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| 1 | The Tartary Buckwheat Genome Provides Insights into Rutin Biosynthesis and Abiotic Stress Tolerance显示文摘 | Zhang, Lijun Li, Xiuxiu Ma, Bin Gao, Qiang Du, Huilong Han, Yuanhuai Li, Yan Cao, Yinghao Qi, Ming Zhu, Yaxin Lu, Hongwei Ma, Mingchuan Liu, Longlong Zhou, Jianping Nan, Chenghu Qin, Yongjun Wang, Jun Cui, Lin Liu, Huimin Liang, Chengzhi Qiao, Zhijun | 2017 | Molecular Plant2017，10，9： | 53 |
| 2 | TGFβ inhibition enhances the generation of hematopoietic progenitors from human ES cell-derived hemogenic endothelial cells using a stepwise strategy显示文摘 | Chengyan Wang Xuming Tang Xiaomeng Sun Zhenchuan Miao Yaxin Lv Yanlei Yang Huidan Zhang Pengbo Zhang Yang Liu LiyingDu Yang Gao Ming Yin Mingxiao Ding Hongkui Deng | 2012 | Cell Research2012，22，1： | 17 |
| 3 | Molecular mechanism of SCARB2-mediatec attachment and uncoating of EV71显示文摘 | Minghao Dang Xiangxi Wang Quan Wang Yaxin Wang Jianping Lin Yuna Sun Xuemei Li Liguo Zhang Zhiyong Lou Junzhi Wang Zihe Rao | 2014 | Protein & Cell2014，5，9： | 13 |
| 4 | Adsorption of mixed cationic-nonionic surfactant and its effect on bentonite structure显示文摘The adsorption of cationic-nonionic mixed surfactant onto bentonite and its effect on bentonite structure were investigated.The objective was to improve the understanding of surfactant behavior on clay mineral for its possible use in remediation technologies of soil and groundwater contaminated by toxic organic compounds.The cationic surfactant used was hexadecylpyridinium bromide(HDPB),and the nonionic surfactant was Triton X-100(TX100).Adsorption of TX100 was enhanced significantly by the addition of HDPB,but this enhancement decreased with an increase in the fraction of the cationic surfactant.Part of HDPB was replaced by TX100 which decreased the adsorption of HDPB.However,the total adsorbed amount of the mixed surfactant was still increased substantially,indicating the synergistic effect between the cationic and nonionic surfactants.The surfactant-modified bentonite was characterized by Brunauer-Emmett-Teller specific surface area measurement,Fourier transform infrared spectroscopy,and thermogravimetric-derivative thermogravimetric/differential thermal analyses.Surfactant intercalation was found to decrease the bentonite specific surface area,pore volume,and surface roughness and irregularities,as calculated by nitrogen adsorption-desorption isotherms.The co-adsorption of the cationic and nonionic surfactants increased the ordering conformation of the adsorbed surfactants on bentonite,but decreased the thermal stability of the organobentonite system. | Yaxin Zhang Yan Zhao Yong Zhu Huayong Wu Hongtao Wang Wenjing Lu | 2012 | Journal of Environmental Sciences2012，24，8： | 12 |
| 5 | Changes of Precipitation Infiltration Recharge in the Circumstances of Coal Mining Subsidence in the Shen-Dong Coal Field,China显示文摘煤采矿沉淀是在采矿区域的一个通用环境地质的问题。由作为研究领域选择 Shen 盾煤采矿沉淀区域,这篇论文在降水渗入学习变化再装在这种情况下借助于领域的煤采矿沉淀,地质的调查和实验室模拟试验,它被期望在采矿区域为 eco 环境的恢复提供一个科学基础。结果显示在沉淀的不稳定的阶段,在 Shen 盾采矿区域的沉淀的三种类型在降水渗入上有积极效果再装,并且完整厚度的基岩沉淀的类型有最大的影响。在沉淀,在长期的干旱以后的降水渗入进程和在通风地区的潮湿移植的稳定的阶段经历三个不同阶段:在降水前的蒸发渗入,渗入向上的渗入渗入在在降水以后的降水和蒸发渗入期间。在一个重降雨渗入过程期间,在好沙,粗糙的沙和罚款粗糙的沙的二元的结构的弄湿的前面运动由二个阶段组成:在降水,弄湿的前面运动距离与深度在有线性关系期间弄湿前面运动的阶段,和在降水,弄湿的前面运动距离与深度在有力量功能关系以后弄湿前面运动的阶段。弄湿的前面运动速度被降雨数量和岩性学在通风地区影响。作为深度增加,然而,运动速度将指数地腐烂。 | ZHANG Fawang SONG Yaxin ZHAO Hongmei HAN Zhantao WANG Dong | 2012 | Acta Geologica Sinica(English Edition)2012，86，4： | 11 |
| 6 | Plasma metabolomic and lipidomic alterations associated with COVID-19显示文摘The pandemic of the coronavirus disease 2019(COVID-19)has become a global public health crisis.The symptoms of COVID-19 range from mild to severe,but the physiological changes associated with COVID-19 are barely understood.In this study,we performed targeted metabolomic and lipidomic analyses of plasma from a cohort of patients with COVID-19 who had experienced different symptoms.We found that metabolite and lipid alterations exhibit apparent correlation with the course of disease in these patients,indicating that the development of COVID-19 affected their whole-body metabolism.In particular,malic acid of the TCA cycle and carbamoyl phosphate of the urea cycle result in altered energy metabolism and hepatic dysfunction,respectively.It should be noted that carbamoyl phosphate is profoundly down-regulated in patients who died compared with patients with mild symptoms.And,more importantly,guanosine monophosphate(GMP),which is mediated not only by GMP synthase but also by CD39 and CD73,is significantly changed between healthy subjects and patients with COVID-19,as well as between the mild and fatal cases.In addition,dyslipidemia was observed in patients with COVID-19.Overall,the disturbed metabolic patterns have been found to align with the progress and severity of COVID-19.This work provides valuable knowledge about plasma biomarkers associated with COVID-19 and potential therapeutic targets,as well as an important resource for further studies of the pathogenesis of COVID-19. | Di Wu Ting Shu Xiaobo Yang Jian-Xin Song Mingliang Zhang Chengye Yao Wen Liu Muhan Huang Yuan Yu Qingyu Yang Tingju Zhu Jiqian Xu Jingfang Mu Yaxin Wang Hong Wang Tang Tang Yujie Ren Yongran Wu Shu-Hai Lin Yang Qiu Ding-Yu Zhang You Shang Xi Zhou | 2020 | National Science Review2020，7，7： | 9 |
| 7 | Advances in alternating electromagnetic field data processing for earthquake monitoring in China显示文摘The alternating electromagnetic(EM) field is one of the most sensitive physical fields related to earthquakes. There have been a number of publications reporting EM anomalies associated with earthquakes. With increasing applications and research of artificial-source extremely low frequency EM and satellite EM technologies in earthquake studies, the amount of observed data from the alternating EM method increases rapidly and exponentially, so it is imperative to develop suitable and effective methods for processing and analyzing the influx of big data. This paper presents research on the self-adaptive filter and wavelet techniques and their applications to analyzing EM data obtained from ground measurements and satellite observations, respectively. Analysis results show that the self-adaptive filter method can identify both natural- and artificial-source EM signals, and enhance the ratio between signal and noise of EM field spectra, apparent resistivity, and others. The wavelet analysis is capable of detecting possible correlation between EM anomalies and seismic events. These techniques are effective in processing and analyzing massive data obtained from EM observations. | ZHAO GuoZe BI YaXin WANG LiFeng HAN Bing WANG Xiao XIAO QiBin CAI JunTao ZHAN Yan CHEN XiaoBin TANG Ji WANG JiJun | 2015 | Science China Earth Sciences2015，58，2： | 7 |
| 8 | Graphene TiO_2 nanocomposites with high photocatalytic activity for the degradation of sodium pentachlorophenol显示文摘A series of graphene–TiO2photocatalysts was synthesized by doping TiO2 with graphene oxide via hydrothermal treatment. The photocatalytic capability of the catalysts under ultraviolet irradiation was evaluated in terms of sodium pentachlorophenol(PCP-Na) decomposition and mineralization. The structural and physicochemical properties of these nanocomposites were characterized by X-ray diffraction, N2adsorption–desorption, transmission electron microscopy, scanning electron microscopy, Ultraviolet–visible diffuse reflectance spectroscopy, X-ray photoelectron spectroscopy, electron paramagnetic resonance spectra, and Fourier-transform infrared spectroscopy. The graphene–TiO2nanocomposites exhibited higher photocatalytic efficiency than commercial P25 for the degradation of PCP-Na, and 63.4% to 82.9% of the total organic carbon was fully mineralized. The improved photocatalytic activity may be attributed to the accelerated interfacial electron-transfer process and the significantly prolonged lifetime of electron-hole pairs imparted by graphene sheets in the nanocomposites. However,excessive graphene and the inhomogeneous aggregation of TiO2 nanoparticles may decrease photodegradation efficiency. | Yaxin Zhang Zeyu Zhou Tan Chen Hongtao Wang Wenjing Lu | 2014 | Journal of Environmental Sciences2014，26，10： | 6 |
| 9 | Mining coterie patterns from Instagram photo trajectories for recommending popular travel routes显示文摘 | Yaxin YU Yuhai ZHAO Ge YU Guoren WANG | 2017 | Frontiers of Computer Science2017，11，6： | 5 |
| 10 | Human rhinovirus C infection is associated with asthma in children determined by x TAG respiratory viral panel FAST显示文摘Dear Editor,Cumulative evidence supports the role of early-life viral infections,especially respiratory syncytial virus(RSV)and human rhinovirus(HRV),as major antecedents of childhood asthma(Lemanske,2002;Jackson et al.,2008).In this study,the x TAG respiratory viral panel FAST(RVP FAST)assay,a multiplex polymerase chain reaction(PCR)-based method(Arens et al.,2010;BaladaLlasat et al.,2011;Gharabaghi et al.,2011;Selvaraju,2012),was used to investigate the association of infec- | Dongmei Chen Qinwei Song Runan Zhu Yuan Qian Yu Sun Jie Deng Fang Wang Yaxin Ding Run Tian Chuanhe Liu Wenjing Zhu Linqing Zhao | 2017 | Virologica Sinica2017，32，2： | 5 |
| 11 | In situ observation of C_(60)(C(COOH)_(2))_(2) interacting with living cells using fluorescence microscopy显示文摘The interactions between nanoparticles and living cells were investigated by an imaging technique of fluorescence microscopy. For this pur- pose, the C60 derivative C60(C(COOH)2)2, a thera- peutic agent for degeneration diseases of central nervous system, was synthesized, purified and characterized. Its interaction with the living cell and penetration of the cellular membrane were in situ studied using the real time imaging technique, and its potential cytotoxicity was also examined by flow cy- tometry. The results indicate that C60(C(COOH)2)2 can easily enter cells, and is mainly located in cytoplasm by fluorescein labeling. Furthermore, C60(C(COOH)2)2 can carry the molecule that cannot cross cellular membranes into cells, because fluo- rescein compound itself cannot enter the cell or ad- here to membrane. At concentrations ranging from 1×10?2 to 1×102 mg/L, C60(C(COOH)2)2 does not show any detectable cytotoxicity. | YE Chang CHEN Chunying CHEN Zhen MENG Huan XING Li JIANG Yaxin YUAN Hui XING Gengmei ZHAO Feng ZHAO Yuliang CHAI Zhifang FANG Xiaohong HAN Dong CHEN Long WANG Chen WEI Taotao | 2006 | Chinese Science Bulletin2006，51，9： | 4 |
| 12 | Multicenter phaseⅡstudy of apatinib single or combination therapy in HER2-negative breast cancer involving chest wall metastasis显示文摘Objective:Breast cancer(BC)with chest wall metastasis(CWM)usually shows rich neovascularization.This trial explored the clinical effect of apatinib on human epidermal growth factor receptor 2(HER2)-negative advanced BC involving CWM.Methods:This trial involved four centers in China and was conducted from September 2016 to March 2020.Patients received apatinib 500 mg/d[either alone or with endocrine therapy if hormone receptor-positive(HR+)]until disease progression or unacceptable toxicity.Progression-free survival(PFS)was the primary endpoint.Results:We evaluated 26 patients for efficacy.The median PFS(mPFS)and median overall survival(mOS)were4.9[range:2.0-28.5;95%confidence interval(95%CI):2.1-8.3]months and 18(range:3-55;95%CI:12.9-23.1)months,respectively.The objective response rate(ORR)was 42.3%(11/26),and the disease-control rate was76.9%(20/26).In the subgroup analysis,HR+patients compared with HR-negative patients had significantly improved mPFS of 7.0(95%CI:2.2-11.8)months vs.2.3(95%CI:1.2-3.4)months,respectively(P=0.001);and mPFS in patients without or with chest wall radiotherapy was 6.4(95%CI:1.6-19.5)months vs.3.0(95%CI:1.3-4.6)months,respectively(P=0.041).In the multivariate analysis,HR+status was the only independent predictive factor for favorable PFS(P=0.014).Conclusions:Apatinib was highly effective for BC patients with CWM,especially when combined with endocrine therapy.PFS improved significantly in patients with HR+status who did not receive chest wall radiotherapy.However,adverse events were serious and should be carefully monitored from the beginning of apatinib treatment. | Huiping Li Cuizhi Geng Hongmei Zhao Hanfang Jiang Guohong Song Jiayang Zhang Yaxin Liu Xinyu Gui Jing Wang Kun Li Zhongsheng Tong Fangyuan Zhao Junlan Yang Guoliang Chen Qianyu Liu Xu Liang | 2021 | Chinese Journal of Cancer Research2021，33，2： | 4 |
| 13 | Growth and magnetic properties of single crystalline Ni nanowire arrays prepared by pulse DC electrodeposition显示文摘Highly textured Ni nanowire arrays were fabricated into anodic aluminum oxide(AAO) templates by pulse DC electrodeposition.The applied voltage and pH value of electrolytes were found strongly affecting the microstructure and magnetic properties of Ni nanowire arrays.Low applied potential and pH value both prefer to form polycrystalline fcc Ni nanowires.Increasing the applied potential or pH value favors the Ni [220] texture and even eventually forms the [220] oriented single crystal Ni wires,while exorbitant potential and pH value will conversely weaken the texture of nanowires.The magnetic properties of Ni wires are closely related to the microstructure of Ni nanowire arrays and large coercivities more than 1000 Oe were achieved at single crystalline Ni nanowire arrays.The mechanisms for the effect of applied potential and pH value on the grain size,texture and magnetic properties of Ni nanowire arrays have been discussed. | ZHANG Jun JIN YaXin WANG HanBin YE Cong TONG WeiMing WANG Hao | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，7： | 4 |
| 14 | Hot deformation behavior and microstructure evolution of the laser solid formed TC4 titanium alloy显示文摘Hot compressive experiments of the laser solid formed(LSFed)TC4 titanium alloy were conducted at a wide temperature range of 650-950℃and strain rate of 0.01-10 s^(-1).The Arrheniustype constitutive models of the LSFed TC4 alloy were established at the temperature range of 800-950℃and of 650-800℃,respectively.The average relative error between the predicted stresses and experimental values in those two temperature ranges are 10.4%and 8.3%,respectively,indicating that the prediction models constructed in this paper are in a good agreement with experimental data.Processing maps were established by the principle of dynamic materials modeling on the basis of the data achieved from the hot compression experiments.The processing parameters corresponding to the stable and unstable regions of material deformation can be determined from the processing maps.The microstructure evolution of the stable and unstable regions of the samples after tests were observed.Finally,the effect of hot compressive parameters on the microstructure were investigated to research the dynamic recrystallization and the texture of the deformed LSFed TC4 alloy. | Xiawei YANG Yanying WANG Xiurong DONG Chong PENG Baijin JI Yaxin XU Wenya LI | 2021 | Chinese Journal of Aeronautics2021，34，5： | 3 |
| 15 | Assessment of effects of best management practices on agricultural non-point source pollution in Xiangxi River watershed显示文摘 | Ruimin Liu Peipei Zhang Xiujuan Wang Yaxin Chen Zhenyao Shen | 2013 | Agricultural Water Management2013，，： | 3 |
| 16 | Earthquake Electromagnetic Precursor Anomalies Detected by a New Ground-based Observation Network显示文摘It is a debated topic if there are any observable precursor anomalies prior to the earthquake(EQ hereafter)and if the stronger EQ can be successfully predicted.During last few decades quite a lot of observable electromagnetic(EM)precursors were published by using techniques equipped in either satellites or on ground-based stations.But there are only a few cases that the shortterm precursor anomalies of EM field before earthquakes were observed by using alternate EM fields on ground.This paper will present a new EM observation network built in recent years and show a new finding of EM field with the variation of a one-year cycle observed using the network.As an example,the short-term precursor anomalies of apparent resistivity before the Yangbi EQ(Ms 5.1)occurred on March 27,2017 in Yunnan Province will be studied.The observed anomalous phenomena indicate that the anomaly before the EQ can be captured only if reasonable effective methods including sophisticated analytical techniques are used,and it is believed that continuously observed data on the fixed observation network for a long time is an effective means for studying anomalies that appeared before earthquakes.This network can also play an important role in studying the EM environment from space. | Bing HAN Guoze ZHAO Lifeng WANG Ji TANG Yaxin BI Yan ZHAN Xiaobin CHEN Qibin XIAO Jihong ZHANG | 2021 | Journal of Geodesy and Geoinformation Science2021，4，1： | 3 |
| 17 | Involvement of MyoD and PEA3 in regulation of transcription activity of MDR1 gene显示文摘在癌症的 multidrug 抵抗 1 的 Overexpression (MDR1 ) 为化疗的失败仍然是主要原因之一。在现在的学习,我们发现 MyoD 和 PEA3 能激活 P-glycoprotein (P-gp ) 在 SGC7901 房间的表示。MyoD 和 PEA3 击倒稀释了 MDR1 表示并且增加了 multidrug 的敏感抵抗癌症房间到被 P-gp 在 SGC7901/VCR 房间搬运的细胞毒素的药。MyoD 或 PEA3 能在 MDR1 倡导者上绑在电子盒子和 PEA3 地点并且激活它的抄写。由 MyoD 和 PEA3 的 MDR1 表示的规定可以提供潜在的方法在癌症治疗克服 MDR。 | Yaxin Zhao Jiefan Liu Qi Hong Chen Yang Li Chen Ying Chen Qiaoqiao Wang Kuaile Zhao Wei Jin | 2010 | Acta Biochimica et Biophysica Sinica2010，42，12： | 3 |
| 18 | Observation and research of deep underground multi-physical fields—Huainan–848 m deep experiment显示文摘Compared with the surface,the deep environment has the advantages of allowing“super-quiet and ultra-clean”-geophysical field observation with low vibration noise and little electromagnetic interference,which are conducive to the realization of long-term and high-precision observation of multi-physical fields,thus enabling the solution of a series of geoscience problems.In the Panyidong Coal Mine,where there are extensive underground tunnels at the depth of 848 m below sea level,we carried out the first deep-underground geophysical observations,including radioactivity,gravity,magnetic,magnetotelluric,background vibration and six-component seismic observations.We concluded from these measurements that(1)the background of deep subsurface gravity noise in the long-period frequency band less than 2 Hz is nearly two orders of magnitude weaker than that in the surface observation environment;(2)the underground electric field is obviously weaker than the surface electric field,and the relatively high frequency of the underground field,greater than 1 Hz,is more than two orders of magnitude weaker than that of the surface electric field;the east-west magnetic field underground is approximately the same as that at the surface;the relatively high-frequency north-south magnetic field underground,below 10 Hz,is at least one order of magnitude lower than that at the surface,showing that the underground has a clean electromagnetic environment;(3)in addition to the highfrequency and single-frequency noises introduced by underground human activities,the deep underground space has a significantly lower background vibration noise than the surface,which is very beneficial to the detection of weak earthquake and gravity signals;and(4)the underground roadway support system built with ferromagnetic material interferes the geomagnetic field.We also found that for deep observation in the“ultra-quiet and ultra-clean”environment,the existing geophysical equipment and observation technology have problems of poor adaptability and insufficient precision as well as data cleaning problems,such as the effective separation of the signal and noise of deep observation data.It is also urgent to interpret and comprehensively utilize these high-precision multi-physics observation data. | Yun WANG Yaxin YANG Heping SUN Chengliang XIE Qisheng ZHANG Xiaoming CUI Chang CHEN Yongsheng HE Qiangqiang MIAO Chaomin MU Lianghui GUO Jiwen TENG | 2023 | Science China Earth Sciences2023，66，1： | 3 |
| 19 | Recombinant human PDCD5 protein enhances chemosensitivities of hematologic malignancies显示文摘PDCD5 is a novel apoptosis-related gene. Overexpression of PDCD5 facilitates apoptosis in various tumor cells. Here, we investigated the roles of recombinant human PDCD5 (rhPDCD5) protein in chemosensitivities of hematologic malignancies. The rhPDCD5 increased the in vitro cytotoxicity of daunorubicin (DNR), adriamycin (ADM) and As2O3 in three hematologic tumor cell lines. In vivo studies showed that DNR combined with rhPDCD5 significantly suppressed tumor growth of U937 xenograft nude mice compared with DNR alone. In conclusion, rhPDCD5 combined with the chemotherapeutic drug has greater efficacy than chemotherapy alone, and rhPDCD5 is a very promising chemosensitizer. | WANG YanFang SHI Lin SONG QuanSheng ZHANG YingMei LOU YaXin ZHENG Yi MA DaLong WANG Ying KE XiaoYan | 2009 | Chinese Science Bulletin2009，54，21： | 3 |
| 20 | Solitary beam propagation in periodic layered Kerr media enables high-efficiency pulse compression and mode self-cleaning显示文摘Generating intense ultrashort pulses with high-quality spatial modes is crucial for ultrafast and strong-field science and can be achieved by nonlinear supercontinuum generation(SCG)and pulse compression.In this work,we propose that the generation of quasi-stationary solitons in periodic layered Kerr media can greatly enhance the nonlinear lightmatter interaction and fundamentally improve the performance of SCG and pulse compression in condensed media.With both experimental and theoretical studies,we successfully identify these solitary modes and reveal their unified condition for stability.Space-time coupling is shown to strongly influence the stability of solitons,leading to variations in the spectral,spatial and temporal profiles of femtosecond pulses.Taking advantage of the unique characteristics of these solitary modes,we first demonstrate single-stage SCG and the compression of femtosecond pulses from 170 to 22 fs with an efficiency>85%.The high spatiotemporal quality of the compressed pulses is further confirmed by highharmonic generation.We also provide evidence of efficient mode self-cleaning,which suggests rich spatiotemporal self-organization of the laser beams in a nonlinear resonator This work offers a route towards highly efficient,simple,stable and highly flexible SCG and pulse compression solutions for state-of-the-art ytterbium laser technology. | Sheng Zhang Zongyuan Fu Bingbing Zhu Guangyu Fan Yudong Chen Shunjia Wang Yaxin Liu Andrius Baltuska Cheng Jin Chuanshan Tian Zhensheng Tao | 2021 | Light(Science & Applications)2021，10，4： | 3 |
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