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| 1 | Efficacy and Safety of Yanggan Jian in Hepatitis B Virusrelated Decompensated Cirrhosis:A Randomized,Doubleblind,Controlled Trial显示文摘Background and Aims:The aim was to evaluate the efficacy and safety of Yanggan Jian(YGJ)in HBV-infected patients with decompensated cirrhosis.Methods:This randomized,double-blind controlled trial enrolled 160 patients with HBV-related decompensated cirrhosis who were already receiving or about to start antiviral therapy.Patients were randomly assigned to receive YGJ or placebo for 24 weeks,and were followed-up to 36 weeks.The primary outcome was the proportion of patients with a≥2 point reduction in Child-Turcotte-Pugh(CTP)score from baseline at week 24.Secondary outcomes were CTP class and score,serum liver function indices,mortality,incidence of hepatocellular carcinoma and variceal bleeding.Results:The proportion of patients with a CTP score reduction≥2 was significantly greater in the YGJ than in the placebo group(p=0.009);the percentage of patients with CTP class C was significantly less than that in the placebo group(p<0.05),and the YGJ group had a significantly greater mean change from baseline in CTP score at week 24(p=0.034).The improvement in measured values and change from baseline of prothrombin time,serum albumin,platelets,cholinesterase,international normalized ratio,and activated partial thromboplastin time were significantly better with YGJ than with placebo.Between-group differences in cumulative rates of variceal bleeding,hepatocellular carcinoma,death,or the frequency of any adverse event(AE),AEs related to treatment,or discontinuation because of AEs were not significant.Conclusions:YGJ significantly improved CTP scores and hepatic synthetic and reserve function in patients with HBV-related decompensated cirrhosis,and was safe and well tolerated. | Long Chen Chaoqun Zhao Weili Yao Wei Liu Hua Zhang Yongping Mu Hong Cai Dongying Xue Chengbao Wang Wan’e Wang Yuehong Lin Jiamei Chen Ping Liu | 2023 | Journal of Clinical and Translational Hepatology2023，11，1： | 3 |
| 2 | The nonlinear absorption and optical limiting in phenoxy-phthalo- cyanines liquid in nano-and femto-second regime: Experi- mental studies显示文摘 | Zhang Yundong Zhao Zhenyu Yao Chengbao | 2014 | Optics Laser Technol2014，58，： | 1 |
| 3 | A Hybrid Fluid-Solid Interaction Scheme Combining the Multi-Component Diffuse Interface Method and the Material Point Method显示文摘We propose a hybrid scheme combing the diffuse interface method and the material point method to simulate the complex interactions between the multiphase compressible flow and elastoplastic solid.The multiphase flow is modelled by the multi-component model and solved using a generalized Godunov method in the Eulerian grids,while the elastoplastic solid is solved by the classical material point method in a combination of Lagrangian particles and Eulerian background grids.In order to facilitate the simulation of fluid-solid interactions,the solid variables are further interpolated to the cell center and coexist with the fluid in the same cell.An instantaneous relaxation procedure of velocity and pressure is adopted to simulate the momentum and energy transfers between various materials,and to keep the system within a tightly coupled interaction.Several numerical examples,including shock tube problem,gasbubble problem,air blast,underwater explosion and high speed impact applications are presented to validate the numerical scheme. | Meiyan Fu Ruo Li Tiao Lu Chengbao Yao | 2022 | Communications in Computational Physics2022，32，10： | 0 |
| 4 | ARobust Riemann Solver for Multiple Hydro-Elastoplastic Solid Mediums显示文摘We propose a robust approximate solver for the hydro-elastoplastic solid material,a general constitutive law extensively applied in explosion and high speed impact dynamics,and provide a natural transformation between the fluid and solid in the case of phase transitions.The hydrostatic components of the solid is described by a family of general Mie-Gruneisen equation of state(EOS),while the deviatoric component includes the elastic phase,linearly hardened plastic phase and fluid phase.The approximate solver provides the interface stress and normal velocity by an iterative method.The well-posedness and convergence of our solver are proved with mild assumptions on the equations of state.The proposed solver is applied in computing the numerical flux at the phase interface for our compressible multi-medium flow simulation on Eulerian girds.Several numerical examples,including Riemann problems,shock-bubble interactions,implosions and high speed impact applications,are presented to validate the approximate solver. | Ruo Li Yanli Wang Chengbao Yao | 2020 | Advances in Applied Mathematics and Mechanics2020，12，1： | 0 |
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