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| 1 | Kupffer cell restoration after partial hepatectomy is mainly driven by local cell proliferation in IL-6-dependent autocrine and paracrine manners显示文摘Kupffer cells(KCs),which are liver-resident macrophages,originate from the fetal yolk sac and represent one of the largest macrophage populations in the body.However,the current data on the origin of the cells that restore macrophages during liver injury and regeneration remain controversial.Here,we address the question of whether liver macrophage restoration results from circulating monocyte infiltration or local KC proliferation in regenerating livers after partial hepatectomy(PHx)and uncover the underlying mechanisms.By using several strains of genetically modified mice and performing immunohistochemical analyses,we demonstrated that local KC proliferation mainly contributed to the restoration of liver macrophages after PHx.Peak KC proliferation was impaired in Il6-knockout(KO)mice and restored after the administration of IL-6 protein,whereas KC proliferation was not affected in Il4-KO or Csf2-KO mice.The source of IL-6 was identified using hepatocyte-and myeloid-specific Il6-KO mice and the results revealed that both hepatocytes and myeloid cells contribute to IL-6 production after PHx.Moreover,peak KC proliferation was also impaired in myeloid-specific Il6 receptor-KO mice after PHx,suggesting that IL-6 signaling directly promotes KC proliferation.Studies using several inhibitors to block the IL-6 signaling pathway revealed that sirtuin 1(SIRT1)contributed to IL-6-mediated KC proliferation in vitro.Genetic deletion of the Sirt1 gene in myeloid cells,including KCs,impaired KC proliferation after PHx.In conclusion,our data suggest that KC repopulation after PHx is mainly driven by local KC proliferation,which is dependent on IL-6 and SIRT1 activation in KCs. | Yeni Ait Ahmed Yaojie Fu Robim M.Rodrigues Yong He Yukun Guan Adrien Guillot Ruixue Ren Dechun Feng Juan Hidalgo Cynthia Ju Fouad Lafdil Bin Gao | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | 一种独特的“保护-被保护”策略在嘌呤类核苷类药物生物合成中被破解显示文摘文章简介喷司他丁(Pentostain)是美国FDA批准治疗白血病的一线药物,而阿糖腺苷(Vidarabine)则在临床上广泛用来治疗疱疹病毒、巨细胞病毒及乙型肝炎病毒所引起的疾病。 | Pan Wu Dan Wan Gudan Xu Gui Wang Hongmin Ma Tingting Wang Yaojie Gao Jianzhao Qi Xiaoxia Chen Jian Zhu 李永泉 Zixin Deng 陈文青 | 2018 | 科学新闻2018，0，4： | 0 |
| 3 | Numerical solutions of 2-D steady compressible natural convection using high-order flux reconstruction显示文摘Low Mach number flows are common and typical in industrial applications. When simulating these flows, performance of traditional compressible flow solvers can deteriorate in terms of both efficiency and accuracy. In this paper, a new high-order numerical method for two-dimensional(2-D)state low Mach number flows is proposed by combining flux reconstruction(FR)and preconditioning. Firstly, a Couette flow problem is used to assess the efficiency and accuracy of preconditioned FR. It is found that the FR scheme with preconditioning is much more efficient than the original FR scheme. Meanwhile,this improvement still preserves the numerical accuracy. Using this new method and without the Boussinesq assumption,classic natural convection is directly simulated for cases of small and large temperature differences. For the small temperature difference, a p and h refinement study is conducted to verify the grid convergence and accuracy. Then, the influence of the Rayleigh number (Ra) is analyzed. By comparing with the reference results, the numerical results of preconditioned FR is very close to that calculated by incompressible solvers. Furthermore, a large temperature difference test case is calculated and analyzed, indicating this method is not limited by the Boussinesq assumption and is also applicable to heat convection with large temperature differences. | Yaojie Yu Feng Liu Tingbo Zhou Chao Gao Ya Liu | 2019 | Acta Mechanica Sinica2019，35，2： | 0 |
| 4 | Curing mechanism of furan resin modified with different agents and their thermal strength显示文摘The curing mechanism of furfuryl alcohol and urea-formaldehyde furan resins was investigated using infrared spectroscopy(IR) technique.The curing productions of urea-formaldehyde furan resins modified with different agents(i.e.sorbitol,polyester polyol,phenol and acetone) and the productions of incomplete curing were characterized by differential thermal analysis(DTA) and thermal gravity analysis(TG).The results indicate that except for polyester polyol,the other modifiers have little effect on the thermal strength of urea-formaldehyde furan resin.Furthermore,the thermal strength can be improved at a temperature of higher than 550℃. | Huang Renhe Gao Hongmei Tang Yaoji Liu Qingyun | 2011 | China Foundry2011，8，2： | 0 |
| 5 | 2-16 Experimental Study of 13N(α,p)16O at the Stellar Energies显示文摘The presolar SiC grains[1]carry the original stellar nucleosynthesis signature.Their isotopic anomalies compared to the sun are the strong constrains in the supernovae(SN)model calculations.The 15N-excess in some SiC-AB grains(12C/13C<10 and 14N/15N<272)is one of the challenges of core-collapse supernovae(CCSNe)models[2].Recently,Pignatari pointed out that the entrainment of H-rich material into the He shell before the SN explosion allows the coproduction of 13C,15N and 26Al,which provides a new production scenario for SiC-AB grains[2].In the He shell nucleosynthesis,the 13C is produced through 12C(p,γ)13N(β+γ)13C reaction.The 14N is synthesized through 13N(n,γ)and 13C(p,γ)reactions. | Lin Weiping Ma Shaobo Hu Jun Bai Zhen Chen Han Chen Zhijun Duan Fangfang Gao Bingshui Gao Zhihao Hou Suqing Ji Liancheng Jia Baolu Jiao Lei Jin ShuYa Liu Xingquan Li Kuoang Lu Tan Ma Junbing Ma Peng Tang Xiaodong Wang Xinyu Xu Shiwei Yang Yanyun Yu Gongming Yu Xiangqing Zhai Yaojie Zhang Ningtao Zhang Xing | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
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