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| 1 | Epidemiological Investigation of an Inhalational Anthrax Patient Traveling for Medical Treatment in Beijing Municipality,China,August 2021显示文摘Summary What is already known about this topic?Inhalational anthrax,also known as pulmonary anthrax,is an infectious disease caused by Bacillus anthracis.The patients are usually infected by inhaling aerosolized B.anthracis spores from dead animals or animal products.Compared to cutaneous anthrax,inhalational anthrax is rare and deadly and few cases in China were reported.What is added by this report?This report covers all information of clinical features,laboratory testing,and epidemiological characteristics as well as exposure history of a recent primary inhalational anthrax patient who was seeking medical treatment in Beijing Municipality in August 2021.New laboratory techniques,including second-generation sequencing,polymerase chain reaction,and rapid test for serum antibody,played an important role in the process.What are the implications for public health practice?The information provided in this report,including the correct sample type,epidemiological investigation details,and application of the new diagnostic criteria of anthrax,could assist public health professionals in dealing with anthrax epidemics. | Changying Lin Xiangfeng Dou Daitao Zhang Yinqi Sun Huiqiang Han Chunzhi Chen Xiaojun Zhang Shuang Li Yanwei Chen Hongbin Zhang Bin Wang Zhichao Liang Xin Zhang Feng Wei Jiangli Wang Feng Liu Quanyi Wang Jian Shi Peng Yang | 2022 | China CDC weekly2022，4，1： | 3 |
| 2 | An inspiration to the studies on mechanisms of acupuncture and moxibustion action derived from 2021 Nobel Prize in Physiology or Medicine显示文摘The editorial board of Acupuncture and Herbal Medicine recently convened an academic seminar with a focus on studies regarding the mechanisms mediating acupuncture efficacy and moxibustion action inspired by the 2021 Nobel Prize in Physiology or Medicine.Specifically,Professor Bailong Xiao introduced the Nobel Prize for research on the mechanically activated Piezo ion channel,evaluating the structure of the Piezo channel and its physiological and pathological functions,and proposed a possible role for the Piezo channel in acupuncture mechanical stimulation.Professor Michael Xi Zhu introduced the discovery of the transient receptor potential(TRP)family,reporting that the therapeutic effects of Chinese medicine and acupuncture may be achieved via the TRP family,and that information regarding associations between the meridian and lymphatic systems may have important research and medical value.In addition,Professor Tianle Xu reviewed the history of ion channel research,particularly the physiological and pharmacological effects of non-classical ion channels(eg,the acid sensing ion channel family)and pointed out that the characterization and neural circuits of acupuncture deqi manipulation are important for elucidating the mechanisms of acupuncture actions.Professor Yongming Li similarly proposed that the 2021 Nobel Prize may open the door to disclosing the histological basis of acupuncture and moxibustion and analyzing the main scientific concerns regarding the clinical translation of acupuncture and moxibustion from basic to translational research.Finally,Professor Yi Guo summarized the study progress of the acupoint microenvironment induced by acupuncture over the course of nearly 30 years and put forward the hypothesis that acupuncture may initiate the physical-chemical coupling network by activating ion channel receptors in acupoints via physical and mechanical stimulation.Therefore,we conclude that a primary achievement of the 2021 Nobel Prize in Physiology or Medicine is in helping interpret how acupuncture and moxibustion adjust homeostasis(ie,by activating mechanical and thermal sensation),which is conducive to validating and promoting the clinical efficacy of acupuncture modalities. | Yi Guo Yongming Li Tianle Xu Michael Xi Zhu Zhifang Xu Baomin Dou Yanwei Li Zhihan Chen | 2022 | Acupuncture and Herbal Medicine2022，2，1： | 2 |
| 3 | IL-22 + CD4 + T Cells Promote Colorectal Cancer Stemness via STAT3 Transcription Factor Activation and Induction of the Methyltransferase DOT1L显示文摘 | Ilona Kryczek Yanwei Lin Nisha Nagarsheth Dongjun Peng Lili Zhao Ende Zhao Linda Vatan Wojciech Szeliga Yali Dou Scott Owens Witold Zgodzinski Marek Majewski Grzegorz Wallner Jingyuan Fang Emina Huang Weiping Zou | 2014 | Immunity2014，，5： | 1 |
| 4 | Therapeutic potential and mechanism of Chinese herbal medicines in treating fibrotic liver disease显示文摘Liver fibrosis is a pathological condition characterized by replacement of normal liver tissue with scar tissue,and also the leading cause of liver-related death worldwide.During the treatment of liver fibrosis,in addition to antiviral therapy or removal of inducers,there remains a lack of specific and effective treatment strategies.For thousands of years,Chinese herbal medicines(CHMs)have been widely used to treat liver fibrosis in clinical setting.CHMs are effective for liver fibrosis,though its mechanisms of action are unclear.In recent years,many studies have attempted to determine the possible mechanisms of action of CHMs in treating liver fibrosis.There have been substantial improvements in the experimental investigation of CHMs which have greatly promoted the understanding of anti-liver fibrosis mechanisms.In this review,the role of CHMs in the treatment of liver fibrosis is described,based on studies over the past decade,which has addressed the various mechanisms and signaling pathways that mediate therapeutic efficacy.Among them,inhibition of stellate cell activation is identified as the most common mechanism.This article provides insights into the research direction of CHMs,in order to expand its clinical application range and improve its effectiveness. | LI Yanwei LU Yunrui NIAN Mozuo SHENG Qiuju ZHANG Chong HAN Chao DOU Xiaoguang DING Yang | 2023 | Chinese Journal of Natural Medicines2023，21，9： | 1 |
| 5 | HBeAg-negative Patients with Chronic Hepatitis B Virus Infection and Normal Alanine Aminotransferase:Wait or Treat?显示文摘Alanine aminotransferase(ALT)is a common clinical indicator of liver inflammation.The current Chinese guidelines for the management of chronic hepatitis B(CHB)recommend antiviral treatment for patients with detectable hepatitis B virus(HBV)DNA and persistent ALT levels(ALTs)exceeding the upper limit of normal.However,it has been recently reported that patients with chronic HBV infection,especially HBeAg-negative patients with persistently normal ALTs,may have liver biopsy findings of significant inflammation and fibrosis.For HBeAg-negative patients with chronic HBV infection and normal ALTs,many controversial questions have been asked.To treat or not?When to initiate the treatment?Which drug is appropriate?In this review,we summarize the available data on the management of HBeAg-negative patients with chronic HBV infection and normal ALTs with the aim of improving the current clinical management. | Qiuju Sheng Ning Wang Chong Zhang Yaoxin Fan Yanwei Li Chao Han Ziyi Wang Shuqi Wei Xiaoguang Dou Yang Ding | 2022 | Journal of Clinical and Translational Hepatology2022，10，5： | 1 |
| 6 | The first local case of mpox caused by an imported case in the Chinese mainland显示文摘Monkeypox (mpox) is a zoonotic disease caused by the mpox virus (MPXV) that has been primarily limited to Central and West African nations since its discovery. The recent spread of the West African lineage of MPXV in historically unaffected countries has raised concerns for global public health. Despite a significant decrease in global mpox cases, there is still a risk of a global resurgence. This study reports the first local case of mpox caused by an imported case in the Chinese mainland. Polymerase chain reaction (PCR) diagnosed the two cases, and the viral genomes were obtained by next-generation sequencing. Genomic analysis revealed that the two strains shared an identical genome sequence and belonged to the B.1.3 branch of the West African lineage, which is the first local case of mpox caused by an imported case in the Chinese mainland, highlighting the potential threat of mpox in China and the immediate need for adequate surveillance measures. | Daitao Zhang Xiao Qi Fu Li Yanhui Chu Ke Wu Jia Li Xin Meng Xiangfeng Dou Zhenyong Ren Haoyuan Jin Shuang Li Yulan Sun Yanwei Chen Renqing Li Dan Li Weihong Li Yang Yang Yang Pan Wenjie Tan Quanyi Wang | 2023 | Biosafety and Health2023，5，4： | 1 |
| 7 | Environmental Benefits for Phase-Out HCFC-22 in the Residential Air-Conditioner Sector in China显示文摘中国是 hydrochlorofluorocarbons (HCFC ) 的最大的制片人和消费者,并且 HCFC-22 的生产占超过 80% 所有 HCFC。这份报纸专注于居住空调机工业并且分析在中国加速 HCFC-22 的逐步淘汰的环境好处。根据基线的比较和 HCFC-22 的逐步淘汰情形,将直接作为一种致冷的选择用 HC-290 (丙烷) 减少温室效应,并且间接地在电消费由于减小减少温室气体的排放的调查结果表演。HC-290 和 HFC-410A 的二种情形的比较致冷的选择证明 HC-290 致冷的愿望的使用比 HFC-410A 生产显著地更高的环境好处致冷。引证苍白, T. , Y。Dou, L. 王,等, 2011:为在在中国的居住空调机部门的逐步淘汰 HCFC-22 的环境好处。副词。Clim。变化物件, 2 (2 ) , doi:10.3724/SP .J.1248.2011.00086。 | Tingting Wan Yanwei Dou Lei Wang Lirong Yang Xiaofang Zhou Dan Wan Jianxin Hu | 2011 | Advances in Climate Change Research2011，2，2： | 0 |
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