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| 1 | CRISPR/Cas9-introduced single and multiple mutagenesis in strawberry显示文摘CRISPR/Cas9-mediated genome editing is a powerful tool for life science research.Recently,strawberry (Fragaria × ananassa),an important horticultural crop,has emerged as a model organism for investigating the regulatory mechanisms of fruit development and ripening (Shulaev et al.,2011;Jia et al.,2013,2017;Kang et al.,2013;Han et al.,2015).While most cultivated strawberries (e.g.,F.× ananassa)are octoploid,most wild strawberries (e.g.,F.vesca)are diploid.Although CRISPR/Cas9 methods have been established in many plants,the use of this tool in strawberry needs to be further explored (Zhou et al.,2018). | Sinian Xing Meiru Jia Lingzhi Wei Wenwen Mao Usman Ali Abbasi Yaoyao Zhao Yating Chen Minglin Cao Kai Zhang Zhengrong Dai Zhechao Dou Wensuo Jia Bingbing Li | 2018 | Journal of Genetics and Genomics2018，45，12： | 4 |
| 2 | Discovering small molecules as Wnt inhibitors that promote heart regeneration and injury repair显示文摘There are intense interests in discovering pro regenerative medicine leads that can promote cardiac differentiation and regeneration,as well as repair damaged heart tissues.We have combined zebrafish embryo-based screens with cardiomyogenesis assays to discover selective small molecules that modulate heart development and regeneration with minimal adverse effects.Two related compounds with novel structures,named as Cardiomogen 1 and 2(CDMG1 and CDMG2),were identified for their capacity to promote myocardial hyperplasia through expansion of the cardiac progenitor cell population.We find that Cardiomogen acts as a Wnt inhibitor by targeting p-catenin and reducing Tcf/Lef-mediated transcription in cultured cells.CDMG treatment of amputated zebrafish hearts reduces nuclear p-catenin in injured heart tissue,increases cardiomyocyte(CM)proliferation,and expedites wound healing,thus accelerating cardiac muscle regeneration.Importantly,Cardiomogen can alleviate the functional deterioration of mammalian hearts after myocardial infarction.Injured hearts exposed to CDMG1 display increased newly formed CMs and reduced fibrotic scar tissue,which are in part attributable to the^-catenin reduction.Our findings indicate Cardiomogen as a Wnt inhibitor in enhancing injury-induced CM proliferation and heart regeneration,highlighting the values of embryo-based small molecule screens in discovery of effective and safe medicine leads. | Shuying Xie Wenbin Fu Guangju Yu Xueli Hu Kaa Seng Lai Xiangwen Peng Yating Zhou Xuejiao Zhu Ptamen Christov Leah Sawyer Terri T.Ni Gary A.Sulikowski Zhongzhou Yang Ethan Lee Chunyu Zeng Wei E.Wang Tao P.Zhong | 2020 | Journal of Molecular Cell Biology2020，12，1： | 4 |
| 3 | Self-powered,flexible,and ultrabroadband ultraviolet-terahertz photodetector based on a laser-reduced graphene oxide/CsPbBr3 composite显示文摘Self-powered and flexible ultrabroadband photodetectors(PDs)are desirable in a wide range of applications.The current PDs based on the photothermoelectric(PTE)effect have realized broadband photodetection.However,most of them express low photoresponse and lack of flexibility.In this work,high-performance,self-powered,and flexible PTE PDs based on laser-scribed reduced graphene oxide(LSG)∕CsPbBr3 are developed.The comparison experiment with LSG PD and fundamental electric properties show that the LSG∕CsPbBr3 device exhibits enhanced ultrabroadband photodetection performance covering ultraviolet to terahertz range with high photoresponsivity of 100 mA/W for 405 nm and 10 mA/W for 118μm at zero bias voltage,respectively.A response time of 18 ms and flexible experiment are also acquired at room temperature.Moreover,the PTE effect is fully discussed in the LSG∕CsPbBr3 device.This work demonstrates that LSG∕CsPbBr3 is a promising candidate for the construction of high-performance,flexible,and self-powered ultrabroadband PDs at room temperature. | YIFAN LI YATING ZHANG ZHILIANG CHEN QINGYAN LI TENGTENG LI MENGYAO LIHONGLIANG ZHAO QUAN SHENG WEI SHI JIANQUAN YAO | 2020 | Photonics Research2020，8，8： | 3 |
| 4 | Environmental and energy gains from using molten magnesium–sodium–potassium chlorides for electro-metallisation of refractory metal oxides显示文摘The molten eutectic mixture of magnesium,sodium and potassium chlorides(Mg Cl2–Na Cl–KCl) has inappreciable solubility for oxide ions,and can help disengage a carbon anode from the oxide ions generated at a metal oxide cathode,and effectively avoid carbon dioxide formation.This 'disengaging strategy' was successfully demonstrated in electro-reduction of solid oxides of zirconium and tantalum.It has led to significantly higher current efficiency(93%),and lower energy consumption(1.4 k W h kg 1) in electrolysis of tantalum oxide to tantalum metal compared to the conventional electrolysis in molten calcium chloride(e.g.78% and 2.4 k W h/kg-Ta). | Wei Li Yating Yuan Xianbo Jin Hualin Chen George Z.Chen | 2015 | Progress in Natural Science:Materials International2015，25，6： | 2 |
| 5 | A full-process intelligent trial system for smart court显示文摘In constructing a smart court,to provide intelligent assistance for achieving more efficient,fair,and explainable trial proceedings,we propose a full-process intelligent trial system(FITS).In the proposed FITS,we introduce essential tasks for constructing a smart court,including information extraction,evidence classification,question generation,dialogue summarization,judgment prediction,and judgment document generation.Specifically,the preliminary work involves extracting elements from legal texts to assist the judge in identifying the gist of the case efficiently.With the extracted attributes,we can justify each piece of evidence’s validity by establishing its consistency across all evidence.During the trial process,we design an automatic questioning robot to assist the judge in presiding over the trial.It consists of a finite state machine representing procedural questioning and a deep learning model for generating factual questions by encoding the context of utterance in a court debate.Furthermore,FITS summarizes the controversy focuses that arise from a court debate in real time,constructed under a multi-task learning framework,and generates a summarized trial transcript in the dialogue inspectional summarization(DIS)module.To support the judge in making a decision,we adopt first-order logic to express legal knowledge and embed it in deep neural networks(DNNs)to predict judgments.Finally,we propose an attentional and counterfactual natural language generation(AC-NLG)to generate the court’s judgment. | Bin WEI Kun KUANG Changlong SUN Jun FENG Yating ZHANG Xinli ZHU Jianghong ZHOU Yinsheng ZHAI Fei WU | 2022 | Frontiers of Information Technology & Electronic Engineering2022，23，2： | 2 |
| 6 | Comprehensive Strategy for Keloid Treatment:Experience at Shanghai Ninth People's Hospital显示文摘Keloids are a notorious fibroproliferative disorder that may cause cosmetic concerns and life inconvenience.Various methods such as surgery,injection,and laser have been used;however,single treatments are at risk of recurrence;therefore,comprehensive therapy is the better solution.Here,we focused on the management of different medical interventions according to subjective and objective conditions of keloid patients and summarized several clinical comprehensive strategies based on our clinical experience.One original concept of laser combined with radiotherapy was also introduced as a promising method,especially for wide-based pathological scars. | Xiaoli WU Yating YANG Wei LIU Wenbo WANG Lingling XIA Xiaoqing WANG Qiong ZHAO Zhen GAO | 2020 | Chinese Journal Of Plastic and Reconstructive Surgery2020，2，2： | 2 |
| 7 | Targeting EZH1/2 induces cell cycle arrest and inhibits cell proliferation through reactivation of p57CDKN1C and TP53INP1 in mantle cell lymphoma显示文摘Objective: To explore the effect of dysregulation of epigenetic regulator EZH1 and EZH2 on the proliferation in MCL and the underlying mechanisms.Methods: In this study, we elucidated the role of EZH1 and EZH2 overexpression by immunohistochemistry and correlated them to clinical outcome in 41 MCL patients.Quantitative real-time PCR and Western blot were applied to confirm the level of EZH1 and EZH2 in well-characterized MCL cell lines which were compared to those of na?ve B cells.Then we manipulated the expression of EZH1 and EZH2 in MCL cells using CRISPR/Cas9 system to directly investigate their functional roles in MCL.We also evaluated the effect of two small molecule selective inhibitors, EPZ005687 and UNC1999, on MCL cell proliferation, cell cycle distribution and apoptosis in vitro.Finally, we performed RNA-sequencing(RNA-Seq) and Chromatin immunoprecipitation(ChIP) assay to further gain insight into the underlying molecular mechanisms.Results: We found that EZH2 protein is overexpressed in approximately half of this cohort of MCL cases.More importantly, the overexpression of EZH2 is associated with poor OS in the patients.Nevertheless, simple EZH2 depletion in vitro has little impact on the viability of MCL cells, predominantly because of the consequent up-regulation of EZH1.Consistently, UNC1999, a dual EZH1/2 inhibitor, unlike the EZH2 selective inhibitor EPZ005687, exerts a potent inhibitory effect on MCL cells.Furthermore, we discover CDKN1C and TP53 INP1 as the two important cell cycle regulators, the expression of which are repressed by EZH1/2 mediated epigenetic regulation and are restored by EZH1/2 dual inhibition.Conclusions: Our study suggests that EZH2 participates in the pathogenesis of MCL which may serve as a potential biomarker for prognosis prediction.The dual inhibition of EZH1/2 is a promising therapeutic strategy for MCL. | Wei Li Chengfeng Bi Yating Han Tian Tian Xianhuo Wang Huijing Bao Xiaoying Xu Xuhan Zhang Lu Liu Weiwei Zhang Hai Gao Huaqing Wang Huilai Zhang Bin Meng Xi Wang Kai Fu | 2019 | Cancer Biology & Medicine2019，16，3： | 2 |
| 8 | Rethinking phonons:The issue of disorder显示文摘Current understanding of phonons treats them as plane waves/quasi-particles of atomic vibration that propagate and scatter.The problem is that conceptually,when any level of disorder is introduced,whether compositional or structural,the character of vibrational modes in solids changes,yet nearly all theoretical treatments continue to assume phonons are still waves.For example,the phonon contributions to alloy thermal conductivity(TC)rely on this assumption and are most often computed from the virtual crystal approximation(VCA).Good agreement is obtained in some cases,but there are many instances where it fails—both quantitatively and qualitatively.Here,we show that the conventional theory and understanding of phonons requires revision,because the critical assumption that all phonons/normal modes resemble plane waves with well-defined velocities is no longer valid when disorder is introduced.Here we show,surprisingly,that the character of phonons changes dramatically within the first few percent of impurity concentration,beyond which phonons more closely resemble the modes found in amorphous materials.We then utilize a different theory that can treat modes with any character and experimentally confirm its new insights. | Hamid Reza Seyf Luke Yates Thomas L.Bougher Samuel Graham Baratunde A.Cola Theeradetch Detchprohm Mi-Hee Ji Jeomoh Kim Russell Dupuis Wei Lv Asegun Henry | 2017 | npj Computational Materials2017，，1： | 1 |
| 9 | Tuned selectivity and enhanced activity of CO_(2) methanation over Ru catalysts by modified metal-carbonate interfaces显示文摘Carbonate-modified metal-support interfaces allow Ru/MnCO_(3) catalyst to exhibit over 99% selectivity,great specific activity and long-term anti-CO poisoning stability in atmospheric CO_(2) methanation.As a contrast,Ru/MnO catalyst with metal-oxide interfaces prefers reverse water-gas shift rather than methanation route,along with a remarkably lower activity and a less than 15% CH_(4) selectivity.The carbonatemodified interfaces are found to stabilize the Ru species and activate CO_(2) and H_(2) molecules.Ru-CO^(4) species are identified as the reaction intermediates steadily formed from CO_(2) dissociation,which show moderate adsorption strength and high reactivity in further hydrogenation to CH_(4),Furthermore,carbonates of Ru/MnCO_(3) are found to be consumed by hydrogenation to form CH_(4) and replenished by exchange with CO_(2),which are in a dynamic equilibrium during the reaction.Modification with surface carbonates is proved as an efficient strategy to endow metal-support interfaces of Ru-based catalysts with unique catalytic functions for selective CO_(2) hydrogenation. | Qiaojuan Wang Yating Gao Chantsalmaa Tumurbaatar Tungalagtamir Bold Fei Wei Yihu Dai Yanhui Yang | 2022 | Journal of Energy Chemistry2022，31，1： | 1 |
| 10 | Effect of intergranular β phase on the rupture plasticity of the low expansion Inconel 783 superalloy显示文摘High temperature rupture specimens with different rupture plasticity are investigated.The rupture fracture failure of Inconel 783 superalloy is researched by analyzing the fracture surface and microstructure of the rupture specimens.The intergranular β phase precipitated sufficiently with favorable morphology can efficiently strengthen grain boundaries that can achieve a full plastic deformation of grains.Additionally,the intergranular β phase can effectively restrain the occurrence and expansion of intergranular cracks during the rupture test.The intergranular β phase insufficiently precipitated can weaken the intergranular cohesion and lead to the occurrence and expansion of cracks; thus,the grains cannot be fully deformed before breaking.Therefore,the β phase precipitated in the grain boundaries can significantly increase the rupture plasticity of Inconel 783 superalloy. | WEI Zhigang ZHAO Yating XIE Wei CHEN Guosheng | 2011 | Baosteel Technical Research2011，5，4： | 1 |
| 11 | Reducing 1,3- Dichloropropene Emissions from Soil Columns Amended with Thiourea显示文摘 | ZHENG Wei YATES S R PAPIERNIK S K | 2006 | Environ Sci Technol2006，40，7： | 1 |
| 12 | Electrically driven single-photon sources显示文摘Single-photon sources are building blocks for photonic quantum information processes. Of the many single-photon generation schemes, electrically driven single-photon sources have the advantages of realizing monolithic integration of quantum light sources and detectors without optical filtering, thus greatly simplify the integrated quantum photonic circuits. Here, we review recent advances on electrically driven single-photon sources based on solid-state quantum emitters, such as semiconductor epitaxial quantum dots, colloidal quantum dots, carbon nanotubes, molecules, and defect states in diamond, SiC and layered semiconductors. In particular, the merits and drawbacks of each system are discussed. Finally, the article is concluded by discussing the challenges that remain for electrically driven single-photon sources. | Yating Lin Yongzheng Ye Wei Fang | 2019 | Journal of Semiconductors2019，40，7： | 1 |
| 13 | Redirecting soluble antigen for MHC class I cross‐presentation during phagocytosis显示文摘 | Aswin Hari Anutosh Ganguly Libing Mu Shevaun P. Davis Melanie D. Stenner Raymond Lam Fay Munro Inana Namet Enaam Alghamdi Tobias Fürstenhaupt Wei Dong Pascal Detampel Lian Jun Shen Matthias W. Amrein Robin M. Yates Yan Shi | 2015 | Eur. J. Immunol2015，，： | 1 |
| 14 | High-Resolution Coupled Climate Runoff Simulations of Seasonal Snowfall over Colorado: A Process Study of Current and Warmer Climate显示文摘 | Rasmussen Roy Liu Changhai Ikeda Kyoko Gochis David Yates David Chen Fei Tewari Mukul Barlage Michael Dudhia Jimy Yu Wei Miller Kathleen Arsenault Kristi Grubisic Vanda Thompson Greg Gutmann Ethan | 2011 | Journal of Climate2011，，12： | 1 |
| 15 | In vivo and in vitro effects of heme oxygenase-1 silencing on the survivalof acute myelocytic leukemia-M2 cells显示文摘 | Sixi Wei Yating Wang Qixiang Chai Qin Fang Yaming Zhang Jishi Wang | 2015 | Experimental and Therapeutic Medicine2015，，： | 1 |
| 16 | Glycyrrhizic acid as the antiviral component of Glycyrrhiza uralensis Fisch. against coxsackievirus A16 and enterovirus 71 of hand foot and mouth disease显示文摘 | Jingjing Wang Xiaoqing Chen Wei Wang Yating Zhang Ziying Yang Yu Jin Hui Ming Ge Erguang Li Guang Yang | 2013 | Journal of Ethnopharmacology2013，，1： | 1 |
| 17 | Optimization and standardization of transient expression assays for gene functional analyses in strawberry fruits显示文摘Strawberry is increasingly used as a model plant for research on fruit growth and development.The transient gene manipulation(TGM)technique is widely used to determine the function of plant genes,including those in strawberry fruits.However,its reliable application for the precise identification of gene function has been difficult owing to the lack of conditional optimization.In this study,we found that successful transient gene manipulation requires optimization,with the vector type,temperature,and fruit developmental stage being three major factors determining success.Notably,we found that transient gene manipulation was feasible only from the large green fruit stage onwards,making it especially suitable for identifying genes involved in strawberry fruit ripening.Furthermore,we established a method called percentage difference of phenotype(PDP),in which the functional effect of a gene could be precisely and efficiently identified in strawberry fruits.This method can be used to estimate the functional effect of a gene as a value from 0 to 100%,such that different genes can be quantitatively compared for their relative abilities to regulate fruit ripening.This study provides a useful tool for accelerating research on the molecular basis of strawberry fruit ripening. | Yaoyao Zhao Wenwen Mao Yating Chen WeiWang Zhengrong Dai Zhechao Dou Kai Zhang Lingzhi Wei Tianyu Li Baozhen Zeng Ting Liu Yijuan Fan Jiaqi Yan Bingbing Li Wensuo Jia | 2019 | Horticulture Research2019，6，1： | 1 |
| 18 | Distribution and fate of perfluoroalkyl substances in municipal wastewater treatment plants in economically developed areas of China显示文摘 | Wei Zhang Yating Zhang Sachi Taniyasu Leo W.Y. Yeung Paul K.S. Lam Jianshe Wang Xinhai Li Nobuyoshi Yamashita Jiayin Dai | 2013 | Environmental Pollution2013，，： | 1 |
| 19 | An interpretation of the genetic polymorphism and population genetic background of Ankang Han population via a novel InDel panel显示文摘In this research,genotyping data of 43 InDel loci in 311 Han individuals in Ankang City,Shaanxi Province,China were detected using a self-developed five-dye multiplex amplification panel.The allelic frequencies and forensic parameters of all InDel loci were calculated.The combined power of discrimination and probability of exclusion values were 0.99999999999999999882739 and 0.999887424,respectively,which demonstrated that this 43-InDel panel was powerful for individual identifications in Ankang Han population.Moreover,genetic distances,pairwise F_(ST)values,principal component analyses,phylogenetic trees and STRUCTURE analyses were performed to investigate the genetic affinities between Ankang Han and reference groups.Population genetic investigations indicated that Ankang Han population had a close genetic relationship with Southern Han population compared with other reference groups. | Wei Cui Xiaoye Jin Yating Fang Qiong Lan Jiangwei Lan Man Chen Shuyan Mei Tong Xie Bofeng Zhu | 2022 | Forensic Sciences Research2022，7，4： | 0 |
| 20 | Electrocatalytic CO_(2) Reduction over Bimetallic Bi-Based Catalysts:A Review显示文摘Electrocatalytic reduction of carbon dioxide(CO_(2))to valuable fuels is an up-and-coming approach.Owing to the low cost,environmental friendliness,and high selectivity to formate single product at low overpotentials,bismuth(Bi)-based catalysts have attracted extensive research attention.In this review,the reaction mechanisms of Bi-based catalysts are first introduced,and the bimetallic Bi-based catalysts synthesized by alloying,doping,and loading strategies are reviewed from the aspects of catalyst component,morphology,synthesis procedure,and performance optimization for electrocatalytic CO_(2)reduction.We provide an in-depth discussion of the existing challenges and an outlook for this highly promising kind of electrocatalysis. | Wei Chen Yating Wang Yuhang Li Chunzhong Li | 2023 | CCS Chemistry2023，5，3： | 0 |
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