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| 1 | Kaempferol protects ethanol-induced gastric ulcers in mice via pro-inflammatory cytokines and NO显示文摘胃的溃疡(GU ) 是在全世界影响许多人的普通病理。过多的白酒消费是 GU 的主要原因之一;然而,仍然有为 GU 的预防或治疗的有效的药的缺乏。在这研究,我们在老鼠把保护的效果和 kaempferol (KAE ) 的可能的机制与尖锐导致乙醇的损害作比较到胃的 mucosa。Fasted 老鼠口头上地被给车辆(0.9% 盐) , omeprazole (20 mg/kg ) ,或为在在由有绝对乙醇(10 ml/kg ) 的挑战的 GU 模型的建立以前的不同试验性的集合的 1 h 的 KAE (40, 80,或 160 mg/kg ) 。动物是 euthanized 在乙醇吸入以后的 1 h,和他们的血浆和胃纸巾服从于进一步的检查。宏观、显微镜的损害,和免疫学的和生物化学的参数被观察。发炎的效果用下列指示物被调查:肿瘤坏死因素 --(TNF-) , interleukin-1 (IL-1 ) , IL-6, myeloperoxidase (军邮局) ,和氮的氧化物(没有) 。结果证明 KAE 显著地减少了溃疡索引,增加了预防索引,完全保护了 mucosa 免受损害,和保存胃的 mucosal glycoprotein 的伤害。KAE 减少了军邮局活动和支持 inflammatory cytokine (TNF- ,和 IL-1 ) 铺平,并且没改进层次。KAE 的 gastroprotective 活动可能被归因于胃的有粘液的 glycoproteins 层次的保藏,这样由禁止嗜中性的累积和军邮局活动,调整支持 inflammatory cytokines 的层次,并且不改进生产。 | Qinchen Li Xinxin Hu Yanhan Xuan Jianghua Ying Yujia Fei Jielu Rong Yong Zhang Jian Zhang Chunyan Liu Zheng Liu | 2018 | Acta Biochimica et Biophysica Sinica2018，50，3： | 18 |
| 2 | Polymorphic Alu insertions and their associations with MHC class I alleles and haplotypes in Han and Jinuo populations in Yunnan Province,southwest of China显示文摘The associations of polymorphic Alu insertions (POALINs) with major histocompatibility complex (MHC) class I genes enable us to better identify origins and evolution of MHC class I region haplotypes in different populations. For further studying origins and evolution of MHC class I region haplotypes in Han and Jinuo populations in Yunnan Province, we investigated frequencies of five POALINs, their associations with HLA-A and -B, the three-loci POALINs haplotype frequencies and HLA/POALIN four-loci haplotype frequencies within the alpha block of MHC class I region. We found that a strong positive association between AluHG and HLA-A*02 is in Jinuo, but not in Yunnan Han. These results suggest that MHC class I region haplotypes of the two studied populations might derive from different progenitor haplotypes and MHC I-POALINs are informative genetic markers for investigating origins and evolution of MHC class I region haplotypes in different populations. | Yufeng Yao 1, Li Shi 1, Lei Shi, Keqin Lin, Yufen Tao, Liang Yu, Hao Sun, Xiaoqin Huang, Yanhan Li, Jiayou Chu Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming 650118, China | 2009 | Journal of Genetics and Genomics2009，36，1： | 2 |
| 3 | Role of matrix metalloproteinases in chronic wound healing: diagnostic and therapeutic implications显示文摘Matrix metalloproteinases (MMPs) are members of the family of zinc-dependent endopeptidases.MMPs are active during normal wound healing,but also in serious illnesses,such as cancers.1 Metalloproteinases participate in the inflammatory stage of wound healing by inducing inflammatory factors and assisting in cellular migration.2 However,when MMPs build up during inflammation,3 the wounds can become chronic and fail to reach the remodeling stage.4 Cell apoptosis,cancer,and other life-threatening illnesses can evolve as the condition worsens,causing the wound to remain permanently open.5 Fortunately,the technology of medical biomarkers has shed light on this endless cycle.6 By determining the baseline for metalloproteinase concentrations near wound sites,physicians may understand the severity or presence of certain disease states and the stage of wound healing. | Ren Yanhan Gu Guosheng Yao Min Vickie R. Driver | 2014 | Chinese Medical Journal2014，，8： | 2 |
| 4 | Marine-inspired molecular mimicry generates a drug-free, but immunogenic hydrogel adhesive protecting surgical anastomosis显示文摘Herein,we report the synthesis of a biomimic hydrogel adhesive that addresses the poor healing of surgical anastomosis.Dopamine-conjugated xanthan gum(Da-g-Xan)is fabricated using deep insights into the molecular similarity between mussels'adhesive and dopamine as well as the structural similarity between barnacle cement proteins and xanthan gum.The hydrogel mimics marine animals’adherence to wet tissue surfaces.Upon applying this adhesive to colonic anastomosis in a rat model,protective effects were shown by significantly improving the bursting pressure.Mechanistically,the architecture of Da-g-Xan hydrogel is maintained by dynamic intermolecular hydrogen bonds that allow the quick release of Da-g-Xan.The free Da-g-Xan can regulate the inflammatory status and induce type 2 macrophage polarization(M2)by specifically interacting with mannose receptors(CD206)revealed by RNA-sequencing and molecular binding assays.Consequently,an appropriate microenvironment for tissue healing is created by the secretion of chemokines and growth factors from M2 macrophages,strengthening the fibroblast migration and proliferation,collagen synthesis and epithelial vascularization.Overall,this study demonstrates an unprecedented strategy for generating an adhesive by synergistic mimicry inspired by two marine animals,and the results show that the Da-g-Xan adhesive augments native tissue regenerative responses,thus enabling enhanced recovery following surgical anastomosis. | Jinjian Huang Yungang Jiang Ye Liu Yanhan Ren Ziyan Xu Zongan Li Yun Zhao Xiuwen Wu Jianan Ren | 2021 | Bioactive Materials2021，6，3： | 2 |
| 5 | Decreased concentration of IL-35 in plasma of patients with asthma and COPD显示文摘 | CHEN Chen DENG Yanhan CHEN Huilong | 2014 | Asian Pacific Journal of Allergy and Immunology2014，32，3： | 1 |
| 6 | Amperometric NADH Biosensor Based on Magnetic Chitosan Microspheres/Poly(thionine) Modified Glassy Carbon Electrode显示文摘 | YaLiu Hai‐LiZhang Guo‐SongLai Ai‐MinYu Yu‐MeiHuang De‐YanHan | 2010 | Electroanalysis2010，，15： | 1 |
| 7 | Solvothermal process for grafting maleic anhydride onto poly(ethylene-1-octene)显示文摘 | Qiaochu Liu Rongrong Qi Yanhan Shen | 2007 | Journal of Molecular Structure2007，，23： | 1 |
| 8 | Terahertz Ima- ging With a Time-Reversed Finite Difference Time-Do- main Method 显示文摘 | Bardak C Yanhan Z Bernussi A | 2014 | IEEE Transactions on Terahertz Sci- ence and Technology2014，4，2： | 1 |
| 9 | Terahertz two - layer frequency selective surface with improved transmission characteristics 显示文摘 | Subash Vegesna ZHU Yanhan | 2012 | IEEE Transactions on Terahertz Science and Technology2012，2，4： | 1 |
| 10 | Grafting copolymerization of maleic anhydride onto styrene-butadiene-styrene block copolymer through solvothermal process 显示文摘 | QI Rongrong YU Qiuming SHEN Yanhan | 2006 | J Appl Polym Sci2006，102，6： | 1 |
| 11 | Pain, fatigue, disturbed sleep and distress comprised a symptom cluster that related to quality of life and functional status of lung cancer surgery patients显示文摘 | Shuanglan Lin Yanhan Chen Liu Yang Jianrong Zhou | 2013 | J Clin Nurs (-)2013，，9： | 1 |
| 12 | Effect of High-density Polyethylene-g-maleic Anhydride on the Morphology and Properties of High density Polyethylene/(Ethylene-vinyl alcohol) Copolymer Alloy显示文摘 | Qifei Wang Rongrong Qi Yanhan Shen | 2007 | Journal of Applied Polymer Science(submitted)2007，106，： | 1 |
| 13 | Thermalpreparation and Characterization of Maleic Anhydride Grafting High Den- sity Polyethylene Copolyme显示文摘 | Yanhan S Rongrong Q Solvo | 2007 | Journal of Applied Poly- mer Science2007，104，5： | 1 |
| 14 | 显示文摘 | YANHan(闫晗) DONGJun(董君) HUANGJing etal(黄静等) | 2012 | 应用化工2012，03，： | 1 |
| 15 | Bibliometric Analysis of Status Quo and Trend of the Research on Duck Based on the Web of Science Database显示文摘[Objectives] This study was conducted to understand the current status of duck related research. [Methods] CiteSpace knowledge graph analysis tool, VOSviewer visual analysis software and HistCite citation graph analysis tool were used to analyze the number of publications and subject distribution of duck-related research fields in the Web of Science core collection database. The main countries(regions) and institutions, the main academic journals, the main research scholars, the main research hotspots and their changing trends were used for quantitative analysis. [Results](1) Duck-related research is receiving more and more attention, which further supports ducks’ important significance in the livestock and poultry industry.(2) Countries such as China, the United States, Canada, and France had published more articles in this field, and there was close cooperation between countries.(3) The top two journals with local citations in the duck-related research fields were PLOS ONE and JOURNAL OF VIROLOGY, and the journal with the highest impact factor in 2019 was JOURNAL OF VIROLOGY.(4) High-yield scholars in duck related research fields included Cheng Anchun, Wang Mingshu, Jia Renyong, etc.(5) Infection was a research hotspot in duck-related research. Typical pathogenic microorganisms included Newcastle disease, Avian influenza, and campylobacter.(6) The future trend of duck-related research mainly focuses on breeds, living environment, diseases, and molecular mechanisms. [Conclusions] Based on data from the Web of Science core collection database, this paper provides a complete bibliometric analysis of the current research status of ducks. | Piao ZHANG Xia YANG Maoqin ZENG Yanhan LIU Yangzi ZHANG Ying YANG Guilan WEN Zhentao CHENG Ming WEN | 2021 | Agricultural Biotechnology2021，10，1： | 0 |
| 16 | Damps’role in inflammatory bowel disease:a paradoxical player of mtDNA-STING signaling pathway in gut homeostasis显示文摘The inflammatory bowel disease(IBD),including Crohn’s disease(CD)and ulcerative colitis,are chronic,relapsing immune mediated disorders of the gastrointestinal homeostasis and intestinal inflammation[1].Failure to resolve mucosal inflammation and maintain gut barrier are notable shared clinical challenges in IBD,in particular when they activate immune cells within the gut lamia propria.Clinical trials and animal model studies aiming towards DAMPs have demonstrated that they can be effective therapeutic targets in mucosal inflammation of IBD. | Qiongyuan Hu Yanhan Ren Dominic ASlade Quan Zhou Xiuwen Wu Jinjian Huang Guosheng Gu Gefei Wang Jianan Ren Jieshou Li | 2019 | Science Bulletin2019，64，19： | 0 |
| 17 | Prolonged control of insulin-dependent diabetes via intramuscular expression of plasmid-encoded single-strand insulin analogue显示文摘Daily insulin injection is necessary for the treatment of the insulin-dependent diabetes. However, the process is painful and inconvenient. Accordingly, we have made exploratory efforts to establish an alternative method for continuous insulin supply via intramuscular injection of a designed plasmid encoding the single-strand insulin analogue (SIA), which provides safe, effective and prolonged control of insulin-dependent diabetes. To generate a SIA, a short flexible peptide was alternatively introduced into the natural proinsulin to replace its original long and rigid C-peptide. Then, the synthetic promoter SP301 was used to drive potent and specific expression of SIA in skeletal muscle cells. By combining the Pluronic L64 and low-voltage electropulse (L/E), the specialized gene delivery technique was applied to efficiently transfer the constructed plasmid into skeletal muscle cells via intramuscular injection. Through these efforts, a plasmid-based intramuscular gene expression system was established and improved, making it applicable for gene therapy. The plasmid-expressed SIA showed biological functions that were similar to that of natural insulin. A single L/E-pSP301-SIA administration provided sustained SIA expression in vivo for about 1.5 months. In addition, the diabetic mice treated with L/E-pSP301-SIA were much healthier than those with other treatments. This plasmid-based system was safe for the treatment of diabetes and did not cause immune responses or pathological damage. The results confirmed that, in a mouse model, long-term positive effects were achieved by a single intramuscular L/E-pSP301-SIA injection, which consequently provided reliable experimental basis for its clinical application for the treatment of diabetes mellitus with promising prospects. | Lu Deng Ping Yang Caixia Li Lifang Xie Wanling Lu Yanhan Zhang Ming Liu Gang Wang | 2023 | Genes & Diseases2023，10，3： | 0 |
| 18 | Tumor necrosis factor alpha receptor 1 deficiency in hepatocytes does not protect from non-alcoholic steatohepatitis, but attenuates insulin resistance in mice显示文摘BACKGROUND End-stage liver disease caused by non-alcoholic steatohepatitis(NASH)is the second leading indication for liver transplantation.To date,only moderately effective pharmacotherapies exist to treat NASH.Understanding the pathogenesis of NASH is therefore crucial for the development of new therapies.The inflammatory cytokine tumor necrosis factor alpha(TNF-α)is important for the progression of liver disease.TNF signaling via TNF receptor 1(TNFR1)has been hypothesized to be important for the development of NASH and hepatocellular carcinoma in whole-body knockout animal models.AIM To investigate the role of TNFR1 signaling in hepatocytes for steatohepatitis development in a mouse model of diet-induced NASH.METHODS NASH was induced by a western-style fast-food diet in mice deficient for TNFR1 in hepatocytes(TNFR1ΔHEP)and their wild-type littermates(TNFR1fl/fl).Glucose tolerance was assessed after 18 wk and insulin resistance after 19 wk of feeding.After 20 wk mice were assessed for features of NASH and the metabolic syndrome such as liver weight,liver steatosis,liver fibrosis and markers of liver inflammation.RESULTS Obesity,liver injury,inflammation,steatosis and fibrosis was not different between TNFR1ΔHEP and TNFR1fl/fl mice.However,Tnfr1 deficiency in hepatocytes protected against glucose intolerance and insulin resistance.CONCLUSION Our results indicate that deficiency of TNFR1 signaling in hepatocytes does not protect from diet-induced NASH.However,improved insulin resistance in this model strengthens the role of the liver in glucose homeostasis. | Sena Bluemel Yanhan Wang Suhan Lee Bernd Schnabl | 2020 | World Journal of Gastroenterology2020，26，33： | 0 |
| 19 | Study on Squeeze Casting Metal-zirconium Composite Die Material by Hot Press Sintering显示文摘ZrO_(2)-5CrMnMo composite samples were prepared by hot press sintering.When NiCoCrAlY powders were used as the bonding layer and the different mixtures of NiCoCrAlY alloy and 3YSZ (3mol% yttria stabilized zirconia) ceramic powders were used as the transition layers,the connection between zirconia ceramic and 5CrMnMo steel were strengthened.Three composite samples with different structures were fabricated by heat spraying and hot press sintering.Shear and thermal shock cycle tests were conducted to characterize connection strength and thermal shock resistance of these samples.The shear strength reached 95.69 MPa,and the heating shock cycles achieved to the maximum value of 27.7 times.Microstructures and connection interfaces were analyzed by scanning electron microscopy.The hardness and wearing resistance of 3YSZ coat and 5CrMnMo substrate were compared,and the heat insulation property of composite samples were also discussed.It is shown that these composite materials fabricated in this research are benefited to be used as squeeze casting dies. | 孙永根 杜之明 CHEN Lili FEI Yanhan CHENG Yuansheng | 2021 | Journal of Wuhan University of Technology(Materials Science)2021，36，4： | 0 |
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