|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Clinical applications of MARSALA for preimplantation genetic diagnosis of spinal muscular atrophy显示文摘Conventional PCR methods combined with linkage analysis based on short tandem repeats(STRs) or Karyomapping with single nucleotide polymorphism(SNP) arrays, have been applied to preimplantation genetic diagnosis(PGD) for spinal muscular atrophy(SMA), an autosome recessive disorder. However, it has limitations in SMA diagnosis by Karyomapping, and these methods are unable to distinguish wildtype embryos with carriers effectively. Mutated allele revealed by sequencing with aneuploidy and linkage analyses(MARSALA) is a new method allowing embryo selection by a one-step next-generation sequencing(NGS) procedure, which has been applied in PGD for both autosome dominant and X-linked diseases in our group previously. In this study, we carried out PGD based on MARSALA for two carrier families with SMA affected children. As a result, one of the couples has given birth to a healthy baby free of mutations in SMA-causing gene. It is the first time that MARSALA was applied to PGD for SMA, and we can distinguish the embryos with heterozygous deletion(carriers) from the wild-type(normal) ones accurately through this NGS-based method. In addition, direct mutation detection allows us to identify the affected embryos(homozygous deletion), which can be regarded as probands for linkage analysis, in case that the affected family member is absent. In the future, the NGS-based MARSALA method is expected to be used in PGD for all monogenetic disorders with known pathogenic gene mutation. | Yixin Ren Xu Zhi Xiaohui Zhu Jin Huang Ying Lian Rong Li Hongyan Jin Yan Zhang Wenxin Zhang Yanli Nie Yuan Wei Zhaohui Liu Donghong Song Ping Liu Jie Qiao Liying Yan | 2016 | Journal of Genetics and Genomics2016，43，9： | 9 |
| 2 | MiR-181a-5p inhibits cell proliferation and migration by targeting Kras in non-small cell lung cancer A549 cells显示文摘MicroRNAs 玩在 carcinogenesis 和肿瘤的重要角色进行。肺癌症是世界范围的癌症死亡的领先的原因。在这研究, miR-181a-5p 的功能在 non-small-cell 肺癌症(NSCLC ) 被调查。结果证明 miR-181a-5p 显著地在 NSCLC 纸巾和房间线被减少。有 miR-181a-5p 的 A549 房间 transfected 的增长和迁居模仿显著地被禁止。酶活动试金结果证明 Kras 的二个有约束力的地点能被 miR-181a-5p 直接指向。而且, Kras 由在 transcriptional 和翻译层次的 miR-181a-5p 是下面调整的。调停 SiRNA 的 Kras 下面规定能模仿 miR-181a-5p 的效果在 A549 模仿房间。我们的调查结果建议 miR-181a-5p 由部分指向 Kras 在肿瘤抑制起一个潜在的作用并且在 NSCLC 病人有潜在的治疗学的申请。 | Zhongliang Ma Xiang Qiu Detao Wang Yanli Li Bingjie Zhang Tianwei Yuan Jiali Wei Botao Zhao Xintai Zhao Jiatao LOU Yan Jin Youxin Jin | 2015 | Acta Biochimica et Biophysica Sinica2015，47，8： | 8 |
| 3 | Effect of Preparation Process on Compressive Strength and Hydrogenation Performance of Raney-Ni/Al2O3 Catalyst显示文摘In this study, Raney-Ni/Al_2O_3 catalysts were prepared from precursors which were calcined in different atmosphere(argon and air) and leached for different time. XRD, SEM, H_2-TPR and BET techniques were introduced to characterize the catalysts, and hydrogenation of unsaturated hydrocarbons, including vinyltoluene, dicyclopentadiene and indene, was used as probe reaction to evaluate the catalytic hydrogenation performance of the catalysts. The results demonstrated that the calcination atmosphere had noticeable effects on the compressive strength and hydrogenation performance of Raney-Ni/Al_2O_3. The catalyst calcined in argon exhibited better compressive strength and catalytic performance than the one calcined in air. The compressive strength and activity stability of catalyst were also determined by the leaching time. A too longer leaching time was not conducive to improving the compressive strength and catalytic performance of catalysts. When the precursor calcined in argon was treated in a 15%(by wt.) sodium hydroxide solution at 343 K for 5 h, a catalyst with higher compressive strength(at 26.10 N/mm) was obtained and the conversion of vinyltoluene, dicyclopentadiene(DCPD), and indene could amount to more than 87.5%, 99% and even 100%, respectively, under the reaction conditions covering a temperature of 493 K, a hydrogen pressure of 2.0 MPa, a LSHV of 3.0 h^(-1), and a hydrogen/oil ratio of 200:1. | Luo Guohua Wang Yanli Sun Daming Xu Xin Jin Haibo | 2017 | China Petroleum Processing & Petrochemical Technology2017，19，2： | 5 |
| 4 | Evaluating Suitability of Multiple Precipitation Products for the Lancang River Basin显示文摘Global reanalysis precipitation products could provide valuable meteorological information for flow forecasting in poorly gauged areas, helping to overcome a long-standing challenge in the field. But not all data sources are suitable for all regions or perform the same way in hydrological modeling, so it is essential to test the suitability of precipitation products before applying them. In this study, five widely used global high-resolution precipitation products—Asian Precipitation Highly Resolved Observational Data Integration Towards Evaluation of Water Resources(APHRODITE), National Centers for Environmental Prediction Climate Forecast System Reanalysis(NCEP-CFSR), Climate Hazards Group InfraRed Precipitation with Station Data(CHIRPS), China Gauge-based Daily Precipitation Analysis developed by China Meteorological Administration(CMA) and Agricultural Model Intercomparison and Improvement Project based on the NASA Modern-Era Retrospective Analysis for Research and Applications(AgMERRA)—were evaluated using statistical methods and a hydrological approach for their suitability for the Lancang River Basin. The results indicated that APHRODITE, CMA, AgMERRA and CHIRPS were more accurate precipitation indicators than NCEP-CFSR in terms of the multiyear average and seasonal spatial distribution pattern, all of the CHIRPS, Ag MERRA and APHRODITE perform better than CMA and NCEP-CFSR at the small, medium and high precipitation intensities ranges in subbasin11 and sunbabsin46. All five products performed better in subbasin46(a low-altitude region) than in subbasin11(a high-altitude region) on the daily and monthly scales. In addition to NCEP-CFSR, the other four products all presented encouraging potential for streamflow simulation at daily(Yunjinghong) and monthly(Yunjinghong, Jiuzhou and Gajiu) scale. Hydrological simulations forced with APHRODITE were the best of the five for the Yunjinghong station in capturing daily and monthly measured streamflow. Except for NCEP-CFSR, all products were very good for hydrological simulations for the Gajiu and Jiuzhou stations. | TANG Xiongpeng ZHANG Jianyun WANG Guoqing YANG Qinli YANG Yanqing GUAN Ti-esheng LIU Cuishan JIN Junliang LIU Yanli BAO Zhenxin | 2019 | Chinese Geographical Science2019，29，1： | 5 |
| 5 | A polyimide cathode with superior stability and rate capability for lithium-ion batteries显示文摘Organic-based electrode materials for lithium-ion batteries (LIBs) are promising due to their high theoretical capacity,structure versatility and environmental benignity.However,the poor intrinsic electric conductivity of most polymers results in slow reaction kinetics and hinders their application as electrode materials for LIBs.A binder-free self-supporting organic electrode with excellent redox kinetics is herein demonstrated via in situ polymerization of a uniform thin polyimide (PI) layer on a porous and highly conductive carbonized nanofiber (CNF) framework.The PI active material in the porous PI@CNF film has large physical contact area with both the CNF and the electrolyte thus obtains superior electronic and ionic conduction.As a result,the PI@CNF cathode exhibits a discharge capacity of 170 mAh·g^-1 at 1 C (175 mA·g^-1),remarkable rate-performance (70.5% of 0.5 C capacity can be obtained at a 100 C discharge rate),and superior cycling stability with 81.3% capacity retention after 1,000 cycles at 1 C.Last but not least,a four-electron transfer redox process of the PI polymer was realized for the first time thanks to the excellent redox kinetics of the PI@CNF electrode,showing a discharge capacity exceeding 300 mAh·g^-1 at a current of 175 mA·g^-1. | Jianghui Zhao Tuo Kang Yanli Chu Peng Chen Feng Jin Yanbin Shen Liwei Chen | 2019 | Nano Research2019，12，6： | 3 |
| 6 | A novel pathogenic mutation in FBN2 associated with congenital contractural arachnodactyly for preimplantation genetic diagnosis显示文摘Congenital contractural arachnodactyly(CCA,OMIM:121050),also known as Beals syndrome,belongs to a group of rare autosomal dominant(AD)diseases of connective tissue(Maslen et al.,1997).People with CCA share many distinguishing features,such as arachnodactyly,camp tod actyly,multiple joint contractures(especially finger,elbow,and knee joints),crumpled ears,scoliosis,pectus deformities,and muscular hypoplasia(Jurko et al.,2013).It exhibits no specific geographic or ethnic predilection(Frederic et al.,2009). | Jiaxin Li Yuqian Wang Xiaohui Zhu Yanli Nie Ying Kuo Shuo Guan Jin Huang Ying Lian Yangyu Zhao Rong Li Yuan Wei Jie Qiao Liying Yan | 2020 | Journal of Genetics and Genomics2020，47，5： | 2 |
| 7 | Modulation of red-light emission from carbon quantum dots in acid-based environment and the detection of chromium(Ⅲ)ions显示文摘ⅢIn this study,the carbon quantum dots,which can emit sharp red light(R-CQDs)under optical excitation,were synthesized via simple heat treatment of wine lees.The features of the photoluminescence(PL)emission from R-CQDs in solutions with different p H values and with metal ions were examined.The intensity of the PL emission from R-CQDs depends sensitively on the p H values of the solutions with the R-CQDs.Interestingly,the p H-response of the PL intensity is reversible and can be enhanced linearly in the p H value range from 4 to 12,indicating that the R-CQDs can be applied for the p H sensor.Furthermore,the quench of the PL emission from R-CQDs can be observed when adding chromium(Ⅲ)ions into the solution with R-CQDs.This effect can be utilized for selective and quick detection of chromium(Ⅲ)ions in solutions simply via the standard PL measurement.The interesting and important findings from this work can be applied to explore more practical applications of the CQDs prepared cheaply and easily. | Ju Tang Jin Zhang Weizuo Zhang Yiming Xiao Yanli Shi Fanquan Kong Wen Xu | 2021 | Journal of Materials Science & Technology2021，，24： | 2 |
| 8 | A Review of the Design and Architecture of Starch-Based Dietary Foods显示文摘Carbohydrates,which are mostly present in sugar,starch,and fiber,are one of the main ingredients of food and the primary source of energy in the human diet.Among these three main sources,starch stands out as one of the most abundant reserves of carbohydrates.Investigating starch would not only enhance our understanding of the functionality of starch in the human body but also aid in the design of novel starch-based dietary foods.The present review first provides a state-of-the-art understanding of the various classifications of dietary starches,including rapidly digesting starch(RDS),slowly digesting starch(SDS),and resistant starch(RS).Moreover,both the in vivo and in vitro determination methods of the digestibility of starch-based dietary foods are discussed.Based on the current understanding,present research strategies to design novel starch-based dietary foods through either the direct addition of modified starch or the alteration of processing conditions are highlighted.Furthermore,certain perspectives related to the future research directions of starch-based foods are also included. | Yuxiang Bai Xiaoxiao Li Hangyan Ji Yu Wang Danni Zheng Yanli Wang Zhengyu Jin | 2021 | Engineering2021，7，5： | 2 |
| 9 | Opportunities andchallenges for renewable energy policy in China显示文摘 | Z Peidong Y Yanli S Jin | 2009 | Renewable and Sustainable Energy Review2009，13，2： | 1 |
| 10 | Opportunities and challenges in renewable energy policy in china显示文摘 | Zhang Peidong Yang Yanli Shi Jin | 2009 | Renewable and Sustainable Energy Reviews2009，13，2： | 1 |
| 11 | The Study of Vegetation Carbon Storage in Qinghai Lake Valley Based on Remote Sensing and CASA Model显示文摘 | Chen Kelong Han Yanli Cao Shengkui Ma Jin Cao Guangchao Lu Hui | 2011 | Procedia Environmental Sciences2011，，： | 1 |
| 12 | Critical involvement of lysyl oxidase in seizure-induced neuronal damage through ERK-Alox5-dependent ferroptosis and its therapeutic implications显示文摘Recent insights collectively suggest the important roles of lysyl oxidase(LysOX)in the pathological processes of several acute and chronic neurological diseases,but the molecular regulatory mechanisms remain elusive.Herein,we explore the regulatory role of LysOX in the seizure-induced ferroptotic cell death of neurons.Mechanistically,LysOX promotes ferroptosis-associated lipid peroxidation in neurons via activating extracellular regulated protein kinase(ERK)-dependent 5-lipoxygenase(Alox5)signaling.In addition,overexpression of LysOX via adeno-associated viral vector(AAV)-based gene transfer enhances ferroptosis sensitivity and aggravates seizure-induced hippocampal damage.Our studies show that pharmacological inhibition of LysOX withβ-aminopropionitrile(BAPN)significantly blocks seizure-induced ferroptosis and thereby alleviates neuronal damage,while the BAPN-associated cardiotoxicity and neurotoxicity could further be reduced through encapsulation with bioresponsive amorphous calcium carbonate-based nanocarriers.These findings unveil a previously unrecognized LysOX-ERK-Alox5 pathway for ferroptosis regulation during seizure-induced neuronal damage.Suppressing this pathway may yield therapeutic implications for restoring seizure-induced neuronal injury. | Xiaoyuan Mao Xuan Wang Mingzhu Jin Qin Li Jining Jia Menghuan Li Honghao Zhou Zhaoqian Liu Weilin Jin Yanli Zhao Zhong Luo | 2022 | Acta Pharmaceutica Sinica B2022，12，9： | 1 |
| 13 | Prolonged Cold Ischemia Does Not Trigger Lethal Rejection or Accelerate the Acute Rejection in Two Allogeneic Rat Liver Transplantation Models显示文摘 | Hao Jin Uta Dahmen Anding Liu Hai Huang Yanli Gu Olaf Dirsch | 2012 | Journal of Surgical Research2012，，2： | 1 |
| 14 | Anomalous in-plane magnetoresistance of electron-doped cuprate La_(2.x)Ce_xCuO_(4±δ)显示文摘We report systematic in-plane magnetoresistance measurements on the electron-doped cuprate La_(2.x)Ce_xCuO_(4±δ) thin films as a function of Ce doping and oxygen content in the magnetic field up to 14 T. A crossover from negative to positive magnetoresistance occurs between the doping level x = 0.07 and 0.08. Above x = 0.08, the positive magnetoresistance effect appears, and is almost indiscernible at x = 0.15. By tuning the oxygen content, the as-grown samples show negative magnetoresistance effect, whereas the optimally annealed ones display positive magnetoresistance effect at the doping level x = 0.15. Intriguingly, a linear-field dependence of in-plane magnetoresistance is observed at the underdoping level x = 0.06, the optimal doping level x = 0.1 and slightly overdoping level x = 0.11. These anomalies of in-plane magnetoresistance may be related to the intrinsic inhomogeneity in the cuprates, which is discussed in the framework of network model. | Heshan Yu Ge He Yanli Jia Xu Zhang Jie Yuan Beiyi Zhu A.Kusmartseva F.V.Kusmartsev Kui Jin | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，9： | 1 |
| 15 | Attribution for decreasing streamflow of the Haihe River basin, northern China: Climate variability or human activities?显示文摘 | Zhenxin Bao Jianyun Zhang Guoqing Wang Guobin Fu Ruimin He Xiaolin Yan Junliang Jin Yanli Liu Aijing Zhang | 2012 | Journal of Hydrology2012，，： | 1 |
| 16 | FGOALS-g3 Model Datasets for CMIP6 Flux-Anomaly-Forced Model Intercomparison Project显示文摘The Flux-Anomaly-Forced Model Intercomparison Project(FAFMIP)is an endorsed Model Intercomparison Project in phase 6 of the Coupled Model Intercomparison Project(CMIP6).The goal of FAFMIP is to investigate the spread in the atmosphere–ocean general circulation model projections of ocean climate change forced by increased CO2,including the uncertainties in the simulations of ocean heat uptake,global mean sea level rise due to ocean thermal expansion and dynamic sea level change due to ocean circulation and density changes.The FAFMIP experiments have already been conducted with the Flexible Global Ocean–Atmosphere–Land System Model,gridpoint version 3.0(FGOALS-g3).The model datasets have been submitted to the Earth System Grid Federation(ESGF)node.Here,the details of the experiments,the output variables and some baseline results are presented.Compared with the preliminary results of other models,the evolutions of global mean variables can be reproduced well by FGOALS-g3.The simulations of spatial patterns are also consistent with those of other models in most regions except the North Atlantic and the Southern Ocean,indicating large uncertainties in the regional sea level projections of these two regions. | Yaqi WANG Zipeng YU Pengfei LIN Hailong LIU Jiangbo JIN Lijuan LI Yanli TANG Li DONG Kangjun CHEN Yiwen LI Qian YANG Mengrong DING Yao MENG Bowen ZHAO Jilin WEI Jinfeng MA and Zhikuo SUN | 2020 | Advances in Atmospheric Sciences2020，37，10： | 1 |
| 17 | A Robust and Fast Non-local Means Algorithm for Image Denoising显示文摘 | Liu Yanli Wang Jin Chen Xichen | | 0，，04： | 1 |
| 18 | Opportunities and challenges for renewable energy policy in China 显示文摘 | ZHANG Peidong YANG Yanli SHI Jin | 2009 | Renewable and Sustainable Energy Reviews2009，13，： | 1 |
| 19 | The Study of Vegetation Carbon Storage in Qinghai Lake Valley Based on Remote Sensing and CASA Model显示文摘 | Chen Kelong Han Yanli Cao Shengkui Ma Jin Cao Guangchao Lu Hui | 2011 | Procedia Environmental Sciences2011，，： | 1 |
| 20 | Tanshinones suppress non-small cell lung cancer through up-regulating miR-137显示文摘大进步在肺癌症的治疗被取得了,尤其是在基于 PD-1 包括象那些那样的免疫疗法的治疗学的药的多样化。在这些之中,有许多反疾病分子,从中国传统的药提取,例如 artemisinin 和 tanshinones。Tanshinones,包括 Tanshinone 我(T1 ) , Tanshinone IIA (T2A ) ,并且 ? cryptotanshinone (CT ) ,是 Salia miltiorrhiza 的 liposoluble 成分,传统的植物,它有利药用的价值。特别兴趣中是 tanshinone 在肿瘤房间上有的细胞毒素的效果,它被认为首先通过 apoptosis 的正式就职和房间周期前进, angiogenesis,房间侵略,和转移的禁止发生。以前的研究显示了 tanshinones 的导致 apoptosis 效果可能有效地指向并且禁止人的肺癌症细胞的生长[1 ] 。因此,推测那 tanshinones 是合理的可以在非小的房间肺癌症(NSCLC ) 的治疗起一个重要作用。研究已经证明了 tanshinone 分子能在 vitro 禁止肺癌症细胞的生长[2 ] ,并且机制可能通过细胞周期前进和细胞 apoptosis 的正式就职的打断,导致 miR-137 的起来规定表示。 | Bingjie Zhang Zhongliang Ma Xue Li Caiyan Zhang Yang Shao Zhenguo Liu Yanli Li Youxin Jin | 2016 | Acta Biochimica et Biophysica Sinica2016，48，8： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员