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| 1 | Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway显示文摘 | Youjun Li Hao Zhou Fengzhi Li Siew Wee Chan Zhijie Lin Zhiyi Wei Zhou Yang Fusheng Guo Chun Jye Lim Wancai Xing Yuequan Shen Wanjin Hong Jiafu Long Mingjie Zhang | 2015 | Cell Research2015，25，7： | 9 |
| 2 | Mouse models of colorectal cancer显示文摘Colorectal cancer is one of the most common malignancies in the world. Many mouse models have been developed to evaluate features of colorectal cancer in humans. These can be grouped into genetically-engineered, chemically-induced, and inoculated models. However, none recapitulates all of the characteristics of human colorectal cancer. It is critical to use a specific mouse model to address a particular research question. Here, we review commonly used mouse models for human colorectal cancer. | Yunguang Tong Wancai Yang H. Phillip Koeffler | 2011 | Chinese Journal of Cancer2011，30，7： | 7 |
| 3 | Bridging the US and China together to conquer cancer: report of the 4th annual meeting of the US Chinese Anti-Cancer Association (USCACA)显示文摘A global collaborative effort is pivotal to conquer cancer. Themed 'Emerging role of China in global clinical development of novel anti-cancer drugs', the US Chinese Anti-Cancer Association (USCACA) held its 4th annual meeting in Chicago on June 2, 2012, in conjunction with the American Society of Clinical Oncology (ASCO) annual meeting to further bridge the US and China together to outsmart cancer. Although a young organization, USCACA has made significant contributions to this goal in the 3 years since its inception through extensive collaboration with academic organizations, the pharmaceutical industry, and governmental agencies. USCACA has engaged various stakeholders in developing translational and personalized medical strategies to facilitate new anti-cancer drug development and clinical trials in China. USCACA has initiated and implemented the USCACA-National Foundation for Cancer Research (NFCR) scholarship to encourage overseas returnees to continue cancer research in China. USCACA announced the Hengrui-USCACA scholarship to fund clinical trial staff from China to conduct the observation of early oncologic clinical trials in the US. During the annual meeting, distinguished panelists and the audience discussed the following critical topics:(1) oncologic translational research and early development capabilities in China;(2) novel chemical entity development and partnership with Chinese companies; and (3) Chinese participation in global anti-cancer drug development. USCACA will continue to promote collaborations among cancer researchers and clinicians in the US and China by engaging in more frequent communications and joint efforts across fields, disciplines, and countries, diligently working together toward curing and eliminating cancers. | Wancai Yang Lingjie Guan | 2012 | Chinese Journal of Cancer2012，31，7： | 5 |
| 4 | Metal ion-promoted fabrication of melanin-like poly(L-DOPA)nanoparticles for photothermal actuation显示文摘Melanin-inspired polymers are currently the focus of growing interest for a wide range of applications ranging from energy to biomedical area.Whilst researchers have made numerous attempts to prepare and utilize polydopamine nanoparticles(PDA NPs),they have made limited progress in developing and discovering another typical functional mimic of natural melanin,poly(levodopa)(P(L-DOPA))NPs,probably due to the lack of facile synthetic strategies towards satisfactory structural and functional control of melanin-like NPs.Herein,we reported a one-pot preparation method towards P(L-DOPA)NPs with good yields and controllable size/property in an aqueous solution assisted by various metal ions(i.e.,Ni(II),Mg(II),Ca(II),Fe(III),Mn(II),Co(II),Zn(II)and Cd(II)).Interestingly,the resulting P(L-DOPA)NPs exhibited enhanced light absorption and photothermal behaviors compared with well-established PDA NPs,which can be employed to further fabricate kinds of photothermal composite actuators with promising performances such as folding,switching,and forward-moving.This study offers a facile and robust way to synthesize new synthetic melanins beyond PDA,and facilitates further functional discovery and evolution of melanin-inspired polymers and composites. | Xianheng Wang Lei Yang Peng Yang Wancai Guo Quan-Ping Zhang Xianhu Liu Yiwen Li | 2020 | Science China Chemistry2020，63，9： | 3 |
| 5 | Biological functions of decorin in cancer显示文摘Decorin is a member of the extracellular matrix small leucine-rich proteoglycans family that exists and functions in stromal and epithelial cells. Accumulating evidence suggests that decorin affects the biology of various types of cancer by directly or indirectly targeting the signaling molecules involved in cell growth, survival, metastasis, and angiogenesis. More recent studies show that decorin plays important roles during tumor development and progression and is a potential cancer therapeutic agent. In this article, we summarize recent studies of decorin in cancer and discuss decorin′s therapeutic and prognostic value. | Xiu-Li Bi Wancai Yang | 2013 | Chinese Journal of Cancer2013，32，5： | 3 |
| 6 | The USCACA hosted symposiums at the 7th CACA annual meeting and the 15th CSCO annual meeting in Beijing显示文摘In September 2012,the US Chinese Anti-Cancer Association(USCACA) hosted two symposiums in Beijing.The USCACA hosted the first joint session at the 7th annual meetings of the Chinese Anti-Cancer Association(CACA),themed on 'Collaboration between the US and China in Cancer Research.' Six experts from the United States and China presented their latest work on basic and translational cancer research.During this symposium,5 young Chinese scholars,returnees after their training in the United States,were honored the'AFCR-USCACA Scholarships Award.' The USCACA hosted a second symposium during the 15th annual meeting of the Chinese Society of Clinical Oncology(CSCO),focused on the 'US-China Collaboration in Cancer Drug Clinical Development.' An international delegation of oncology experts presented the innovative clinical trial strategies and discussed the biomarkers for cancer early detection and clinical trials,targeted therapy,and new drug development.The Oncology Drug Clinical Development and Safety Evaluation Committee was also launched to promote an innovative environment and to provide a collaborative platform for anti-cancer drug development in China. | Michael Shi Wancai Yang Pascal Qian Li Yan | 2012 | Chinese Journal of Cancer2012，31，11： | 2 |
| 7 | Transforming growth factor-β1 induces glutathione peroxidase-1 and protectsfrom H2O2-induced cell death in colon cancer cells via the Smad2/ERK1/2/HIF-1αpathway显示文摘 | Ying Huang Wenfeng Fang Yulei Wang Wancai Yang Bin Xiong | 2012 | International Journal of Molecular Medicine2012，，5： | 1 |
| 8 | Proanthocyanidins extracted from grape seeds inhibit the growth of hepatocellular carcinoma cells and induce apoptosis through the MAPK/AKT pathway显示文摘Proanthocyanidins naturally occur in various fruits,some vegetables and beverages.Increasing evidence has shown that dietary intake of proanthocyanidins is a promising alternative to tumor chemoprevention or chemotherapy.Grape seeds are the most abundant source of proanthocyanidins,and grape seed proanthocyanidins(GSPs)show an anticancer effect on hepatocellular carcinoma(HCC),which accounts for approximately 85-90%of all primary liver malignancies.Although an increasing number of studies have investigated the effects of GSPs on HCC and the associated mechanisms,the precise mechanism of GSP therapy in HCC remains unclear.This study aimed to understand the cytotoxic effect of GSPs on HepG2 cells by investigating morphology and growth inhibition.Cell proliferation and apoptosis were estimated by an MTT assay and flow cytometry,and the protein expression of HepG2 cells was determined through Western blotting.The results indicated that GSPs could markedly inhibit HepG2 liver cancer cells and induce apoptosis,with the effects varying by dose and treatment time.Furthermore,GSPs inhibited the phosphorylation of extracellular regulated protein kinases(ERK),c-Jun NH2-terminal kinase(JNK),p38 mitogen-activated protein kinase(p38 MAPK),IκBα,pyruvate dehydrogenase kinase 1(PDK1),glycogen synthase kinase-3 beta(GSK3β)and protein kinase B(AKT),which accounted for the inactivation of mitogen-activated protein kinase/AKT(MAPK/AKT)pathways.These results indicate that GSPs are a potential source of natural chemopreventive agents for the treatment of HCC. | Wancai Zheng a Yujing Feng Yujia Bai Zuoshan Feng Xijuan Yang Bin Dang Ming Xiao Jianmei Zhang Sheng-Qiang Han | 2022 | Food Bioscience2022，45，1： | 1 |
| 9 | A sequence variant in the phospholipase C epsilon C2 domain is associated with esophageal carcinoma and esophagitis显示文摘 | Li‐Dong Wang Xiuli Bi Xin Song Nicole M. Pohl Yulan Cheng Yixing Zhou Stephen Shears Emmanuel Ansong Mengtao Xing Shaomeng Wang Xiao‐Chun Xu Peng Huang Liyan Xu Liang Wang Zongmin Fan Xueke Zhao Huali Dong Stephen J. Meltzer Ivan Ding Wancai Yang | 2013 | Mol Carcinog2013，，1： | 1 |
| 10 | Soy isoflavones and prostate cancer: a review of molecular mechanisms显示文摘 | Mahmoud Abeer M Yang Wancai Bosland Maarten C | 2014 | The Journal of Steroid Biochemistry and Molecular Biology2014，140，： | 1 |
| 11 | Soy isoflavones and prostate cancer: A review of molecular mechanisms显示文摘 | Abeer M. Mahmoud Wancai Yang Maarten C. Bosland | 2013 | Journal of Steroid Biochemistry and Molecular Biology2013，，： | 1 |
| 12 | Control of paleogeographic pattern on sedimentary differentiation of evaporite-carbonate symbiotic system:A case study of the sixth sub-member of Ordovician Majiagou Formation M5 Member in central-eastern Ordos Basin,NW China显示文摘The relationship between paleogeographic pattern and sedimentary differentiation of evaporite-carbonate symbiotic system is examined based on logging,core and thin section data,by taking the sixth sub-member of fifth member of Ordovician Majiagou Formation(M56)in the central-eastern Ordos Basin as an example.(1)Seven sub-geomorphic units(Taolimiao west low,Taolimiao underwater high,Taolimiao east low,Hengshan high,East salt low,North slope and Southwest slope)developed in the study area.(2)The“three lows”from west to east developed dolomitic restricted lagoon,evaporite evaporative lagoon and salt evaporative lagoon sedimentary facies respectively,the'two highs'developed high-energy grain beach and microbial mound,and the north and south slopes developed dolomitic flats around land.(3)The paleogeographic pattern caused natural differentiation of replenishment seawater from the northwest Qilian sea,leading to the eccentric sedimentary differentiation of dolomite,evaporite and salt rock symbiotic system from west to east,which is different from the classic“bull's eye”and“tear drop”distribution patterns.(4)As the Middle Qilian block subducted and collided into the North China Plate,the far-end compression stress transferred,giving rise to the alternate highland and lowland in near north to south direction during the sedimentary period of M56 sub-member.(5)Taolimiao underwater high and Hengshan high developed favorable zones of microbial mounds and grain shoals in south to north strike in M56 sub-member,making them favorable exploration areas with great exploration potential in the future. | ZHONG Shoukang TAN Xiucheng HU Guang NIE Wancai YANG Mengying ZHANG Daofeng ZHENG Jianfeng XU Jie DONG Guodong XIAO Di LU Zixing | 2022 | Petroleum Exploration and Development2022，49，4： | 0 |
| 13 | A new treatment for cognitive disorders related to in utero exposure to alcohol显示文摘Maternal alcohol consumption during pregnancy has detrimental effects on fetal central nervous system development. Maternal alcohol consumption prior to and during pregnancy significantly affects cognitive functions in offspring, which may be related to changes in cyclin-dependent kinase 5 because it is associated with modulation of synaptic plasticity and impaired learning and memory. In this study, we examined adult offspring in a maternal alcohol consumption model in rats. Y-maze test results showed that in utero exposure to alcohol impairs learning and memory capacities. Cyclin-dependent kinase 5 mRNA and protein expressions in the hippocampus of the offspring were significantly elevated, as assayed by quantitative real-time PCR and reverse transcription-PCR, immunofluorescence, and immuno-precipitation. Our experimental findings strongly suggest that altered cyclin-dependent kinase 5 may mediate impaired learning and memory in adult rats that were exposed to alcohol by maternal consumption while in utero. | Shuang Li Yan Zhang Feng Zhu Bin Zhang Jianying Lin Chunyang Xu Wancai Yang Wei Hao Ruiling Zhang | 2013 | Neural Regeneration Research2013，8，18： | 0 |
| 14 | Dispersal patterns in Yunnan snub-nosed monkeys显示文摘Sex-biased dispersal is common in group-living animals.Due to differences in local demographic and environmental factors,sex-biased dispersal presents many irregular patterns.In this study,a habituated,individually identified Yunnan snub-nosed monkey Rhinopithecus bieti group was observed over 9 years;192 dispersal events,including 97 male dispersal events(25 natal dispersal and 72 secondary dispersal)and 95 female dispersal events(34 natal dispersal and 61 secondary dispersal)were observed.Males and females showed different dispersal paths,dispersal ages,and dispersal patterns.Females had 2 dispersal paths,whereas males had 4 paths.In terms of age of dispersal,the male age of natal dispersal was younger than for females.Males prefer single dispersal,whereas females prefer parallel dispersal.Our study indicates that the dispersal pattern of R.bieti should be classified as a bisexual dispersal pattern.The differences in dispersal path,average age at dispersal,and dispersal path pattern indicate that Yunnan snub-nosed monkeys may still retain a loose matrilineal social system. | Wancai XIA Fan WANG Dali WANG Xiaoqin ZENG Chan YANG Ali KRZTON Baoping REN Dayong LI | 2022 | Current Zoology2022，68，3： | 0 |
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