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| 1 | Effect of Korean red ginseng on blood pressure and nitric oxide production显示文摘AIM: To investigate the effect of crude saponin and non-saponin fraction of Korean red ginseng (KRG) on the blood pressure and nitric oxide (NO) production in the conscious rats and cultured endothelial cell line, ECV 304 cells. METHODS: Systolic blood pressure and heart rate were monitored in the conscious rats. Nitric oxide levels and the expression of nitric oxide synthase were measured by a spectrophotometric assay using Griess reagents and Western blotting, respectively. Nitric-oxide synthase activity was measured based on the conversion rate of [3H]arginine to [3H]citrulline. RESULTS: Systolic blood pressure was decreased by crude saponin (100 mg/kg, iv) of KRG in the conscious control and one-kidney, one-clip Goldblatt hypertensive (IK, 1C-GBH) rats. The hypotensive effect induced by crude saponin of KRG reached maximum at 2 - 4 min and slowly recovered after 20 min to the initial level in both groups. Crude saponin of KRG induced tachycardia in the conscious rats but induced bradycardia in the | JEON Byeong Hwa KIM Cuk Seong KIM Hoe-Suk PARK Jin-Bong NAM Ki Yeul CHANG Seok Jong | 2000 | Acta Pharmacologica Sinica2000，21，12： | 12 |
| 2 | Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): a phase 3 open-label, randomised controlled trial显示文摘 | Yung-Jue Bang Young-Woo Kim Han-Kwang Yang Hyun Cheol Chung Young-Kyu Park Kyung Hee Lee Keun-Wook Lee Yong Ho Kim Sang-Ik Noh Jae Yong Cho Young Jae Mok Yeul Hong Kim Jiafu Ji Ta-Sen Yeh Peter Button Florin Sirzén Sung Hoon Noh | 2012 | The Lancet2012，，9813： | 10 |
| 3 | Individual having a parent with early-onset gastric cancer may need screening at younger age显示文摘AIM: To evaluate whether individuals with gastric cancer(GC) are diagnosed earlier if they have firstdegree relatives with GC.METHODS: A total of 4282 patients diagnosed with GC at National Cancer Center Hospital from 2002 to 2012 were enrolled in this retrospective study. We classified the patients according to presence or absence of first-degree family history of GC and compared age at diagnosis and clinicopathologic characteristics. In addition, we further classified patients according to specific family member with GC(father, mother, sibling, or offspring) and compared age at GC diagnosis among these patient groups. Baseline characteristics were obtained from a prospectively collected database. Information about the family member's age at GC diagnosis was obtained by questionnaire.RESULTS: A total of 924 patients(21.6%) had a firstdegree family history of GC. The mean age at GC diagnosis in patients having paternal history of GC was 54.4 ± 10.4 years and was significantly younger than in those without a first-degree family history(58.1 ± 12.0 years, P < 0.001). However, this finding was not observed in patients who had an affected mother(57.2 ± 10.0 years) or sibling(62.2 ± 9.8 years). Among patients with family member having early-onset GC(< 50 years old), mean age at diagnosis was 47.7 ± 10.3 years for those with an affected father, 48.6 ± 10.4 years for those with an affected mother, and 57.4 ± 11.5 years for those with an affected sibling. Thus, patients with a parent diagnosed before 50 years of age developed GC 10.4 or 9.5 years earlier than individuals without a family history of GC(both P <0.001).CONCLUSION: Early-onset GC before age of 50 was associated with parental history of early-onset of GC. Individual having such family history need to start screening earlier. | Hee-Won Kwak Il Ju Choi Chan Gyoo Kim Jong Yeul Lee Soo-Jeong Cho Bang Wool Eom Hong Man Yoon Jungnam Joo Keun Won Ryu Young-Woo Kim | 2015 | World Journal of Gastroenterology2015，21，15： | 7 |
| 4 | Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): a phase 3 open-label, randomised controlled trial显示文摘 | Yung-Jue Bang Young-Woo Kim Han-Kwang Yang Hyun Cheol Chung Young-Kyu Park Kyung Hee Lee Keun-Wook Lee Yong Ho Kim Sang-Ik Noh Jae Yong Cho Young Jae Mok Yeul Hong Kim Jiafu Ji Ta-Sen Yeh Peter Button Florin Sirzén Sung Hoon Noh | 2012 | The Lancet . 2012 (9813)2012，，9813： | 7 |
| 5 | Current status and challenges in sentinel node navigation surgery for early gastric cancer显示文摘Although a number of feasibility studies for sentinel node(SN) concepts in gastric cancer have been conducted since 2000, there remains a debate regarding detailed detection techniques and oncological safety. Two important multicenter phase II clinical trials were performed in Japan that used different methods and reached different conclusions; one confirmed acceptable results with a false-negative rate of 7%, and the other showed an unacceptably high false-negative rate of 46.4%. The Sentinel Node Oriented Tailored Approach(SENORITA)trial is a multicenter randomized controlled phase III trial being performed in Korea. Patient enrollment is now complete and the long-term results are currently awaited. Recently, an image-guided SN mapping technique using infrared ray/fluorescence was introduced. This method might be a promising technology because it allows the clear visualization of SNs. With regard to the primary tumor, the non-exposed endoscopic wall-inversion surgery technique and non-exposure endolaparoscopic full-thickness resection with simple suturing technique have been reported. These methods prevent abdominal infection and tumor seeding and can be good alternatives to conventional laparoscopic gastric wedge resection. For indications, SN navigation surgery can be extended to patients who underwent non-curative endoscopic resection. Although a few studies have been performed on these patients, sentinel concepts may be beneficial to patients as they omit the need for additional gastrectomy. SN navigation surgery can lead to actual organ-preserving surgery and plays a key role in improving the quality of life of patients with early gastric cancer in the future. | Bang Wool Eom Young-II Kim Hong Man Yoon Soo-Jeong Cho Jong Yeul Lee Chan GyooKim Soo Jin Kim Ji Yoon Rho Seok Ki Kim Myeong-Cherl Kook Young-Woo Kim Keun Won | 2017 | Chinese Journal of Cancer Research2017，29，2： | 5 |
| 6 | CT评估隧道式多孔聚乙烯植入材料修复眼眶骨折眶容积的改变显示文摘目的探讨CT图像和计算机眼眶容积测算程序评估和预测隧道式多孔聚乙烯植入材料(MCI)修复大范围眼眶骨折后眼眶容积改变的临床意义。方法收集单眼大范围眼眶骨折行MCI植入术且手术前、后检查资料完整患者16例,利用计算机Volume程序根据CT图像回顾性定量分析手术前、后眼眶容积的改变,使用Hertel突眼计测量手术前、后的眼球突出度。患者受伤到接受手术的平均时间为(17.4±10.0)d,平均随访时间为9个月。结果手术后CT图像显示全部患者眼眶内前中段MCI位置良好。手术前伤眼眼眶容积[(28.16±4.32)cm^3]与对侧健眼[(23.94±3.47)cm^3]比较,差异有统计学意义(t=3.044,P〈0.01);手术后双眼眼眶容积比较,差异无统计学意义(t=0.069,P〉0.05)。手术前、后眼眶容积的改变量与手术前眼球内陷程度相关(r=0.715,P〈0.01),缓解眼球内陷2mm需手术整复眼眶容积2.86cm^3。结论利用计算机客观测量眼眶容积可对创伤后眼眶骨折的严重程度和可能出现的眼球内陷进行预测。在大范围眼眶骨折导致眼眶容积改变时,在适应证范围内利用MCI行手术治疗是重建眼眶的有效方法,CT图像和计算机眼眶容积测算程序可为手术提供重要数据。 | 叶娟 吴涵 高涛 吴仁毅 姚克 Sang Yeul Lee | 2007 | 中华眼科杂志2007，43，12： | 3 |
| 7 | 不同粒径级砂土渗透破坏特性试验研究显示文摘砂土渗透破坏的本质是水土相互作用的结果,由于土体内部单个颗粒的实际受力情况差异较大,影响土体管涌破坏的参数的研究甚少。利用自主改进组装的渗透破坏试验装置,进行了一系列砂土室内渗透破坏试验,采用误差及回归方程方法研究了颗粒级配、约束应力等对砂土渗透破坏特性的影响,得出了试样渗透破坏过程中涌砂量、渗流流速、水头差等的变化规律。试验结果表明:在应力为150 kPa,最大粒径为5 mm时,管涌破坏的流沙量达到最小值;基于试验数据,研究了砂土管涌破坏过程中管涌参数的变化规律以及管涌侵蚀机理,为管涌险情的预警预报进一步提供科学的理论依据。 | 穆林钧 钟加录 Lim Jeong Yeul 金光日 | 2018 | 人民珠江2018，39，7： | 3 |
| 8 | Endoscopic submucosal dissection for metachronous tumor in the remnant stomach after distal gastrectomy显示文摘 | Jong Yeul Lee Il Ju Choi Soo-Jeong Cho Chan Gyoo Kim Myeong-Cherl Kook Jun Ho Lee Keun Won Ryu Young-Woo Kim | 2010 | Surgical Endoscopy2010，，6： | 3 |
| 9 | Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): a phase 3 open-label, randomised controlled trial显示文摘 | Yung-Jue Bang Young-Woo Kim Han-Kwang Yang Hyun Cheol Chung Young-Kyu Park Kyung Hee Lee Keun-Wook Lee Yong Ho Kim Sang-Ik Noh Jae Yong Cho Young Jae Mok Yeul Hong Kim Jiafu Ji Ta-Sen Yeh Peter Button Florin Sirzén Sung Hoon Noh | 2012 | The Lancet2012，，9813： | 3 |
| 10 | Improvement of diabetes and hypertension after gastrectomy: A nationwide cohort study显示文摘AIM: To evaluate the effect of gastrectomy on diabetes mellitus(DM) and hypertension(HTN) in non-obese gastric cancer patients. METHODS: A total of 100000 patients, diagnosed with either type 2 DM or HTN, were randomly selected from the 2004 Korean National Health Insurance System claims. Among them, 360 diabetes and 351 hypertensive patients with gastric cancer who had been regularly treated without chemotherapy from January 2005 to December 2010 were selected. They were divided into three groups according to their treatment methods: total gastrectomy(TG), subtotal gastrectomy(STG) and endoscopic resection(ER). RESULTS: The drug discontinuation rate of antidiabetic and anti-hypertensive agents after gastric cancer treatment was 9.7% and 11.1% respectively. DM appeared to be improved more frequently(22.8%) and earlier(mean ± SE 28.6 ± 1.8 mo) in TG group than in the two other groups [improved in 9.5% of ER group(37.4 ± 1.1 mo) and 6.4% of STG group(47.0 ± 0.8 mo)]. The proportion of patients treated with multiple drugs decreased more notably in TG group compared to others(P = 0.001 in DM, and P = 0.035 in HTN). In TG group, adjusted hazard ratio for theimprovement of DM was 2.87(95%CI: 1.15-7.17) in a multi-variate analysis and better control of DM was observed with survival analysis(P < 0.001).CONCLUSION: TG was found to decrease the need for anti-diabetic medications which can be reflective of improved glycemic control, to a greater extent than either ER or STG in non-obese diabetic patients. | Eun Kyung Lee So Young Kim You Jin Lee Mi Hyang Kwak Hak Jin Kim Il Ju Choi Soo-Jeong Cho Young Woo Kim Jong Yeul Lee Chan Gyoo Kim Hong Man Yoon Bang Wool Eom Sun-Young Kong Min Kyong Yoo Jong Hyock Park Keun Won Ryu | 2015 | World Journal of Gastroenterology2015，21，4： | 3 |
| 11 | Addition of docetaxel to S-1 without platinum prolongs survival of patients with advanced gastric cancer: a randomized study (START)显示文摘 | Wasaburo Koizumi Yeul Hong Kim Masashi Fujii Hoon Kyo Kim Hiroshi Imamura Kyung Hee Lee Takuo Hara Hyun Cheol Chung Taroh Satoh Jae Yong Cho Hisashi Hosaka Akihito Tsuji Akinori Takagane Mikito Inokuchi Kazuaki Tanabe Tatsuya Okuno Mariko Ogura Kazuhiro Y | 2014 | Journal of Cancer Research and Clinical Oncology2014，，2： | 2 |
| 12 | Increased serum interleukin-17 in Graves’ ophthalmopathy显示文摘 | Sung Eun Kim Jin Sook Yoon Keun Ho Kim Sang Yeul Lee | 2012 | Graefe’s Archive for Clinical and Experimental Ophthalmology2012，，： | 2 |
| 13 | Surgical Indication for Non-curative Endoscopic Resection in Early Gastric Cancer显示文摘 | Keun Won Ryu MD Il Ju Choi MD Young Woo Doh MD Myeong-Cherl Kook MD Chan Gyoo Kim MD Hyun-Jung Park RN Jun Ho Lee MD Jong-Seok Lee MD Jong Yeul Lee MD Young Woo Kim MD Jae-Moon Bae MD | 2007 | Annals of Surgical Oncology2007，，12： | 2 |
| 14 | uPAR expression under hypoxic conditions depends on iNOS modulated ERK phosphorylation in the MDA-MB-231 breast carcinoma cell line显示文摘尿激 plasminogen 使活跃之物受体(uPAR ) 戏在癌症侵略和转移和 uPAR 表示的一个主要角色在各种各样的癌症类型与差的预后被相关。而且, uPAR 的表示在 hypoxic 条件下面被增加。氮的氧化物(没有) 并且它可诱导的氮的氧化物 synthase (i NOS ) 生产的代谢物是 hypoxic 应力的重要产品,并且可以不激活或调制细胞外的信号调整 kinase (英皇家空军之阶级最低之兵) 。这里,我们在 MDA-MB-231 人的乳癌房间线在 hypoxic 条件,和 i NOS 并且不的调节效果下面在 A, uPAR,和激活的英皇家空军之阶级最低之兵层次上面评估了。房间在 hypoxic 或 normoxic 孵卵器被孵化并且与 PD98059 对待(一个 MEK 1/2 禁止者,它废除英皇家空军之阶级最低之兵 phosphorylation ) 并且 aminoguanidine (选择 i NOS 禁止者) 。uPAR 表示,英皇家空军之阶级最低之兵 phosphorylation,并且在 A 上面,活动被发现在 hypoxic 条件下面被增加。而且当房间在 hypoxic 条件下面与 PD98059 被对待时, uPAR 低调整,而 aminoguanidine 显著地以一种剂量依赖者方式增加了英皇家空军之阶级最低之兵 phosphorylation。而且, aminoguanidine 增加了 uPAR 表示并且由 PD98059 阻止了 uPAR 表示的抑制。这些结果证明 uPAR 被组织缺氧导致,那增加的 uPAR 表情被英皇家空军之阶级最低之兵 phosphorylation 调停,它被 iNOS/NO 接着在 MDA-MB-231 房间调制。我们结束那 iNOS/NO 在下面经由英皇家空军之阶级最低之兵小径调整在 hypoxic 条件下面调整 uPAR 的表示。 | So Young Yoon Yoo Jung Lee Jae Hong Seo Hwa Jung Sung Kyong Hwa Park In Keun Choi Seok Jin Kim Sang Cheul Oh Chul Won Choi Byung Soo Kim Sang Won Shin Yeul Hong Kim Jun Suk Kim | 2006 | Cell Research2006，16，1： | 2 |
| 15 | Covered versus uncovered self-expandable metallic stents for palliation of malignant pyloric obstruction in gastric cancer patients: a randomized, prospective study显示文摘 | Chan Gyoo Kim Il Ju Choi Jong Yeul Lee Soo-Jeong Cho Sook Ryun Park Jun Ho Lee Keun Won Ryu Young-Woo Kim Young Iee Park | 2010 | Gastrointestinal Endoscopy2010，，1： | 2 |
| 16 | Paclitaxel, 5-fluorouracil, andcisplatin combination chemotherapy for the treatment Of advancedgas-triccarcinoma 显示文摘 | Yeul HK Sang WS Byung SK | 1999 | Cancer1999，85，2： | 1 |
| 17 | Sentinel Node Mapping and Skip Metastases in Patients with Early Gastric Cancer显示文摘 | Sang Eok Lee MD Jun Ho Lee MD Keun Won Ryu MD Soo Jeong Cho MD Jong Yeul Lee MD Chan Gyoo Kim MD Il Ju Choi MD Myung Cherl Kook MD Byung-Ho Nam PhD Sook Ryun Park MD Jong Seok Lee MD Young-Woo Kim MD | 2009 | Annals of Surgical Oncology2009，，3： | 1 |
| 18 | Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): a phase 3 open-label, randomised controlled trial显示文摘 | Yung-Jue Bang Young-Woo Kim Han-Kwang Yang Hyun Cheol Chung Young-Kyu Park Kyung Hee Lee Keun-Wook Lee Yong Ho Kim Sang-Ik Noh Jae Yong Cho Young Jae Mok Yeul Hong Kim Jiafu Ji Ta-Sen Yeh Peter Button Florin Sirzén Sung Hoon Noh | 2012 | 2012 (9813)2012，，9813： | 1 |
| 19 | Endoscopic submucosal dissection for metachronous tumor in the remnant stomach after distal gastrectomy显示文摘 | Jong Yeul Lee Il Ju Choi Soo-Jeong Cho Chan Gyoo Kim Myeong-Cherl Kook Jun Ho Lee Keun Won Ryu Young-Woo Kim | 2010 | Surgical Endoscopy2010，，6： | 1 |
| 20 | RASSF1A suppresses the C-Jun-NH2-Kinase pathway and inhibits cell cycle progression显示文摘 | Young Mi Whang Yeul Hong Kim Jun suk kim | 2005 | Cancer Res2005，65，9： | 1 |
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