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| 1 | A novel synthetic small molecule YF-452 inhibits tumor growth through antiangiogenesis by suppressing VEGF receptor 2 signaling显示文摘Tumor angiogenesis is characterized by abnormal vessel morphology, endowing tumor with highly hypoxia and unresponsive toward treatment. To date, mounting angiogenic factors have been discovered as therapeutic targets in antiangiogenic drug development. Among them, vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors exerts potent antiangiogenic activity in tumor therapy. Therefore, it may provide a valid strategy for cancer treatment through targeting the tumor angiogenesis via VEGFR2 pathway. In this study, we established a high-profile compounds library and certificated a novel compound named N-(N-pyrrolidylacetyl)-9-(4-bromobenzyl)-1,3,4,9-tetrahydro-β-carboline (YF-452), which remarkably inhibited the migration, invasion and tube-like structure formation of human umbilical vein endothelial cells (HUVECs) with little toxicity invitro. Rat thoracic aorta ring assay indicated that YF-452 significantly blocked the formation of microvascular exvivo. In addition, YF-452 inhibited angiogenesis in chick chorioallantoic membrane (CAM) and mouse corneal micropocket assays. Moreover, YF-452 remarkably suppressed tumor growth in xenografts mice model. Furthermore, investigation of molecular mechanism revealed that YF-452 inhibited VEGF-induced phosphorylation of VEGFR2 kinase and the downstream protein kinases including extracellular signal regulated kinase (ERK), focal adhesion kinase (FAK) and Src. These results indicate that YF-452 inhibits angiogenesis and may be a potential antiangiogenic drug candidate for cancer therapy. | Yongrui Liu Yuan He Feifei Yang Xiaonan Cong Jinhua Wang Shihong Peng Dan Gao Weifang Wang Liping Lan Xuexiang Ying Mingyao Liu Yihua Chen Zhengfang Yi | 2017 | Science China(Life Sciences)2017，60，2： | 2 |
| 2 | Synthesis and properties of poly(acrylic acid)/mica superabsorbent nanocomposite显示文摘 | Lin Jianming Wu Jihuai Yang Zhengfang | 2001 | Macromolecular Rapid Communication2001，22，： | 1 |
| 3 | Synthesis and properties of poly(acrylic acid)/mica superabsorbent nanocomposite显示文摘 | Lin Jianming Wu Jihuai Yang Zhengfang | 2001 | Macromolecular Rapid Communications2001，22，6： | 1 |
| 4 | Friction and characteristics of mullite,ZTM and TZP ceramic显示文摘 | Kong Yongfa Yang Zhengfang Zhang Guangyin | 1998 | Wear1998，218，： | 1 |
| 5 | 显示文摘 | Lin Jianming Yang Zhengfang Pu Minli | 2001 | Acta Mineralogica Sinica2001，9，： | 1 |
| 6 | Oligo-fluoropolymer Modified Cycloaliphatic Epoxy Resins with Excellent Compatibility, Waterproof and Mechanical Properties for LED Encapsulation显示文摘 | SUN Yang LIU Weiqu WANG Zhengfang TAN Jianquan | 2018 | Chemical Research in Chinese Universities2018，34，2： | 1 |
| 7 | Synthesis and properties of pely ( acrylic acid )/mica superabsorbent nanocomposite显示文摘 | Jianming Lin Jihuai Wu Zhengfang Yang | | Macromolecular Rapid Communications0，22，6： | 1 |
| 8 | One-time sintering process to modify xLi2MnO3(1-x)LiMO2 hollow architecture and studying their enhanced electrochemical performances显示文摘To solve the critical problems of lithium rich cathode materials, e.g., structure instability and short cycle life, we have successfully prepared a ZrO2-coated and Zr-doping xLi2MnO3·(1–x)LiMO2 hollow architecture via one-time sintering process. The modified structural materials as lithium-ion cathodes present good structural stability and superior cycle performance in LIBs. The discharge capacity of the ZrO2-coated and Zr-doped hollow pristine is 220 mAh g-1 at the 20th cycle at 0.2 C(discharge capacity loss, 2.7%)and 150 m Ah g-1 at the 100 th cycle at 1 C(discharge capacity loss, 17.7%), respectively. However, hollow pristine electrode only delivers 203 m Ah g-1 at the 20 th cycle at 0.2 C and 124 mAh g-1 at the 100 th cycle at 1 C, respectively, and the corresponding to capacity retention is 92.2% and 72.8%, respectively.Diffusion coefficients of modified hollow pristine electrode are much higher than that of hollow pristine electrode after 100 cycles(approach to 1.4 times). In addition, we simulate the adsorption reaction of HF on the surface of ZrO2-coated layer by the first-principles theory. The calculations prove that the adsorption energy of HF on the surface of ZrO2-coated layer is about-1.699 e V, and the ZrO2-coated layer could protect the hollow spherical xLi2MnO3·(1–x)LiMO2 from erosion by HF. Our results would be applicable for systematic amelioration of high-performance lithium rich material for anode with the respect of practical application. | Renheng Wang Yiling Sun Kaishuai Yang Junchao Zheng Yan Li Zhengfang Qian Zhenjiang He Shengkui Zhong | 2020 | Journal of Energy Chemistry2020，29，11： | 1 |
| 9 | Lowering the synthesis temperature of zircon powder by yttria addition显示文摘 | DU Chunsheng YUAN Qiming YANG Zhengfang | 1999 | Journal of Materials Science Letters1999，18，： | 1 |
| 10 | Synthesis and properties of poly(acrylic acid)/mica superabsorbent nanocomposite显示文摘 | Lin Jianming Wu Jihuai Yang Zhengfang | 2001 | Macromolecular Rapid Communication2001，22，42： | 1 |
| 11 | Spectral Tetris Fusion Frame Constructions显示文摘 | Peter G. Casazza Matthew Fickus Andreas Heinecke Yang Wang Zhengfang Zhou | 2012 | Journal of Fourier Analysis and Applications2012，，4： | 1 |
| 12 | Necessary and sufficient conditions to perform Spectral Tetris显示文摘 | Peter G. Casazza Andreas Heinecke Keri Kornelson Yang Wang Zhengfang Zhou | 2012 | Linear Algebra and Its Applications2012，，： | 1 |
| 13 | Constructing tight fusion frames显示文摘 | Peter G. Casazza Matthew Fickus Dustin G. Mixon Yang Wang Zhengfang Zhou | 2010 | Applied and Computational Harmonic Analysis2010，，2： | 1 |
| 14 | Synthesis and properties of poly(acrylic acid) / mica superabsorbent nanocomposite 显示文摘 | JIANMING LIN JIHUAI WU ZHENGFANG YANG | 2001 | Macromolecular Rapid Communications2001，22，6： | 1 |
| 15 | Lowering the synthesis temperature of zircon powder by yttria addition显示文摘 | DU Chunsheng YUAN Qiming YANG Zhengfang | 1999 | Journal of Materials Science Letters1999，18，： | 1 |
| 16 | Synthesis and propertier of poly-acrylic acid/mica superabsorbent nanocomposite显示文摘 | Lin Jianming Wu Jihuai Yang Zhengfang | 2001 | Macromolecular Rapid Communications2001，，6： | 1 |
| 17 | Synthesis and properties of poly-acrylic acid/mica superabsorbent composite显示文摘 | Lin Jianming Wu Jihuai Yang Zhengfang | 2001 | Macromolecular Rapid Communications2001，22，6： | 1 |
| 18 | 显示文摘 | Lin Jianming Yang Zhengfang Pu Minli | 2001 | Acta Mineralogica Sinica2001，9，： | 1 |
| 19 | Preparation and properties of the AEQ/alcohol/alkane/ water reverse microemulsion ceramic inks 显示文摘 | Ruisong Guo Haitao Qi Zhengfang Yang | 2004 | Ceramics International2004，30，： | 1 |
| 20 | Comparison of four aquatic plant treatment systems for nutrient removal from eutrophied water显示文摘 | Jihua Li Xiaoying Yang Zhengfang Wang Ying Shan Zheng Zheng | 2014 | Bioresource Technology2014，，： | 1 |
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