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| 1 | Effects of different resuscitation fluid on severe acute pancreatitis显示文摘AIM: To compare effects of different resuscitation fluid on microcirculation, inflammation, intestinal barrier and clinical results in severe acute pancreatitis (SAP). METHODS: One hundred and twenty patients with SAP were enrolled at the Pancreatic Disease Institute between January 2007 and March 2010. The patients were randomly treated with normal saline (NS group), combination of normal saline and hydroxyethyl starch (HES) (SH group), combination of normal saline, hydroxyethyl starch and glutamine (SHG group) in resuscitation. The ratio of normal saline to HES in the SH and SHG groups was 3:1. The glutamine (20% glutamine dipeptide, 100 mL/d) was supplemented into the resuscitation liquid in the SHG group. Complications and outcomes including respiratory and abdominal infection, sepsis, abdominal hemorrhage, intra-abdominal hypertension, abdominal compartment syndrome (ACS), renal failure, acute respiratory distress syndrome (ARDS), multiple organ dysfunction syndrome (MODS), operation intervention, length of intensive care unit stay, length of hospital stay, and mortality at 60 d were compared. Moreover, blood oxygen saturation (SpO 2 ), gastric intramucosal pH value (pHi), intra-abdominal pressure (IAP), inflammation cytokines, urine lactulose/mannitol (L/M) ratio, and serum endotoxin were investigated to evaluate the inflammatory reaction and gut barrier. RESULTS: Compared to the NS group, patients in the SH and SHG groups accessed the endpoint more quickly (3.9 ± 0.23 d and 4.1 ± 0.21 d vs 5.8 ± 0.25 d, P < 0.05) with less fluid volume (67.26 ± 28.53 mL/kg/d, 61.79 ± 27.61 mL/kg per day vs 85.23 ± 21.27 mL/kg per day, P < 0.05). Compared to the NS group, incidence of renal dysfunction, ARDS, MODS and ACS in the SH and SHG groups was obviously lower. Furthermore, incidence of respiratory and abdominal infection was significantly decreased in the SH and SHG groups, while no significant difference in sepsis was seen. Moreover, less operation time was needed in the SH and SHG group than the NS group, but the difference was not significant. The mortality did not differ significantly among these groups. Blood SpO 2 and gastric mucosal pHi in the SH and SHG groups increased more quickly than in the NS group, while IAP was significantly decreased in the SH and SHG group. Moreover, the serum tumor necrosis factor-α, interleukin-8 and C-reactive protein levels in the SH and SHG groups were obviously lower than in the NS group at each time point. Furthermore, urine L/M ratio and serum endotoxin were significantly lower in the SH group and further decreased in the SHG group.CONCLUSION: Results indicated that combination of normal saline, HES and glutamine are more efficient in resuscitation of SAP by relieving inflammation and sustaining the intestinal barrier. | Gang Zhao Jun-Gang Zhang He-Shui Wu Jin Tao Qi Qin Shi-Chang Deng Yang Liu Lin Liu Bo Wang Kui Tian Xiang Li Shuai Zhu Chun-You Wang | 2013 | World Journal of Gastroenterology2013，19，13： | 56 |
| 2 | Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 in Wuhan,China:a retrospective study显示文摘Background:The 2019 novel coronavirus has caused the outbreak of the acute respiratory disease in Wuhan,Hubei Province of China since December 2019.This study was performed to analyze the clinical characteristics of patients who succumbed to and who recovered from 2019 novel coronavirus disease(COVID-19).Methods:Clinical data were collected from two tertiary hospitals in Wuhan.A retrospective investigation was conducted to analyze the clinical characteristics of fatal cases of COVID-19(death group)and we compare them with recovered patients(recovered group).Continuous variables were analyzed using the Mann-WhitneyU test.Categorical variables were analyzed byχ2 test or Fisher exact test as appropriate.Results:Our study enrolled 109 COVID-19 patients who died during hospitalization and 116 recovered patients.The median age of the death group was older than the recovered group(69[62,74]vs.40[33,57]years,Z=9.738,P<0.001).More patients in the death group had underlying diseases(72.5%vs.41.4%,χ2=22.105,P<0.001).Patients in the death group had a significantly longer time of illness onset to hospitalization(10.0[6.5,12.0]vs.7.0[5.0,10.0]days,Z=3.216,P=0.001).On admission,the proportions of patients with symptoms of dyspnea(70.6%vs.19.0%,χ2=60.905,P<0.001)and expectoration(32.1%vs.12.1%,χ2=13.250,P<0.001)were significantly higher in the death group.The blood oxygen saturation was significantly lower in the death group(85[77,91]%vs.97[95,98]%,Z=10.625,P<0.001).The white blood cell(WBC)in death group was significantly higher on admission(7.23[4.87,11.17]vs.4.52[3.62,5.88]×109/L,Z=7.618,P<0.001).Patients in the death group exhibited significantly lower lymphocyte count(0.63[0.40,0.79]vs.1.00[0.72,1.27]×109/L,Z=8.037,P<0.001)and lymphocyte percentage(7.10[4.45,12.73]%vs.23.50[15.27,31.25]%,Z=10.315,P<0.001)on admission,and the lymphocyte percentage continued to decrease during hospitalization(7.10[4.45,12.73]%vs.2.91[1.79,6.13]%,Z=5.242,P<0.001).Alanine transaminase(22.00[15.00,34.00]vs.18.70[13.00,30.38]U/L,Z=2.592,P=0.010),aspartate transaminase(34.00[27.00,47.00]vs.22.00[17.65,31.75]U/L,Z=7.308,P<0.001),and creatinine levels(89.00[72.00,133.50]vs.65.00[54.60,78.75]μmol/L,Z=6.478,P<0.001)were significantly higher in the death group than those in the recovered group.C-reactive protein(CRP)levels were also significantly higher in the death group on admission(109.25[35.00,170.28]vs.3.22[1.04,21.80]mg/L,Z=10.206,P<0.001)and showed no significant improvement after treatment(109.25[35.00,170.28]vs.81.60[27.23,179.08]mg/L,Z=1.219,P=0.233).The patients in the death group had more complications such as acute respiratory distress syndrome(ARDS)(89.9%vs.8.6%,χ2=148.105,P<0.001),acute cardiac injury(59.6%vs.0.9%,χ2=93.222,P<0.001),acute kidney injury(18.3%vs.0%,χ2=23.257,P<0.001),shock(11.9%vs.0%,χ2=14.618,P<0.001),and disseminated intravascular coagulation(DIC)(6.4%vs.0%,χ2=7.655,P=0.006).Conclusions:Compared to the recovered group,more patients in the death group exhibited characteristics of advanced age,pre-existing comorbidities,dyspnea,oxygen saturation decrease,increased WBC count,decreased lymphocytes,and elevated CRP levels.More patients in the death group had complications such as ARDS,acute cardiac injury,acute kidney injury,shock,and DIC. | Yan Deng Wei Liu Kui Liu Yuan-Yuan Fang Jin Shang Ling Zhou Ke Wang Fan Leng Shuang Wei Lei Chen Hui-Guo Liu | 2020 | Chinese Medical Journal2020，，11： | 29 |
| 3 | Cold adaptation in pigs depends on UCP3 in beige adipocytes显示文摘 | Jun Lin Chunwei Cao Cong Tao Rongcai Ye Meng Dong Qiantao Zheng Chao Wang Xiaoxiao Jiang Guosong Qin Changguo Yan Kui Li John R. Speakman Yanfang Wang Wanzhu Jin Jianguo Zhao | 2017 | Journal of Molecular Cell Biology2017，9，5： | 20 |
| 4 | Flame retardant polyamide 6 by in situ polymerization of ε-caprolactam in the presence of melamine derivatives显示文摘An improved method for preparing melamine cyanurate (MCA) based flame retardant polyamide 6 (FRPA6) materials has been proposed. This processing method, i.e., improved in situ polymerization, was used to synthesize flame retardant PA6. In situ formed MCA nanoparticles were supposed to be linked to PA6 chains in the e-caprolactam hydrolytic polymerization system to obtain star- type polymers for the first time. Through TEM photographs, it can be found that the in situ formed MCA nanoparticles with diametric size of less than 50 nm, are nanoscaled, highly uniformly dispersed in the PA6 matrix. Synthesized ?ame retardant PA6 have good fire performance which can achieve UL-94 V-0 rating at 1.6 mm thickness with the presence of 7.34 wt.% MCA in the matrix. | Zhi Yong Wu Wei Xu Jin Kui Xia Yao Chi Liu Qian Xin Wu Wei Jian Xu | 2008 | Chinese Chemical Letters2008，19，2： | 15 |
| 5 | The Chromosome-Based Rubber Tree Genome Provides New Insights into Spurge Genome Evolution and Rubber Biosynthesis显示文摘The rubber tree,Hevea brasiliensis,produces natural rubber that serves as an essential industrial raw material.Here,we present a high-quality reference genome for a rubber tree cultivar GT1 using single-molecule real-time sequencing(SMRT)and Hi-C technologies to anchor the~1.47-Gb genome assembly into 18 pseudochromosomes.The chromosome-based genome analysis enabled us to establish a model of spurge chromosome evolution,since the common paleopolyploid event occurred before the split of Hevea and Manihot.We show recent and rapid bursts of the three Hevea-specific LTR-retrotransposon families during the last 10 million years,leading to the massive expansion by~65.88%(~970 Mbp)of the whole rubber tree genome since the divergence from Manihot.We identify large-scale expansion of genes associated with whole rubber biosynthesis processes,such as basal metabolic processes,ethylene biosynthesis,and the activation of polysaccharide and glycoprotein lectin,which are important properties for latex production.A map of genomic variation between the cultivated and wild rubber trees was obtained,which contains~15.7 million high-quality single-nucleotide polymorphisms.We identified hundreds of candidate domestication genes with drastically lowered genomic diversity in the cultivated but not wild rubber trees despite a relatively short domestication history of rubber tree,some of which are involved in rubber biosynthesis.This genome assembly represents key resources for future rubber tree research and breeding,providing novel targets for improving plant biotic and abiotic tolerance and rubber production. | Jin Liu Cong Shi Cheng-Cheng Shi Wei Li Qun-Jie Zhang Yun Zhang Kui Li Hui-Fang Lu Chao Shi Si-Tao Zhu Zai-Yun Xiao Hong Nan Yao Yue Xun-Ge Zhu Yu Wu Xiao-Ning Hong Guang-Yi Fan Yan Tong Dan Zhang Chang-Li Mao Yun-Long Liu Shi-Jie Hao Wei-Qing Liu Mei-Qi Lv Hai-Bin Zhang Yuan Liu Ge-Ran Hu-tang Jin-Peng Wang Jia-Hao Wang Ying-Huai Sun Shu-Bang Ni Wen-Bin Chen Xing-Cai Zhang Yuan-Nian Jiao Evan E.Eichler Guo-Hua Li Xin Liu Li-Zhi Gao | 2020 | Molecular Plant2020，13，2： | 15 |
| 6 | A Prospective Randomized Multicenter Controlled Trial on Salvianolate for Treatment of Unstable Angina Pectoris in A Chinese Elderly Population显示文摘Objective: To evaluate the efficacy and safety of salvianolate in elderly patients with unstable angina pectoris(UAP). Methods: A prospective double-blind randomized placebo-controlled multicenter trial in elderly patients with UAP from 13 third-grade class-A hospitals in China was performed. A total of 318 patients were randomly allocated in a 1:1 ratio to an experimental group(160 patients) and a control group(158 patients). The experimental group was treated with salvianolate for 14 days on the basis of conventional medicine, and the control group was given a placebo for 14 days with the same criteria. Follow-up was lasted 28 days in both groups. The primary endpoint was biweekly frequency of angina pectoris attacks. The secondary endpoints included biweekly dosage of nitroglycerin, the Seattle Angina Questionnaire, angina pectoris severity and duration, myocardial injury markers, high-sensitivity C-reactive protein(hs-CRP) and N-terminal pro-B-type natriuretic peptide(NT-proBNP), as well as major adverse cardiovascular events(MACEs). Safety was assessed according to adverse events and serious adverse events. Results: Baseline characteristics were similar between treatment groups. Compared with those in the control group, the frequency of biweekly angi na attacks(2.92 vs. 4.08, P =0.025), th e biweekly dosage of nitroglycerin, as well as the severity and duration of angina attacks(P <0.01) were reduced by salvianolate. The Seattle Angina Questionnaire score was also significantly improved in the experimental group than in the control group(P <0.05). No significant differences were observed between the two groups with respect to the incidence of MACEs. Salvianolate was well tolerated. Conclusions: Salvianolate appear to have efficacy and well tolerated for elderly patients with UAP. | CUI Hua LI Xiao-ying GAO Xue-wen LU Xiang WU Xiu-ping WANG Xiao-fei ZHENG Xiang-qing HUANG Kui LIU Feng LUO Zhi YUAN Hui-shu SUN Gang KONG Jian DU Xiao-hong ZHENG Jin LIU Hong-ying ZHANG Wen-ju | 2019 | Chinese Journal of Integrative Medicine2019，25，10： | 13 |
| 7 | The Cambrian sedimentary characteristics and their implications for oil and gas exploration in north margin of Middle-Upper Yangtze Plate显示文摘Using data from tens of measured and observed outcrop successions,thin rock slices and sample analyses,we comprehensively studied the Cambrian sedimentary environments and evolutionary characteristics in the north margin of the Middle-Upper Yangtze Plate.During the Cambrian,platform,slope,and deep sea basin environments were developed in the study area.On the platform,both clastic rocks and carbonate rocks were deposited.Clastic rocks mainly occur in the Lower Cambrian,and were deposited in marine shore and shelf environments.Carbonate rocks are dominant in the Middle and Upper Cambrian,and were deposited in the open platform,restricted platform,tidal flat,beach,and reef environments.Carbonate gravity flow deposits were developed on the slope.In the basin,mainly black shales and chert beds were deposited.The Cambrian represents one large transgression-regression cycle,and maximum transgression occurred in the Qiongzhusi Age of the Early Cambrian.Tectonics and sea level fluctuations had important impacts on sedimentary environments.The Chengkou-Fangxian-Xiangfan Fracture controlled the position of the platform,slope and basin,as well as the silica supply for chert deposition in basin.Sea level fluctuations controlled types of sediments and sedimentary facies on the platform.In the study area,there are good reservoir rocks,including dolomites,grainstones,debris flow deposits,sandstones,and conglomerates;there are good source rocks,including black shales,dark micrites,and chert beds;and there are also good reservoir-source rock assemblages.The hydrocarbon potential of the study area is great. | YU KuanHong JIN ZhenKui SU Kui DONG XiaoDong ZHANG Wei DU HongYu CHEN Ying ZHANG WeiDan | 2013 | Science China Earth Sciences2013，56，6： | 9 |
| 8 | Variations in paleoproductivity and the environmental implications over the past six decades in the Changjiang Estuary显示文摘Total organic carbon and organic carbon stable isotope, biogenic silica, chlorin were measured from a high resolution sediment core to indicate the variation in paleoproductivity and the environmental implications over the past decades (1942 to 1997) in the Changjiang Estuary. Based on these biomarkers, the shift in the phytoplankton community structure in the past decades was discussed in response to the long-term variations in nutrient concentrations and nutrient ratios. The results showed that the δ 13 C values varied from –26.15‰ to –19.5‰, suggesting the combined organic carbon sources of riverine and marine organisms. Based on the biogenic proxies, paleoproductivity changes were categorized into three stages: low production before 1950; an increase in production with the dominance of diatoms during 1950 to 1980, consistent with increasing of nutrient concentrations; a decrease in production after 1980 when the diatom production decreased while the production of non-silicious phytoplankton increased due to high nutrient inputs, and high N/P and P/Si ratios in the Changjiang Estuary. The sedimentation records also indicated that the riverine organic carbon increased since 1980. | JIN Haiyan CHEN Jianfang WENG Huanxin LI Hongliang ZHANG Weiyan XU Jie BAI Youcheng WANG Kui | 2010 | Acta Oceanologica Sinica2010，29，3： | 8 |
| 9 | Bio-inspired Graphene-enhanced Thermally Conductive Elastic Silicone Rubber as Drag Reduction Material显示文摘这研究介绍了 graphene 血小板 / 硅酮橡胶(GPL/SR ) 象 drag 减小材料合成,由加热的边界启发了拖海豚皮肤的减小机制。Graphene 在 0.17 wt% , 0.33 wt% 和 0.67 wt% 的重量部分作为热地传导性的 filler 被加到太古的硅酮橡胶(PSR ) 。热传导性和张力的性质的测试证明分别地, 0.17 wt% , 0.33 wt% 和 0.67 wt% graphene 的所有三 GPL/SR 材料的热传导性比 PSR 的高是 20% , 40% 和 50% , 0.17 wt% GPL/SR 材料的有弹性的模量最低。微滴速度测试,它能反映加热边界的 drag 减小机制由 GPL/SR 控制了合成,在 0.33 wt% GPL/SR 之间被执行,它典型地展出好机械性质和热电导率性能,和 PSR。结果证明在 0.33 wt% GPL/SR 上,微滴速度更高,滚动角度更低,暗示 GPL/SR 合成让拖减少工作。以 drag 减小机制, GPL/SR 的热传导性表演加速了在 GPL/SR 合成表面和微滴之间的热转移。在分子之间的力量减少了并且微滴动态粘性被减少。滑动的水微滴的 drag 与动态粘性成正比,它导致了拖减小。到控制液体媒介的 GPL/SR 材料的应用程序应该为液体机械有重要价值。 | Limei Tian E Jin Haoran Mei Qingpeng Ke Ziyuan Li Hailin Kui | 2017 | Journal of Bionic Engineering2017，14，1： | 6 |
| 10 | Relationship of the preoperative NRS 2002 score,PG-SGA score,and serum indices with postoperative complications in patients with gastric cancer显示文摘Objective To examine the utility of the Nutrition Risk Screening 2002(NRS 2002),Patient-Generated Subjective Global Assessment(PG-SGA)and serum factors for the preoperative evaluation of gastric cancer patients.Methods We examined 181 gastric cancer patients treated at the First Affiliated Hospital of Guangxi Medical University from January 2015 to January 2018.Nutritional assessments were administered within 48 h of admission.The body mass index(BMI)and serum factors were measured,and information on preoperative nutritional support and postoperative complications was recorded.Results Both the NRS 2002 and PG-SGA had positive correlations with age(P<0.05),and negative correlations with albumin,prealbumin,transferrin,hemoglobin,BMI,and bodyweight(P<0.05).The NRS 2002 and PG-SGA scores were positively correlated with each other(r=0.683,P<0.01),but had poor consistency(κ=0.357,P<0.01).During the preoperative period,33.2%of patients received nutritional support,mainly enteral nutrition.The nutritional risk group(NRS 2002≥3)received more support than the group without nutritional risk(NRS 2002<3;P<0.05).Patients with nutritional risk or malnutrition who received preoperative nutritional support had fewer postoperative complications than unsupported patients.The overall rate of complications was 12.2%,and the rate of severe complications(gradeⅢor above)was 5.5%.The malnutrition and nutritional risk groups had higher rates of severe complications.Conclusions The combined application of the NRS 2002,PG-SGA,BMI,and serum nutritional indices was useful for the nutritional screening and assessment of preoperative gastric cancer patients.The NRS 2002 and PG-SGA provided guidance on the need for nutritional support during the preoperative period. | Dao Lai Huang Xiang Hua Wu Chang Li Wang Jun Qiang Chen Kui Jia Jing Zhou Li Sheng Lu Yong Sheng Zhang Jing Jin Ke Ke Huang | 2021 | Journal of Nutritional Oncology2021，6，2： | 5 |
| 11 | Surface morphology and electronic structure in stoichiometric superconductor CaKFe_(4)As_(4) robed by scanning tunneling microscopy/spectroscopy显示文摘CaKFe_(4)As_(4) is a new-type superconductor with a relatively high transition temperature of 35 K among stoichiometric iron-based superconductors. Based on scanning tunneling microscopy/spectroscopy, the surface morphology and electronic structure of CaKFe_(4)As_(4) single crystal were systematically investigated. The cleaved CaKFe_(4)As_(4) showed various morphologies, such as atomically resolved 1×1, 1×2, and √2×√2 lattices. By analyzing the geometrical correlations of these morphologies, the 1×1 and 1×2 lattices were identified as the original and reconstructed As layers, respectively, whereas the √2×√2 lattice was distinguished as the reconstructed alkaline-earth-metal or alkali-metal layer. The superconducting energy gap of 7.3 me V and bosonic mode of 12.7 me V were resolved in the scanning tunneling spectra. In addition, the superconducting energy gaps measured on different terminations were identical and consistent with the values obtained by bulk-sensitive techniques, indicating that the electronic structures of CaKFe_(4)As_(4) were insensitive to the surface reconstructions. Our study clarifies the relationships between complex surface reconstructions and surface terminations and preliminarily presents that there is no obvious effect of surface reconstructions on electronic states. | Xiaodong Yu Zhongxu Wei Zhanyi Zhao Tao Xie Chang Liu Ge He Qihong Chen Lei Shan Huiqian Luo Qing Huan Jie Yuan Kui Jin | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，12： | 5 |
| 12 | Microstructure of Carbides at Grain Boundaries in Nickel Based Superalloys显示文摘It is well known that carbides at grain boundaries play an important role in affecting mechanical properties of nickel based superalloys. In order to deeply understand the relationship between grain boundary structures and properties, in this work, we have investigated the microstructure of grain boundaries with different misorientation angles in bicrystals of nickel based superalloys. It is found that the bicrystals with smaller misorientation angles contain denser M 23 C 6 but sparse MC particles at grain boundaries, and this kind of bicrystals presents longer stress rupture lives. It was observed that MC carbides were decorated by M 23 C 6 and M 6 C particles at grain boundaries. The formation of these carbide particles, therefore, is likely due to the local fluctuation of chemical composition around MC carbides. In addition, the orientation relationships between MC carbides and γ/γ matrix were also determined. | Xiaoming Dong Xiaoli Zhang Kui Du Yizhou Zhou Tao Jin Hengqiang Ye | 2012 | Journal of Materials Science & Technology2012，28，11： | 4 |
| 13 | Development of catalytic combustion and CO_(2)capture and conversion technology显示文摘Changes are needed to improve the efficiency and lower the CO_(2)emissions of traditional coal-fired power generation,which is the main source of global CO_(2)emissions.The integrated gasification fuel cell(IGFC)process,which combines coal gasification and high-temperature fuel cells,was proposed in 2017 to improve the efficiency of coal-based power generation and reduce CO_(2)emissions.Supported by the National Key R&D Program of China,the IGFC for nearzero CO_(2)emissions program was enacted with the goal of achieving near-zero CO_(2)emissions based on(1)catalytic combustion of the flue gas from solid oxide fuel cell(SOFC)stacks and(2)CO_(2)conversion using solid oxide electrolysis cells(SOECs).In this work,we investigated a kW-level catalytic combustion burner and SOEC stack,evaluated the electrochemical performance of the SOEC stack in H2O electrolysis and H2O/CO_(2)co-electrolysis,and established a multiscale and multi-physical coupling simulation model of SOFCs and SOECs.The process developed in this work paves the way for the demonstration and deployment of IGFC technology in the future. | Zhibin Yang Ze Lei Ben Ge Xingyu Xiong Yiqian Jin Kui Jiao Fanglin Chen Suping Peng | 2021 | International Journal of Coal Science & Technology2021，8，3： | 3 |
| 14 | An Outbreak of Leptospirosis in Lezhi County, China in 2010 May Possibly Be Linked to Rainfall显示文摘A total of 26 leptospirosis cases occurred in the outbreak,of whom six died after hospitalization.All26 patients were clinically diagnosed as leptospirosis.Microscopic agglutination test(MAT)revealed that13 of 26 patients were affected with laboratory confirmed leptospirosis.Furthermore,MAT data suggested that serogroup Icterohaemorrhagiae were the main pathogens responsible for this outbreak.And the rainfall data suggested that the increased rainfall might be responsible for the leptospirosis outbreak in Lezhi County.This outbreak has reminded us that leptospirosis should not be neglected,especially during flood season,although its incidence rate is low. | WANG Ya Lin QIN Jin Hong ZHANG Cui Cai GUO Xiao Kui JIANG Xiu Gao HE Ping | 2014 | Biomedical and Environmental Sciences2014，27，1： | 3 |
| 15 | Multi-physics-resolved digital twin of proton exchange membrane fuel cells with a data-driven surrogate model显示文摘The development of multi-physics-resolved digital twins of proton exchange membrane fuel cells(PEMFCs)is sig-nificant for the advancement of this technology.Here,to solve this scientific issue,a surrogate modelling method that combines a state-of-the-art three-dimensional PEMFC physical model and data-driven model is proposed.The surrogate modelling prediction results demonstrate that the test-set relative root mean square errors(rRMSEs)of the multi-physics fields range from 3.88%to 24.80%and can mirror the multi-physics field distribution charac-teristics well.In summary,for multi-physics field prediction,the data-driven surrogate model has a comparable accuracy to the comprehensive 3D physical model;however,it considerably reduces the cost of computation and time and achieves the efficient multi-physics-resolved digital-twin.Two model-based designs based on the as-developed digital twin framework,i.e.the PEMFC healthy operation envelope and the PEMFC state map,are demonstrated.This study highlights the potential of combining data-driven approaches and comprehensive physical models to develop the digital twin of complex systems,such as PEMFCs. | Bowen Wang Guobin Zhang Huizhi Wang Jin Xuan Kui Jiao | 2020 | Energy and AI2020，1，1： | 3 |
| 16 | Management of regional citrate anticoagulation for continuous renal replacement therapy:guideline recommendations from Chinese emergency medical doctor consensus显示文摘Continuous renal replacement therapy(CRRT)is widely used for treating critically-ill patients in the emergency department in China.Anticoagulant therapy is needed to prevent clotting in the extracorporeal circulation during CRRT.Regional citrate anticoagulation(RCA)has been shown to potentially be safer and more effective,and is now recommended as the preferred anticoagulant method for CRRT.However,there is still a lack of unified standards for RCA management in the world,and there are many problems in using this method in clinical practice.The Emergency Medical Doctor Branch of the Chinese Medical Doctor Association(CMDA)organized a panel of domestic emergency medicine experts and international experts of CRRT to discuss RCA-related issues,including the advantages and disadvantages of RCA in CRRT anticoagulation,the principle of RCA,parameter settings for RCA,monitoring of RCA(mainly metabolic acid-base disorders),and special issues during RCA.Based on the latest available research evidence as well as the paneled experts'clinical experience,considering the generalizability,suitability,and potential resource utilization,while also balancing clinical advantages and disadvantages,a total of 16 guideline recommendations were formed from the experts'consensus. | Shu-Yuan Liu Sheng-Yong Xu Lu Yin Ting Yang Kui Jin Qiu-Bin Zhang Feng Sun Ding-Yu Tan Tian-Yu Xin Yu-Guo Chen Xiao-Dong Zhao Xue-Zhong Yu Jun Xu Emergency Medical Doctor Branch of the Chinese Medical Doctor Association | 2023 | Military Medical Research2023，10，6： | 3 |
| 17 | Thin-layered MoS_2/polyaniline nanocomposite for highly sensitive electrochemical detection of chloramphenicol显示文摘In this study, we synthesized molybdenum disulfide/polyaniline(MoS_2/PANI) nanocomposite via in situ polymerization of aniline in the presence of thin-layered MoS_2. The as-prepared MoS_2/PANI nanocomposite obtained an improved electrochemical performance due to the physisorption interaction between aromatic aniline and the basal plane of MoS_2. Furthermore, we constructed a new kind of electrochemical sensor based on MoS_2/PANI nanocomposite for the detection of chloramphenicol, which showed an excellent performance. The sensor has a high sensitivity and wide detection range from 1 x10^(-7)mol/L to 1x10^(-4)mol/L, with a low detection limit of 6.9 x 10^(-8)mol/L. | Huai-Yin Chen Jin Wang Le Meng Tao Yang Kui Jiao | 2016 | Chinese Chemical Letters2016，27，2： | 3 |
| 18 | Two New Steroidal Glycosides from Fermented Leaves of Agave americana显示文摘Two new spirostanol glycosides named agamenoside A and B, were isolated from the fermented leaves of Agave americana. Their structures were elucidated as (23S, 25R)-5a -spirostan-3b, 6a, 23-triol 3-O-a-L-rhamnopyranosyl-(13)- b-D-glucopyranosyl-(12)-[b-D- xylopyranosyl-(13)]-b-D-glucopyranosyl-(14)-b-D-galactopyranoside (1) and (25R)-5a-spiro- stan-3b, 6a-diol 3-O-b-D-glucopyranosyl-(12)-[ b-D-xylopyranosyl-(13)]- b-D-glucopyra- nosyl-(14)- b-D-galactopyranoside (2) by a combination of chemical and spectral methods. | Jian Ming JIN, Xi Kui LIU, Rong Wei TENG, Chong Ren YANG* Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204 | 2002 | Chinese Chemical Letters2002，13，7： | 2 |
| 19 | Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial显示文摘Recent evidence suggests that CD147 serves as a novel receptor for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection.Blocking CD147 via anti-CD147 antibody could suppress the in vitro SARS-CoV-2 replication.Meplazumab is a humanized anti-CD147 IgG_(2) monoclonal antibody,which may effectively prevent SARS-CoV-2 infection in coronavirus disease 2019(COVID-19)patients.Here,we conducted a randomized,double-blinded,placebo-controlled phase 1 trial to evaluate the safety,tolerability,and pharmacokinetics of meplazumab in healthy subjects,and an open-labeled,concurrent controlled add-on exploratory phase 2 study to determine the efficacy in COVID-19 patients.In phase 1 study,59 subjects were enrolled and assigned to eight cohorts,and no serious treatment-emergent adverse event(TEAE)or TEAE grade≥3 was observed.The serum and peripheral blood Cmax and area under the curve showed non-linear pharmacokinetic characteristics.No obvious relation between the incidence or titer of positive anti-drug antibody and dosage was observed in each cohort.The biodistribution study indicated that meplazumab reached lung tissue and maintained>14 days stable with the lung tissue/cardiac blood-pool ratio ranging from 0.41 to 0.32.In the exploratory phase 2 study,17 COVID-19 patients were enrolled,and 11 hospitalized patients were involved as concurrent control.The meplazumab treatment significantly improved the discharged(P=0.005)and case severity(P=0.021),and reduced the time to virus negative(P=0.045)in comparison to the control group.These results show a sound safety and tolerance of meplazumab in healthy volunteers and suggest that meplazumab could accelerate the recovery of patients from COVID-19 pneumonia with a favorable safety profile. | Huijie Bian Zhao-Hui Zheng Ding Wei Aidong Wen Zheng Zhang Jian-Qi Lian Wen-Zhen Kang Chun-Qiu Hao Jing Wang Rong-Hua Xie Ke Dong Jie-Lai Xia Jin-Lin Miao Wen Kang Guoquan Li Di Zhang Mingru Zhang Xiu-Xuan Sun Likun Ding Kui Zhang Junfeng Jia Jin Ding Zhiqin Li Yanyan Jia Lin-Na Liu Zhe Zhang Zhao-Wei Gao Hong Du Na Yao Qing Wang Ke Wang Jie-Jie Geng Bin Wang Ting Guo Ruo Chen Yu-Meng Zhu Li-Juan Wang Qian He Rui-Rui Yao Ying Shi Xiang-Min Yang Jian-Sheng Zhou Yi-Nan Ma Ya-Tao Wang Xue Liang Fei Huo Zhe Wang Yang Zhang Xu Yang Ye Zhang Lu-Hua Gao Ling Wang Xiao-Chun Chen Hao Tang Shuang-Shuang Liu Qing-Yi Wang Zhi-Nan Chen Ping Zhu | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 20 | Enhanced Potassium‑Ion Storage of the 3D Carbon Superstructure by Manipulating the Nitrogen‑Doped Species and Morphology显示文摘Potassium-ion batteries(PIBs)are attractive for gridscale energy storage due to the abundant potassium resource and high energy density.The key to achieving high-performance and large-scale energy storage technology lies in seeking eco-efficient synthetic processes to the design of suitable anode materials.Herein,a spherical sponge-like carbon superstructure(NCS)assembled by 2D nanosheets is rationally and efficiently designed for K+storage.The optimized NCS electrode exhibits an outstanding rate capability,high reversible specific capacity(250 mAh g^(−1) at 200 mA g^(−1) after 300 cycles),and promising cycling performance(205 mAh g^(−1) at 1000 mA g^(−1) after 2000 cycles).The superior performance can be attributed to the unique robust spherical structure and 3D electrical transfer network together with nitrogen-rich nanosheets.Moreover,the regulation of the nitrogen doping types and morphology of NCS-5 is also discussed in detail based on the experiments results and density functional theory calculations.This strategy for manipulating the structure and properties of 3D materials is expected to meet the grand challenges for advanced carbon materials as high-performance PIB anodes in practical applications. | Yanhua Li Kui Xiao Cong Huang Jin Wang Ming Gao Aiping Hu Qunli Tang Binbin Fan Yali Xu Xiaohua Chen | 2021 | Nano-Micro Letters2021，13，1： | 2 |
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