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| 1 | MiR-122 in hepatic function and liver diseases显示文摘As the most abundant liver-specific microRNA,mi-croRNA-122(miR-122)is involved in various physio-logical processes in hepatic function as well as in liver pathology.There is now compelling evidence that miR-122,as a regulator of gene networks and pathways in hepatocytes,plays a central role in diverse aspects of hepatic function and in the progress of liver diseases.This liver-enriched transcription factors-regulated miRNA promotes differentiation of hepatocytes and regulates lipid metabolism.With regard to liver diseases,miR-122 was shown to stimulate hepatitis C virus(HCV)replication through a unique and unusual interaction with two binding sites in the 5′-UTR of HCV genome to mediate the stability of the viral RNA,whereas inhibit the expression and replication of hepatitis B virus(HBV)by a miR-122-cylin G1/p53-HBV enhancer regulatory pathway.In addition,miR-122 acts as a suppressor of cell prolif-eration and malignant transformation of hepatocytes with remarkable tumor inhibition activity.Notably,a clinical trial targeting miR-122 with the anti-miR-122 oli-gonucleotides miravirsen,the first miRNA targeted drug,has been initiated for treatment of HCV infection.With further understanding of the comprehensive roles of miR-122 in hepatic functions and the mechanisms in-volved in miR-122 down-regulation in chronic hepatitis or hepatocellular carcinoma,miR-122 appears to be a promising candidate for effective therapeutic ap-proaches against tumor and infectious diseases. | Jun Hu Yaxing Xu Junli Hao Saifeng Wang Changfei Li Songdong Meng | 2012 | Protein & Cell2012，3，5： | 22 |
| 2 | Characteristics and Source Identification of Polycyclic Aromatic Hydrocarbons (PAHs) in Urban Soils: A Review显示文摘Polycyclic aromatic hydrocarbons(PAHs) are mainly produced by combustion processes and consist of a number of toxic compounds.They are always emitted as a mixture and have become a major type of pollutants in urban areas.The degree of soil contamination by PAHs is of special concern in areas immediately in proximity to cities with heavy traffic,factories,older buildings,and infrastructure.The accumulation of soil PAHs is also affected by non-anthropogenic factors,such as climate,vegetation,and soil property.This paper reviews three typical source identification techniques,including diagnostic ratios,positive matrix factorization,and principle components analysis.The advantages or disadvantages of these techniques are analyzed.It is recommended that multiple identification techniques be used to determine the sources in order to minimize the weaknesses inherent in each method and thereby to strengthen the conclusions for PAH source identification. | WANG Chunhui WU Shaohua ZHOU Shenglu SHI Yaxing SONG Jing | 2017 | Pedosphere2017，27，1： | 18 |
| 3 | Spatial and temporal variations of vegetation in Qinghai Province based on satellite data显示文摘这篇论文使用了五年(2001 ¨ C 2006 ) 有 1-km 的 MODIS NDVI 图象的时间系列在中国生产 Qinghai 省的一张陆地盖子地图的空间分辨率。为有植被上的特殊强调的不同陆地盖子类型的一条分类途径, | WANG Liwen WEI Yaxing NIU Zheng | 2008 | Journal of Geographical Sciences2008，18，1： | 9 |
| 4 | Gα_s signaling controls intramembranous ossification during cranial bone development by regulating both Hedgehog and Wnt/β-catenin signaling显示文摘How osteoblast cells are induced is a central question for understanding skeletal formation. Abnormal osteoblast differentiation leads to a broad range of devastating craniofacial diseases. Here we have investigated intramembranous ossification during cranial bone development in mouse models of skeletal genetic diseases that exhibit craniofacial bone defects. The GNAS gene encodes Gαs that transduces GPCR signaling. GNAS activation or loss-of-function mutations in humans cause fibrous dysplasia(FD) or progressive osseous heteroplasia(POH) that shows craniofacial hyperostosis or craniosynostosis, respectively. We find here that, while Hh ligand-dependent Hh signaling is essential for endochondral ossification, it is dispensable for intramembranous ossification, where Gαsregulates Hh signaling in a ligand-independent manner. We further show that Gαscontrols intramembranous ossification by regulating both Hh and Wnt/β-catenin signaling. In addition, Gαsactivation in the developing cranial bone leads to reduced ossification but increased cartilage presence due to reduced cartilage dissolution, not cell fate switch. Small molecule inhibitors of Hh and Wnt signaling can effectively ameliorate cranial bone phenotypes in mice caused by loss or gain of Gnas function mutations, respectively. Our work shows that studies of genetic diseases provide invaluable insights in both pathological bone defects and normal bone development, understanding both leads to better diagnosis and therapeutic treatment of bone diseases. | Ruoshi Xu Sanjoy Kumar Khan Taifeng Zhou Bo Gao Yaxing Zhou Xuedong Zhou Yingzi Yang | 2018 | Bone Research2018，6，4： | 7 |
| 5 | Clinical curative effect analysis and predictors of prognosis in patients with temporal lobe epilepsy after anterior temporal lobectomy: results after five years显示文摘 | Sun Zhenxing Yuan Dan Sun Yaxing Zhang Jianguo Zuo Huancong Zhang Kai | 2014 | Chinese Medical Journal2014，，14： | 6 |
| 6 | Spatial scaling of net primary productivity model based on remote sensing显示文摘Spatial scaling for net primary productivity (NPP) refers to the transferring process of establishing quantitative correlation between simulated NPP derived from data at different spatial resolutions. How to transfer NPP at one scale by the algorithm with smaller error to at another is the urgent problem. Nonlinearity and effects from land cover type are two main problems in NPP scaling. In this paper, the contextural approach based on mixed pixels and support vector machine (SVM) algorithm are used to make the scaling model from the fine resolution (TM) to the coarse resolution (MODIS). Spatial scaling from NPP retrieved from fine resolution data to NPP derived from coarse resolution images is performed, and the correction of scale effect to NPP retrieved from coarse resolution data of MODIS is accomplished. The result shows that the correlation between Rj_coereted of the correction factor for scale effect and 1-Fmiddle dessity grassland estimated by SVM regression model is higher (R2=0.81). Before the correction for scale effect, the correlation between NPPMODIS and NPPTM is lower (R2=0.69; RMSE=3.47), while the correlation between NPPTM and corrected NPPMODIS_corrected is higher (R2=0.84; RMSE= 1.87). Therefore, NPP corrected for scale effect has been greatly improved in both correlation and error. | WANG Liwen WEI Yaxing NIU Zheng | 2010 | 遥感学报2010，14，6： | 5 |
| 7 | The histone methyltransferase EZH2 primes the early differentiation of follicular helper T cells during acute viral infection显示文摘Epigenetic modifications to histones dictate the differentiation of naïve CD4^(+) T cells into different subsets of effector T helper(TH)cells.The histone methyltransferase enhancer of zeste homolog 2(EZH2)has been implicated in the mechanism regulating the differentiation of TH1,TH2 and regulatory T(Treg)cells.However,whether and how EZH2 regulates follicular helper T(TFH)cell differentiation remain unknown.Using a mouse model of acute lymphocytic choriomeningitis virus(LCMV)infection,we observed abundant EZH2 expression and associated H3K27me3 modifications preferentially in the early committed virus-specific TFH cells compared to those in TH1 cells.Ablation of EZH2 in LCMV-specific CD4^(+) T cells leads to a selective impairment of early TFH cell fate commitment,but not late TFH differentiation or memory TFH maintenance.Mechanistically,EZH2 specifically stabilizes the chromatin accessibility of a cluster of genes that are important for TFH fate commitment,particularly B cell lymphoma 6(Bcl6),and thus directs TFH cell commitment.Therefore,we identified the chromatin-modifying enzyme EZH2 as a novel regulator of early TFH differentiation during acute viral infection. | Xiangyu Chen Guoshuai Cao Jialin Wu Xinxin Wang Zhiwei Pan Jianbao Gao Qin Tian Lifan Xu Zhirong Li Yaxing Hao Qizhao Huang Pengcheng Wang Minglu Xiao Luoyingzi Xie Shupei Tang Zhenyu Liu Li Hu Jianfang Tang Ran He Li Wang Xinyuan Zhou Yuzhang Wu Mengjie Chen Beicheng Sun Bo Zhu Jun Huang Lilin Ye | 2020 | Cellular & Molecular Immunology2020，17，3： | 4 |
| 8 | A critical survey of technologies of large offshore wind farm integration: summary, advances, and perspectives显示文摘Offshore wind farms(OWFs)have received widespread attention for their abundant unexploited wind energy poten-tial and convenient locations conditions.They are rapidly developing towards having large capacity and being located further away from shore.It is thus necessary to explore effective power transmission technologies to connect large OWFs to onshore grids.At present,three types of power transmission technologies have been proposed for large OWF integration.They are:high voltage alternating current(HVAC)transmission,high voltage direct current(HVDC)transmission,and low-frequency alternating current(LFAC)or fractional frequency alternating current transmission.This work undertakes a comprehensive review of grid connection technologies for large OWF integration.Compared with previous reviews,a more exhaustive summary is provided to elaborate HVAC,LFAC,and five HVDC topologies,consisting of line-commutated converter HVDC,voltage source converter HVDC,hybrid-HVDC,diode rectifier-based HVDC,and all DC transmission systems.The fault ride-through technologies of the grid connection schemes are also presented in detail to provide research references and guidelines for researchers.In addition,a comprehensive evalu-ation of the seven grid connection technologies for large OWFs is proposed based on eight specific indicators.Finally,eight conclusions and six perspectives are outlined for future research in integrating large OWFs. | Bo Yang Bingqiang Liu Hongyu Zhou Jingbo Wang Wei Yao Shaocong Wu Hongchun Shu Yaxing Ren | 2022 | Protection and Control of Modern Power Systems2022，7，1： | 4 |
| 9 | EXPERIMENTAL STUDY OF FRETTING WEAR OF TITANIUM ALLOY BEFORE AND AFTER LASER BEAM QUENCHING显示文摘EXPERIMENTALSTUDYOFFRETTINGWEAROFTITANIUMALLOYBEFOREANDAFTERLASERBEAMQUENCHINGDaiZhendong,TangYaxing,ZhangHong,WangMin(Depart... | Dai Zhendong, Tang Yaxing, Zhang Hong, Wang Min (Department of Mechanical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, 210016, China) Yang Shenrong, Zhang Xueshou (Laboratory of Solid Lubrication, Lanzhou Institu | 1997 | Chinese Journal of Aeronautics1997，10，3： | 4 |
| 10 | Constructing confidence intervals of extreme rainfall quantiles using Bayesian,bootstrap,and profile likelihood approaches显示文摘Hydrological risk is highly dependent on the occurrence of extreme rainfalls.This fact has led to a wide range of studies on the estimation and uncertainty analysis of the extremes.In most cases,confidence intervals(CIs)are constructed to represent the uncertainty of the estimates.Since the accuracy of CIs depends on the asymptotic normality of the data and is questionable with limited observations in practice,a Bayesian highest posterior density(HPD)interval,bootstrap percentile interval,and profile likelihood(PL)interval have been introduced to analyze the uncertainty that does not depend on the normality assumption.However,comparison studies to investigate their performances in terms of the accuracy and uncertainty of the estimates are scarce.In addition,the strengths,weakness,and conditions necessary for performing each method also must be investigated.Accordingly,in this study,test experiments with simulations from varying parent distributions and different sample sizes were conducted.Then,applications to the annual maximum rainfall(AMR)time series data in South Korea were performed.Five districts with 38-year(1973–2010)AMR observations were fitted by the three aforementioned methods in the application.From both the experimental and application results,the Bayesian method is found to provide the lowest uncertainty of the design level while the PL estimates generally have the highest accuracy but also the largest uncertainty.The bootstrap estimates are usually inferior to the other two methods,but can perform adequately when the distribution model is not heavy-tailed and the sample size is large.The distribution tail behavior and the sample size are clearly found to affect the estimation accuracy and uncertainty.This study presents a comparative result,which can help researchers make decisions in the context of assessing extreme rainfall uncertainties. | CHEN Si LI YaXing SHIN JiYae KIM TaeWoong | 2016 | Science China(Technological Sciences)2016，59，4： | 4 |
| 11 | A Nonlinear Interval Portfolio Selection Model and Its Application in Banks显示文摘在古典 Markowitzs 吝啬变化的模型,象内在的财产未来回来的平均数和协变性那样的参数被假定确切被知道。然而,这不总是是盒子。参数经常对应于在一个范围以内的秋天,或罐头在投资决定必须被做的时间暧昧地被知道的数量。处于如此的状况,投资者在投资和风险等等上决定回来并且基于经验和经济智慧做公事包决定。这份报纸试着在模糊集合理论使用间隔数字的概念与一个银行的流畅要求的考虑把古典吝啬变化的公事包选择模型递一个吝啬缺点的半变化模型。半变化限制被采用控制缺点风险,填基于描绘缺点风险的线性半绝对的偏差的存在间隔公事包优化模型。模拟结果证明模型与回来的最高或最低的吝啬的历史的率为危险财产要用体力地表现,最佳的投资比例有好稳定性。这建议为这些种财产,模型能减少偏差根据决定制造者经验和经济智慧引起的高偏差的风险。 | YAN Dawen HU Yaxing LAI Kin Keung | 2018 | Journal of Systems Science & Complexity2018，31，3： | 3 |
| 12 | Progress on major genes for high fecundity in ewes显示文摘The existence of major genes affecting fecundity in sheep flocks throughout the world has been demonstrated.Three major genes whose mutations can increase ovulation rate have been discovered,and all related to the transforming growth factorβ(TGF-β)superfamily.The mutant FecB of bone morphogenetic protein receptor 1B(BMPR1B)has an additive effect on ovulation rate.Six mutations(Fec^(XI),Fec^(XH),Fec^(XG),Fec^(XB),Fec^(XL),Fec^(XR))of bone morphogenetic protein 15(BMP15)related with fertility have been identified that share the same mechanism.All the mutants can increase ovulation rate in heterozygotes and cause complete sterility in homozygotes.Homozygous ewes with two new mutations(FecX^(Gr),FecX^(O))of BMP15 had increased ovulation rate without causing sterility.There are five mutations in growth differentiation factor 9(GDF9)associated with sheep prolificacy where FecG^(E) and FecG^(F) have additive an effect on ovulation rate and litter size.The newly identifiedβ-1,4-N-acetylgalactosaminyltransferase 2(B4GALNT2)gene of FecL is proposed as a new mechanism of ovulation rate regulation in sheep.Woodlands is an X-linked maternally imprinted gene which increases ovulation rate.In addition,several putative major genes need to be verified.This review is focused on the identification of the mutations and mechanisms whereby the major genes affecting ovulation rate. | Qiuyue LIU Zhangyuan PAN Xiangyu WANG Wenping HU Ran DI Yaxing YAO Mingxing CHU | 2014 | Frontiers of Agricultural Science and Engineering2014，1，4： | 3 |
| 13 | Application of intraoperative O-arm-assisted real-time navigation technique for spinal fixation显示文摘This study explored the combined use of the O-arm and real-time navigation during spinal fixation. The clinical data for 60 patients undergoing spinal fixation, at Beijing Tsinghua Chang Gung Hospital between May 5, 2015 and May 1, 2017, were retrospectively analyzed. Pre-, intra-, and postoperative imaging findings were assessed. The patients were classified into the occipitocervical fusion(32 cases) and thoracic/lumbar/sacral spine fixation(28 cases, including 6 cases of percutaneous pedicle screw) groups. Lesion resections were performed microscopically. An O-arm, combined with real-time navigation, was used to assess spinal fixation. Efficacy was evaluated using operative times, X-ray times, screw positioning, and complications. Within the occipitocervical fusion group, 182 screws were placed in the cervical spine and 96 in the occipital bone. However, 6 screws penetrated the bone cortex and were adjacent to the vertebral arteries, based on O-arm three-dimensional imaging; therefore, the precision rate was 96.7%. Within the thoracic/lumbar/sacral spine fixation group, 148 pedicle screws were implanted, with 4 initially outside the vertebral body,yielding a precision rate of 97.3%. Ten percutaneous pedicle screws were implanted and well positioned. O-arm scans were performed 3 times/patient, with an average of 20–30 min/time. Screw implantation times were 5–7 min(cervical spine), 8–10 min(thoracic spine), and 6–8 min(lumbar spine). Intraoperative O-arm scans, combined with real-time navigation technology, allow real-time observation of screw angles and depths, improving the accuracy and safety of posterior screw fixations and reducing the radiation dose and frequency experienced by patients and surgeons. | Zhenxing Sun Dan Yuan Yaxing Sun Zhanquan Zhang Guihuai Wang Yi Guo Guoqin Wang Dongkang Liu Peng Chen Linkai Jing Feng Yang Peihai Zhang Huifang Zhang Youtu Wu Wei Shi James Wang | 2017 | Translational Neuroscience and Clinics2017，3，3： | 2 |
| 14 | Ophthalmology: potential future developments in China and worldwide显示文摘 | Jost B. Jonas Songhomitra Panda-Jonas Wang Yaxing Wei Wenbin | 2014 | Chinese Medical Journal2014，，8： | 2 |
| 15 | Configurations and Control of Traction Motors for Electric Vehicles:A Review显示文摘In recent decades,worldwide global warming and reduction in petroleum resources have accelerated researcher’s attention to produce alternative sustainable and environmentally clean transportation systems.Electrification of vehicular technology is capable of curbing the environmental pollution problem in an efficient and effective way,due to high efficiency electric motors,development and advancement in the field of power electronic devices,digital signal processing and advanced control techniques.This article presents a comprehensive review on different configurations/architecture of electric vehicles(EVs)and hybrid electric vehicles(HEVs),traction motors for electric propulsion system and high performance speed sensorless control of traction drive.The basic architecture key components of hybrid vehicle and different power train configurations with respect to applications and limitations are discussed.The integral part of electric propulsion system,traction motor classes for desired operational characteristics and limitations are summarized from a system perspective with the latest improvements.High performance traction motor control techniques are discussed with respect to automotive applications.Finally,speed sensorless control techniques research trends as well as an extensive review on rotor speed estimation techniques for robust and efficient sensorless traction drive control are highlighted.This article provides state of the art key global trends and tradeoff of various technologies with future trends and potential areas of research. | Saqib Jamshed Rind Yaxing Ren Yihua Hu Jibing Wang Lin Jiang | 2017 | Chinese Journal of Electrical Engineering2017，3，3： | 2 |
| 16 | Efficient separation between trivalent americium and lanthanides enabled by a phenanthroline-based polymeric organic framework显示文摘Separation of the minor actinides(Am and Cm)from lanthanides in high-level liquid wastes(HLLW)is one of the most challenging chemical separation tasks known owing to their chemical similarities and is highly significant in nuclear fuel reprocessing plants because it could practically lead to sustainable nuclear energy by closing the nuclear fuel cycle.The solid phase extraction is proposed to be a possible strategy but all reported sorbent materials severely suffer from limited stability and/or efficiency caused by the harsh conditions of high acidity coupled with intense irradiation.Herein,a phenanthroline-based polymeric organic framework(PhenTAPB-POF)was designed and tested for the separation of trivalent americium from lanthanides for the first time.Due to its fully conjugated structure,PhenTAPB-POF exhibits previously unachieved stability under the combined extreme conditions of strong acids and high irradiation field.The americium partitioning experiment indicates that PhenTAPB-POF possesses an ultrahigh adsorption selectivity towards Am(Ⅲ)over lanthanides(e.g.,SFAm(Ⅲ)/Eu(Ⅲ)=3326)in highly acidic simulated HLLW and relatively fast adsorption kinetics in both static and dynamic experiments.Am(Ⅲ)can be almost quantitatively eluted from the PhenTAPB-POF packed-column using a concentrated nitric acid elution.The high stability and superior separation performance endow PhenTAPB-POF with the promising alternative for separating minor actinides over lanthanides from highly acidic HLLW streams. | Afshin Khayambashi Long Chen Xue Dong Kai Li Zhipeng Wang Linwei He Suresh Annam Lixi Chen Yaxing Wang Matthew V.Sheridan Chao Xu Shuao Wang | 2022 | Chinese Chemical Letters2022，33，7： | 1 |
| 17 | A Spectral-element Time-Domain Solution of MAXWELL's Equations显示文摘 | Yaxing Liu Joon-Ho Lee Tian Xiao etc | 2006 | Microwave and Optical Technology Letters2006，48，4： | 1 |
| 18 | The laser measurement for slight deformation of large-scale structure显示文摘 | YI YAXING LI ZHONGKE LI XINGSHE DENG FANGLIN | 2000 | Proceeding of SPIE2000，4221，： | 1 |
| 19 | Correction to:Efficient derivation of extended pluripotent stem cells from NOD-scid II2rg^-/-mice显示文摘Figure 1.Generation of NOD-scid II2rg^-1-extended pluripotent stem cells.(A)Schematic of two approaches used for generating NOD-scid II2rg^-1-extended pluripotent stem cells:de novo derivation from blastocysts(upper panels)and chemical reprogramming from embryonic fibroblasts(lower panels).(B)Phase-contrast images of de novo derived outgrowth and EPS colonies for 17 passages in LCDM medium.Scale bars,100 pm.(C)qRT-PCR analysis of XEN marker genes expression during the chemical induction process(day 16).Error bars indicate SEM(n=2).(D)Co-immunostaining of XEN marker genes during the chemical induction process(day 16).Upper panels:GATA6 and SALL4;lower panels:SOX17 and SALL4.Scale bars,100 pm. | Yaqin Du Ting Wang Jun Xu Chaoran Zhao Haibo Li Yao Fu Yaxing Xu Liangfu Xie Jingru Zhao Weifeng Yang Ming Yin Jinhua Wen Hongkui Deng | 2019 | Protein & Cell2019，10，2： | 1 |
| 20 | Use of grid computing for modeling virtual geospatial prod- ucts显示文摘 | Chen Aijun Di Liping Wei Yaxing Bai Yuqi and Liu Yang | 2009 | International Journal of Geographical Information Science2009，23，5： | 1 |
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