|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Essential sequence of the N-terminal cytoplasmic localization-related domain of huntingtin and its effect on huntingtin aggregates显示文摘Huntington's disease(HD) is caused by abnormal CAG repeat expansion in the 5′-end of the Huntingtin(HTT) gene.In addition to the canonical C-terminal full-length huntingtin(htt) nuclear export signal,a cytoplasmic localization-related domain(CLRD) in the N-terminus of htt has recently been reported.Here,we analyzed this domain by introducing deletion and substitution mutations in a truncated N-terminal htt protein and subsequently monitored htt expression,aggregation and subcellular localization by immunocytochemistry and Western blot analysis.We demonstrated that Htt4-17 was the essential sequence for htt cytoplasmic localization.We also found that the subcellular distribution of htt was altered when Htt1-17 was mutated to contain amino acids of different charges,suggesting a structural requirement of Htt1-17 for the cytoplasmic localization of htt. Deletion of the first three amino acids did not affect its association with mitochondria.We observed that defective cytoplasmic localization resulted in a reduction of total htt aggregates and increased nuclear aggregates,indicating that the subcellular distribution of the protein might influence the aggregation process.These studies provide new insight into the molecular mechanism of htt aggregation in HD. | YAN YaPing PENG DanTao TIAN Jun CHI JingWei TAN JieQiong YIN XinZhen PU JiaLi XIA Kun ZHANG BaoRong | 2011 | Science China(Life Sciences)2011，54，4： | 4 |
| 2 | Revisiting the Climatology of Atmospheric Blocking in the Northern Hemisphere显示文摘In addition to the occurrence of atmospheric blocking,the climatology of the characteristics of blocking events,including duration,intensity,and extension,in four seasons over the Northern Hemisphere was analyzed for the period 1950-2009.The seasonality and spatial variations of these characteristics were studied according to their longitudinal distributions.In general,there were sharp discrepancies in the blocking characteristics between winter and summer,and these differences were more prominent over the Atlantic and Pacific Oceans.The blocking not only occurred more frequently but also underwent stronger amplification in winter;likewise,the blocking occurred less frequently and underwent weaker amplification in summer.There are very strong interrelationships among different blocking characteristics,suggesting that they are supported by similar physical factors.In addition,the relationship between blocking over different regions and East Asian circulation was examined.Ural-Siberia is a major blocking formation region in all seasons that may exert a downstream impact on East Asia.The impact is generally weak in summer,which is due to its lower intensity and smaller duration.However,the extratropical circulation over East Asia in summer can be disturbed persistently by the frequent occurrence of blocking over the Asian continent or the Western Pacific.In particular,the blocking frequency over the Western Pacific significantly increased during the study period.This climatological information provides a background for studying the impact of blocking on East Asian circulation under both present and future climate conditions. | Ho Nam CHEUNG 周文 Hing Yim MOK Man Chi WU Yaping SHAO | 2013 | Advances in Atmospheric Sciences2013，30，2： | 1 |
| 3 | Optimization of centrifugal impellers for uniform discharge flow and wide operating range显示文摘 | JU Yaping ZHANG Chuhua CHI Xuelin | 2012 | A/AA Journal of Propulsion and Power2012，28，5： | 1 |
| 4 | Characteristics of CFRP-concrete Interface Subjected to Cold Region Environments Including Three-dimensional Topography显示文摘 | Yail J Kim Mozahid Hossain Yaping Chi | 2011 | Cold Regions Science and Technology2011，，67： | 1 |
| 5 | EduASAC:A Blockchain-Based Education Archive Sharing and Access Control System显示文摘In the education archive sharing system,when performing homomorphic ciphertext retrieval on the storage server,there are problems such as low security of shared data,confusing parameter management,and weak access control.This paper proposes an Education Archives Sharing and Access Control(EduASAC)system to solve these problems.The system research goal is to realize the sharing of security parameters,the execution of access control,and the recording of system behaviors based on the blockchain network,ensuring the legitimacy of shared membership and the security of education archives.At the same time,the system can be combined with most homomorphic ciphertext retrieval schemes running on the storage server,making the homomorphic ciphertext retrieval mechanism controllable.This paper focuses on the blockchain access control framework and specifically designs smart contracts that conform to the business logic of the EduASAC system.The former adopts a dual-mode access control mechanism combining Discretionary Access Control(DAC)and Mandatory Access Control(MAC)and improves the tagging mode after user permission verification based on the Authentication and Authorization for Constrained Environments(ACE)authorization framework of Open Authorization(OAuth)2.0;the latter is used in the system to vote on nodes to join requests,define access control policies,execute permission verification processes,store,and share system parameters,and standardize the behavior of member nodes.Finally,the EduASAC system realizes the encryption,storage,retrieval,sharing,and access control processes of education archives.To verify the performance of the system,simulation experiments were conducted.The results show that the EduASAC system can meet the high security needs of education archive sharing and ensure the system’s high throughput,low latency,fast decision-making,and fine-grained access control ability. | Ronglei Hu Chuce He Yaping Chi Xiaoyi Duan Xiaohong Fan Ping Xu Wenbin Gao | 2023 | Computers, Materials & Continua2023，77，12： | 0 |
| 6 | Structural plasticity-based hydrogel optical Willshaw model for one-shot on-the-fly edge learning显示文摘Autonomous one-shot on-the-fly learning copes with the high privacy,small dataset,and in-stream data at the edge.Implementing such learning on digital hardware suffers from the well-known von-Neumann and scaling bottlenecks.The optical neural networks featuring large parallelism,low latency,and high efficiency offer a promising solution.However,ex-situ training of conventional optical networks,where optical path configuration and deep learning model optimization are separated,incurs hardware,energy and time overheads,and defeats the advantages in edge learning.Here,we introduced a bio-inspired material-algorithm co-design to construct a hydrogel-based optical Willshaw model(HOWM),manifesting Hebbian-rule-based structural plasticity for simultaneous optical path configuration and deep learning model optimization thanks to the underlying opto-chemical reactions.We first employed the HOWM as an all optical in-sensor AI processor for one-shot pattern classification,association and denoising.We then leveraged HOWM to function as a ternary content addressable memory(TCAM)of an optical memory augmented neural network(MANN)for one-shot learning the Omniglot dataset.The HOWM empowered one-shot on-the-fly edge learning leads to 1000boost of energy efficiency and 10boost of speed,which paves the way for the next-generation autonomous,efficient,and affordable smart edge systems. | Dingchen Wang Dingyao Liu Yinan Lin Anran Yuan Woyu Zhang Yaping Zhao Shaocong Wang Xi Chen Hegan Chen Yi Zhang Yang Jiang Shuhui Shi Kam Chi Loong Jia Chen Songrui Wei Qing Wang Hongyu Yu Renjing Xu Dashan Shang Han Zhang Shiming Zhang Zhongrui Wang | 2023 | InfoMat2023，5，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员