and the timing model parameters from radio observations, the pre-fit timing residuals with a level of 67.66 μs are obtained. By fitting the slope of the timing residuals affected by the faked frequency-biased reference clock, we estimated successfully the relative frequency deviation of the reference clock. For a satellite clock with frequency deviation of the order about 10^(-12), a calibration accuracy with relative error of about 2% can be obtained from the Crab pulsar’s data for one year.The stability of the time scale based on Crab pulsar is about 10^(-12) for an interval of one year. | Mengna HAN Minglei TONG Liansheng LI Yongqiang SHI Tinggao YANG Yuping GAO | 2023 | Chinese Journal of Aeronautics2023，36，6： | 3 |
| 7 | Generation and characterization of stable pig pregastrulation epiblast stem cell lines显示文摘Pig epiblast-derived pluripotent stem cells are considered to have great potential and broad prospects for human therapeutic model developme nt and livestock breeding.Despite on going attempts since the 1990s,no stably defined pig epiblast-derived stem cell line has bee n established.Here,guided by in sights from a large-scale sin gle-cell tran scriptome an alysis of pig embryos from embryonic day(E)0 to E14,specifically,the tracing of pluripotency changes during epiblast development,we developed an in vitro culture medium for establishing and maintaining stable pluripotent stem cell lines from pig E10 pregastrulation epiblasts(pgEpiSCs).Enabled by chemical inhibition of WNT-related signaling in combination with growth factors in the FGF/ERK,JAK/STAT3,and Activin/Nodal pathways,pgEpiSCs maintain their pluripotency transcriptome features,similar to those of E10 epiblast cells,and normal karyotypes after more than 240 passages and have the potential to differentiate into three germ layers.Strikingly,ultradeep in situ Hi-C analysis revealed functional impacts of chromatin 3D-spatial associations on the transcriptional regulation of pluripote ncy marker genes in pgEpiSCs.I n practice,we con firmed that pgEpiSCs readily tolerate at least three rounds of successive gene editi ng and gene rated cloned gen e-edited live piglets.Our findings deliver on the long-a nticipated promise of pig pluripote nt stem cells and open new avenues for biological research,animal husbandry,and regenerative biomedicine. | Minglei Zhi Jinying Zhang Qianzi Tang Dawei Yu Shuai Gao Dengfeng Gao Pengliang Liu Jianxiong Guo Tang Hai Jie Gao Suying Cao Zimo Zhao Chongyang Li Xiaogang Weng Mengnan He Tianzhi Chen Yingjie Wang Keren Long Deling Jiao Guanglei Li Jiaman Zhang Yan Liu Yu Lin Daxin Pang Qianqian Zhu Naixin Chen Jingjing Huang Xinze Chen Yixuan Yao Jingcang Yang Zicong Xie Xianya Huang Mengxin Liu Ran Zhang Qiuyan Li Yiliang Miao Jianhui Tian Xingxu Huang Hongsheng Ouyang Bofeng Liu Wei Xie Qi Zhou Zhonghua Liu Caihong Zheng Mingzhou Li Jianyong Han | 2022 | Cell Research2022，32，4： | 3 |
| 8 | Development and challenges of planning and scheduling for petroleum and petrochemical production显示文摘Production planning and scheduling are becoming the core of production management,which support the decision of a petrochemical company.The optimization of production planning and scheduling is attempted by every refinery because it gains additional profit and stabilizes the daily production.The optimization problem considered in industry and academic research is of different levels of realism and complexity,thus increasing the gap.Operation research with mathematical programming is a conventional approach used to address the planning and scheduling problem.Additionally,modeling the processes,objectives,and constraints and developing the optimization algorithms are significant for industry and research.This paper introduces the perspective of production planning and scheduling from the development viewpoint. | Fupei LI Minglei YANG Wenli DU Xin DAI | 2020 | Frontiers of Engineering Management2020，7，3： | 3 |
| 9 | Engineering Geological Mapping and Land-Capability Analysis in Tangshan City显示文摘Geological environment in Tangshan City is under investigation with reference to the Tangshan Urban Earth Science, geo hazards maps. The expected loss for urban land utilization is calculated by employing relevant economic mathematic models. Quantitative analysis and comprehensive evaluation are then exercised for the capability of land utilization and a series of charts for the analysis of land use capability are worked out to provide the basis for the formulation of controlling measures for urban planning and to ensure the utmost conformity between land use and geological environment in urban planning. | Li Xianzhong Institute of Earth Science, Ocean University of Qingdao, Qingdao 266003 Department of Mechanic Engineering, Tsinghua University, Beijing 100084 Yang Zousheng Institute of Earth Science, Ocean University of Qingdao, Qingdao 266003Yang Huizhu Department of Mechanic Engineering, Tsinghua University, Beijing 100084 Hu Zunguo Shi Minglei Comprehensive Institute of Geotechnical Investigation and Surveying, Ministry of Construction, Beijing 100007 | 2002 | Journal of China University of Geosciences2002，13，3： | 2 |
| 10 | Rice In Vivo RNA Structurome Reveals RNA Secondary Structure Conservation and Divergence in Plants显示文摘RNA 第二等的结构在基因规定起一个关键作用。瑞斯(Oryza sativa ) 是在世界上的最重要的食物庄稼之一。然而,在米饭的 RNA 结构几乎没被学习。这里,我们成功地产生了在 ? 在米饭的 vivo Structure-seq 图书馆。我们发现 mRNAs 的结构的灵活性可能与生物功能的动力学联系。更高的 N 6-methyladenosine (m 6 一) 修正趋于在 3 UTR 有更少的 RNA 结构,而 GC 内容显著地不影响在 ? 维持象翻译那样的有效生物过程的 vivo mRNA 结构。在米饭和 Arabidopsis 之间的 RNA structurome 的比较分析揭示了内容不导致的那更高的 GC 更强壮的结构和更少 RNA 结构的灵活性。而且,我们发现了在顺序和在米饭和 Arabidopsis 之间的 orthologs 的结构保存之间的弱关联。顺序并且在的保存和分叉 ? vivo RNA 结构对应于多样、特定的生物过程。我们的结果显示那 RNA 第二等的结构可能把选择的分开的层提供给在 monocot 和 dicot 之间的顺序。因此,我们的学习暗示那 RNA 结构在各种各样的生物进程不同地演变在被子植物进化期间在开发和 adaptational 灵活性维持坚韧性。 | Hongjing Deng Jitender Cheema Hang Zhang Hugh Woolfenden Matthew Norris Zhenshan Liu Qi Liu Xiaofei Yang Minglei Yang Xian Deng Xiaofeng Cao Yiliang Ding | 2018 | Molecular Plant2018，11，4： | 2 |
| 11 | Electrochemical Sensor for Sensitive Determination of Ga(III) Ion Based on β-Cyclodextrin Incorporated Multi-walled Carbon Nanotubes and Imprinted Sol-gel Composite Film显示文摘为踪迹镓离子的察觉的一个新奇传感器[Ga (III )] 被一个金电极的逐步的修正与 -cyclodextrin 创造(-CD)/multi-walled 碳 nanotubes (MWCNT ) 和一个离子印了聚合物(IIP ) 。传感器表面形态学被扫描电子显微镜学描绘。印的传感器的电气化学的表演被周期的 voltammetry,微分脉搏 voltammetry 和 chronoamperometry 调查。传感器向目标 Ga (III ) 离子显示了优秀选择。同时,介绍 MWCNT 显示了显著催化活动,并且 CD 表明了重要丰富能力。一条线性刻度曲线被获得从 5.0 | Hu,Yufang Zhang,Zhaohui Zhang,Huabin Luo,Lijuan Zhang,Minglei Yang,Xiao Yao,Shouzhuo | 2012 | Chinese Journal of Chemistry2012，30，2： | 2 |
| 12 | Internet Counseling Ethics:Tools,Culture,or Context?A View of Deconstruction and Interpretation显示文摘 | Yang Minglei | 2001 | Counseling&Guidance2001，168，： | 1 |
| 13 | Plant growth forsewage sludge ecological stabilization 显示文摘 | CUI Yubo SUN Hongjie YANG Minglei | 2012 | Journal of ResidualsScience & Technology2012，9，1： | 1 |
| 14 | Unitary ES-PRIT algorithm for bistatic MIMO radar 显示文摘 | Zheng Guimei Chen Baixiao Yang Minglei | 2012 | Electronics Letters2012，48，3： | 1 |
| 15 | Selective oxi- dation of hydrogen in the presence of propylene over Pt-based core-shell nanocatalysts 显示文摘 | Yang Minglei Fan Chen Zhu Yi-An | 2015 | J Phys Chem C2015，119，21： | 1 |
| 16 | Preparation and characterization of multiresponsive polymer composite microspheres with core–shell structure显示文摘 | Jie Cai Jia Guo Minglei Ji Wuli Yang Changchun Wang Shoukuan Fu | 2007 | Colloid and Polymer Science2007，，14： | 1 |
| 17 | A rhodamine-based chromogenic and fluorescent chemosensor for copper ion in aqueous media显示文摘 | Minglei Zhao Xiao-Feng Yang Shenfeng He Liping Wang | 2008 | Sensors & Actuators: B Chemical2008，，2： | 1 |
| 18 | Clinical outcomes of atezolizumab in combination with etoposide/platinum for treatment of extensive-stage small-cell lung cancer:A real-world,multicenter,retrospective,controlled study in China显示文摘Objective:Atezolizumab along with chemotherapy has prolonged the survival of patients with extensive-stage small-cell lung cancer(ES-SCLC)worldwide,although real-world(RW)data are lacking in China.This study was designed to evaluate the efficacy and clinical outcomes of atezolizumab plus etoposide/platinum(EP).Methods:Data obtained in this retrospective study were captured from six oncology units of five medical facilities from January 2019 to April 2022.For first-line treatments,atezolizumab combined with EP vs.EP alone,we primarily evaluated progression-free survival(PFS);other efficacy indicators,including overall survival(OS),objective response rate(ORR),and patterns of SCLC progression and adverse events(AEs)were assessed.Results:The primary analysis included data from 225 patients,of whom 133 received EP along with atezolizumab(atezolizumab group)and 92 received EP alone(EP group).The PFS duration of the atezolizumab group[7.10 months;95%confidence interval(95%CI),6.53-9.00]exceeded that of the EP group(6.50 months;95%CI,4.83-7.53).Overall,the hazard ratio(HR)was 0.69(95%CI,0.49-0.97)(P=0.029);particularly,the HR was 0.54(95%CI,0.36-0.80)among patients undergoing≥4 chemotherapy cycles and 0.33(95%CI,0.20-0.56)among individuals with atezolizumab maintenance.The ORR and disease-control rate(DCR)were similar between the two groups.Because of incomplete OS data,the median OS was not determined for either group.Bone marrow suppression was the most common AE detected(58.6%)in the atezolizumab group.Immune-related AEs occurred in 19 patients in the atezolizumab group(14.3%),with only one case of grade 3 encephalitis.Conclusions:This RW study in China demonstrated improved clinical outcomes of atezolizumab along with EP for ES-SCLC,particularly in the chemosensitive population.These results align with the results of the IMpower133 study,although the impact of this treatment modality on OS warrants additional follow-up studies. | Hanxiao Chen Xiangjuan Ma Jie Liu Yu Yang Yong Fang Liping Wang Jian Fang Jun Zhao Minglei Zhuo | 2022 | Chinese Journal of Cancer Research2022，34，4： | 1 |
| 19 | Influence of Chemotherapy on EGFR Mutation Status Among Patients With Non–Small-Cell Lung Cancer显示文摘 | Hua Bai Zhijie Wang Keneng Chen Jun Zhao J. Jack Lee Shuhang Wang Qinghua Zhou Minglei Zhuo Li Mao Tongtong An Jianchun Duan Lu Yang Meina Wu Zhen Liang Yuyan Wang Xiaozheng Kang Jie Wang | 2012 | Journal of Clinical Oncology2012，，25： | 1 |
| 20 | Unitary ES- PRIT Algorithm for Bistatic MIMO Radar 显示文摘 | Zheng Guimei Chen Baixiao Yang Minglei | 2012 | Electronics Letters2012，48，3： | 1 |
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