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| 1 | Toripalimab plus chemotherapy as second-line treatment in previously EGFR-TKI treated patients with EGFR-mutant-advanced NSCLC:a multicenter phase-II trial显示文摘This multicenter phase-II trial aimed to investigate the efficacy,safety,and predictive biomarkers of toripalimab plus chemotherapy as second-line treatment in patients with EGFR-mutant-advanced NSCLC.Patients who failed from first-line EGFR-TKIs and did not harbor T790M mutation were enrolled.Toripalimab plus carboplatin and pemetrexed were administrated every three weeks for up to six cycles,followed by the maintenance of toripalimab and pemetrexed.The primary endpoint was objective-response rate(ORR).Integrated biomarker analysis of PD-L1 expression,tumor mutational burden(TMB),CD8+tumor-infiltrating lymphocyte(TIL)density,whole-exome,and transcriptome sequencing on tumor biopsies were also conducted.Forty patients were enrolled with an overall ORR of 50.0%and disease-control rate(DCR)of 87.5%.The median progression free survival(PFS)and overall survival were 7.0 and 23.5 months,respectively.The most common treatment-related adverse effects were leukopenia,neutropenia,anemia,ALT/AST elevation,and nausea.Biomarker analysis showed that none of PD-L1 expression,TMB level,and CD8+TIL density could serve as a predictive biomarker.Integrated analysis of whole-exome and transcriptome sequencing data revealed that patients with DSPP mutation had a decreased M2 macrophage infiltration and associated with longer PFS than those of wild type.Toripalimab plus chemotherapy showed a promising anti-tumor activity with acceptable safety profiles as the second-line setting in patients with EGFR-mutant NSCLC.DSPP mutation might serve as a potential biomarker for this combination.A phase-III trial to compare toripalimab versus placebo in combination with chemotherapy in this setting is ongoing(NCT03924050). | Tao Jiang Pingyang Wang Jie Zhang Yanqiu Zhao Jianying Zhou Yun Fan Yongqian Shu Xiaoqing Liu Helong Zhang Jianxing He Guanghui Gao Xiaoqian Mu Zhang Bao Yanjun Xu Renhua Guo Hong Wang Lin Deng Ningqiang Ma Yalei Zhang Hui Feng Sheng Yao Jiarui Wu Luonan Chen Caicun Zhou Shengxiang Ren | 2021 | Signal Transduction and Targeted Therapy2021，6，11： | 8 |
| 2 | A mechanically tuned Kerr comb in a dispersion-engineered silica microbubble resonator显示文摘This paper discusses the developement and investigation of a silica microbubble resonator(MBR) that is optimized to cancel mode dispersion with material dispersion, at a wavelength of approximately 1550 nm and maintain a quality factor of an optical mode as large as 5.4 × 10~7. Benefitting from the near-zero dispersion and high quality factor, a primary optical comb is generated in the MBR using cascaded four-wave mixing processes, which span over 300 nm with several tens of teeth. Furthermore, the frequency comb could be gradually tuned by mechanically stretching the MBR. This tunable Kerr comb has multiple potential applications in precision measurements and sensing applications, such as molecular spectroscopy and ranging. | FangJie Shu PeiJi Zhang YanJun Qian ZhengYu Wang Shuai Wan Chang Ling Zou GuangCan Guo ChunHua Dong | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，5： | 5 |
| 3 | Career adaptability, job search self-efficacy and outcomes: A three-wave investigation among Chinese university graduates显示文摘 | Yanjun Guan Hong Deng Jiaqing Sun Yanan Wang Zijun Cai Lihui Ye Ruchunyi Fu Yang Wang Shu Zhang Yuhui Li | 2013 | Journal of Vocational Behavior2013，，3： | 1 |
| 4 | Stochastic differential equation software reliability growth model with change-point显示文摘This paper presents software reliability growth models(SRGMs) with change-point based on the stochastic differential equation(SDE).Although SRGMs based on SDE have been developed in a large scale software system,considering the variation of failure distribution in the existing models during testing time is limited.These SDE SRGMs assume that failures have the same distribution.However,in practice,the fault detection rate can be affected by some factors and may be changed at certain point as time proceeds.With respect to this issue,in this paper,SDE SRGMs with changepoint are proposed to precisely reflect the variations of the failure distribution.A real data set is used to evaluate the new models.The experimental results show that the proposed models have a fairly accurate prediction capability. | 张楠 Cui Gang Shu Yanjun Liu Hongwei | 2014 | High Technology Letters2014，20，4： | 1 |
| 5 | An Analysis and Validation Toolkit to Support the Undergraduate Course of Computer Organization and Architecture显示文摘As an important part of the computer organization and architecture(COA)course,the experiment teaching is generally about the computer system design.Students use the hardware description languages(HDLs)tools to implement the computer system on the Field Programmable Gate Array(FPGA)based platform.However,the HDLs tools are made for expert hardware engineers and the computer system is a very complex hardware project.It is hard for students to implement their computer system design in the limited lab hours.How to help students get the design validation and find the failure root is important in COA experiment teaching.To this end,an analysis and validation toolkit which is special for COA experiment teaching is designed.For two main steps of FPGA-based hardware design,waveform simulation and on-board testing,two packages were implemented for them respectively.The comparison results of using and not using our toolkit show it improves the effectiveness of experiment teaching greatly. | Yanjun Shu Zhuangyu Ma Hongwei Liu Zhan Zhang Dongxin Wen Bing Xu Danyan Luo Decheng Zuo | 2021 | 国际计算机前沿大会会议论文集2021，，2： | 0 |
| 6 | Research on the Training Mode of College Students’Computational Thinking Ability Based on Issues-driven and Course Objectives显示文摘Computer science concept and ability is crucial to modern information technology.As a basic computer science education,computational thinking has become one of the first courses for college students and the foundation for training for non-computer professionals.Computational thinking is a way of thinking that students in all majors should master.In the process of teaching,students learn to use computational thinking to solve professional and technical problems and make good use of computer’s powerful tools.It is one of the major themes of recent teaching research.We set course objectives from issues-driven and correspond each class to the module objectives,so that the focus of course content is clear.The learning clues for the students are clear,which is conducive to the cultivation and improvement of computational thinking. | Dongxin Wen Danyan Luo Hongwei Liu Yanjun Shu | 2022 | 计算机教育2022，，12： | 0 |
| 7 | Bottom-Up Teaching Reformation for the Undergraduate Course of Computer Organization and Architecture显示文摘According to the building requirements of “China’s double first class” discipline, traditional computer organization and architecture (COA) course has new challenges including various course expectations and the limited teaching hours. Considering the hierarchy feature of COA, a bottom-up teaching mode is adopted in teaching reformation to meet the challenges. In this paper, details about COA teaching reforms were shown from aspects of teaching contents, teaching methods, handson assignments, and examination methods. These reform experience will benefit teachers who embark on courses related to computer hardware. | Yanjun Shu Wei Emma Zhang Yanxin Liu Chunpei Wang Jian Dong Zhan Zhang Dongxi Wen Decheng Zuo | 2019 | 国际计算机前沿大会会议论文集2019，，2： | 0 |
| 8 | Proximity Chemistry in Living Systems显示文摘Enzyme-and catalyst-generated reactive species have been leveraged in the past decade to covalently label biomolecules within a short range of a defined site or space inside cells or at the cell–cell interface.Due to their high spatial resolution,such proximity labeling strategies have been coupled with various bioanalytical techniques for dissecting dynamic and complex biological processes.Here,we review the development of enzyme-and catalyst-triggered proximity chemistry and their applications to identifying protein interaction networks as well as cell–cell communications in living systems. | Yanjun Liu Yun Ge Ruxin Zeng William Shu Ching Ngai Xinyuan Fan Peng R.Chen | 2023 | CCS Chemistry2023，5，4： | 0 |
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