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| 1 | Bipolar transurethral enucleation and resection of the prostate:Whether it is ready to supersede TURP?显示文摘Objective:According to the EAU Guidelines,transurethral resection of the prostate(TURP)has so far still been considered as the gold standard for surgical treatment for patients with obstructing clinical benign prostate hyperplasia(BPH).However,its relatively high rate of complications and postoperative recurrence necessitates further modification and innovation on the surgery technique.We reported the patient outcomes with our technique.Methods:We retrospectively analyzed 52 patients with obstructing clinical BPH who underwent bipolar transurethral enucleation and resection of the prostate(B-TUERP)between March 2015 and September 2015.Pre-and perioperative parameters were obtained from medical charts.Postoperative follow-ups were administrated at 1,3,6,12 and 24 month(s)after surgery,respectively.Results:All the operations were performed successfully with a mean operative time of 43.1 min and an average tissue removal rate of 74.7%.Qmax was significantly improved immediately after surgery,followed by a continuous improvement throughout the follow-ups.Following a steep decrease in mean prostate specific antigen(PSA)and post void residual(PVR)observed within the first half year after surgery,the serum PSA was then maintained at a constant level of 0.61 ng/mL.Temporary urinary retention was found in four cases(7.7%).Stress urinary incontinence occurred in five patients(9.6%),with the condition resolved in 1e2 weeks without extra treatment.Urethral strictures and bladder neck contractures,as the most commonly observed long-term complications,developed in four patients(7.7%).No recurrence was found during 2 years of follow-ups.An improvement in International Index of Erectile Function(IIEF-5)scores was witnessed in 17 patients preoperatively with normal sexual function during the first 6 months after surgery,and sustained throughout the 24-month period.Conclusions:Enucleation reflects an improvement on surgical technique in many ways with a need for surgical equipment that can be broadly accessible in clinical practice.Currently,bipolar resection is a commonly employed procedure in clinical settings,and its similarity shared with bipolar enucleation technique warrants a quick learning of B-TUERP by urologists.Based on these findings,we believe that the substitution of TURP by TUERP as the gold standard for prostate endoscopic procedure can be expected in the future. | Peng Xu Abai Xu Binshen Chen Shaobo Zheng Yawen Xu Hulin Li Haiyan Shen Chunxiao Liu | 2018 | Asian Journal of Urology2018，5，1： | 19 |
| 2 | Transurethral Enucleation and Resection of Prostate in Patients With Benign Prostatic Hyperplasia by Plasma Kinetics显示文摘 | Chunxiao Liu Shaobo Zheng Hulin Li Kai Xu | 2010 | The Journal of Urology2010，，6： | 2 |
| 3 | Reactive oxygen species generation is essential for cisplatininduced accelerated senescence in hepatocellular carcinoma显示文摘因为这个过程涉及肿瘤抑制并且被许多化学疗法的代理人导致了,加速的老朽是重要的。基于铂的化学疗法的代理人 cisplatin 显示大量 antitumor 活动。然而,在 hepatocellular 癌(HCC ) 的导致 cisplatin 的加速的老朽的分子的机制仍然保持不清楚。在现在的学习,生长 HepG2 和 SMMC-7721 细胞上的 cisplatin 的禁止的效果被 3-(4,5-dimethylthiazol-2-yl ) 检测 -2,5-diphenyltetrazolium 溴化物试金。细胞的老朽然后被牛乳糖试金估计。包括 p53, p21,和 p16,老朽相关的因素被量的反向的抄写聚合酶链反应评估。反应的氧种类(ROS ) 被流动 cytometry 分析。我们的结果表明 cisplatin 在一个剂量依赖者和时间依赖者举止减少了 HepG2 和 SMMC-7721 房间的增长。在 cisplatintreated hepatoma 房间观察的衰老的显型依赖于 p53 和 p21 激活然而并非在 p16 激活上。而且, cisplatininduced 加速了取决于的老朽细胞内部的 ROS 产生。ROS scavenger N-acetyl-L-cysteine 显著地也压制了 HepG2 和 SMMC-7721 房间的导致 cisplatin 的老朽。在结论,我们的结果揭示了在细胞内部的 ROS 产生和导致 cisplatin 的加速的老朽之间的一个功能的连接,并且这个连接可以被用作 HCC 的一个潜在的目标。 | Kai Qu Ting Lin Zhixin Wang Sinan Liu Hulin Chang Xinsen Xu Fandi Meng Lei Zhou Jichao Wei Minghui Tai Yafeng Dong Chang Liu | 2014 | Frontiers of Medicine2014，8，2： | 2 |
| 4 | Pt support of multidimensional active sites and radial channels formed by SnO 2 flower-like crystals for methanol and ethanol oxidation显示文摘 | Hulin Zhang Chenguo Hu Xiaoshan He Liu Hong Guojun Du Yan Zhang | 2011 | Journal of Power Sources2011，，10： | 1 |
| 5 | Transurethml enucleation and resection of prostate for patients in benign prostate hyperplasia by plasmakinetic system显示文摘 | Chunxiao Liu Shaobo Zheng Hulin Li | 2010 | J Urol2010，184，6： | 1 |
| 6 | Pt support of multidimensional active sites and radial channels formed by SnO 2 flower-like crystals for methanol and ethanol oxidation显示文摘 | Hulin Zhang Chenguo Hu Xiaoshan He Liu Hong Guojun Du Yan Zhang | 2011 | Journal of Power Sources2011，，10： | 1 |
| 7 | Percutaneous Nephrolithotomy under Local Infiltration Anesthesia: A Single-Center Experience of 2000 Chinese Cases显示文摘 | Hulin Li Kai Xu Bingkun Li Binshen Chen Abai Xu Yuanbo Chen Yawen Xu Yong Wen Shaobo Zheng Chunxiao Liu | 2013 | Urology2013，，： | 1 |
| 8 | Titanium dioxide doped polyaniline 显示文摘 | Xu Jichuan Liu Weimin Li Hulin | 2005 | Materials Science and Engineer- ing: C2005，25，4： | 1 |
| 9 | Transurethral enu- eleation and resection of prostate in patients with benign prostatic hyperplasia by plasma kinetics 显示文摘 | LIU Chunxiao ZHENG Shaobo LI Hulin | 2010 | The Journal of Urology2010，184，6： | 1 |
| 10 | Improving anti-Gram-positive-bacterial performance and osteogenesis for zinc alloy via mussel mimetic polydopamine with non-antibiotic lysozyme and parathyroid hormone显示文摘In this work,a novel coating with a non-antibiotic agent for inhibiting Gram-positive bacteria and promoting osteogenesis was prepared on zinc-aluminium alloy(ZA6-1)via mussel mimetic polydopamine(PDA)containing lysozyme(LYS)and parathyroid hormone(PTH).The results indicate that as-deposited coatings can efficiently decrease the degradation rate of ZA6-1 from 0.52 to 0.16 mm/year,and the addition of LYS weakens the coating resistance,while the addition of PTH enhances the coating resis-tance.In spite that no obvious inhibition of Escherichia coli is observed,the coated zinc alloys show good in vitro antibacterial performance against Staphylococcus aureus.Compared with ZA6-1 zinc alloys,the increase of antibacterial efficacy reaches 86.9%-90.1%.Furthermore,the lower hydrophilicity(26.4°),higher osteoblast cell viability(>100%),good osteoblast cell morphology and better osteoblast cell differentiation(ALP=107.7%)for PDA-LYS/PTH coated samples support that as-prepared coating is promising for modifying biodegradable zinc implants. | Deren Zhao Tianhao Chen Jinqian Chen Banglun Huang Jihua Nie Hulin Liu Yangkai Liu Zilin Chen Feng Zou Qiqi Lu Xiaodong Tan Yunjie Xiang Jing Li Yongping Zhang Xue Feng Xi Rao | 2023 | Biosurface and Biotribology2023，9，4： | 0 |
| 11 | Discovery of a first-in-class ANXA3 degrader for the treatment of triple-negative breast cancer显示文摘Triple-negative breast cancer(TNBC)is a nasty disease with extremely high malignancy and poor prognosis.Annexin A3(ANXA3)is a potential prognosis biomarker,displaying an excellent correlation of ANXA3 overexpression with patients'poor prognosis.Silencing the expression of ANXA3effectively inhibits the proliferation and metastasis of TNBC,suggesting that ANXA3 can be a promising therapeutic target to treat TNBC.Herein,we report a first-in-class ANXA3-targeted small molecule(R)-SL18,which demonstrated excellent anti-proliferative and anti-invasive activities to TNBC cells.(R)-SL18 directly bound to ANXA3 and increased its ubiquitination,thereby inducing ANXA3 degradation with moderate family selectivity.Importantly,(R)-SL18 showed a safe and effective therapeutic potency in a high ANXA3-expressing TNBC patient-derived xenograft model.Furthermore,(R)-SL18 could reduce theβ-catenin level,and accordingly inhibit the Wnt/β-catenin signaling pathway in TNBC cells.Collectively,our data suggested that targeting degradation of ANXA3 by(R)-SL18 possesses the potential to treat TNBC. | Yongxi Liang Delin Min Hulin Fan Kunlin Liu Juchuanli Tu Xueyan He Bingjie Liu Lu Zhou Suling Liu Xun Sun | 2023 | Acta Pharmaceutica Sinica B2023，13，4： | 0 |
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