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| 1 | Fluid-structure Interaction Analysis and Lifetime Estimation of a Natural Gas Pipeline Centrifugal Compressor under Near-choke and Near-surge Conditions显示文摘Up to present, there have been no studies concerning the application of fluid-structure interaction(FSI) analysis to the lifetime estimation of multi-stage centrifugal compressors under dangerous unsteady aerodynamic excitations. In this paper, computational fluid dynamics(CFD) simulations of a three-stage natural gas pipeline centrifugal compressor are performed under near-choke and near-surge conditions, and the unsteady aerodynamic pressure acting on impeller blades are obtained. Then computational structural dynamics(CSD) analysis is conducted through a one-way coupling FSI model to predict alternating stresses in impeller blades. Finally, the compressor lifetime is estimated using the nominal stress approach. The FSI results show that the impellers of latter stages suffer larger fluctuation stresses but smaller mean stresses than those at preceding stages under near-choke and near-surge conditions. The most dangerous position in the compressor is found to be located near the leading edge of the last-stage impeller blade. Compressor lifetime estimation shows that the investigated compressor can run up to 102.7 h under the near-choke condition and 200.2 h under the near-surge condition. This study is expected to provide a scientific guidance for the operation safety of natural gas pipeline centrifugal compressors. | JU Yaping LIU Hui YAO Ziyun XING Peng ZHANG Chuhua | 2015 | Chinese Journal of Mechanical Engineering2015，28，6： | 11 |
| 2 | Robust Design Optimization Method for Centrifugal Impellers under Surface Roughness Uncertainties Due to Blade Fouling显示文摘Blade fouling has been proved to be a great threat to compressor performance in operating stage. The current researches on fouling-induced performance degradations of centrifugal compressors are based mainly on simplified roughness models without taking into account the realistic factors such as spatial non-uniformity and randomness of the fouling-induced surface roughness. Moreover, little attention has been paid to the robust design optimization of centrifugal compressor impellers with considerations of blade fouling. In this paper, a multi-objective robust design optimization method is developed for centrifugal impellers under surface roughness uncertainties due to blade fouling. A three-dimensional surface roughness map is proposed to describe the nonuniformity and randomness of realistic fouling accumulations on blades. To lower computational cost in robust design optimization, the support vector regression(SVR) metamodel is combined with the Monte Carlo simulation(MCS) method to conduct the uncertainty analysis of fouled impeller performance. The analyzed results show that the critical fouled region associated with impeller performance degradations lies at the leading edge of blade tip. The SVR metamodel has been proved to be an efficient and accurate means in the detection of impeller performance variations caused by roughness uncertainties. After design optimization, the robust optimal design is found to be more efficient and less sensitive to fouling uncertainties while maintaining good impeller performance in the clean condition. This research proposes a systematic design optimization method for centrifugal compressors with considerations of blade fouling, providing a practical guidance to the design of advanced centrifugal compressors. | JU Yaping ZHANG Chuhua | 2016 | Chinese Journal of Mechanical Engineering2016，29，2： | 9 |
| 3 | A Survey on Emerging Computing Paradigms for Big Data显示文摘The explosive growth of data volume and the ever-increasing demands of data value extraction have driven us into the era of big data. The '5V'(Variety,Velocity, Volume, Value, and Veracity) characteristics of big data pose great challenges to traditional computing paradigms and motivate the emergence of new solutions.Cloud computing is one of the representative technologies that can perform massive-scale and complex data computing by taking advantages of virtualized resources, parallel processing and data service integration with scalable data storage. However, as we are also experiencing the revolution of Internet-of-things(IoT), the limitations of cloud computing on supporting lightweight end devices significantly impede the flourish of cloud computing at the intersection of big data and IoT era. It also promotes the urgency of proposing new computing paradigms. We provide an overview on the topic of big data, and a comprehensive survey on how cloud computing as well as its related technologies can address the challenges arisen by big data.Then, we analyze the disadvantages of cloud computing when big data encounters IoT, and introduce two promising computing paradigms, including fog computing and transparent computing, to support the big data services of IoT. Finally, some open challenges and future directions are summarized to foster continued research efforts into this evolving field of study. | ZHANG Yaoxue REN Ju LIU Jiagang XU Chugui GUO Hui LIU Yaping | 2017 | Chinese Journal of Electronics2017，26，1： | 8 |
| 4 | Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies显示文摘Neutralizing monoclonal antibodies(nAbs)to severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)represent promising candidates for clinical intervention against coronavirus disease 2019(COVID-19).We isolated a large number of nAbs from SARS-CoV-2-infected individuals capable of disrupting proper interaction between the receptor binding domain(RBD)of the viral spike(S)protein and the receptor angiotensin converting enzyme 2(ACE2).However,the structural basis for their potent neutralizing activity remains unclear.Here,we report cryo-EM structures of the ten most potent nAbs in their native full-length IgG-form or in both IgG-form and Fab-form bound to the trimeric S protein of SARS-CoV-2.The bivalent binding of the full-length IgG is found to associate with more RBDs in the“up”conformation than the monovalent binding of Fab,perhaps contributing to the enhanced neutralizing activity of IgG and triggering more shedding of the S1 subunit from the S protein.Comparison of a large number of nAbs identified common and unique structural features associated with their potent neutralizing activities.This work provides a structural basis for further understanding the mechanism of nAbs,especially through revealing the bivalent binding and its correlation with more potent neutralization and the shedding of S1 subunit. | Renhong Yan Ruoke Wang Bin Ju Jinfang Yu Yuanyuan Zhang Nan Liu Jia Wang Qi Zhang Peng Chen Bing Zhou Yaning Li Yaping Shen Shuyuan Zhang Long Tian Yingying Guo Lu Xia Xinyue Zhong Lin Cheng Xiangyang Ge Juanjuan Zhao Hong-Wei Wang Xinquan Wang Zheng Zhang Linqi Zhang Qiang Zhou | 2021 | Cell Research2021，31，5： | 4 |
| 5 | A Rapid and Automatic Optimal Design Method for Six-Stage Axial-Flow Industry Compressor显示文摘Existing aerodynamic design systems for multi-stage axial-flow compressor suffer from several limitations,such as experience dependent models and time costly simulations.Few attempts,however,have been devoted to the rapid and automatic optimization of aerodynamic performance at the preliminary design phase,which plays a crucial role in the final aerodynamic performance.In this work,a rapid and automatic aerodynamic optimal design method is developed for the multi-stage axial-flow compressor based on one-dimensional meanline design method,radial-equilibrium equation and genetic algorithm.The one-dimensional performance prediction model includes some popular empirical correlations to calculate the flow loss,incidence angle,deviation angle and flow blockage.The radial-equilibrium equation is solved to obtain the spanwise distribution of aerodynamic and thermodynamic parameters at the inlet and outlet of each blade row.The genetic algorithm is used for an automatic search of the global optimal compressor configuration aiming at maximizing the design efficiency.The developed method is illustrated with the aerodynamic optimal design of a 6-stage axial-flow industry compressor and verified by computational fluid dynamics simulations.The results show that the developed method is capable of improving effectively the design efficiency and predicting accurately the aerodynamic performance of the 6-stage axial-flow industry compressor in a few minutes.This work is of scientific significance to improve the axial-flow compressor design system and of engineering importance to release the designers from the heavy experience dependence especially at the preliminary design phase. | LEI Fan JU Yaping ZHANG Chuhua | 2021 | Journal of Thermal Science2021，30，5： | 3 |
| 6 | OsSRK1,an Atypical S-Receptor-Like Kinase Positively Regulates Leaf Width and Salt Tolerance in Rice显示文摘Receptor-like kinases(RLKs)are important for plant growth,development and defense responses.The S-receptor protein kinases(SRKs),which represent an RLK subfamily,control the selfincompatibility among Brassica species.However,little information is available regarding SRK functions in rice.We identified a gene OsSRK1 encoding an atypical SRK.The transcript of OsSRK1 was induced by abscisic acid(ABA),salt and polyethylene glycol.OsSRK1 localized to the plasma membrane and cytoplasm.Leaf width was increased in OsSRK1-overexpression(OsSRK1-OX)transgenic rice plants,likely because of an increase in cell number per leaf.Furthermore,the expression levels of OsCYCA3-1 and OsCYCD2-1,which encode positive regulators of cell division,were up-regulated in leaf primordium of OsSRK1-OX rice plants relative to those in wild type.Meanwhile,the expression level of OsKRP1,which encodes cell cycle inhibitor,was down-regulated in the OsSRK1-OX plants.Therefore,it is deduced that OsSRK1 regulates leaf width by promoting cell division in the leaf primordium.Additionally,OsSRK1-OX plants exhibited enhanced ABA sensitivity and salt tolerance compared with wild type.These results suggest that OsSRK1 plays important roles in leaf development and salt responses in rice. | ZHOU Jinjun JU Peina ZHANG Fang ZHENG Chongke BAI Bo LI Yaping WANG Haifeng CHEN Fan XIE Xianzhi | 2020 | Rice science2020，27，2： | 2 |
| 7 | DNA methylation and alternative splicing modulate FBXW11 gene expression in Holstein bull testis and are correlated with sperm quality显示文摘F-box and WD-40 domain protein 11(FBXW11)is an important component of the E3 ubiquitin-ligase enzyme that plays a key role in the ubiquitin-dependent regulation of spermatogenesis.In our previous research,the mRNA expression of FBXW11 in bull sperm with high motility is significantly higher than that with low motility.In the present study,the protein expression levels of FBXW11 in bull testicular tissues with low-performance sperm quality groups were significantly higher than those in normal performance groups.The immunohistochemistry result demonstrated that FBXW11 protein was located in the periphery of Leydig cells and seminiferous tubules.Three splice variants of the FBXW11 gene,namely,FBXW11-tv1,FBXW11-tv2,and FBXW11-tv3,were identified in testicular tissues.The splicing patterns of the three variants are exon skipping.The transcript FBXW11-tv2 expressions were the highest in each sample.The low-performance groups displayed higher FBXW11-tv1 and FBXW11-tv2 transcript expressions than the normal performance groups.Two CpG islands were located within the 5’UTR and exon 1-2 region of the FBXW11 gene.Bisulfite sequencing PCR results demonstrated that the methylation levels of 11 methylation sites in the CpG island 2 from−99 to−43 in the normal performance groups were significantly lower than those in the low-performance groups.Pearson correlation analysis suggested that the CpG island 2 methylation level was negatively correlated with sperm motility and the transcript FBXW11-tv2 expression level.Our data revealed that alternative splicing and DNA methylation jointly regulated FBXW11 gene expression and were correlated with sperm quality traits during spermatogenesis in Holsteins. | YONG LIU ZHIHUA JU QIANG JIANG WENHAO LIU CHUNHONG YANG YARAN ZHANG XIUGE WANG YAPING GAO XIAOCHAO WEI YAN SUN JINPENG WANG MINGHAI HOU LING YANG JINMING HUANG | 2021 | BIOCELL2021，45，1： | 1 |
| 8 | Using Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry to analyze differentially expressed brain polypeptides in scrapie strain 22L-infected BALB/c mice显示文摘Differentially expressed polypeptides in the brain of a BALB/c mouse model infected with scrapie strain 22L were analyzed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.The results showed that 21 peptides were down-regulated,with peptides of mass-to-charge ratio 758.772 5 and mass-to-charge ratio 5 432.206 9,demonstrating the most significant decreases.These finding suggest that these peptides are candidate biomarkers and may play an important role in the pathogenesis of prion disease. | Xiangyu Liao Jiayu Wan Wensen Liu Xin Tang Wufei Zhu Na XU Jing Xu Nan Li Yaping Chang Chuanjing Ju | 2011 | Neural Regeneration Research2011，6，23： | 1 |
| 9 | A generalizable strategy based on the rule of“like dissolves like”to construct porous liquids with low viscosity for CO_(2)capture显示文摘Porous liquids(PLs),an emerging porous material with permanent cavities,have attracted extensive attention in recent years.However,the current construction methods are complicated and resulting PLs possess high viscosity values,which cannot meet the requirements of practical industrial applications.Herein,we demonstrate a generalizable and simple strategy to prepare type III PLs with low viscosity based on the rule of“like dissolves like”.Specifically,the monoglycidyl ether terminated polydimethylsiloxane(denoted by E-PDMS)is attached to the surface of Universitetet i Oslo(UiO)-66-NH_(2)via covalent linkage,constructing the pore generator(UiO-66-NH_(2)-E-PDMS,denoted by P-UiO-66).Then,P-UiO-66 is dispersed into different types and amounts of sterically hindered solvents(PDMS400 or PDMS6000),obtaining a series of type III PLs(denoted by P-UiO-66-PLs)with permanent cavities and low viscosities.The gas sorption-desorption test shows that P-UiO-66-PLs have an enormous potential for CO_(2)/N_(2) selective separation.Besides,the porosity of P-UiO-66-PLs and the CO_(2)sorption mechanism are demonstrated by molecular simulation.Furthermore,the generality of the synthesis strategy is confirmed by the successful construction of PLs using two other amino-metal-organic frameworks(MOFs)(MIL-53(Al)-NH_(2)and MIL-88B(Fe)-NH_(2)).Importantly,it’s worth noting that the strategy based on the rule of“like dissolves like”sheds light on the preparation of other types of PLs for task-specific applications. | Yangyang Xin Hailong Ning Dechao Wang(✉) Xiaoqian Li Wendi Fan Xiaoqian Ju Hongni Wang Yichi Zhang Zhiyuan Yang Dongdong Yao Yaping Zheng | 2023 | Nano Research2023，16，7： | 1 |
| 10 | Multi-point robust design optimization of wind turbine airfoil under geometric uncertainty显示文摘 | JU Yaping ZHANG Chnhua | 2012 | Proceedings of the 1MechE Part A: Journal of Power and Energy2012，226，2： | 1 |
| 11 | Multi-point and multi-objective optimization design method for industrial axial compressor cascades显示文摘 | JU Yaping ZHANG Chuhua | 2011 | Proceedings of the IMechE Part C: Journal of MechanicalEngineering2011，225，6： | 1 |
| 12 | Optimization of centrifugal impellers for uniform discharge flow and wide operating range显示文摘 | JU Yaping ZHANG Chuhua CHI Xuelin | 2012 | A/AA Journal of Propulsion and Power2012，28，5： | 1 |
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