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您的检索式：作者名="Yangzi Shi"
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| 1 | SIRT7 orchestrates melanoma progression by simultaneously promoting cell survival and immune evasion via UPR activation显示文摘Melanoma is the most lethal type of skin cancer,originating from the malignant transformation of melanocyte.While the development of targeted therapy and immunotherapy has gained revolutionary advances in potentiating the therapeutic effect,the prognosis of patients with melanoma is still suboptimal.During tumor progression,melanoma frequently encounters stress from both endogenous and exogenous sources in tumor microenvironment.SIRT7 is a nuclear-localized deacetylase of which the activity is highly dependent on intracellular nicotinamide adenine dinucleotide(NAD+),with versatile biological functions in maintaining cell homeostasis.Nevertheless,whether SIRT7 regulates tumor cell biology and tumor immunology in melanoma under stressful tumor microenvironment remains elusive.Herein,we reported that SIRT7 orchestrates melanoma progression by simultaneously promoting tumor cell survival and immune evasion via the activation of unfolded protein response.We first identified that SIRT7 expression was the most significantly increased one in sirtuins family upon stress.Then,we proved that the deficiency of SIRT7 potentiated tumor cell death under stress in vitro and suppressed melanoma growth in vivo.Mechanistically,SIRT7 selectively activated the IRE1α-XBP1 axis to potentiate the pro-survival ERK signal pathway and the secretion of tumorpromoting cytokines.SIRT7 directly de-acetylated SMAD4 to antagonize the TGF-β-SMAD4 signal,which relieved the transcriptional repression on IRE1αand induced the activation of the IRE1α-XBP1 axis.Moreover,SIRT7 up-regulation eradicated anti-tumor immunity by promoting PD-L1 expression via the IRE1α-XBP1 axis.Additionally,the synergized therapeutic effect of SIRT7 suppression and anti-PD-1 immune checkpoint blockade was also investigated.Taken together,SIRT7 can be employed as a promising target to restrain tumor growth and increase the effect of melanoma immunotherapy. | Xiuli Yi Huina Wang Yuqi Yang Hao Wang Hengxiang Zhang Sen Guo Jianru Chen Juan Du Yangzi Tian Jingjing Ma Baolu Zhang Lili Wu Qiong Shi Tianwen Gao Weinan Guo Chunying | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 1 |
| 2 | Bi-layer collagen/microporous electrospun nanofiber scaffold improves the osteochondral regeneration显示文摘 | Shufang Zhang Longkun Chen Yangzi Jiang Youzhi Cai Guowei Xu Tong Tong Wei Zhang Linlin Wang Junfeng Ji Peihua Shi Hong Wei Ouyang | 2013 | Acta Biomaterialia2013，，7： | 1 |
| 3 | Quantifying spatial distribution of interrill and rill erosion in a loess at different slopes using structure from motion(SfM)photogrammetry显示文摘The spatial distribution of interrill and rill erosion is essential for unravelling soil erosion principles and the application of soil and water conservation practices.To quantify interrill and rill erosion and their spatial development,four 30-min rainfalls at 90 mm h^(-1)intensity were consecutively simulated on runoff plots packed with a loess at six slopes of 10°,15°,20°,25°,30°and 35°.The soil surface was measured using the structure from motion(SfM)photogrammetry upon each simulation run,and the runoff and sediment samples were collected and measured at every 10 min.Rills did not develop until the third simulation run.During the initial two runs,the lower third section was more severely eroded than the upper and middle thirds along the slope direction,yet the interrill erosion was statistically uniform from left to right.Rills tended to emerge by both sidewalls and in the lower portion in the third run.The corresponding rill erosion increased with slope from 10°to 20°and then decreased for the slopes steeper,which was consistent with the slope trend of the sediment yield directly measured.The rills expanded substantially primarily via head retreat and to a lesser extent via sideward erosion after receiving another 30-min rainfall.Rill erosion contributed 69.3%of the total erosion loss,and shifted the critical slope corresponding to the maximum loss from 20°to 25°.These findings demonstrate the significance of rill erosion not only in total soil loss but also in its relation to slope,as well as the effectiveness of SfM photogrammetry in quantifying interrill and rill erosion. | Tao He Yang Yang Yangzi Shi Xiaozhen Liang Suhua Fu Gege Xie Baoyuan Liu Yingna Liu | 2022 | International Soil and Water Conservation Research2022，10，3： | 0 |
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