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| 1 | Body mass index is associated with age-at-onset of HCV-infected hepatocellular carcinoma patients显示文摘AIM: To identify factors associated with the age at onset of hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC). METHODS: Five hundred and fifty-six consecutive patients positive for HCV antibody and treatment-nafive HCC diagnosed between 1995 and 2004 were analyzed. Patients were classified into three groups according to age at HCC onset: < 60 years (n = 79), 60-79 years (n = 439), or ≥ 80 years (n = 38). Differences among groups in terms of sex, body mass index (BMI), lifestyle characteristics, and liver function were assessed. Factors associated with HCC onset in patients < 60 or ≥ 80 years were analyzed by logistic regression analysis. RESULTS: Significant differences emerged for sex, BMI, degree of smoking and alcohol consumption, mean bilirubin, alanine aminotransferase (ALT), and γ-glutamyl transpeptidase (GGT) levels, prothrombin activity, and platelet counts. The mean BMI values of male patients > 60 years old were lower and mean BMI values of female patients < 60 years old were higher than those of the general Japanese population. BMI > 25 kg/m2 [hazard ratio (HR), 1.8, P = 0.045], excessive alcohol consumption (HR, 2.5, P = 0.024), male sex (HR, 3.6, P = 0.002), and GGT levels > 50 IU/L (HR, 2.4, P = 0.014) were independently associated with HCC onset in patients < 60 years. Low ALT level was the only factor associated with HCC onset in patients aged ≥ 80 years. CONCLUSION: Increased BMI is associated with increased risk for early HCC development in HCV-infected patients. Achieving recommended BMI and reducing alcohol intake could help prevent hepatic carcinogenesis. | Takumi Akiyama Toshihiko Mizuta Seiji Kawazoe Yuichiro Eguchi Yasunori Kawaguchi Hirokazu Takahashi Iwata Ozaki Kazuma Fujimoto | 2011 | World Journal of Gastroenterology2011，17，7： | 6 |
| 2 | Toxic effects of 2,3,7,8-tetrachlorodibenzo- p -dioxin on the peripheral nervous system of developing red seabream ( Pagrus major )显示文摘 | Midori Iida Eun-Young Kim Yasunori Murakami Yasuhiro Shima Hisato Iwata | 2012 | Aquatic Toxicology2012，，： | 1 |
| 3 | Vitamin K2 augments 5-fluorouracil-induced growth inhibition of humanhepatocellular carcinoma cells by inhibiting NF-κB activation显示文摘 | Hao Zhang Iwata Ozaki Hiroshi Hamajima Shinji Iwane Hirokazu Takahashi Yasunori Kawaguchi Yuichiro Eguchi Kyosuke Yamamoto Toshihiko Mizuta | 2011 | Oncology Reports2011，，1： | 1 |
| 4 | Efficacy of pegylated interferon plus ribavirin in combination with corticosteroid for two cases of combined hepatitis C and autoimmune hepatitis显示文摘 | Satoshi Oeda Toshihiko Mizuta Hiroshi Isoda Takuya Kuwashiro Noriko Oza Shinji Iwane Hirokazu Takahashi Yasunori Kawaguchi Yuichiro Eguchi Shuji Toda Iwata Ozaki Keizo Anzai Kazuma Fujimoto | 2012 | Clinical Journal of Gastroenterology2012，，2： | 1 |
| 5 | Inhibition of matrix metalloproteinase expression by menatetrenone,a vitamin K2 analogue显示文摘 | Yasushi Ide Hao Zhang Hiroshi Hamajima Yasunori Kawaguchi Yuichiro Eguchi Toshihiko Mizuta Kyosuke Yamamoto Kazuma Fujimoto Iwata Ozaki | 2009 | Oncology Reports2009，，3： | 1 |
| 6 | Long-Term Outcomes of Japanese Type 2 Diabetic Patients With Biopsy-Proven Diabetic Nephropathy显示文摘 | Miho Shimizu Kengo Furuichi Tadashi Toyama Shinji Kitajima Akinori Hara Kiyoki Kitagawa Yasunori Iwata Norihiko Sakai Toshinari Takamura Mitsuhiro Yoshimura Hitoshi Yokoyama Shuichi Kaneko Takashi Wada | 2013 | Diabetes Care2013，，11： | 1 |
| 7 | Detection of Mycoplasma pneumoniae by loop-mediated isothermal amplification (LAMP) assay and serology in pediatric community-acquired pneumonia显示文摘 | Kensei Gotoh Naoko Nishimura Yasunori Ohshima Yasuko Arakawa Haruki Hosono Yasuto Yamamoto Yasushi Iwata Kazumasa Nakane Keiji Funahashi Takao Ozaki | 2012 | Journal of Infection and Chemotherapy2012，，5： | 1 |
| 8 | Long-term prognosis of focal segmental glomerulosclerosis treated with therapeutic low-density lipoprotein-apheresis in patients with severe kidney dysfunction and proteinuria显示文摘Background:The prognosis of focal segmental glomerulosclerosis patients with nephrotic syndrome is estimated to be 10%-20%in 5 years and 30%-50%in 10 years,leading to end-stage kidney disease.The response rate with steroid therapy is 40%-60%.Therapeutic low-density lipoprotein-apheresis(LDL-A)may be effective in patients with steroid resistance.Information regarding the long-term prognosis of patients with focal segmental glomerulosclerosis receiving this therapy is scarce.Methods:We investigated the effectiveness of treatment in 50 patients with primary focal segmental glomerulosclerosis diagnosed between 1961 and 2017 at Kanazawa University Hospital and related facilities.The patients were observed at least 12 months after biopsy or until end-stage kidney disease occurrence or death.Results:LDL-A was performed in four patients who presented with steroidresistant nephrotic syndrome(two patients had concurrent acute renal failure for which hemodialysis was performed).In comparison with 17 patients who did not receive LDL-A after 1989,the LDL-A group had higher urinary protein excretion(13.7 vs.5.2 g/day,P=0.053)and serum creatinine(4.11 vs.1.65 mg/dL)levels at onset,and a numerically higher remission rate(75.0%vs.58.7%)compared with the nonlipoprotein-apheresis group.Conclusion:Therapeutic LDL-A can be performed for critical cases and may improve the remission rate. | Shinji Kitajima Megumi Osima Hisayuki Ogura Shiori Nakagawa Yuta Yamamura Taito Miyake Taro Miyagawa Tadashi Toyama Akinori Hara Norihiko Sakai Miho Shimizu Takashi Wada Yasunori Iwata | 2023 | Rheumatology & Autoimmunity2023，3，1： | 0 |
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