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| 1 | Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms显示文摘The infusion of coronavirus disease 2019(COVID-19)patients with mesenchymal stem cells(MSCs)potentially improves clinical symptoms,but the underlying mechanism remains unclear.We conducted a randomized,single-blind,placebo-controlled(29 patients/group)phase II clinical trial to validate previous findings and explore the potential mechanisms.Patients treated with umbilical cord-derived MSCs exhibited a shorter hospital stay(P=0.0198)and less time required for symptoms remission(P=0.0194)than those who received placebo.Based on chest images,both severe and critical patients treated with MSCs showed improvement by day 7(P=0.0099)and day 21(P=0.0084).MSC-treated patients had fewer adverse events.MSC infusion reduced the levels of C-reactive protein,proinflammatory cytokines,and neutrophil extracellular traps(NETs)and promoted the maintenance of SARS-CoV-2-specific antibodies.To explore how MSCs modulate the immune system,we employed single-cell RNA sequencing analysis on peripheral blood.Our analysis identified a novel subpopulation of VNN2+hematopoietic stem/progenitorlike(HSPC-like)cells expressing CSF3R and PTPRE that were mobilized following MSC infusion.Genes encoding chemotaxis factors—CX3CR1 and L-selectin—were upregulated in various immune cells.MSC treatment also regulated B cell subsets and increased the expression of costimulatory CD28 in T cells in vivo and in vitro.In addition,an in vivo mouse study confirmed that MSCs suppressed NET release and reduced venous thrombosis by upregulating kindlin-3 signaling.Together,our results underscore the role of MSCs in improving COVID-19 patient outcomes via maintenance of immune homeostasis. | Rongjia Zhu Tingdong Yan Yingmei Feng Yan Liu Hongcui Cao Gongxin Peng Yanlei Yang Zhen Xu Jingqi Liu Wei Hou Xiaoyue Wang Zhe Li Luchan Deng Shihua Wang Jing Li Qin Han Hongling Li Guangliang Shan Yinghao Cao Xingyan An Jianshe Yan Zhonghui Zhang Huafei Li Xuebin Qu Jiaqi Zhu Shumin Zhou Jiao Wang Fengchun Zhang Jinming Gao Ronghua Jin Dayong Xu Yan-Qing Ma Tao Huang Shuang Peng Zhi Zheng Ilia Stambler Eric Gilson Lee Wei Lim Alexey Moskalev Antonio Cano Sasanka Chakrabarti Brun Ulfhake Huanxing Su Haoying Xu Sihuan Xu Feng Wei Holly MBrown-Borg Kyung-Jin Min Georgina Ellison-Hughes Calogero Caruso Kunlin Jin Robert Chunhua Zhao | 2021 | Cell Research2021，31，12： | 5 |
| 2 | Antifouling Property Improvement of Poly(vinyl butyra!) Ultrafiltra- tion Membranes Through Acid Treatment显示文摘 | Ma Xiaole Sun Qiang Su Yanlei | 2007 | Separation and Purification Technology2007，54，： | 1 |
| 3 | Enhanced permeation performance of cellulose acetate ultrafiltration membrane by incorporation of Pluronic F127显示文摘 | Lv Cailing Su Yanlei Wang Yanqiang | 2007 | J Membr Sci2007，294，： | 1 |
| 4 | Sandwich- structured enzyme membrane reactor for efficient con- version of maltose into isomaltooligosaecharides 显示文摘 | Zhang Lei Su Yanlei Zheng Yang | 2010 | Bioresource Technology2010，101，23： | 1 |
| 5 | Preparation of proteinadsorption-resistant polyethersulfone ultrafiltration membranes through surface segregation of amphiphilic comb copolymer 显示文摘 | Ma Xiaole Su Yanlei Sun Qiang | 2007 | Journal of Membrane Science2007，292，12： | 1 |
| 6 | Separation of oil/water emulsion using Pluronic F127 modified polyethersulfone ultrafiltration membranes显示文摘 | Wenjuan Chen Jinming Peng Yanlei Su Lili Zheng Lijun Wang Zhongyi Jiang | 2009 | Separation and Purification Technology2009，，3： | 1 |
| 7 | Dopamine composite nanofiltration membranes prepared by self-polymerization and interracial polymerization 显示文摘 | Jiaojiao Zhao Yanlei Su Zhongyi Jiang | 2014 | Joumal of Membrane Science2014，465，： | 1 |
| 8 | Separation of Oil/Water Emulsion Using Pluronic F127 Modified Polyethersul- fone Ultrafiltration Membranes显示文摘 | Chen Wenjuan Peng Jinming Su Yanlei | 2009 | Sep Purif Technol2009，66，3： | 1 |
| 9 | The Improved Oil/ Water Separation Performance of Cellulose Acetate-Graft-Polyac- rylonitrile Membranes显示文摘 | Chen Wenjuan Su Yanlei Zheng Lili | 2009 | J Membr Sci2009，337，12： | 1 |
| 10 | Enhanced Per- meation Performance of Cellulose Acetate Ultrafiltration Mem- brane by Incorporation of Ploronic Fl27 显示文摘 | Lii Cailing Su Yanlei Wang Yanqiang | 2007 | J Membr Sci2007，294，12： | 1 |
| 11 | Separation of Oil/Water Emulsion Using Pluronic F127 Modified Polyether sulfone Ultraf: ltration membranes 显示文摘 | Wenjuan Chen Jinming Peng Yanlei Su | 2009 | Separation and Purification Technology2009，，66： | 1 |
| 12 | Remarkable Reduction of Irreversible Fouling and Improvement of the Permeation Properties of Poly ( Ether Sulfone ) Ultrafiltration Membranes by Blending with Pluronic F127 显示文摘 | Wang Yanqiang Wang Ting Su Yanlei | 2005 | Langmuir2005，21，11： | 1 |
| 13 | Covalent Functionalization of Multi-walled Carbon Nanotubes by Lipase显示文摘 | Shi Qing Yang Dong Su Yanlei | 2007 | Journal of Nanoparticle Research2007，9，6： | 1 |
| 14 | Graft polymeri- zation of methacrylic acid onto polyethersulfone for po- tential pH-responsive membrane materials显示文摘 | Shi Qing Su Yanlei Ning Xue etal | 2010 | J Menbr Sci2010，347，12： | 1 |
| 15 | Melt,hydration,and micellization of the PEO PPO PEO blockcopolymer studied by FT-IR spectroscopy显示文摘 | Su Yanlei Wang Jing Liu Huizhou | | 0，，02： | 1 |
| 16 | 显示文摘 | Chen Wenjuan Peng Jinming Su Yanlei | 2009 | Separation and Puri? cation Technology2009，66，3： | 1 |
| 17 | Fabrication ofantifouling polyethersulfone ultrafiltration membranes using Pluronic F127 as both surface modifier and pore-forming agent 显示文摘 | Wei Zhao Yanlei Su Chao Li | 2008 | Joumal of Membrane Science2008，318，： | 1 |
| 18 | Formation ofa hydrophobic microenvironment in aqueous PEO-PPO-PEO block copolymer solutions investigated by Fourier transform infiared spectroscopy显示文摘 | SU Yanlei WANG Jing LIU Huizhou | 2002 | J Phys Chem B2002，106，11： | 1 |
| 19 | Enhanced Permeation Performance of Cellulose Acetate Ultrafitration Membrane by Incorporation of Pluronic F127 显示文摘 | Lv Calling Su Yanlei Wang Yanqiang | 2007 | J Membr Sci2007，294，： | 1 |
| 20 | Re-markable improvement of the performance of poly(vi-nylidene fluoride)microfiltration membranes by the ad-ditive cellulose acetate显示文摘 | Mu Chunxia Su Yanlei Sun Mengmeng | 2010 | J Membr Sci2010，350，： | 1 |
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