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| 1 | Concentration and source identification of polycyclic aromatic hydrocarbons and phthalic acid esters in the surface water of the Yangtze River Delta,China显示文摘The pollution from polycyclic aromatic hydrocarbons(PAHs) and phthalic acid esters(PAEs) in the surface water of the rapidly urbanized Yangtze River Delta region was investigated.Fourteen surface water samples were collected in June 2010.Water samples were liquid-liquid extracted using methylene chloride and analyzed by gas chromatography-mass spectrometry.Concentrations of PAHs and PAEs ranged 12.9-638.1 ng/L and 61-28550 ng/L,respectively.Fluoranthene,naphthalene,pyrene,phenanthrene,di-2ethylhexyl phthalate,and di-n-butyl phthalate were the most abundant compounds in the samples.The water samples were moderately polluted with benzo[a]pyrene according to China's environmental quality standard for surface water.The two highest concentrations of PAHs and PAEs occurred in samples from Taihu Lake,Wuxi City and the western section of Yangchenghu Lake.Potential sources of pollution at S7 were petroleum combustion and the plastics industry,and at Yangchenghu Lake were petroleum combustion and domestic waste.Pollution in samples from the Beijing-Hangzhou Grand Canal originated from diesel engines.There were no obvious sources of pollution for the other water samples.These results can be used as reference levels for future monitoring programs of pollution from PAHs and PAEs. | Lifei Zhang Liang Dong Lijun Ren Shuangxin Shi Li Zhou Ting Zhang Yeru Huang | 2012 | Journal of Environmental Sciences2012，24，2： | 56 |
| 2 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 3 | The Tartary Buckwheat Genome Provides Insights into Rutin Biosynthesis and Abiotic Stress Tolerance显示文摘 | Zhang, Lijun Li, Xiuxiu Ma, Bin Gao, Qiang Du, Huilong Han, Yuanhuai Li, Yan Cao, Yinghao Qi, Ming Zhu, Yaxin Lu, Hongwei Ma, Mingchuan Liu, Longlong Zhou, Jianping Nan, Chenghu Qin, Yongjun Wang, Jun Cui, Lin Liu, Huimin Liang, Chengzhi Qiao, Zhijun | 2017 | Molecular Plant2017，10，9： | 53 |
| 4 | Transplantation of UC-MSCs on collagen scaffold activates follicles in dormant ovaries of POF patients with long history of infertility显示文摘Premature ovarian failure(POF) is a refractory disease for clinical treatment with the goal of restoring fertility. In this study,umbilical cord mesenchymal stem cells on a collagen scaffold(collagen/UC-MSCs) can activate primordial follicles in vitro via phosphorylation of FOXO3 a and FOXO1. Transplantation of collagen/UC-MSCs to the ovaries of POF patients rescued overall ovarian function, evidenced by elevated estradiol concentrations, improved follicular development, and increased number of antral follicles. Successful clinical pregnancy was achieved in women with POF after transplantation of collagen/UC-MSCs or UC-MSCs. In summary, collagen/UC-MSC transplantation may provide an effective treatment for POF. | Lijun Ding Guijun Yan Bin Wang Lu Xu Yan Gu Tong Ru Xiaoying Cui Lei Lei Jingyu Liu Xiaoqiang Sheng Bin Wang Chunxue Zhang Yanjun Yang Ruiwei Jiang Jianjun Zhou Na Kong Feifei Lu Huaijun Zhou Yannan Zhao Bing Chen Yali Hu Jianwu Dai Haixiang Sun | 2018 | Science China(Life Sciences)2018，61，12： | 43 |
| 5 | Transplantation of collagen scaffold with autologous bone marrow mononuclear cells promotes functional endometrium reconstruction via downregulating ΔNp63 expression in Asherman's syndrome显示文摘Asherman's syndrome(AS) is a common disease that presents endometrial regeneration disorder. However, little is known about its molecular features of this aregenerative endometrium in AS and how to reconstruct the functioning endometrium for the patients with AS. Here, we report that ΔNp63 is significantly upregulated in residual epithelial cells of the impaired endometrium in AS; the upregulated-ΔNp63 induces endometrial quiescence and alteration of stemness. Importantly, we demonstrate that engrafting high density of autologous bone marrow mononuclear cells(BMNCs) loaded in collagen scaffold onto the uterine lining of patients with AS downregulates ΔNp63 expression, reverses ΔNp63-induced pathological changes, normalizes the stemness alterations and restores endometrial regeneration. Finally, five patients achieved successful pregnancies and live births. Therefore, we conclude that ΔNp63 is a crucial therapeutic target for AS. This novel treatment significantly improves the outcome for the patients with severe AS. | Guangfeng Zhao Yun Cao Xianghong Zhu Xiaoqiu Tang Lijun Ding Haixiang Sun Juan Li Xinan Li Chenyan Dai Tong Ru Hui Zhu Jingjie Lu Caimei Lin Jingmei Wang Guijun Yan Huiyan Wang Lei Wang Yimin Dai Bin Wang Ruotian Li Jianwu Dai Yan Zhou Yali Hu | 2017 | Science China(Life Sciences)2017，60，4： | 39 |
| 6 | A landscape shape index-based sampling approach for land cover accuracy assessment显示文摘Spatial sampling design is one of the key steps in land cover accuracy assessment,and many traditional sampling approaches may not achieve credible spatial sampling due to the high spatial heterogeneity of land cover.This paper characterizes the spatial heterogeneity with three-level LSIs and determines the subsequent sample sizes and their spatial distributions.The three-level LSIs are rLSI in a region,cLSI for each land cover class and uLSI in each geographic sampling unit in the region.The rLSIs are used to derive appropriate sample sizes in the target regions.The cLSIs are used to assure that larger sample numbers are allocated to land cover classes with higher spatial heterogeneity.The uLSIs provide useful measures for selecting optimal geographic units in which sample sites will be located.This LSI-based sampling approach can derive the sample sizes and determine their distributions in an adaptive way according to the spatial heterogeneity.An experimental case study further demonstrates that the LSI-based sampling approach obtains more appropriate sample sizes for each region,sufficient sample numbers for rare classes,and optimal sample distributions in the geographical space. | CHEN Fei CHEN Jun WU Hao HOU DongYang ZHANG WeiWei ZHANG Jun ZHOU XiaoGuang CHEN LiJun | 2016 | Science China(Information Sciences)2016，59，12： | 17 |
| 7 | Land Use Effects on Soil Organic Carbon, Microbial Biomass and Microbial Activity in Changbai Mountains of Northeast China显示文摘Land use changes are known to alter soil organic carbon(SOC) and microbial properties, however, information about how conversion of natural forest to agricultural land use as well as plantations affects SOC and microbial properties in the Changbai Mountains of Northeast China is meager. Soil carbon content, microbial biomass carbon(MBC), basal respiration and soil carbon mineralization were studied in five selected types of land use: natural old-growth broad-leaved Korean pine mixed forest(NF); spruce plantation(SP) established following clear-cutting of NF; cropland(CL); ginseng farmland(GF) previously under NF; and a five-year Mongolian oak young forest(YF) reforested on an abandoned GF, in the Changbai Mountains of Northeast China in 2011. Results showed that SOC content was significantly lower in SP, CL, GF, and YF than in NF. MBC ranged from 304.4 mg/kg in CL to 1350.3 mg/kg in NF, which was significantly higher in the soil of NF than any soil of the other four land use types. The SOC and MBC contents were higher in SP soil than in CL, GF, and YF soils, yielding a significant difference between SP and CL. The value of basal respiration was also higher in NF than in SP, CL, GF, and YF. Simultaneously, higher values of the metabolic quotient were detected in CL, GF, and YF soils, indicating low substrate utilization of the soil microbial community compared with that in NF and SP soil. The values of cumulative mineralized carbon and potentially mineralized carbon(C0) in NF were significantly higher than those in CL and GF, while no significant difference was observed between NF and SP. In addition, YF had higher values of C0 and C mineralization rate compared with GF. The results indicate that conversion from NF into agricultural land(CL and GF) uses and plantation may lead to a reduction in soil nutrients(SOC and MBC) and substrate utilization efficiency of the microbial community. By contrast, soils below SP were more conducive to the preservation of soil organic matter, which was reflected in the comparison of microbial indicators among CL, GF, and YF land uses. This study can provide data for evaluating soils nutrients under different land use types, and serve as references for the rational land use of natural forest in the study area. | FANG Xiangmin WANG Qingli ZHOU Wangming ZHAO Wei WEI Yawei NIU Lijun DAI Limin | 2014 | Chinese Geographical Science2014，24，3： | 16 |
| 8 | High salt primes a specific activation state of macrophages, M(Na)显示文摘 | Wu-Chang Zhang Xiao-Jun Zheng Lin-Juan Du Jian-Yong Sun Zhu-Xia Shen Chaoji Shi Shuyang Sun Zhiyuan Zhang Xiao-qing Chen Mu Qin Xu Liu Jun Tao Lijun Jia Heng-yu Fan Bin Zhou Ying Yu Hao Ying Lijian Hui Xiaolong Liu Xianghua Yi Xiaojing Liu Lanjing Zhang Sheng-Zhong Duan | 2015 | Cell Research2015，25，8： | 15 |
| 9 | Bio-leaching effects of Leptospirillum ferriphilum on the surface chemical properties of pyrite显示文摘Leptospirillum ferriphilum cultured using different energy sources(either soluble ferrous ion or pyrite) changed the surface properties of pyrite.Cell adsorption,zeta-potential,hydrophobicty,FT-IR spectra and surface morphology were investigated.Adhesion of bacterial cells to the pyrite surface is a fast process.Furthermore,the adsorption of cells grown in pyrite is greater than of cells grown in soluble ferrous ion.The Iso-Electric Point(IEP) of pyrite treated with L.ferriphilum approaches that of the cells themselves.The contact angle of the pyrite surface was observed to decrease due to the surface formation of some hydrophilic substances during bio-leaching.Changes in pyrite surface properties after bacterial treatment support the idea that ferric ion plays an important role and that indirect bio-oxidation is the principal mechanism of pyrite bio-leaching. | GU, Guohua SU, Lijun CHEN, Minglian SUN, Xiaojun ZHOU, Hongbo | 2010 | Mining Science and Technology2010，20，2： | 14 |
| 10 | Low Frequency Dispersion Mechanism of Dielectric Response for Oil-paper Insulation Diagnosis显示文摘Both the real part and imaginary part of complex permittivity approximately have a log-linear frequency dependency at low fre- quencies, especially at ultra-low frequencies under conditions of different moisture concentrations and temperatures, which is recognized as the low frequency dispersion (LFD). In order to explain this dispersion, a new mechanism of dielectric response of LFD of oil-paper insula- tion is proposed. A simplified one-dimensional mathematical model of concentration polarization carrier caused by slow migration is developed and solved, which indicates that ion mobility is closely related to the size of gap and the adsorption capacity of cellulose molecu- lar chains to ions. A stochastic statistical model of the carrier mobility induced LFD is also developed. Moreover, actual tests under 50 °C and 2% moisture content were put forward, as well as simulations with according current waveforms. The simulation results agreed well with the experimental data in that concentration polarization of carriers caused by slow migration is the probable cause of low frequency dispersion of dielectric response for oil-paper insulation diagnosis. | ZHOU Lijun LI Xianlang WU Guangning | 2013 | 高电压技术2013，39，8： | 14 |
| 11 | PepperHub, an Informatics Hub for the Chili Pepper Research Community显示文摘 | Feng Liu Huiyang Vu Yingtian Deng Jingyuan Zheng Minglei Liu Lijun Ou Bozhi Yang Xiongze Dai Yanqing Ma Shengyu Feng Shuang He Xuefeng Li Zhuqing Zhang Wenchao Chen Shudong Zhou Rong Chen Minmin Liu Sha Yang Ruimin Wei Huadong Li Feng Li Bo Ouyang Xuexiao Zou | 2017 | Molecular Plant2017，10，8： | 13 |
| 12 | Experimental study on the bolt–cable combined supporting technology for the extraction roadways in weakly cemented strata显示文摘Aiming at the characteristics of the poor steady ability, the short stable time and severe deformation behavior of weakly cemented soft surrounding rock around extraction roadway, a bolt–cable combined supporting technology was proposed. Numerical simulation was performed by using FLAC3 D software to study the effects of different supporting systems. The simulation result proves that those supporting systems have good practical values. Based on real-time monitoring and analysis of the deformation of surrounding rock and the stress of supporting structure, real time information of deformation of surrounding rock and stress state of supporting structure of extraction roadway within weakly cemented strata was obtained. Monitoring results show that large deformation and failure of surrounding rock of extraction roadway within weakly cemented strata can be effectively controlled by the bolt–cable combined supporting technology, which ensures the long-term stability and safety of surrounding rock and supporting structure. | Meng Qingbin Han Lijun Sun Jingwu Min Fengqing Feng Wei Zhou Xing | 2015 | International Journal of Mining Science and Technology2015，25，1： | 13 |
| 13 | First mass measurement of short-lived nuclides at HIRFL-CSR显示文摘Recent commissioning of the HIRFL-CSR has demonstrated its ability to perform direct mass measurement for short-lived nuclides. Projectile fragments produced by the 78Kr ions at 481.88 MeV/u were separated with the new radioactive beam line in Lanzhou (RIBLL2), and injected into and stored in the experimental storage ring (CSRe). By operating the CSRe as an isochronous mass spectrometry, a typical mass resolution around 2.0×10?5 has been achieved. The masses for 63Ge, 65As and 67Se were measured for the first time. The measured masses are compared with theoretical predictions and the location of the proton drip-line for As isotopes is discussed. The implication of the 65As mass in the astrophysical rapid proton capture process has also been addressed. | XU HuShan TU XiaoLin YUAN YouJin XIA JiaWen ZANG YongDong WANG Meng MAO RuiShi HU ZhengGuo MEI Bo SHUAI Peng ZHU ZhiChao TANG ShuWen GENG Peng LIU Yong ZHAO TieCheng ZHANG XueYing YANG JianCheng MAO LiJun ZHANG YuHu ZHOU XiaoHong HUANG WenXue XIAO GuoQing ZHAO HongWei ZHAN WenLong | 2009 | Chinese Science Bulletin2009，54，24： | 11 |
| 14 | The spectrum for large sets of pure directed triple systems显示文摘An LPDTS(υ) is a collection of 3(υ - 2) disjoint pure directed triple systems on the same set of υ elements. It is showed in Tian's doctoral thesis that there exists an LPDTS(υ) for υ≡ 0,4 (mod 6), υ≥ 4. In this paper, we establish the existence of an LPDTS(υ) for υ≡ 1, 3 (mod 6), υ> 3. Thus the spectrum for LPDTS(υ) is completely determined to be the set {υ:υ≡0, 1 (mod 3),υ≥4}. | ZHOU Junling, CHANG Yanxun & Jl Lijun Institute of Mathematics, Beijing Jiaotong University, Beijing 100044, China Department of Mathematics, Suzhou University, Suzhou 215006, China | 2006 | Science China Mathematics2006，49，8： | 9 |
| 15 | Grhl3 induces human epithelial tumor cell migration and invasion via downregulation of E-cadherin显示文摘Grainyhead 基因涉及愈合弯屈和发展神经试管闭合。转移在细胞从主要肿瘤的地点传播哪个癌症并且在远器官建立第二等的肿瘤期间是一个 multistep 过程。粘附蛋白质 E-cadherin 在转移起一个必要作用。考虑到在在皮或乳癌发生在侵略的获得期间的愈合创伤的过程和 EMT 发生的 epithelialmesenchymal 转变(EMT ) 的类似的高度,我们在癌症侵略调查了 Grainyhead 基因的角色。这里,我们证明在象 Grainyhead 一样之间有一种反的关系 3 (Grhl3 ) 并且在某上皮的肿瘤房间的 E-cadherin 表示排队。在 E-cadherin-positive 上皮的肿瘤房间线的 Grhl3 的 Overexpression,由更少的侵略描绘了,产生了 E-cadherin 基因的 transcriptional 阻塞并且支持了房间移植和房间侵略。相反地, Grhl3 弄空禁止了房间移植和房间侵略并且与 E-cadherin 表示的获得被联系。为了推进,探索 Grhl3 由调整了 E-cadherin 表示的机制, E-cadherin 倡导者报告分析被表现,结果出现了那 Grhl3 镇压 E-cadherin 基因表示由对在近似 E-cadherin 倡导者在场的电子盒子直接或间接地有约束力。一起拿,我们的调查结果在癌症房间由 E-cadherin 的 downregulation 在移植和侵略的正式就职为 Grhl3 定义一个主要角色。 | Pan Zhao Sijia Guo Zhenzhen Tu Lijun Di Xiaoiun Zha Haisheng Zhou Xuejun Zhang | 2016 | Acta Biochimica et Biophysica Sinica2016，0，3： | 9 |
| 16 | Identification of microRNA transcriptome reveals that miR-100 is involved in the renewal of porcine intestinal epithelial cells显示文摘MicroRNAs play important roles in various cellular processes, including differentiation, proliferation and survival. Using a pig model, this study sought to identify the miRNAs responsible for crypt-villus axis renewal of the small intestinal epithelium.Compared to the villus upper cells, there were 15 up-regulated and 41 down-regulated miRNAs in the crypt cells of the jejunum.Notably, we found that miR-100 was expressed more in the villus upper cells than in the crypt cells, suggesting an effect on intestinal epithelium differentiation. Overexpression of miR-100 increased the activity of alkaline phosphatase, confirming that miR-100 promoted IPEC-J2 cell differentiation. MiR-100 can inhibit cell proliferation as evidenced by CCK-8 and cell cycle assay results. We also showed that miR-100 significantly inhibited the migration of IPEC-J2 cells and promoted cell apoptosis through caspase-3-dependent cleavage of Bcl-2. Furthermore, FGFR3 was identified as a potential target of miR-100 by bioinformatics analysis. We confirmed that overexpression of miR-100 suppressed FGFR3 expression in IPEC-J2 cells by directly targeting the FGFR3 3′-UTR. This is the first report of miRNAs acting on the renewal of the intestinal crypt-villus axis.Our results also showed that miR-100 promotes the differentiation and apoptosis, and inhibits the proliferation and migration of enterocytes of pigs. | Lijun Zou Xia Xiong Huansheng Yang Kexing Wang Jian Zhou Dinghong Lv Yulong Yin | 2019 | Science China(Life Sciences)2019，62，6： | 9 |
| 17 | Reproducing past subduction and mantle flow using high-resolution global convection models显示文摘Plate subduction drives both the internal convection and the surface geology of the solid Earth.Despite the rapid increase of computational power,it remains challenging for geodynamic models to reproduce the history of Earth-like subduction and associated mantle flow.Here,based on an adaptive approach of sequential data assimilation,we present a high-resolution global model since the mid-Mesozoic.This model incorporates the thermal structure and surface kinematics of tectonic plates based on a recent plate reconstruction to reproduce the observed subduction configuration and Earth-like convection.Introduction of temperature-and composition-dependent rheology allows for incorporation of many natural complexities,such as initiation of subduction zones,reversal of subduction polarity,and detailed plate-boundary dynamics.The resultant present-day slab geometry well matches Benioff zones and seismic tomography at depths < 1500 km,making it possible to hindcast past subduction dynamics and mantle flow.For example,the model produces a flat Farallon slab beneath North America during the Late Cretaceous to Early Cenozoic,a feature that has been geodynamically challenging to reproduce.This high-resolution model can also capture details of the 4-D evolution of slabs and the ambient mantle,such as temporally and spatially varying mantle flow associated with evolving slab geometry and buoyancy flux,as well as the formation of shallow slab tears due to subduction of young seafloors and the resulting complex mantle deformation.Such a geodynamic framework serves to further constrain uncertain plate reconstruction in the geological past,and to better understand the origin of enigmatic mantle seismic features. | JiaShun Hu LiJun Liu Quan Zhou | 2018 | Earth and Planetary Physics2018，2，3： | 9 |
| 18 | Sintilimab versus docetaxel as second-line treatment in advanced or metastatic squamous non-small-cell lung cancer:an open-label,randomized controlled phase 3 trial(ORIENT-3)显示文摘Background:Treatment options for Chinese patients with locally advanced or metastatic squamous-cell non-small-cell lung cancer(sqNSCLC)after failure of first-line chemotherapy are limited.This study(ORIENT-3)aimed to evaluate the efficacy and safety of sintilimab versus docetaxel as second-line treatment in patients with locally advanced or metastatic sqNSCLC.Methods:ORIENT-3 was an open-label,multicenter,randomized controlled phase 3 trial that recruited patients with stage IIIB/IIIC/IV sqNSCLC after failure with first-line platinum-based chemotherapy.Patients were randomized in a 1:1 ratio to receive either 200 mg of sintilimab or 75 mg/m^(2) of docetaxel intravenously every 3 weeks,stratified by the Eastern Cooperative Oncology Group performance status.The primary endpoint was overall survival(OS)in the full analysis set(FAS).Secondary endpoints included progression-free survival(PFS),objective response rate(ORR),disease control rate(DCR),duration of response(DoR)and safety.Results:Between August 25,2017,and November 7,2018,290 patients were randomized.For FAS,10 patients fromthe docetaxel armwere excluded.Themedian OS was 11.79(n=145;95%confidence interval[CI],10.28-15.57)months with sintilimab versus 8.25(n=135;95%CI,6.47-9.82)months with docetaxel(hazard ratio[HR]:0.74;95%CI,0.56-0.96;P=0.025).Sintilimab treatment significantly prolonged PFS(median 4.30 vs.2.79 months;HR:0.52;95%CI,0.39-0.68;P<0.001)and showed higher ORR(25.50%vs.2.20%,P<0.001)and DCR(65.50%vs.37.80%,P<0.001)than the docetaxel arm.The median DoRwas 12.45(95%CI,4.86-25.33)months in the sintilimab arm and 4.14(95%CI,1.41-7.23)months in the docetaxel arm(P=0.045).Treatment-related adverse events of grade≥3were reported in 26(18.1%)patients in the sintilimab arm and 47(36.2%)patients in the docetaxel arm.Exploratory biomarker analysis showed potential predictive values of expression levels of two transcription factors,including OVOL2(HR:0.35;P<0.001)and CTCF(HR:3.50;P<0.001),for sintilimab treatment.Conclusions:Compared with docetaxel,sintilimab significantly improved the OS,PFS,and ORR of Chinese patients with previously treated locally advanced or metastatic sqNSCLC. | Yuankai Shi Lin Wu Xinmin Yu Puyuan Xing Yan Wang Jianying Zhou Airong Wang Jianhua Shi Yi Hu Ziping Wang Guangyu An Yong Fang Sanyuan Sun Caicun Zhou Changli Wang Feng Ye Xingya Li Junye Wang Mengzhao Wang Yunpeng Liu Yanqiu Zhao Ying Yuan Jifeng Feng Zhendong Chen Jindong Shi Tao Sun Gang Wu Yongqian Shu Qisen Guo Yi Zhang Yong Song Shucai Zhang Yuan Chen Wei Li Hongrui Niu Wenwei Hu Lijun Wang Jianan Huang Yang Zhang Ying Cheng Zhengdong Wu Bo Peng Jiya Sun Christoph Mancao Yanqi Wang Luyao Sun | 2022 | Cancer Communications2022，42，12： | 8 |
| 19 | Plasma membrane proteome analysis of the early effect of alcohol on liver: implications for alcoholic liver disease显示文摘在人,酒精的在消费上能导致严肃的肝疾病。在肝疾病上检验酒精的早效果,老鼠被给足够的乙醇开发肝肝硬化。在纤维变性的发作前的老鼠在这个工作被学习。肝的血浆膜(下午) 被提取由两次蔗糖密度坡度 centrifugation。从对待乙醇的老鼠和控制的下午的 proteome 侧面为相对、绝对的 quantitation (iTRAQ ) 用二维的胶化电气泳动(2-DE ) 和等压的标签被分析技术。乙醇处理改变了 15 不同的肝蛋白质的数量:他们中的 10 个被 2-DE 检测并且 5 由 iTRAQ。角质素 8 被两个方法检测。这些差别的基因本体论分析检测了显示的蛋白质他们的那个大多数涉及象有约束力的活动那样的重要房间函数(包括离子, DNA, ATP 绑定,等等) ,房间结构,或酶活动。在这些之中, annexin A2,角质素 8,和角质素 18 进一步用西方的污点分析被验证, annexin A2 被 immunohistochemistry 验证。我们的结果建议酒精有潜力由在 PM 改变几相关蛋白质的表示层次影响房间结构,粘附和酶活动。就我们的知识而言,这是第一次在肝下午 proteome 上学习酒精的效果,它可能对理解导致白酒的肝疾病的可能的机制有用。 | Lijun Zhang Xiaofang Jia Yanling Feng Xia Peng Zhiyong Zhang Wenjiang Zhou Zhanqing Zhang Fang Ma Xiaohui Liu Ye Zheng Pengyuan Yang Zhenghong Yuan | 2011 | Acta Biochimica et Biophysica Sinica2011，43，1： | 8 |
| 20 | Simulation Researches on Influence of Different Axial Magnetic Fields on Anode Activity in High-current Vacuum Arcs显示文摘纵向磁场对阳极活动的控制效果对于大电流真空电弧成功开断十分关键。采用建模仿真的方法,分析不同纵向磁场强度对阳极活动的影响。基于大电流真空电弧模型,仿真得到不同纵向磁场强度下输入阳极的能流密度分布,并以此作为阳极活动模型的边界条件,得到不同磁场强度下的阳极熔化、蒸发情况。仿真结果表明:对于工频电流(50Hz)电弧,阳极温度的最大值出现7ms时刻附近;随着纵向磁场的增大,阳极表面温度、饱和蒸汽压、阳极蒸汽流量都相应减小;随着纵向磁场的增大,熔化半径增大,但是熔化深度减小,改善了阳极的烧蚀情况。 | WANG Lijun JIA Shenli CHEN Bin ZHOU Xin YANG Dingge SHI Zongqian | 2012 | 中国电机工程学报2012，32，13： | 8 |
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