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| 1 | Discovering small molecules as Wnt inhibitors that promote heart regeneration and injury repair显示文摘There are intense interests in discovering pro regenerative medicine leads that can promote cardiac differentiation and regeneration,as well as repair damaged heart tissues.We have combined zebrafish embryo-based screens with cardiomyogenesis assays to discover selective small molecules that modulate heart development and regeneration with minimal adverse effects.Two related compounds with novel structures,named as Cardiomogen 1 and 2(CDMG1 and CDMG2),were identified for their capacity to promote myocardial hyperplasia through expansion of the cardiac progenitor cell population.We find that Cardiomogen acts as a Wnt inhibitor by targeting p-catenin and reducing Tcf/Lef-mediated transcription in cultured cells.CDMG treatment of amputated zebrafish hearts reduces nuclear p-catenin in injured heart tissue,increases cardiomyocyte(CM)proliferation,and expedites wound healing,thus accelerating cardiac muscle regeneration.Importantly,Cardiomogen can alleviate the functional deterioration of mammalian hearts after myocardial infarction.Injured hearts exposed to CDMG1 display increased newly formed CMs and reduced fibrotic scar tissue,which are in part attributable to the^-catenin reduction.Our findings indicate Cardiomogen as a Wnt inhibitor in enhancing injury-induced CM proliferation and heart regeneration,highlighting the values of embryo-based small molecule screens in discovery of effective and safe medicine leads. | Shuying Xie Wenbin Fu Guangju Yu Xueli Hu Kaa Seng Lai Xiangwen Peng Yating Zhou Xuejiao Zhu Ptamen Christov Leah Sawyer Terri T.Ni Gary A.Sulikowski Zhongzhou Yang Ethan Lee Chunyu Zeng Wei E.Wang Tao P.Zhong | 2020 | Journal of Molecular Cell Biology2020，12，1： | 4 |
| 2 | A pulsed wave excitation system to characterize micron-scale magne- toelastic biosensors 显示文摘 | XIE Hong CHAI Yating HORIKAWA S | 2014 | Sens Actuators A Phys2014，205，： | 1 |
| 3 | 4-(Trifluoromethyl)-benzonitrile: A novel electrolyte additive for lithium nickel manganese oxide cathode of high voltage lithium ion battery显示文摘 | Wenna Huang Lidan Xing Yating Wang Mengqing Xu Weishan Li Fengchao Xie Shengan Xia | 2014 | Journal of Power Sources2014，，： | 1 |
| 4 | Effect of intergranular β phase on the rupture plasticity of the low expansion Inconel 783 superalloy显示文摘High temperature rupture specimens with different rupture plasticity are investigated.The rupture fracture failure of Inconel 783 superalloy is researched by analyzing the fracture surface and microstructure of the rupture specimens.The intergranular β phase precipitated sufficiently with favorable morphology can efficiently strengthen grain boundaries that can achieve a full plastic deformation of grains.Additionally,the intergranular β phase can effectively restrain the occurrence and expansion of intergranular cracks during the rupture test.The intergranular β phase insufficiently precipitated can weaken the intergranular cohesion and lead to the occurrence and expansion of cracks; thus,the grains cannot be fully deformed before breaking.Therefore,the β phase precipitated in the grain boundaries can significantly increase the rupture plasticity of Inconel 783 superalloy. | WEI Zhigang ZHAO Yating XIE Wei CHEN Guosheng | 2011 | Baosteel Technical Research2011，5，4： | 1 |
| 5 | A pulsed wave excitation system to characterize micron-scale magnetoelastic biosensors显示文摘 | Xie Hong Chai Yating Horikawa S | 2014 | Sensors and Actuators A:Physical2014，205，： | 1 |
| 6 | MMI-0100 inhibits cardiac fibrosis in myocardial infarction by direct actions on cardiomyocytes and fibroblasts via MK2 inhibition显示文摘 | Xu L Yates C C Lockyer P Xie L Bevilacqua A He J | 2014 | J Mol Cell Cardiol2014，77，： | 1 |
| 7 | Levels of the EMT ‐related protein S nail/ S lug are not correlated with p53/p63 in cutaneous squamouscell carcinoma显示文摘 | Hongxiang Chen Masakazu Takahara Lining Xie Satoshi Takeuchi Yating Tu Takeshi Nakahara Hiroshi Uchi Yoichi Moroi Masutaka Furue | 2013 | J Cutan Pathol2013，，7： | 1 |
| 8 | An interpretation of the genetic polymorphism and population genetic background of Ankang Han population via a novel InDel panel显示文摘In this research,genotyping data of 43 InDel loci in 311 Han individuals in Ankang City,Shaanxi Province,China were detected using a self-developed five-dye multiplex amplification panel.The allelic frequencies and forensic parameters of all InDel loci were calculated.The combined power of discrimination and probability of exclusion values were 0.99999999999999999882739 and 0.999887424,respectively,which demonstrated that this 43-InDel panel was powerful for individual identifications in Ankang Han population.Moreover,genetic distances,pairwise F_(ST)values,principal component analyses,phylogenetic trees and STRUCTURE analyses were performed to investigate the genetic affinities between Ankang Han and reference groups.Population genetic investigations indicated that Ankang Han population had a close genetic relationship with Southern Han population compared with other reference groups. | Wei Cui Xiaoye Jin Yating Fang Qiong Lan Jiangwei Lan Man Chen Shuyan Mei Tong Xie Bofeng Zhu | 2022 | Forensic Sciences Research2022，7，4： | 0 |
| 9 | Determination of Fosthiazate Residue in Ginger by Gas Chromatography显示文摘[Objectives] An analytical method was established for determining fosthiazate residue in ginger by gas chromatography with flame photometric detector(GC-NPD) to evaluate the safety of fosthiazate in ginger. [Methods] The fosthiazate residue in ginger was extracted with dichloromethane, and subjected to sodium chloride salt-out and liquid-liquid extraction with hexane and dichloromethane(the plant and soil samples had no need for the later two steps). The analysis was performed on gas chromatograph equipped with a flame photometric detector(GC-FPD), and the fosthiazate residue was quantitatively determined by calculating the peak area. [Results] The results of degradation dynamics showed that the half-life of fosthiazate was 7.2-8.7 d in ginger plants, and was 9.9-19.8 d in the soil. The results of the final residue test showed that after applying the fosthiazate granules according to the recommended high dose(active component 58.2 g a.i/m^2,WK) and low dose(38.8 g a.i/m^2,WK) once, the final residual amounts of fosthiazate in the ginger and soil were estimated to be <0.02 mg/kg and <0.02-0.103 mg/kg, respectively, while no fosthiazate residue was detected in all control samples(<0.02 mg/kg). The maximum residue limit(MRL) of fosthiazate in ginger was not established in China, and was 0.2 mg/kg in Japan. [Conclusions] The method was proved to meet the basic requirements of pesticide residue analysis on sensitivity, accuracy and precision and have good linearity. It is recommended that when using fosthiazate granules to control root-knot nematode and root rot in ginger, it is applied at the highest dose of 38.8 g ai/m^2,WK once 30 d before ginger cultivation to treat the soil, and ginger is harvested in the ginger harvest period. | Kailing PENG Yating XIE Chenzhong JIN Xiaoming OU Han XI Xiu LIU Qiangyong SONG Guiping LIANG Zhifu YANG Shunli XIAO Xuye ZHANG | 2019 | Agricultural Biotechnology2019，8，2： | 0 |
| 10 | Analysis of the Lost Circulation Problem显示文摘The well-known“lost circulation”problem refers to the uncontrolled flow of whole mud into a formation.In order to address the problem related to the paucity of available data,in the present study,a model is introduced for the lost-circulation risk sample profile of a drilled well.The model is built taking into account effective data(the Block L).Then,using a three-dimensional geological modeling software,relying on the variation function and sequential Gaussian simulation method,a three-dimensional block lost-circulation risk model is introduced able to provide relevant information for regional analyses. | Xingquan Zhang Renjun Xie Kuan Liu Yating Li Yuqiang Xu | 2023 | Fluid Dynamics & Materials Processing2023，19，6： | 0 |
| 11 | Real-time detection of LMP1/LMP1 interaction in MβCD-induced apoptosis of nasopharyngeal carcinoma cells using FRET method显示文摘Latent mermbrane protein 1(LMP1)is known as an oncoprotein in nasopharyngeal carcinoma(NPC)cells,which is considered to have a strong association with growth,invasion and metastasis of NPC cells through lipid rafts.Met hy-A-cyclodextrin(M3CD)can disrupt lipid rafts through cholesterol depletion.In this study,we revealed that MICD induced apoptosis in two kinds of NPC cells including CNE1 cells,a LMP1 negative nasopharyngeal squamous carcinoma cell line,and CNE1-LMP1 cells,a LMP1-positive nasopharyngeal squamous carcinoma cell line.Furthermore,the impact of MBCD on LMP1 was investigated by fuorescence resonance energy transfer(FRET)method in NPC cells.Synchronized tempo spatial and spectral detection of LMP1/LMP1 interaction were performed using fluorescence microscope and spectrograph.FRET efficiency indicated that LMP1/LMP1 interaction gradully enhanced after M9CD treatment.MTT assays showed that M8CD caused strong cytotoxicity in CNE1 cells,but cauused relatively weaker cytotoxicity in CNE1-LMP1 cells,which indicated that LMP1 may regulate sensitivity of NPC cells to MBCD.Then,detection of cleaved caspase-3 in two kinds of NPC cells indicated that LMP1 may inhibit activation of caspase 3.These results strongly suggested that MBCD can induce apoptosis of NPC cells,but enhancing of LMP1/LMP1 interaction may likely resist apoptosis through inhibiting cleavage of caspase-3. | Zhiwei Wu Qing Ye Yimei Huang Yating Lin Mengmeng Zheng Xiaoyan Wang Shusen Xie Juqiang Lin | 2019 | Journal of Innovative Optical Health Sciences2019，，6： | 0 |
| 12 | Facile 3D cell culture protocol based on photocurable hydrogels显示文摘Introduction Why 3D cell culture urgently needed?Tissue engineering has extremely influenced the development process of basic biological studies and biomedical technology.For quite a long time,the vast majority of these researches have been relying on the experimental results of conventional two-dimensional(2D)cell culture in flask,petri dish or well plate.However,these 2D culture results could be very different with or even totally opposite to the actual situations in vivo where cells grow inside a 3D extracellular matrix(ECM).Therefore,3D cell culture has been playing a more and more significant role because of its higher accuracy and authenticity[1–4]. | Mingjun Xie Yating Zheng Qing Gao Yong He | 2021 | Bio-Design and Manufacturing2021，4，1： | 0 |
| 13 | Research Progress of Application of Microbial Inoculants in Agricultural Production显示文摘Microbial inoculants have received increasing attention in strengthening plant biological barriers,antagonizing and inhibiting harmful microorganisms,and ensuring the safe production of agricultural products.This paper summarized the research status of agricultural microbial inoculants,the application of microbial inoculants in agriculture,and the trends and prospects of agricultural microbial research. | Yunyun ZHOU Yating XIE Xiu LIU Kaifa GUO Chenzhong JIN Shunli XIAO | 2020 | Agricultural Biotechnology2020，9，4： | 0 |
| 14 | Quantitative analysis of the difference of lesion degree between male and female COVID-19 based on digital modeling显示文摘The purpose of this study is to research the difference of lesion volume and its constituent ratio of lung volume of Novel Coronavirus Pneumonia(NCP)between male and female by digital technology.In this study,the CT imaging data and clinical data of 40 NCP patients in Huaihua were collected and divided into two groups:male(n=22)and female(n=18)according to gender. | Yu Huan Liu Guangxing Zhan Meizhi Zhang Zhenwu Sheng Ting Liu Yating Mi Sirong Xie Liang Zhang Feng Hu Luying He Wenyan Rao Libing | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 15 | Study on bone morphology and development of children based on digital three dimensional reconstruction显示文摘This study aims to construct the skeletal system of children at different ages through digital modeling techniques,explore the law of morphological development of childen's skeletal system,so as to provide a reference for the study of children's bone development and digital anatomy.In this study,12 normal boys were selected from 6 age stages(0-6 months,6-12 months,1-3 years old,3-5 years old,5-7 years old,7-10 years old).All patients underwent CT plain scan with a slice thickness of 0.625 mm.The collected CT data was imported into Mimics 19.0 software for three dimensional reconstruction of children's whole body bones.3D printing of children's bone model was used to construct children's bone system.T wo dissected bone specimens were randomly selected and compared with 3D printed models for specific bony landmarks to verify the accuracy of modeling. | Mi Sirong Xie Liang Hu Luying Zhang Feng He Wenyan Liu Guangxing Zhang Zhenwu Yu Huan Zhan Meizhi Liu Yating Sheng Ting Peng Wen Liu Qiangsheng Rao Libing | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 16 | A Predictive Nomogram for Predicting Improved Clinical Outcome Probability in Patients with COVID-19 in Zhejiang Province,China显示文摘The aim of this research was to develop a quantitative method for clinicians to predict the probability of improved prognosis in patients with coronavirus disease 2019(COVID-19).Data on 104 patients admitted to hospital with laboratory-confirmed COVID-19 infection from 10 January 2020 to 26 February 2020 were collected.Clinical information and laboratory findings were collected and compared between the outcomes of improved patients and non-improved patients.The least absolute shrinkage and selection operator(LASSO)logistics regression model and two-way stepwise strategy in the multivariate logistics regression model were used to select prognostic factors for predicting clinical outcomes in COVID-19 patients.The concordance index(C-index)was used to assess the discrimination of the model,and internal validation was performed through bootstrap resampling.A novel predictive nomogram was constructed by incorporating these features.Of the 104 patients included in the study(median age 55 years),75(72.1%)had improved short-term outcomes,while 29(27.9%)showed no signs of improvement.There were numerous differences in clinical characteristics and laboratory findings between patients with improved outcomes and patients without improved outcomes.After a multi-step screening process,prognostic factors were selected and incorporated into the nomogram construction,including immunoglobulin A(IgA),C-reactive protein(CRP),creatine kinase(CK),acute physiology and chronic health evaluation II(APACHE II),and interaction between CK and APACHE II.The C-index of our model was 0.962(95%confidence interval(CI),0.931-0.993)and still reached a high value of 0.948 through bootstrapping validation.A predictive nomogram we further established showed close performance compared with the ideal model on the calibration plot and was clinically practical according to the decision curve and clinical impact curve.The nomogram we constructed is useful for clinicians to predict improved clinical outcome probability for each COVID-19 patient,which may facilitate personalized counselling and treatment. | Jiaojiao Xie Ding Shi Mingyang Bao Xiaoyi Hu Wenrui Wu Jifang Sheng Kaijin Xu Qing Wang Jingjing Wu Kaicen Wang Daiqiong Fang Yating Li Lanjuan Li | 2022 | Engineering2022，8，1： | 0 |
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