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| 1 | Isolation,characterization,and phylogenic analysis of three new severe fever with thrombocytopenia syndrome bunyavirus strains derived from Hubei Province,China显示文摘Hubei Province is a major epidemic area of severe fever with thrombocytopenia syndrome bunyavirus(SFTSV) in China. However, to date, a few SFTSV strains have been isolated from Hubei Province, preventing effective studies of epidemic outbreaks. Here, we report three confirmed patients(2015–2016) with typical symptoms of severe fever with thrombocytopenia syndrome disease(SFTS) who were farmers resident in different regions in Hubei Province. Three new SFTSV strains were isolated from the serum samples of each patient. Characterization of viral growth properties showed that there were no significant differences in virus production. All strains were completely sequenced, and phylogenetic analysis showed that unlike the other strains from Hubei province, which belonged to the SFTSV C3 genotype, one of the three strains belonged to the SFTSV C2 genotype. These results suggested that multiple SFTSV genotypes have been circulating in Hubei Province, providing insights into SFTSV evolution and improving our understanding of SFTSV prevalence in Hubei Province. | Yanfang Zhang Shu Shen Junming Shi Zhengyuan Su Mingyue Li Wenjing Zhang Mengmeng Li Zhihong Hu Cheng Peng Xin Zheng Fei Deng | 2017 | Virologica Sinica2017，32，1： | 21 |
| 2 | Changes in nitrogen budget and potential risk to the environment over 20 years(1990–2010) in the agroecosystems of the Haihe Basin, China显示文摘The nitrogen balance can serve as an indicator of the risk to the environment of nitrogen loss from agricultural land. To investigate the temporal and spatial changes in agricultural nitrogen application and its potential threat to the environment of the Haihe Basin in China, we used a database of county-level agricultural statistics to calculate agricultural nitrogen input, output,surplus intensity, and use efficiency. Chemical fertilizer nitrogen input increased by 51.7% from1990 to 2000 and by 37.2% from 2000 to 2010, concomitant with increasing crop yields.Simultaneously, the nitrogen surplus intensity increased by 53.5% from 1990 to 2000 and by16.5% from 2000 to 2010, presenting a continuously increased environmental risk. Nitrogen use efficiency decreased from 0.46 in 1990 to 0.42 in 2000 and remained constant at 0.42 in 2010,partly due to fertilizer composition and type improvement. This level indicates that more than half of nitrogen inputs are lost in agroecosystems. Our results suggest that although the improvement in fertilizer composition and types has partially offset the decrease in nitrogen use efficiency, the environmental risk has still increased gradually over the past 20 years, along with the increase in crop yields and nitrogen application. It is important to achieve a better nitrogen balance through more effective management to significantly reduce the environmental risk,decrease nitrogen surplus intensity, and increase nitrogen use efficiency without sacrificing crop yields. | Mengmeng Zheng Hua Zheng Yingxia Wu Yi Xiao Yihua Du Weihua Xu Fei Lu Xiaoke Wang Zhiyun Ouyang | 2015 | Journal of Environmental Sciences2015，27，2： | 6 |
| 3 | Dark matter direct search sensitivity of the PandaX-4T experiment显示文摘The Panda X-4T experiment, a 4-ton scale dark matter direct detection experiment, is being planned at the China Jinping Underground Laboratory. In this paper we present a simulation study of the expected background in this experiment. In a 2.8-ton fiducial mass and the signal region between 1-10 keV electron equivalent energy, the total electron recoil background is found to be 4.9 × 10^(-5) kg^(-1) d^(-1) keV^(-1). The nuclear recoil background in the same region is 2.8 × 10^(-7) kg^(-1) d^(-1) keV^(-1). With an exposure of 5.6 ton-years, the sensitivity of Panda X-4 T could reach a minimum spin-independent dark matter-nucleon cross section of 6 × 10^(-48) cm^2 at a dark matter mass of 40 Ge V/c^2. | HongGuang Zhang Abdusalam Abdukerim Wei Chen Xun Chen YunHua Chen XiangYi Cui BinBin Dong DeQing Fang ChangBo Fu Karl Giboni Franco Giuliani LinHui Gu XuYuan Guo ZhiFan Guo Ke Han ChangDa He ShengMing He Di Huang XingTao Huang Zhou Huang Peng Ji XiangDong Ji YongLin Ju ShaoLi Li Yao Li Heng Lin HuaXuan Liu JiangLai Liu YuGang Ma YaJun Mao KaiXiang Ni JinHua Ning XiangXiang Ren Fang Shi AnDi Tan AnQing Wang Cheng Wang HongWei Wang Meng Wang QiuHong Wang SiGuang Wang XiuLi Wang XuMing Wang Zhou Wang MengMeng Wu ShiYong Wu JingKai Xia MengJiao Xiao PengWei Xie BinBin Yan JiJun Yang Yong Yang ChunXu Yu JuMin Yuan JianFeng Yue Dan Zhang Tao Zhang Li Zhao QiBin Zheng JiFang Zhou Ning Zhou XiaoPeng Zhou | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，3： | 6 |
| 4 | Catalysis under shell: Improved CO oxidation reaction confined in Pt@h-BN core-shell nanoreactors显示文摘Core-shell nanostructures consisting of active metal cores and protective shells often exhibit enhanced catalytic performance, in which reactants can access a small part of the core surfaces through the pores in the shells. In this study, we show that Pt nanoparticles (NPs) can be embedded into few-layer hexagonal boron nitride (h-BN) overlayers, forming Pt@h-BN core-shell nanocatalysts. The h-BN shells not only protect the Pt NPs under harsh conditions but also allow gaseous molecules such as CO and O2 to access a large part of the Pt surfaces through a facile intercalation process. As a result, the Pt@h-BN nanostructures act as nanoreactors, and CO oxidation reactions with improved activity, selectivity, and stability occur at the core-shell interfaces. The confinement effect exerted by the h-BN shells promotes the Pt-catalyzed reactions. Our work suggests that two-dimensional shells can function as robust but flexible covers on nanocatalyst surfaces and tune the surface reactivity. | Mengmeng Sun Qiang Fu Lijun Gao Yanping Zheng Yangyang Li Mingshu Chen Xinhe Bao | 2017 | Nano Research2017，10，4： | 5 |
| 5 | Abnormal Behavior Detection and Recognition Method Based on Improved ResNet Model显示文摘The core technology in an intelligent video surveillance system is that detecting and recognizing abnormal behaviors timely and accurately.The key breakthrough point in recognizing abnormal behaviors is how to obtain the effective features of the picture,so as to solve the problem of recognizing them.In response to this difficulty,this paper introduces an adjustable jump link coefficients model based on the residual network.The effective coefficients for each layer of the network can be set after using this model to further improving the recognition accuracy of abnormal behavior.A convolution kernel of 1×1 size is added to reduce the number of parameters for the purpose of improving the speed of the model in this paper.In order to reduce the noise of the data edge,and at the same time,improve the accuracy of the data and speed up the training,a BN(Batch Normalization)layer is added before the activation function in this network.This paper trains this network model on the public ImageNet dataset,and then uses the transfer learning method to recognize these abnormal behaviors of human in the UTI behavior dataset processed by the YOLO_v3 target detection network.Under the same experimental conditions,compared with the original ResNet-50 model,the improved model in this paper has a 2.8%higher accuracy in recognition of abnormal behaviors on the public UTI dataset. | Huifang Qian Mengmeng Zheng Xuan Zhou | 2020 | Computers, Materials & Continua2020，，12： | 3 |
| 6 | Highly efficient perovskite solar cells based on symmetric hole transport material constructed with indaceno[1,2-b:5,6-b’]dithiophene core building block显示文摘Two novel hole transport materials (HTMs) with indaceno[1,2-b:5,6-b’]dithiophene (IDT) as core building blocks,termed IDT1 and IDT2,were designed and synthesized.The side alkyl chains were introduced to regulate and control the morphology and stacking behavior of HTMs,and the peripheral triarylamine arms were introduced to adjust the energy levels and to facilitate efficient hole transport.Applied in mesoporous structured perovskite solar cells (PSCs),HTM IDT1 achieved higher power conversion efficiency (PCE,19.55%) and better stability than Spiro-OMeTAD (19.25%) and IDT2 (15.77%) based PSC.These results suggest the potential of IDTl as a promising HTM for PSCs. | Cheng Wu Cheng Chen Li Tao Xingdong Ding Mengmeng Zheng Hongping Li Gongqiang Li Hongfei Lu Ming Cheng | 2020 | Journal of Energy Chemistry2020，29，4： | 2 |
| 7 | Efficiency against multidrug resistance by co-delivery of doxorubicin and curcumin with a legumain-sensitive nanocarrier显示文摘Multidrug 抵抗蛋白质(MDRP ) 在肿瘤在 multidrug 抵抗的调停被含有,代表主要障碍到成功的化疗。当 curcumin (杂种狗) 在 MDRP 的表示和功能上施加禁止的效果,为杂种狗和 doxorubicin (纪录影片) 的合作交货的 nanocarrier 被准备通过他们的 synergistic 效果克服 MDR 肿瘤。由于在肿瘤的 legumain 的 overexpression,从这 nanocarrier 的纪录影片的版本侧面被设计是调制的 legumain,它被与 legumain 敏感的肽衔接纪录影片到基本材料(chitosan ) 完成。与 nanoparticles 相比仅仅包含纪录影片,纪录影片和杂种狗的 coadministration 显著地禁止了 multidrug 抵抗(P < 0.05 ) 在一个 multidrug 抵抗的癌症房间模型(MCF-7/ADR 房间线) ,与到正常房间(L929 房间线) 的 cytotoxicity。如此的抑制能在 MCF-7/ADR 原子核被归功于到增加的纪录影片累积。合作交货系统整个延长发行量时间,改进指向肿瘤的效率,肿瘤抑制活动的举起,和 MDRP 表示的抑制展出了好 anticancer 效果。这些数据为癌症治疗揭示了这个合作交货系统的庞大的潜力,特别在 multidrug 抵抗可以发展的以后的阶段。 | Sen Lin Peiling Xie Mengmeng Luo Qing Li Ling Li Jinzhao Zhang Qinxiang Zheng Hao Chen Kaihui Nan | 2018 | Nano Research2018，11，7： | 2 |
| 8 | Novel SFTSV Phylogeny Reveals New Reassortment Events and Migration Routes显示文摘Severe fever with thrombocytopenia syndrome virus(SFTSV),the causative agent of a febrile human disease,was first identified from central and eastern provinces in China,and later in Japan and South Korea.Hubei Province is one of the major SFTS epidemic areas in the central part of China.This study reported the isolation of 11 new SFTSV strains from patients in Hubei Province collected in 2017.Extensive phylogenetic analyses were conducted based on the complete coding sequences of SFTSV segments including the new strains.It was suggested that five different SFTSV genotypes were circulating in Hubei,and 15 reassortment patterns and migration pathways correlated with each genotype were identified,which was more than previously recognized.Hubei Province was more involved in the evolutionary events of SFTSV than that previously thought in which the evolutionary events of SFTSV were reported to be independent from those in other epidemic regions.Further divergence of SFTSV strains was suggested by pairwise comparison of SFTSV sequences from each genotype and sequence identity normalized to representative strain in genotype C1.Subsequently,amino acid variations specific for genotype(s),strain(s),or cluster(s)were inspected,which may be related to differential biological activity of SFTSV strains/genotypes.In conclusion,we analyzed the current status of SFTSV phylogeny in Hubei Province and discussed the possible events correlated to SFTSV evolution.It provided an in-depth insight into SFTSV evolution,raising concerns for the use of proper SFTSV strains in future studies. | Xiaoli Wu Mingyue Li Yanfang Zhang Boyun Liang Junming Shi Yaohui Fang Zhengyuan Su Mengmeng Li Wenjing Zhang Ling Xu Jun Wang Qiaoli Wu Shuang Tang Hualin Wang Tao Zhang Cheng Peng Xin Zheng Fei Deng Shu Shen | 2021 | Virologica Sinica2021，36，2： | 2 |
| 9 | Selective coordination and localized polarization in graphene quantum dots: Detection of fluoride anions using ultra-low-field NMR relaxometry显示文摘The development of ultra-sensitive methods for detecting anions is limited by their low charge to radius ratios, microenvironment sensitivity, and p H sensitivity. In this paper, a magnetic sensor is devised that exploits the controllable and selective coordination that occurs between a magnetic graphene quantum dot(GQD) and fluoride anion(F–). The sensor is used to measure the change in relaxation time of aqueous solutions of magnetic GQDs in the presence of F–using ultra-low-field(118 μT) nuclear magnetic resonance relaxometry. The method was optimized to produce a limit of detection of 10 nmol/L and then applied to quantitatively detect F–in domestic water samples. More importantly, the key factors responsible for the change in relaxation time of the magnetic GQDs in the presence of F–are revealed to be the selective coordination that occurs between the GQDs and F–as well as the localized polarization of the water protons. This striking finding is not only significant for the development of other magnetic probes for sensing anions but also has important ramifications for the design of contrast agents with enhanced relaxivity for use in magnetic resonance imaging. | Yongqiang Li Yi Xiao Quan Tao Mengmeng Yu Li Zheng Siwei Yang Guqiao Ding Hui Dong Xiaoming Xie | 2021 | Chinese Chemical Letters2021，32，12： | 2 |
| 10 | 2020 Roadmap on gas-involved photo-and electro-catalysis显示文摘Green reactions not only provide us chemical products without any pollution,but also offer us the viable technology to realize difficult tasks in normal conditions.Photo-,photoelectro-,and electrocatalytic reactions are indeed powerful tools to help us to embrace bright future.Especially,some gas-involved reactions are extremely useful to change our life environments from energy systems to liquid fuels and cost-effective products,such as H2 evolution(H2 production),02 evolution/reduction,CO2 reduction,N2 reduction(or N2 fixation) reactions.We can provide fuel cells clean H2 for electric vehicles from H2 evolution reaction(HER),at the same time,we also need highly efficient 02 reduction reaction(ORR) in fuel cells for improving the reaction kinetics.Moreover,we can get the clean oxidant O2 from water through O2 evolution reaction(OER),and carry out some reactions without posing any pollution to reaction systems.Furthermore,we can translate the greenhouse gas CO2 into useful liquid fuels through CO2 reduction reaction(CRR).Last but not the least,we can get ammonia from N2 reduction reaction(NRR),which can decrease energy input compared to the traditional Hubble process.These reactions,such as HER,ORR,OER,CRR and NRR could be realized through solar-,photoelectro-and electro-assisted ways.For them,the catalysts used play crucial roles in determining the efficiency and kinds of products,so we should consider the efficiency of catalysts.However,the cost,synthetic methods of catalysts should also be considered.Nowadays,significant progress has been achieved,however,many challenges still exist,reaction systems,catalysts underlying mechanisms,and so on.As extremely active fields,we should pay attention to them.Under the background,it has motivated us to contribute with a roadmap on ’GasInvolved Photo-and Electro-Catalysis’. | Yulu Yang Yang Tang Haomin Jiang Yongmei Chen Pingyu Wan Maohong Fan Rongrong Zhang Sana Ullah Lun Pan Ji-Jun Zou Mengmeng Lao Wenping Sun Chao Yang Gengfeng Zheng Qiling Peng Ting Wang Yonglan Luo Xuping Sun Alexander S.Konev Oleg V.Levin Panagiotis Lianos Zhuofeng Hu Zhurui Shen Qinglan Zhao Ying Wang Nadia Todorova Christos Trapalis Matthew V.Sheridan Haipeng Wang Ling Zhang Songmei Sun Wenzhong Wang Jianmin Ma | 2019 | Chinese Chemical Letters2019，30，12： | 1 |
| 11 | Sporophytic control of anther development and male fertility by glucose-6-phosphate/phosphate translocator 1(OsGPT1) in rice显示文摘Coordination between the sporophytic tissue and the gametic pollen within anthers is tightly controlled to achieve the optimal pollen fitness. Glucose-6-phosphate/phosphate translocator(GPT) transports glucose-6-phosphate, a key precursor of starch and/or fatty acid biosynthesis, into plastids. Here, we report the functional characterization of Os GPT1 in the rice anther development and pollen fertility. Pollen grains from homozygous osgpt1 mutant plants fail to accumulate starch granules, resulting in pollen sterility. Genetic analyses reveal a sporophytic effect for this mutation. Os GPT1 is highly expressed in the tapetal layer of rice anther. Degeneration of the tapetum, an important process to provide cellular contents to support pollen development, is impeded in osgpt1 plants. In addition, defective intine and exine are observed in the pollen from osgpt1 plants. Expression levels of multiple genes that are important to tapetum degeneration or pollen wall formation are significantly decreased in osgpt1 anthers. Previously, we reported that At GPT1 plays a gametic function in the accumulation of lipid bodies in Arabidopsis pollen. This report highlights a sporophytic role of Os GPT1 in the tapetum degeneration and pollen development. The divergent functions of Os GPT1 and At GPT1 in pollen development might be a result of their independent evolution after monocots and dicots diverged. | Aili Qu Yan Xu Xinxing Yu Qi Si Xuwen Xu Changhao Liu Liuyi Yang Yueping Zheng Mengmeng Zhang Shuqun Zhang Juan Xu | 2021 | Journal of Genetics and Genomics2021，48，8： | 1 |
| 12 | Nitric oxide participates in the regulation of LeCBF1 gene expression and improves cold tolerance in harvested tomato fruit显示文摘 | Ruirui Zhao Jiping Sheng Shengnan Lv Yang Zheng Jian Zhang Mengmeng Yu Lin Shen | 2011 | Postharvest Biology and Technology2011，，2： | 1 |
| 13 | Ethylene and cold participate in the regulation of LeCBF1 gene expression in postharvest tomato fruits显示文摘 | Danying Zhao Lin Shen Bei Fan Mengmeng Yu Yang Zheng Shengnan Lv Jiping Sheng | 2009 | FEBS Letters2009，，20： | 1 |
| 14 | Gonadotropin-inhibitory hormone (GnIH) and its receptor in the female pig: cDNA cloning, expression in tissues and expression pattern in the reproductive axis during the estrous cycle显示文摘 | Xun Li Juan Su Zhihai Lei Yangyang Zhao Mengmeng Jin Rui Fang Lucheng Zheng Yang Jiao | 2012 | Peptides2012，，2： | 1 |
| 15 | Polyphosphate Accelerates Transformation of Nonstructural Carbohydrates to Improve Growth of ppk-Expressing Transgenic Rice in Phosphorus Deficiency Culture显示文摘Crop yield and quality are often limited by the amount of phosphate fertilizer added to infertile soils,a key limiting factor for sustainable development in modern agriculture.The polyphosphate kinase(ppk)gene-expressing transgenic rice with a single-copy line(ETRS)is constructed to improve phosphate fertilizer utilization efficiency for phosphorus resource conservation.To investigate the potential mechanisms of the increased biomass in ETRS in low phosphate culture,ETRS was cultivated in a low inorganic phosphate(Pi)culture medium(15μmol/L Pi,LP)and a normal Pi culture medium(300μmol/L Pi,CP),respectively.After 89 d of cultivation in different concentrations of phosphate culture media,the total phosphorus,polyphosphate(polyP),biomass,photosynthetic rate,nonstructural carbohydrate(NSC)contents,related enzyme activities,and related gene expression levels were analyzed.The results showed that ETRS had a high polyP amount to promote the photosynthetic rate in LP,and its biomass was almost the same as the wild type(WT)in CP.The NSC content of ETRS in LP was higher than that of WT in LP,but slightly lower than that of WT in CP.PolyP notably promoted the sucrose phosphate synthase activities of ETRS and significantly down-regulated the expression levels of sucrose transporter genes(OsSUT3 and OsSUT4),resulting in inhibiting the transport of sucrose from shoot to root in ETRS.It was concluded that polyP can stimulate the synthesis of NSCs in LP,which improved the growth of ETRS and triggered the biological activities of ETRS to save phosphate fertilizer.Our study provides a new way to improve the utilization rate of phosphate fertilizer in rice production. | ZHU Jinling WEI Ruping WANG Xin ZHENG Chaoqun WANG Mengmeng YANG Yicheng YANG Liuyan | 2023 | Rice science2023，30，3： | 1 |
| 16 | Nitric oxide participates in the regulation of LeCBF1 gene expression and improves cold tolerance in harvested tomato fruit显示文摘 | Ruirui Zhao Jiping Sheng Shengnan Lv Yang Zheng Jian Zhang Mengmeng Yu Lin Shen | 2011 | Postharvest Biology and Technology2011，，： | 1 |
| 17 | Sustainability of SARS-CoV-2 Induced Humoral Immune Responses in COVID-19 Patients from Hospitalization to Convalescence Over Six Months显示文摘Understanding the persistence of antibody in convalescent COVID-19 patients may help to answer the current major concerns such as the risk of reinfection,the protection period of vaccination and the possibility of building an active herd immunity.This retrospective cohort study included 172 COVID-19 patients who were hospitalized in Wuhan.A total of404 serum samples were obtained over six months from hospitalization to convalescence.Antibodies in the specimens were quantitatively analyzed by the capture chemiluminescence immunoassays(CLIA).All patients were positive for the anti-SARS-Co V-2 Ig M/Ig G at the onset of COVID-19 symptoms,and the Ig G antibody persisted in all the patients during the convalescence.However,only approximately 25%of patients can detect the Ig M antibodies,Ig M against N protein(NIg M)and receptor binding domain of S protein(RBD-Ig M)at the 27 th week.The titers of Ig M,N-Ig M and RBD-Ig M reduced to 16.7%,17.6%and 15.2%of their peak values respectively.In contrast,the titers of Ig G,N-Ig G and RBD-Ig G peaked at 4–5 th week and reduced to 85.9%,62.6%and 87.2%of their peak values respectively at the end of observation.Dynamic behavior of antibodies and their correlation in age,gender and severity groups were investigated.In general,the COVID-19 antibody was sustained at high levels for over six months in most of the convalescent patients.Only a few patients with antibody reducing to an undetectable level which needs further attention.The humoral immune response against SARS-Co V-2 infection in COVID-19 patients exhibits a typical dynamic of acquired immunity. | Yang Zheng Qing Zhang Ashaq Ali Ke Li Nan Shao Xiaoli Zhou Zhiqin Ye Xiaomin Chen Shanshan Cao Jing Cui Juan Zhou Dianbing Wang Baidong Hou Min Li Mengmeng Cui Lihua Deng Xinyi Sun Qian Zhang Qinfang Yang Yong li Hui Wang Yake Lei Bo Yu Yegang Cheng Xiaolin Tong Dong Men Xian-En Zhang | 2021 | Virologica Sinica2021，36，5： | 1 |
| 18 | The enhanced photocatalytic activity and self-cleaning properties of mesoporous Si O2coated Cu-Bi2O3thin films显示文摘 | Shan Wenjie Hu Yun Zheng Mengmeng | 2015 | Dalton Trans2015，44，： | 1 |
| 19 | Nitric oxide synthase as a postharvest response in pathogen resistance of tomato fruit显示文摘 | Yang Zheng Lin Shen Mengmeng Yu Bei Fan Danying Zhao Lingyi Liu Jiping Sheng | 2010 | Postharvest Biology and Technology2010，，1： | 1 |
| 20 | The effects of RFRP-3, the mammalian ortholog of GnIH, on the female pig reproductive axis in vitro显示文摘 | Xun Li Juan Su Rui Fang Lucheng Zheng Ruipeng Lei Xiaoye Wang Zhihai Lei Mengmeng Jin Yang Jiao Yuanlong Hou Tingting Guo Zhiyu Ma | 2013 | Molecular and Cellular Endocrinology (-)2013，，1： | 1 |
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