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| 1 | Tomographic SAR imaging with large elevation aperture: a P-band small UAV demonstration显示文摘Elevation resolution is an important indicator in tomographic SAR imaging as it represents the ability to discriminate closed targets in elevation. In general, the elevation resolution is proportional to the length of the elevation aperture. However, as the elevation aperture increases, the geometric consistency of the image will undesirably deteriorate and hence fails the image coregistration approach required by the traditional super-resolution tomographic imaging. In this paper, a new super-resolution tomographic imaging method is proposed to overcome the inconsistency problem caused by the large elevation aperture. The core strategy is to get rid of two-dimensional image coregistration by applying a three-dimensional(3 D) back projection like imaging manner: the 3 D space is firstly divided into a 3 D imaging grid, each of which is individually imaged via compressive sensing for super-resolution. The effectiveness of the proposed approach is evaluated by both computer simulations and real P-band UAV SAR data. | Tao ZENG Minkun LIU Yan WANG Zegang DING Linghao LI Zhen WANG Yangkai WEI Jianping WANG | 2022 | Science China(Information Sciences)2022，65，3： | 2 |
| 2 | Titanium carbide nanosheets with defect structure for photothermal-enhanced sonodynamic therapy显示文摘Sonodynamic therapy(SDT)has attracted widespread interest in biomedicine,owing to its novel and noninvasive therapeutic method triggered by ultrasound(US).Herein,the Ti_(3)C_(2) MXene nanosheets(Ti_(3)C_(2) NSs)are developed as good sonosensitizers via a two-step method of chemical exfoliation and high-temperature treatment.With the high-temperature treatment,the oxygen defect of Ti_(3)C_(2) MXene nanosheets(H-Ti_(3)C_(2) NSs)is greatly increased.Therefore,the electron(e^(-))and hole(h^(+))generated by US can be separated faster due to the improved degree of oxidation,and then the recombination of e^(-)-h^(+)can be prevented with the abundant oxygen defect under US irradiation,which induced the sonodynamic efficiency greatly to improve around 3.7-fold compared with Ti_(3)C_(2) NSs without high-temperature treatment.After PEGylation,the H-Ti_(3)C_(2)-PEG NSs show good stability and biocompatibility.In vitro studies exhibit that the inherent property of mild photothermal effect can promote the endocytosis of H-Ti_(3)C_(2)-PEG NSs,which can improve the SDT efficacy.In vivo studies further display that the increased blood supply by the mild photothermal effect can significantly relieve hypoxia in the tumor microenvironment,showing photothermal therapy(PTT)enhanced SDT.Most importantly,the H-Ti_(3)C_(2)-PEG NSs can be biodegraded and excreted out of the body,showing no significant long-term toxicity.Our work develops the defective H-Ti_(3)C_(2) NSs as high-efficiency and safe sonosensitizers for photothermal-enhanced SDT of cancer,extending the biomedical application of MXene-based nanoplatforms. | Guangqiang Li Xiaoyan Zhong Xianwen Wang Fei Gong Huali Lei Yangkai Zhou Chengfei Li Zhidong Xiao Guoxi Ren Liang Zhang Zhiqiang Dong Zhuang Liu Liang Cheng | 2022 | Bioactive Materials2022，7，2： | 1 |
| 3 | Aldosterone dysregulation predicts the risk of mortality and rehospitalization in heart failure with a preserved ejection fraction显示文摘Serum aldosterone is associated with cardiac remodeling,which contributes to morbidity and mortality in heart failure(HF);however,the prognostic value of aldosterone in HF with a preserved ejection fraction(HFpEF)is unclear.We used liquid chromatography-tandem mass spectrometry to quantify serum aldosterone in 873 patients with HFpEF in a Registry Study of Biomarkers for HF.The retrospective study was conducted at Beijing Anzhen Hospital from May 2017 to October 2019.The primary endpoint was a composite of all-cause mortality and rehospitalization for HF.Aldosterone concentrations in patients with and without events were 124.22 pmol L^(-1)(interquartile range(IQR):48.62–256.20)and 96.33 pmol L^(-1)(IQR:37.33–215.76),respectively(P=0.023).Aldosterone independently predicted all-cause mortality(adjusted hazard ratio(aHR),1.55;95%confidence interval(95%CI),1.06–2.27;P=0.024)and the primary endpoint(a HR,1.43;95%CI,1.11–1.85;P=0.006).Patients with high aldosterone concentrations were at higher risk of concentric remodeling(adjusted odds ratio(aOR),1.45;95%CI,1.03–2.04;P=0.034).Patients with high aldosterone and B-type natriuretic peptide concentrations were at a higher risk of the primary endpoint(hazard ratio(HR),1.85;95%CI,1.29–2.66;P=0.001).We conclude that elevated aldosterone is associated with a risk of rehospitalization with HF and all-cause mortality in patients with HFpEF. | Bingbing Ke Xin Tan Lu Ren Yangkai Fan Yixin Zhang Fengjuan Li Qiqi Sun Tong Liu Lixin Jia Yuan Wang Jie Du | 2022 | Science China(Life Sciences)2022，65，3： | 1 |
| 4 | Construction of Industrialization Development Model for'1+4+X'Community-Based Elderly Care in Gannan Old Revolutionary Base Area in the Context of Population Aging显示文摘In the context of controlling population development in a planned way,China entered an aging society in the early 21 st century.In this context,how to meet the needs of the elderly care and form an effective elderly care model has become a key problem to be solved urgently by local government departments.With the continuous advancement of the elderly care policy,the community-based elderly care has gradually become the mainstream and is in the stage of vigorous promotion.Taking the Gannan old revolutionary base area in Jiangxi Province as an example,this study puts forward'1+4+X'community-based elderly care model based on the policy system of community-based elderly care,the physical and mental health of the elderly,the material space and the construction of evaluation system,and explores how to promote the application of this community model efficiently in the form of industrialization,so as to drive the economic growth of the Gannan old revolutionary base area,promote the employment development and improve the community-based elderly care service. | Chenxin YANG Jun XIAO Liyuan WANG Jiaxin LIU Yangkai LU | 2023 | Asian Agricultural Research2023，15，5： | 0 |
| 5 | Improving anti-Gram-positive-bacterial performance and osteogenesis for zinc alloy via mussel mimetic polydopamine with non-antibiotic lysozyme and parathyroid hormone显示文摘In this work,a novel coating with a non-antibiotic agent for inhibiting Gram-positive bacteria and promoting osteogenesis was prepared on zinc-aluminium alloy(ZA6-1)via mussel mimetic polydopamine(PDA)containing lysozyme(LYS)and parathyroid hormone(PTH).The results indicate that as-deposited coatings can efficiently decrease the degradation rate of ZA6-1 from 0.52 to 0.16 mm/year,and the addition of LYS weakens the coating resistance,while the addition of PTH enhances the coating resis-tance.In spite that no obvious inhibition of Escherichia coli is observed,the coated zinc alloys show good in vitro antibacterial performance against Staphylococcus aureus.Compared with ZA6-1 zinc alloys,the increase of antibacterial efficacy reaches 86.9%-90.1%.Furthermore,the lower hydrophilicity(26.4°),higher osteoblast cell viability(>100%),good osteoblast cell morphology and better osteoblast cell differentiation(ALP=107.7%)for PDA-LYS/PTH coated samples support that as-prepared coating is promising for modifying biodegradable zinc implants. | Deren Zhao Tianhao Chen Jinqian Chen Banglun Huang Jihua Nie Hulin Liu Yangkai Liu Zilin Chen Feng Zou Qiqi Lu Xiaodong Tan Yunjie Xiang Jing Li Yongping Zhang Xue Feng Xi Rao | 2023 | Biosurface and Biotribology2023，9，4： | 0 |
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