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| 1 | Interannual variability in soil respiration from terrestrial ecosystems in China and its response to climate change显示文摘Soil respiration is an important process in terrestrial carbon cycle.Concerning terrestrial ecosystems in China, quantifying the spatiotemporal pattern of soil respiration at the regional scale is critical in providing a theoretical basis for evaluating carbon budget.In this study, we used an empirically based, semi-mechanistic model including climate and soil properties to estimate annual soil respiration from terrestrial ecosystems in China from 1970 to 2009.We further analyzed the relationship between interannual variability in soil respiration and climatic factors (air temperature and precipitation).Results indicated that the distribution of annual soil respiration showed clear spatial patterns.The highest and lowest annual soil respiration rates appeared in southeastern China and northwestern China, respectively, which was in accordance with the spatial patterns of mean annual air temperature and annual precipitation.Although the mean annual air temperature in northwestern China was higher than that in some regions of northeastern china, a greater topsoil organic carbon storage in northeastern China might result in the higher annual soil respiration in this region.By contrast, lower temperature, less precipitation and smaller topsoil organic carbon pool incurred the lowest annual soil respiration in northwestern China.Annual soil respiration from terrestrial ecosystems in China varied from 4.58 to 5.19 PgCa-1 between 1970 and 2009.During this time period, on average, annual soil respiration was estimated to be 4.83 PgCa-1 .Annual soil respiration in China accounted for 4.93%-6.01% of the global annual soil CO2 emission.The interannual variability in soil respiration depended on the interannual variability in precipitation and mean air temperature.In order to reduce the uncertainty in estimating annual soil respiration at regional scale, more in situ measurements of soil respiration and relevant factors (e.g.climate, soil and vegetation) should be made simultaneously and historical soil property data sets should also be established. | CHEN ShuTao HUANG Yao ZOU JianWen SHI YanShu LU YanYu ZHANG Wen HU ZhengHua | 2012 | Science China Earth Sciences2012，55，12： | 8 |
| 2 | Clinical characteristics and survival of 5283 esophageal cancer patients: A multicenter study from eighteen hospitals across six regions in China显示文摘Objective:This study aimed to investigate the potential determining epidemiological and clinical risk factors affecting the survival of esophageal cancer(EC)patients across multiple hospitals in China.Methods:This was a multicenter study comprising of newly diagnosed EC cases from Beijing,Hebei,Henan,Hubei,Zhejiang,and Guangdong Province of China.Their baseline characteristics and treatment methods data were collected from their medical records.The EpiData software was used for data quality control.The Kaplan-Meier method was used to estimate their overall survival(OS),and the Cox’s proportional hazard regression model was used to estimate hazard ratios(HR)and 95%confidence interval(CI).Results:The 3-and 5-year OS rates of the 5283 investigated EC patients were 49.98%and 39.07%,respectively.Their median survival was 36.00 months.The median survival time of females was longer than that of males(females vs.males:45.00 vs.33.00,P<0.001).The 5-year OS rate of patients who never-smoked was higher than that of smokers(never-smokers vs smokers:40.73%vs.37.84%,P=0.001).There was no significant difference in the 5-year OS rate between drinkers and never-drinkers(drinkers vs never-drinkers:34.22%vs.29.65%,P=0.330).In multivariate analysis,pathological stage(stage II:HR=1.80,95%CI=1.40-2.31;stage III:HR=2.62,95%CI=2.06-3.34;stage IV:HR=3.90,95%CI=2.98-5.09),poor differentiation/undifferentiated(HR=1.34,95%CI=1.11-1.63),not married status(HR=2.45,95%CI=1.49-4.04),production and service personnel(HR=1.36,95%CI=1.01-1.83)and farming/fishing(HR=1.40,95%CI=1.12-1.76)were independent prognostic risk factors for poor EC survival.Tumors in the thoracic or abdominal part of the esophagus,female and family history of any cancer were independent factors predictive of a good EC OS.Conclusion:Gender,marital status,occupation,family history of any cancer,tumor topographical site,differentiation status,and pathological stage were associated with the survival rate of EC.This study reveals important clinical characteristics of esophageal cancer patients in China and provides helpful information for their clinical management and surveillance. | Yutong He Di Liang Lingbin Du Tiantian Guo Yanyu Liu Xibin Sun Ning Wang Min Zhang Kuangrong Wei Baoen Shan Wanqing Chen | 2020 | Cancer Communications2020，40，10： | 8 |
| 3 | Anti-P-selectin lectin-EGF domain monoclonal antibody inhibits the maturation of human immature dendritic cells显示文摘Dendritic cells(DCs) are professinal antigen-presenting cells with the ability to initiate primary Tcell responses. While it iswell known that inflammatory stimuli induce the functional maturation of immature DCs, whether adhesion molecule selectins regulate DCmaturation is poorly understood. Using anti-P-selectin lectin-EGF domain monoclonal antibody (PsL-EGFmAb) that blocks the adhesionof P-, E-, and L-selectin, we demonstrate herein that selectins play important role in stimulating functional maturation of immature DCs.Immature DCs are generated from human cord blood CD34+hematopoietic stem/progenitor cells that were cultured in the presence of stemcell factor, Fms-like tyrosine-kinase-3 ligand, granulocyte-macrophage colony stimulating factor, and transform growth factor-β1. Whenstimulated with tumor necrosis factor-alpha(TNF-α), immature DCs differentiated into mature DCs, producing increased levels of costim-ulatory molecules and interleukin (IL)-12 and obtaining the ability to potently activate naive Tcells. Interestingly, in contrast to matureDCs derived from TNF-α-induced immature DC cultures without PsL-EGFmAb, immature DCs treated with PsL-EGFmAb for7 days werecompletely blocked their maturation, as evidenced by decreased expression of costimulatory molecules CD80, CD86, and CD83, inhibi-ted production of IL-12, and inability to activate naive Tcellsin vitro. Thus, blockade of selectins using PsL-EGFmAb will prove to bea valuable tool for the study of the molecuar mechanisms of DC maturation, as well as for the prevention and treatment of DC-mediated au-toimmunity. | Tong Zhou Yanyu Zhang Guizhi Sun Yumei Zhang Dongqing Zhang Yapeng Zhao Nan Chen | 2006 | 上海交通大学学报(医学版)2006，26，5： | 5 |
| 4 | A Phytophthora capsid Effector Targets ACD11 Binding Partners that Regulate ROS-Mediated Defense Response in Arabidopsis显示文摘Reactive oxygen species (ROS) play a vital role in plant immune response, but the genes involved in the regulation of ROS are scantily reported. Phytophthora pathogens produce a large number of effectors to promote infection, but the modes of action adopted are largely unknown. Here, we report that RxLR207 could activate ROS-mediated cell death in Nicotiana benthamiana and was essential for virulence of P. capsici. We found that this effector targeted BPA1 (binding partner of ACD11) and four members of BPLs (BPAl-Like proteins)in Arabidopsis, and the bpa1 and bpl mutants had enhanced ROS accumulation and cell death under biotic or abiotic stresses. Furthermore, we showed that BPA1 and several BPLs functioned redundantly in plant immunity to P. capsici. We discovered that BPA1 and all six BPLs interacted with ACD11, and stabilization of ACD11 was impaired in the bpa 1, bpl2, bpl3, and bpl4 mutants. RxLR207 could promote the degradation of BPA1, BPL1, BPL2, and BPL4 to disrupt ACD11 stabilization in a 26S proteasome-dependent manner. Taken together, these fin dings indicate the important roles of Arabidopsis BPA1 and its homologs in ROS homeostasis and defense response, highlighting the usefulness of a pathogen effector-directed approach as a promising strategy for the discovery of novel plant immune regulators. | Qi Li Gan Ai Danyu Shen Fen Zou Ji Wang Tian Bai Yanyu Chen Shutian Li Meixiang Zhang Maofeng Jing Daolong Dou | 2019 | Molecular Plant2019，12，4： | 5 |
| 5 | Climate and Vegetation Drivers of Terrestrial Carbon Fluxes:A Global Data Synthesis显示文摘The terrestrial carbon(C) cycle plays an important role in global climate change, but the vegetation and environmental drivers of C fluxes are poorly understood. We established a global dataset with 1194 available data across site-years including gross primary productivity(GPP), ecosystem respiration(ER), net ecosystem productivity(NEP), and relevant environmental factors to investigate the variability in GPP, ER and NEP, as well as their covariability with climate and vegetation drivers.The results indicated that both GPP and ER increased exponentially with the increase in mean annual temperature(MAT)for all biomes. Besides MAT, annual precipitation(AP) had a strong correlation with GPP(or ER) for non-wetland biomes.Maximum leaf area index(LAI) was an important factor determining C fluxes for all biomes. The variations in both GPP and ER were also associated with variations in vegetation characteristics. The model including MAT, AP and LAI explained 53%of the annual GPP variations and 48% of the annual ER variations across all biomes. The model based on MAT and LAI explained 91% of the annual GPP variations and 92.9% of the annual ER variations for the wetland sites. The effects of LAI on GPP, ER or NEP highlighted that canopy-level measurement is critical for accurately estimating ecosystem–atmosphere exchange of carbon dioxide. The present study suggests a significance of the combined effects of climate and vegetation(e.g.,LAI) drivers on C fluxes and shows that climate and LAI might influence C flux components differently in different climate regions. | Shutao CHEN Jianwen ZOU Zhenghua HU Yanyu LU | 2019 | Advances in Atmospheric Sciences2019，36，7： | 4 |
| 6 | Therapeutic strategies of glioblastoma (GBM):The current advances in the molecular targets and bioactive small molecule compounds显示文摘Glioblastoma(GBM)is the most common aggressive malignant tumor in brain neuroepithelial tumors and remains incurable.A variety of treatment options are currently being explored to improve patient survival,including small molecule inhibitors,viral therapies,cancer vaccines,and monoclonal antibodies.Among them,the unique advantages of small molecule inhibitors have made them a focus of attention in the drug discovery of glioblastoma.Currently,the most used chemotherapeutic agents are small molecule inhibitors that target key dysregulated signaling pathways in glioblastoma,including receptor tyrosine kinase,PI3K/AKT/mTOR pathway,DNA damage response,TP53 and cell cycle inhibitors.This review analyzes the therapeutic benefit and clinical development of novel small molecule inhibitors discovered as promising anti-glioblastoma agents by the related targets of these major pathways.Meanwhile,the recent advances in temozolomide resistance and drug combination are also reviewed.In the last part,due to the constant clinical failure of targeted therapies,this paper reviewed the research progress of other therapeutic methods for glioblastoma,to provide patients and readers with a more comprehensive understanding of the treatment landscape of glioblastoma. | Hui Liu Weimin Qiu Tianyu Sun Lei Wang Chenxi Du Yanyu Hu Wenyuan Liu Feng Feng Yao Chen Haopeng Sun | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 3 |
| 7 | Research on the Drought Forecast of Potato in Central Inner Mongolia Based on Precipitation Anomaly显示文摘In order to explore the method and index of potato fine drought forecast in central Inner Mongolia,based on the data of potato yield and precipitation in Wuchuan County of Hohhot City,Guyang County of Baotou City,and Chayou Middle Banner of Ulan Qab City from 1979 to 2013,the relationship between precipitation anomaly percentage and meteorological yield during potato growth period in central Inner Mongolia was analyzed by regression analysis.According to the precipitation anomaly percentage meteorological drought index,the light drought,medium drought and heavy drought indexes of the seedling stage and flowering stage in the above-mentioned areas were obtained as follows:-5%--25%,-25%--40%,and<-40%,respectively.The results show that the models are more accurate in determining the yield reduction caused by drought,and can well predict the occurrence of drought. | Shaohuan YANG Yan HUANG Xiaoli GUO Suhua CHEN Yanyu GUO | 2021 | Meteorological and Environmental Research2021，12，2： | 2 |
| 8 | Prospect of China's ambient air quality standards显示文摘Ambient air quality standards are the core strategic goal of ambient air quality management.Countries worldwide have given importance to research on the development of ambient air quality standards.To understand the history of the development of China’s ambient air quality standards,this study analyzed the background associated with all previous formulations and revisions of the standards,classification of functional areas,standard grading,pollutants,and evolution of the standard limits over the past 40 years.The results show that since the initial release of the“Ambient Air Quality Standard”by China in 1982,it has been supplemented once,revised twice,and modified twice.The first ambient air quality standard specified the standard limits of six pollutants commonly found in ambient air.With the development of ambient air quality management,the number of pollutants has increased to ten.Since the release of the“Ambient Air Quality Standards”in 2012,the ambient air quality in China has significantly improved.However,the proportion of cities meeting these standards is still low.At present,China is suitably positioned to make the standards associated with 24 hr SO2concentrations more stringent such that it meets the values defined in the World Health Organization(WHO)interim target-2 and the WHO air quality guideline(AQG).We further suggested that the SO2standard should be revised promptly.Simultaneously,regions with a relatively high proportion of cities meeting the standard are encouraged to introduce more stringent interim target limits in due course to manage the local ambient air quality. | Zongshuang Wang Yufei Tan Min Guo Miaomiao Cheng Yanyue Gu Siyu Chen Xuefang Wu Fahe Chai | 2023 | Journal of Environmental Sciences2023，，1： | 2 |
| 9 | Land-use changes and policy dimension driving forces in China: Present, trend and future显示文摘 | Jing Wang Yongqi Chen Xiaomei Shao Yanyu Zhang Yingui Cao | 2011 | Land Use Policy2011，，4： | 2 |
| 10 | Mathematical simulation of hot metal desulfurization during KR process coupled with an unreacted core model显示文摘A three-dimensional mathematical model was established to predict the multiphase flow,motion and dispersion of desulfurizer particles,and desulfurization of hot metal during the Kanbara reactor(KR)process.The turbulent kinetic energy-turbulent dissipation rate(k-ε)turbulence model,volume-of-fluid multiphase model,discrete-phase model,and unreacted core model for the reaction between the hot metal and particles were coupled.The measured sulfur content of the hot metal with time during the actual KR process was employed to validate the current mathematical model.The distance from the lowest point of the liquid level to the bottom of the ladle decreased from 3170 to2191 mm when the rotation speed increased from 30 to 110 r/min,which had a great effect on the dispersion of desulfurizer particles.The critical rotation speed for the vortex to reach the upper edge of the stirring impeller was 70 r/min when the immersion depth was 1500 mm.The desulfurization rate increased with the increase in the impeller rotation speed,whereas the influence of the immersion depth was relatively small.Formulas for different rotation parameters on the desulfurization rate constant and turbulent energy dissipation rate were proposed to evaluate the variation in sulfur content over time. | Yanyu Zhao Wei Chen Shusen Cheng Lifeng Zhang | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，4： | 2 |
| 11 | Ecotoxicological effects of polycyclic musks and cadmium on seed germination and seedling growth of wheat(Triticum aestivum)显示文摘Single and joint toxic effects of polycyclic musks including 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta[g]-2benzopyran (HHCB) and 7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronapthalene (AHTN) and cadmium (Cd) on seed germination and seedling growth of wheat (Triticum aestivum) were investigated.The results showed that the toxicity sequence of HHCB toxic to wheat seed germination and seedling growth was similar to that of AHTN,that is,germination rate > shoot elongation > root elongation,while the toxicity of Cd was in the sequence of root elongation > shoot elongation > germination rate,according to the LC50 and EC50 values.It is suggested that polycyclic musks and Cd had different toxicological mechanisms.Root and shoot elongation of wheat might be good bioindicators for the contamination of polycyclic musks and Cd in soil.The mixture of polycyclic musks and Cd had synergistic effects on T.aestivum according to the equi-toxic mixture approach when root elongation was selected as the toxicological endpoint.Thus,the joint toxicity of HHCB and Cd was significantly higher than the single toxicity of HHCB or Cd,which was also confirmed by the EC50 mix value of the mixture (EC50 mix=0.530 TU mix).The EC50 mix value of the mixture of AHTN and Cd was 0.614 TU mix,which indicated that the mixture toxicity was strengthened when AHTN coexisted with Cd. | Cuihong Chen Qixing Zhou Yanyu Bao Yaning Li Ping Wang | 2010 | Journal of Environmental Sciences2010，22，12： | 2 |
| 12 | The enhancing effect ofsynthetical borneol on the absorption of tetramethylpyrazine-phos-phate in mouse显示文摘 | Xiao Yanyu Ping Qineng Chen Zhipeng | 2007 | Int J Pharm2007，337，： | 1 |
| 13 | A new estimate of global soil respiration from 1970 to 2008显示文摘土壤呼吸(R s ) 是在陆上的生态系统加重我们碳周期的理解的关键过程之一。在有在最高、最低的估计之间的 70 Pg C a1 的差别的以前的全球 R s 估计的大无常遗体。因此,现在的学习试图估计全球年度 R s 并且用包括了气候的因素(温度和降水) 和表层土(020 厘米) 的一个半机械学的、以经验为主地基于的模型在全球年度 R s 调查 interannual 和空间可变性器官的碳存储。从 147 个测量地点的年度 R s 的大约 657 出版研究在这元分析被包括。气候,表面空气温度,和土壤性质上的从 1970 ~ 2008 的全球数据集合是镇定的。蒙特卡罗方法被用来宣传模拟错误到全球 R s。结果显示吝啬的年度全球 R s 是 94.4 Pg C a1,增加在粗略地从 1970 ~ 2008 的 0.04 Pg C a1 (0.04% a1 ) 。R s 率增加了从更冷,更干燥并且少些玷污充满碳的区域到更温暖、更潮湿、更充满碳的区域。最高的 R s 率出现在热带森林里,当最低的在极、荒芜的区域时。年度 R s 与全球温度异例直接相关,建议在温度的 interannual 可变性为在预言的全球 R s 的 interannual 变化负责。全球 R s 从高纬度的地区增加了到低纬度的地区。进一步的研究被建议探索在土壤呼吸和植被人物之间的关系。 | CHEN ShuTao HUANG Yao XIE Wei ZOU JianWen LU YanYu HU ZhengHua | 2013 | Chinese Science Bulletin2013，58，33： | 1 |
| 14 | Land-use changes and policy dimension driving forces in China: Present, trend and future显示文摘 | Jing Wang Yongqi Chen Xiaomei Shao Yanyu Zhang Yingui Cao | 2011 | Land Use Policy2011，，4： | 1 |
| 15 | Transformation of pollutants in landfill leachate treated by a combined sequence batch reactor, coagulation, Fenton oxidation and biological aerated filter technology显示文摘 | Yanyu Wu Shaoqi Zhou Xiuya Ye Dongyu Chen Ke Zheng Fanghui Qin | 2010 | Process Safety and Environmental Protection2010，，2： | 1 |
| 16 | Preparation and characterization of bipolar membranes modified by photocatalyst nano-ZnO and nano-CeO2显示文摘 | ZHOU Tingjin HU Yanyu CHEN Riyao | 2012 | Applied Surface Science2012，258，44： | 1 |
| 17 | Prepara tion and characterization of bipolar membranes modi lied using photoeatalyst nano-TiOz and nano-ZnO显示文摘 | Chen Riyao Hu Yanyu Chen Zhen | 2011 | J Appl Polym Sci2011，122，： | 1 |
| 18 | Nutrient depletion is the main limiting factor in the crude oil bioaugmentation process显示文摘The biodegradation was considered as the prime mechanism of crude oil degradation.To validate the efficacy and survival of the crude oil-degrading strain in a bioremediation process,the enhanced green fluorescent protein gene(egfp)was introduced into Acinetobacter sp.HC8-3 S.In this study,an oil-contaminated sediment microcosm was conducted to investigate the temporal dynamics of the physicochemical characterization and microbial community in response to bacterium amendment.The introduced strains were able to survive,flourish and degrade crude oil quickly in the early stage of the bioremediation.However,the high abundance cannot be maintained due to the ammonium(NH 4^(+)-N)and phosphorus(PO 4^3--P)contents decreased rapidly after 15 days of remediation.The sediment microbial community changed considerably and reached relatively stable after nutrient depletion.Therefore,the addition of crude oil and degrading cells did not show a long-time impact on the original microbial communities,and sufficient nitrogen and phosphorus nutrients ensures the survive and activity of degrader.Our studies expand the understanding of the crude oil degradative processes,which will help to develop more rational bioremediation strategies. | Yanyu Sun Weiwei Chen Yibo Wang Jie Guo Haikun Zhang Xiaoke Hu | 2021 | Journal of Environmental Sciences2021，33，2： | 1 |
| 19 | Fabrication of ultrathin Zn(OH)2 nanosheets as drug carriers显示文摘Ultrathin 二维(2D ) 多孔的 Zn (哦)2 nanosheets (PN ) 作为脊梁借助于一个维的 Cu nanowires 被制作。PN 有约 3.8 nm 的厚度和 4-10 nm 的毛孔尺寸。形成聪明的多孔的 nanosheets, DNA aptamers covalently 被结合到 PN 的表面。好 biocompatibility,有效细胞的举起,和有希望的刺激 pH 的药释放的这些 ultrathin nanosheets 表演。 | Ren Cai Dan Yang Jin Wu Liqin Zhang Cuichen Wu Xigao Chen Yanyue Wang Shuo Wan Fengwei HOU Qingyu Yan Weihong Tan | 2016 | Nano Research2016，9，8： | 1 |
| 20 | Achieving stable K-storage performance of carbon sphere-confined Sb via electrolyte regulation显示文摘Potassium-ion batteries(PIBs)have been considered as one of the most promising alternatives to lithiumion batteries(LIBs)in view of their competitive energy density with significantly reduced product cost.Moreover,alloy-type materials are expected as a high-performance anode of PIBs thanks to their intrinsic chemical stability as well as high theoretical specific capacity.Unfortunately,the serious incompatibility between alloy-type active materials and electrolytes,especially for the formation of unstable solidelectrolyte interfacial(SEI)films,often leads to insufficient cycle life.Herein,the formation mechanism of SEI films in the K-storage systems based on carbon sphere confined Sb anode(Sb@CS)were investigated in commercially available electrolytes.Physical characterizations and theoretical calculation revealed that the solvents in the dilute electrolyte of 0.8 M KPF_(6)/EC+DEC were excessively decomposed on the interface to generate unstable SEI and thus result in inferior K-storage stability.On the contrary,a salt-concentrated electrolyte(3 M KFSI/DME)can generate inorganic-dominated stable SEI due to the preferential decomposition of anions.As a result,the prepared Sb@CS in the matched 3 M KFSI/DME electrolyte delivered a high reversible capacity of 467.8 m A h g^(-1)after 100 cycles at 100 m A g^(-1),with a slow capacity decay of 0.19%per cycle from the 10th to the 100th cycle.These findings are of great significance for revealing the interfacial reaction between electrodes and electrolytes as well as improving the stability of Sb-based anode materials for PIBs. | Ningning Chen Nailu Shen Xiaoping Yi Yinshuang Pang Jing Zheng Qingxue Lai Yanyu Liang | 2023 | Journal of Energy Chemistry2023，，1： | 1 |
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