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| 1 | Landscape of DILI-related adverse drug reaction in China Mainland显示文摘Drug-induced liver injury(DILI)is a type of bizarre adverse drug reaction(ADR)damaging liver(L-ADR)which may lead to substantial hospitalizations and mortality.Due to the general low incidence,detection of L-ADR remains an unsolved public health challenge.Therefore,we used the data of 6.673 million of ADR reports from January 1st,2012 to December 31st,2016 in China National ADR Monitoring System to establish a new database of L-ADR reports for future investigation.Results showed that totally 114,357 ADR reports were retrieved by keywords searching of liver-related injuries from the original heterogeneous system.By cleaning and standardizing the data fields by the dictionary of synonyms and English translation,we resulted 94,593 ADR records reported to liver injury and then created a new database ready for computer mining.The reporting status of L-ADR showed a persistent 1.62-fold change over the past five years.The national population-adjusted reporting numbers of L-ADR manifested an upward trend with age increasing and more evident in men.The annual reporting rate of L-ADR in age group over 80 years old strikingly exceeded the annual DILI incidence rate in general population,despite known underreporting situation in spontaneous ADR reporting system.The percentage of herbal and traditional medicines(H/TM)L-ADR reports in the whole number was 4.5%,while 80.60%of the H/TM reports were new findings.There was great geographical disparity of reported agents,i.e.more cardiovascular and antineoplastic agents were reported in higher socio-demographic index(SDI)regions and more antimicrobials,especially antitubercular agents,were reported in lower SDI regions.In conclusion,this study presented a large-scale,unbiased,unified,and computer-minable L-ADR database for further investigation.Age-,sex-and SDI-related risks of L-ADR incidence warrant to emphasize the precise pharmacovigilance policies within China or other regions in the world. | Jiabo Wang Haibo Song Feilin Ge Peng Xiong Jing Jing Tingting He Yuming Guo Zhuo Shi Chao Zhou Zixin Han Yanzhong Han Ming Niu Zhaofang Bai Guangbin Luo Chuanyong Shen Xiaohe Xiao | 2022 | Acta Pharmaceutica Sinica B2022，12，12： | 12 |
| 2 | Glutamate and aspartate alleviate testicular/epididymal oxidative stress by supporting antioxidant enzymes and immune defense systems in boars显示文摘Several potential oxidative agents have damaging effects on mammalian reproductive systems.This study was conducted to investigate the effects of glutamate(Glu)and aspartate(Asp)supplementation on antioxidant enzymes and immune defense systems in the outer scrotum of boars injected with H2O2.A total of 24 healthy boars were randomly divided into 4 treatment groups:control(basal diet,saline-treated),H2O2(basal diet,H2O2-challenged outer scrotum(1 m L kg^–1 BW)),Glu(basal diet+2%Glu,H2O2-challenged),and Asp(basal diet+2%Asp,H2O2-challenged).Our results showed that both Glu and Asp supplementation improved testicular morphology and decreased the genital index in the H2O2-treated boars.Glu and Asp administration increased the antioxidant enzyme activities and affected the testicular inflammatory cytokine secretion but had no effect on sex hormone levels.Furthermore,the m RNA expression of CAT,Cu Zn SOD,and GPx4 was altered in the testes and epididymis of boars treated with Asp and Glu.Glu and Asp supplementation also modulated the expression of TGF-β1,IL-10,TNF-α,IL-6 and IL-1βin the testis and epididymis.These results indicate that dietary Glu and Asp supplementation might enhance antioxidant capacity and regulate the secretion and expression of inflammatory cytokines to protect the testes and epididymis of boars against oxidative stress. | Wenjie Tang Jian Wu Shunshun Jin Liuqin He Qinlu Lin Feijun Luo Xingguo He Yanzhong Feng Binsheng He Pingping Bing Tiejun Li Yulong Yin | 2020 | Science China(Life Sciences)2020，63，1： | 9 |
| 3 | Isolation and Characterization of a C-repeat Binding Transcription Factor from Maize显示文摘C-repeat binding proteins (CBFs) are a group of transcription factors that have been proven to be important for stress tolerance in plants. Many of these transcription factors transactivate the promoters of cold-regulated genes via binding to low temperature-or dehydration-responsive cis-elements, thus conferring plants cold acclimation. In the present study, we isolated a C-repeat binding transcription factor from maize using the yeast one-hybrid system with the C-repeat motif from the promoter of the Arabidopsis COR15a gene as bait. The isolated transcription factor is highly similar to the Arabidopsis CBF3 in their predicted amino acid sequences, and is therefore designated ZmCBF3. Point mutation analyses of the ZmCBF3-binding cis-element revealed (A/G)(C/T)CGAC as the core binding sequence. Expression analyses showed that ZmCBF3 was upregulated by both abscisic acid and low temperature, and was actively expressed during embryogenesis, suggesting that ZmCBF3 plays a role in stress response in maize. | Lei Wang Yanzhong Luo Lan Zhang Jun Zhao Zhiqiu Hu Yunliu Fan Chunyi Zhang | 2008 | Journal of Integrative Plant Biology2008，50，8： | 6 |
| 4 | Photoelectrochemical performance of a sub-micron structured film with poly(3-methylthiophene) (P3MT)-modified CdTe/ZnO shell-core sub-micron tube arrays显示文摘A sub-micron structured film with a poly(3-methylthiophene) (P3MT)-modified CdTe/ZnO shell-core sub-micron tube array has been prepared by a series of electrodeposition processes, and a semiconductor-sensitized solar cell based on this structure was also fabricated. Vertically oriented ZnO sub-micron tubes were obtained on an indium tin oxide (ITO) substrate, and then CdTe nanocrystals and a thin P3MT layer were electrodeposited sequentially onto the walls of the ZnO sub-micron tubes. A suitable thickness of CdTe and P3MT could improve the photovoltaic properties of the solar cell, which was attributed to the enhancement in the light absorption and the decrease in the recombination of photogenerated carriers. In addition, a p–n heterojunction formed between the interface of CdTe and P3MT played an important part in the efficient separation and fast transport of photogenerated carriers in the sub-micron structure. A power conversion efficiency of 1.20% was obtained with this type of solar cell. | HAO YanZhong LUO Chong SUN Bao SUN Shuo LI YingPin SHEN ShiGang XU DongSheng | 2013 | Science China Chemistry2013，56，6： | 3 |
| 5 | Influence of tribofilm on superlubricity of highly-hydrogenated amorphous carbon films in inert gaseous environments显示文摘In this study,we mainly focus on the structural morphology and inter-atomic bonding state of tribofilms resulting from a highly-hydrogenated amorphous carbon(a-C:H) film in order to ascertain the underlying mechanisms for its superlubric behavior(i.e.,less than 0.01 friction coefficient).Specifically,we achieved superlubricity(i.e.,friction coefficients of down to 0.003) with this film in dry nitrogen and argon atmospheres especially when the tribo-pair is made of an a-C:H coated Si disk sliding against an a-C:H coated steel ball,while the a-C:H coated disk against uncoated ball does not provide superlubricity.We also found that the state of superlubricity is more stable in argon than in nitrogen and the formation of a smooth and uniformly-thick carbonaceous tribofilm appears to be one of the key factors for the realization of such superlubricity.Besides,the interfacial morphology of sliding test pairs and the atomic-scale bond structure of the carbon-based tribofilms also play an important role in the observed superlubric behavior of a-C:H films.Using Raman spectroscopy and high resolution transmission electron microscopy,we have compared the structural differences of the tribofilms produced on bare and a-C:H coated steel balls.For the a-C:H coated ball as mating material which provided superlow friction in argon,structural morphology of the tribofilm was similar or comparable to that of the original a-C:H coating;while for the bare steel ball,the sp^2-bonded C fraction in the tribofilm increased and a fingerprint-like nanocrystalline structure was detected by high resolution transmission electron microscopy(HRTEM).We also calculated the shear stresses for different tribofilms,and established a relationship between the magnitude of the shear stresses and the extent of sp^3-sp^2 phase transformation. | LIU ShuWei ZHANG ChenHui OSMAN Eryilmaz CHEN XinChun MA TianBao HU YanZhong LUO JianBin ALI Erdemir | 2016 | Science China(Technological Sciences)2016，59，12： | 2 |
| 6 | The relationship between soil,climate and forest development in the mid-mountain zone of the Sangong River watershed in the northern Tianshan Mountains,China显示文摘The mountainous forests in arid regions, being sensitive to climate change, are one of the key research topics related to the mechanism of interaction between climate and the terrestrial ecosystem. In this study, the spatial distribution of a mid-mountain forest and its environmental factors were investigated by using a combination of remote sensing technology, field survey, climate indices and soil nutrient analysis in the Sangong River watershed of the northern Tianshan Mountains. The forest(Picea schrenkiana) was distributed between 1,510 and 2,720 m asl. Tree height and diameter at breast height(DBH) exhibited a bi-modal pattern with increasing elevation, and rested at 2,450 and 2,250 m asl, respectively. The two maxima of DBH appeared at 2,000 and 2,550 m asl, and the taller trees were observed at 2,100 and 2,600 m asl. For the annual mean temperature, the difference was approximately 5.8°C between the lowest and the highest limits of the forest, and the average decreasing rates per hundred meters were 0.49°C and 0.55°C with increasing altitude between 1,500 and 2,000 m asl and above 2,000 m asl, respectively. The annual precipitation in the forest zone first increased and then decreased with the increase of altitude, and the maximum value was at 2,000 m asl. For per hundred meters, the annual precipitation increased with the rate of 31 mm between 1,500 and 2,000 m asl and decreased by 7.8 mm above 2,000 m asl. The SOM, TN and TP were high between 2,000 and 2,700 m asl and low at the lower and upper forest limits. The minimum Ca CO3 concentration, p H value and EC coincided with the maximum precipitation belt at 2,000 m asl. The SOM, TN and TP were high in the topsoil(0–10 cm) and differed significantly from the values observed in the deep soil layers(>10 cm). The soil nutrients exhibited spatial heterogeneity and higher aggregation in the topsoil. In conclusion, soil and climate are closely related to each other, working synergistically to determine the development and spatial distribution of the mid-mountain forest in the study area. The order of the importance of environmental factors to forest development in this study is as follows: soil nutrients>precipitation>elevation>temperature. | Li DAI YiXing FENG GePing LUO YanZhong LI WenQiang XU | 2015 | Journal of Arid Land2015，7，1： | 2 |
| 7 | OsABA8ox2, an ABA catabolic gene, suppresses root elongation of rice seedlings and contributes to drought response显示文摘In rice, OsABA8ox encodes abscisic acid(ABA) 8′-hydroxylase, which catalyzes the committed step of ABA catabolism. The contribution of ABA catabolism in root development remains unclear. We investigated the role of OsABA8ox2 in root growth and development and drought response. GUS staining results showed that OsABA8ox2 was expressed mainly in roots at seedling stage and was strongly expressed in the meristematic zone of the radicle. OsABA8ox2 expression in roots was markedly decreased after 0.5 h polyethylene glycol(PEG) treatment and increased after 0.5 h rehydration, implying that OsABA8ox2 is a drought-responsive gene.OsABA8ox2 knockout mediated by the CRISPR-Cas9 system increased drought-induced ABA and indole-3-acetic acid accumulation in roots, conferred increased ABA sensitivity, and promoted a more vertically oriented root system architecture(RSA) beneficial to drought tolerance.OsABA8ox2 overexpression suppressed root elongation and increased stomatal conductance and transpiration rate. Consequently, OsABA8ox2 knockout dramatically improved rice drought tolerance, whereas OsABA8ox2 overexpression seedlings were hypersensitive to drought stress,suggesting that OsABA8ox2 contributes to drought response in rice. Compared with wild type,functional leaves of OsABA8ox2 knockout seedlings showed higher ABA levels, whereas overexpression lines showed lower ABA levels, suggesting that OsABA8ox2, as an ABA catabolic gene, modulates ABA concentration through ABA catabolism. OsABA8ox2 and OsABA8ox3 were both localized in the endoplasmic reticulum. Together, these results indicate that OsABA8ox2 suppresses root elongation of rice seedlings, increases water transpiration, and contributes to drought response through ABA catabolism, and that OsABA8ox2 knockout dramatically improves rice drought tolerance. They highlight the key role of ABA catabolism mediated by OsABA8ox2 on root growth and development. OsABA8ox2, as a novel RSA gene, would be a potential genetic target for the improvement of rice drought tolerance. | Yan Zhang Xiaoping Wang Yanzhong Luo Lan Zhang Yuan Yao Lu Han Zhenhua Chen Lei Wang Yubin Li | 2020 | The Crop Journal2020，8，3： | 2 |
| 8 | A simple artificial microRNA vector based on ath-miR169d precursor from Arabidopsis显示文摘 | Chong Liu Lan Zhang Jie Sun Yanzhong Luo Ming-Bo Wang Yun-Liu Fan Lei Wang | 2010 | Molecular Biology Reports2010，，2： | 1 |
| 9 | Construction of a genomewide RNA i mutant library in rice显示文摘 | Lei Wang Jie Zheng Yanzhong Luo Tao Xu Qiuxue Zhang Lan Zhang Miaoyun Xu Jianmin Wan Ming‐Bo Wang Chunyi Zhang Yunliu Fan | 2013 | Plant Biotechnol J2013，，8： | 1 |
| 10 | Several problems of computering 2-D point-source field with FEM显示文摘 | LUO YANZHONG MENG YONG HANG | 1986 | Chinese Journal of Geophysics1986，29，1： | 1 |
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