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| 1 | MiR-320a downregulation is associated with imatinib resistance in gastrointestinal stromal tumors显示文摘胃肠的 stromal 肿瘤(大意) 是胃肠的道的最普通的间充质的肿瘤之一。尽管 imatinib 改进结果,药抵抗为扩大耐心的幸存仍然是主要问题。药目标的基因变化是为 imatinib 抵抗的已知的机制。然而,它不能 imatinib 抵抗的现象解释所有,并且众多的另外的机制被建议了在各种各样的模型系统说明 imatinib 抵抗。在这研究,我们使用了屏蔽差别的基于反应的数组途径表示了的 SYBR 绿的量的聚合酶链在主要大意病人和 imatinib 抵抗的病人之间的 miRNAs。选择候选人 miRNAs 在 12 个大意病人的一个队被验证。我们发现 miR-320a 的那低表情与 imatinib 抵抗的短时间被相关,并且为 imatinib 抵抗建议了 miR-320a 的潜在的机制。 | Xiaodong Gao Kuntang Shen Cuizhong Wang Jiaqian Ling Hongshan Wang Yong Fang Yuan Shi Yingyong Hou Jin Qin Yihong Sun Xinyu Qin | 2014 | Acta Biochimica et Biophysica Sinica2014，46，1： | 9 |
| 2 | Expanded endoscopic therapy criteria should be cautiously used in intramucosal gastric cancer显示文摘Objective: Accurate estimation of lymph node metastasis(LNM) in intramucosal gastric cancer is essential to select less invasive treatment options and even avoid surgery. The aim of this study was to evaluate combined clinicopathological features to predict the presence of LNM.Methods: A retrospective review of data from 386 intramucosal gastric cancer patients who underwent gastrectomy with extended lymphadenectomy from 2003 to 2010 was conducted. The mutual relation between clinicopathological characteristics and LNM was analyzed.Results: LNM was detected in 40(10.4%) of the 386 patients. Histological type and vascular or lymphatic invasion presence showed a positive correlation with LNM occurrence by univariate analysis. Multivariate analysis revealed that histological type was the only factor associated with LNM. Combined clinicopathologic characteristics would be more predictable for LNM. We found no LNM when we used combined clinicopathological characteristics conforming to Japanese absolute indications for endoscopic therapy. The LNM rate was as high as 8.7% when Japanese expanded criteria were used. Univariate analysis in cancer conformity to expand endoscopic submucosal dissection(ESD) indication also revealed that the undifferential type was the only significant factor for LNM.Conclusions: It was possible to predict intramucosal gastric cancer cases without LNM using combined clinicopathological characteristic analysis. Extended indication for ESD should be cautiously used for intramucosal gastric cancer patients. | Hongshan Wang Heng Zhang Cong Wang Yong Fang Xuefei Wang Weidong Chen Fenglin Liu Kuntang Shen Xinyu Qin Zhenbin Shen Yihong Sun | 2016 | Chinese Journal of Cancer Research2016，28，3： | 8 |
| 3 | Distribution of IgG galactosylation as a promising biomarker for cancer screening in multiple cancer types显示文摘 | Shifang Ren Zejian Zhang Congjian Xu Lin Guo Renquan Lu Yihong Sun Jianming Guo Ruihuan Qin Wenjun Qin Jianxin Gu | 2016 | Cell Research2016，26，8： | 8 |
| 4 | Phylogeny and evolutionary history of the silkworm显示文摘The silkworm,Bombyx mori,played an important role in the old Silk Road that connected ancient Asia and Europe.However,to date,there have been few studies of the origins and domestication of this species using molecular methods.In this study,DNA sequences of mitochondrial and nuclear loci were used to infer the phylogeny and evolutionary history of the domesticated silkworm and its relatives.All of the phylogenetic analyses indicated a close relationship between the domesticated silkworm and the Chinese wild silkworm.Domestication was estimated to have occurred about 4100 years ago(ya),and the radiation of the different geographic strains of B.mori about 2000 ya.The Chinese wild silkworm and the Japanese wild silkworm split about 23600 ya.These estimates are in good agreement with the fossil evidence and historical records.In addition,we show that the domesticated silkworm experienced a population expansion around 1000 ya.The divergence times and the population dynamics of silkworms presented in this study will be useful for studies of lepidopteran phylogenetics,in the genetic analysis of domestic animals,and for understanding the spread of human civilizations. | SUN Wei YU HongSong SHEN YiHong BANNO Yutaka XIANG ZhongHuai ZHANG Ze | 2012 | Science China(Life Sciences)2012，55，6： | 6 |
| 5 | A Lunar-based Soft X-ray Imager(LSXI)for the Earth's magnetosphere显示文摘We propose to use the Moon as a platform to obtain a global view of Earth's magnetosphere by a Lunar-based Soft X-ray Imager(LSXI).LSXI is a wide field-of-view Soft X-ray telescope,which can obtain X-ray images of Earth's magnetosphere based on the solar wind charge exchange(SWCX)X-ray emission.Global perspective is crucial to understand the overall interaction of the solar wind with magnetosphere.LSXI is capable of continuously monitoring the evolution of geospace conditions under the impact of the solar wind by simultaneous observation of the bow shock,magnetosheath,magnetopause and cusps for the first time.This proposal is answering the call for the Chinese Lunar Exploration Program Phase IV. | Yihong GUO Chi WANG Fei WEI Tianran SUN Xizheng YU Songwu PENG Graziella BRANDUARDI-RAYMONT Steven SEMBAY | 2021 | Science China Earth Sciences2021，64，7： | 5 |
| 6 | Incorporation of NLR into NIH stratificationsystem increases predictive accuracy for surgically resected gastrointestinal stromal tumors显示文摘以前的研究报导了那外科手术前的 neutrophil-to-lymphocyte (NLR ) , platelet-to-lymphocyte 比率为癌症的各种各样的类型是预示的。这研究的目的是与胃肠的 stromal 肿瘤(大意) 在病人调查外科手术前的外部血计数的预兆的实用程序。我们注册了为主要、局部性的大意经历了外科的 510 个连续、以前未经治疗的病人。在没有复发的幸存和结果变量之间的关系被 univariate 和 multivariate 分析估计,当 NLR 的 clinicopathologic 关联用 Chi 平方测试是坚定的时。外科手术前的 NLR 2 在为主要、局部性的大意经历手术的病人与差的预后被联系。它在是分类的病人仅仅是一个独立预言者 ? 健康高风险然而并非在全部人口的国家研究所。外科手术前的 NLR 是帮助为集中的辅助治疗和经常的监视识别病人的可行、可再现的外部 biomarker。 | Anwei Xue Xiaodong Gao Yong Fang Ping Shu Jiaqian Ling Kuntang Shen Yihong Sun Jing Qin Xinyu Qin Yingyong Hou | 2017 | Acta Biochimica et Biophysica Sinica2017，49，2： | 4 |
| 7 | Deriving the magnetopause position from wide field-of-view soft X-ray imager simulation显示文摘Imaging techniques provide essential information in astronomical and space physics studies.The Soft X-ray Imager(SXI)will obtain images of the Earth’s magnetosphere via the solar wind charge exchange process in a global view.However,it is a challenge to reconstruct its 3-D structures from the observed 2-D image(s).In this paper,a recently proposed method,Tangent Fitting Approach(TFA),is validated to reconstruct the large-scale magnetopause from a single X-ray image obtained by instrument simulation.It is revealed that the large-scale magnetopause under a medium solar wind number density can be well reconstructed,although the locations of maximum X-ray photon counts are scattered in the image due to instrumental effects and diffusive sky background.Higher solar wind number density leads to stronger signals and further leads to better reconstruction results.For lower solar wind density,the X-ray maximum photon counts may not be identified from the SXI simulations,preprocessing of the images shall be considered before applying TFA.Furthermore,the subsolar magnetopause can be well derived when the satellite is on the dayside orbits. | Yihong GUO Tianran SUN Chi WANG Steven SEMBAY | 2022 | Science China Earth Sciences2022，65，8： | 4 |
| 8 | Simulation of Typhoon Muifa using a mesoscale coupled atmosphere–ocean model显示文摘A mesoscale coupled atmosphere–ocean model has been developed based on the GRAPES(Global and Regional Assimilation and Prediction System) regional typhoon model(GRAPES_TYM) and ECOM-si(estuary, coast and ocean model(semi-implicit)). Coupling between the typhoon and ocean models was conducted by exchanging wind stress, heat, moisture fluxes, and sea surface temperatures(SSTs) using the coupler OASIS3.0. Numerical prediction experiments were run with and without coupling for the case of Typhoon Muifa in the western North Pacific. To investigate the impact of using more accurate SST information on the simulation of the track and the intensity of Typhoon Muifa, experiments were also conducted using increased SST resolution in the initial condition field of the control test. The results indicate that increasing SST resolution in the initial condition field somewhat improved the intensity forecast, and use of the coupled model improved the intensity forecast significantly, with mean absolute errors in maximum wind speed within 48 and 72 h reduced by 32% and 20%, respectively. Use of the coupled model also resulted in less pronounced over-prediction of the intensity of Typhoon Muifa by the GRAPES_TYM. Moreover, the effects of using the coupled model on the intensity varied throughout the different stages of the development of Muifa owing to changes in the oceanic mixed layer depth. The coupled model had pronounced effects during the later stage of Muifa but had no obvious effects during the earlier stage. The SSTs predicted by the coupled model decreased by about 5–6°C at most after the typhoon passed, in agreement with satellite data. Furthermore, based on analysis on the sea surface heat flux, wet static energy of the boundary layer, atmospheric temperature, and precipitation forecasted by the coupled model and the control test, the simulation results of this coupled atmosphere–ocean model can be considered to reasonably reflect the primary mechanisms underlying the interactions between tropical cyclones and oceans. | SUN Minghua DUAN Yihong ZHU Jianrong WU Hui ZHANG Jin HUANG Wei | 2014 | Acta Oceanologica Sinica2014，33，11： | 3 |
| 9 | Pattern of No.12a lymph node metastasis in gastric cancer显示文摘Objective:The current standard D2 lymphadenectomy for gastric cancer(GC)includes dissection of lymph nodes(LNs)along the proper hepatic artery(No.12 a),however,the survival benefit remains controversial.The purpose of this study was to evaluate the pattern of No.12 a LN metastasis(LNM)in GC and explore the indications for No.12 a LN dissection.Methods:Medical records of 413 consecutive GC patients who underwent curative surgery in Zhongshan Hospital,Fudan University between January 2015 and December 2018 were enrolled and reviewed retrospectively.The correlation between No.12 a LNM and clinicopathologic characteristics of patients was analyzed.Results:The overall incidence of No.12 a LNM was 2.67%(11/413).Tumor location(P=0.012),depth of tumor infiltration(P<0.01)and N stage(P=0.018)were significant factors associated with No.12 a LNM.All the tumors with No.12 a LNM involved the lower third of the stomach and were in T3-4 stages.Patients with No.12 a LNM had extensive LNM than those without(20.91±4.25 vs.5.0±0.54,P<0.001).For advanced GC patients(stage III/IV)with tumors involving the lower third of the stomach,the incidence of No.12 a LNM increased to 10.7%(11/103).Patients with No.12 a LNM had a significantly poorer recurrence-free survival(RFS)(P=0.005)and overall survival(OS)(P=0.017).According to the result of multivariable Cox regression,No.12 a LNM was not an independent impact factor on RFS and OS.Conclusions:The overall incidence of No.12 a LNM was low but it was much higher in GC patients who had very advanced tumors involving the lower third of the stomach.No.12 a LN dissection should be considered for these patients to improve the survival outcomes. | Ping Shu Xiangfei Sun Fenglin Liu Yong Fang Kuntang Shen Yihong Sun Jing Qin Xinyu Qin | 2021 | Chinese Journal of Cancer Research2021，33，1： | 3 |
| 10 | Hazard Footprint-Based Normalization of Economic Losses from Tropical Cyclones in China During 1983–2015显示文摘Loss normalization is the prerequisite for understanding the effects of socioeconomic development,vulnerability, and climate changes on the economic losses from tropical cyclones. In China, limited studies have been done on loss normalization methods of damages caused by tropical cyclones, and most of them have adopted an administrative division-based approach to define the exposure levels. In this study, a hazard footprint-based normalization method was proposed to improve the spatial resolution of affected areas and the associated exposures to influential tropical cyclones in China. The meteorological records of precipitation and near-surface wind speed were used to identify the hazard footprint of each influential tropical cyclone. Provincial-level and national-level(total)economic loss normalization(PLN and TLN) were carried out based on the respective hazard footprints, covering loss records between 1999–2015 and 1983–2015, respectively.Socioeconomic factors—inflation, population, and wealth(GDP per capita)—were used to normalize the losses. A significant increasing trend was found in inflation-adjusted losses during 1983–2015, while no significant trend was found after normalization with the TLN method. The proposed hazard footprint-based method contributes to amore realistic estimation of the population and wealth affected by the influential tropical cyclones for the original year and the present scenario. | Wenfang Chen Yi Lu Shao Sun Yihong Duan Gregor C.Leckebusch | 2018 | International Journal of Disaster Risk Science2018，9，2： | 2 |
| 11 | Epidemiology, Risk Factors for Stroke, and Management of Atrial Fibrillation in China显示文摘 | Dayi Hu Yihong Sun | 2008 | Journal of the American College of Cardiology2008，，： | 2 |
| 12 | Maize ZmVPP5 is a truncated Vacuole H^+-PPase that confers hypersensitivity to salt stress显示文摘In plants, Vacuole H^+-PPases(VPPs) are important Aproton pumps and encoded by multiple genes. In addition to full-length VPPs, several truncated forms are expressed, but their biological functions are unknown. In this study, we functionally characterized maize vacuole H^+-PPase 5(ZmVPP5), a truncated VPP in the maize genome. Although ZmVPP5 shares high sequence similarity with ZmVPP1 ZmVPP5 lacks the complete structure of the conserved proton transport and the inorganic pyrophosphatase-related domain. Phylogenetic analysis suggests that ZmVPP5 might be derived from an incomplete gene duplication event. ZmVPP5 is expressed in multiple tissues, and ZmVPP5 was detected in the plasma membrane, vacuole membrane and nuclei of maize cells. The overexpression of ZmVPP5 in yeast cells caused a hypersensitivity to salt stress. Transgenic maize lines with overexpressed ZmVPP5 also exhibited the salt hypersensitivity phenotype. A yeast two-hybrid analysis identified the ZmBag6 like protein as a putative ZmVPP5-interacting protein. The results of bimolecular luminescence complementation(Bi LC)assay suggest an interaction between ZmBag6-like protein and ZmVPP5 in vivo. Overall, this study suggests that ZmVPP5 might act as a VPP antagonist and participate in the cellular response to salt stress. Our study of ZmVPP5 has expanded the understanding of the origin and functions of truncated forms of plant VPPs. | Xiaoliang Sun Weiwei Qi Yihong Yue Huiling Ling Gang Wang Rentao Song | 2016 | Journal of Integrative Plant Biology2016，58，6： | 2 |
| 13 | Analysis of an Ensemble of High-Resolution WRF Simulations for the Rapid Intensification of Super Typhoon Rammasun(2014)显示文摘Diagnostics are presented from an ensemble of high-resolution forecasts that differed markedly in their predictions of the rapid intensification(RI)of Typhoon Rammasun.We show that the basic difference stems from subtle differences in initializations of(a)500-850-h Pa environmental winds,and(b)midlevel moisture and ventilation.We then describe how these differences impact on the evolving convective organization,storm structure,and the timing of RI.As expected,ascent,diabatic heating and the secondary circulation near the inner-core are much stronger in the member that best forecasts the RI.The evolution of vortex cloudiness from this member is similar to the actual imagery,with the development of an inner cloud band wrapping inwards to form the eyewall.We present evidence that this structure,and hence the enhanced diabatic heating,is related to the tilt and associated dynamics of the developing inner-core in shear.For the most accurate ensemble member:(a)inhibition of ascent and a reduction in convection over the up-shear sector allow moistening of the boundary-layer air,which is transported to the down-shear sector to feed a developing convective asymmetry;(b)with minimal ventilation,undiluted clouds and moisture from the down-shear left quadrant are then wrapped inwards to the up-shear left quadrant to form the eyewall cloud;and(c)this process seems related to a critical down-shear tilt of the vortex from midlevels,and the vertical phase-locking of the circulation over up-shear quadrants.For the member that forecasts a much-delayed RI,these processes are inhibited by stronger vertical wind shear,initially resulting in poor vertical coherence of the circulation,lesser moisture and larger ventilation.Our analysis suggests that ensemble prediction is needed to account for the sensitivity of forecasts to a relatively narrow range of environmental wind shear,moisture and vortex inner-structure. | Xun LI Noel EDAVIDSON Yihong DUAN Kevin JTORY Zhian SUN Qinbo CAI | 2020 | Advances in Atmospheric Sciences2020，37，2： | 2 |
| 14 | Epidemiology, risk factors for stroke, and management of atrial fibrillation in China显示文摘 | Hu DaYi Sun YiHong | 2008 | J Am Coil Cardiol2008，52，10： | 1 |
| 15 | A simple inorganic-solvent-thermal route to nanocrystalline niobium diboride显示文摘 | Jianhua Ma Yihong Du Meining Wu Guoxing Li Zhiqing Feng Ming Guo Yixiu Sun Weihua Song Mingjin Lin Xule Guo | 2008 | Journal of Alloys and Compounds2008，，： | 1 |
| 16 | Synthesis of highly thermally stable lanthanum-doped ordered mesoporous alumina显示文摘 | Qianping Sun Ying Zheng Yong Zheng Yihong Xiao Guohui Cai Kemei Wei | 2011 | Scripta Materialia2011，，11： | 1 |
| 17 | Clinical significance of assessing Her2/neu expression in gastric cancer with dual tumor tissue paraffin blocks显示文摘 | Xiaowen Ge Haixing Wang Haiying Zeng Xuejuan Jin Akesu Sujie Chen Xu Yalan Liu Jie Huang Yuan Ji Yunshan Tan Tianshu Liu Yingyong Hou Jing Qin Yihong Sun Xinyu Qin | 2015 | Human Pathology2015，，6： | 1 |
| 18 | Ubiquitylation of Autophagy Receptor Optineurin by HACE1 Activates Selective Autophagy for Tumor Suppression显示文摘 | Zhengzhao Liu Peng Chen Hong Gao Yu Gu Jiao Yang Hong Peng Xingxing Xu Haifeng Wang Meiqiang Yang Xiaoying Liu Libin Fan Shiyao Chen Jian Zhou Yihong Sun Kangchen Ruan Shuqun Cheng Masaaki Komatsu Eileen White Lin Li Hongbin Ji Daniel Finley Ronggui Hu | 2014 | Cancer Cell2014，，： | 1 |
| 19 | Synthesis of highly thermally stable lanthanum-doped ordered mesoporous alumina显示文摘 | Qianping Sun Ying Zheng Yong Zheng Yihong Xiao Guohui Cai Kemei Wei | 2011 | Scripta Materialia2011，，11： | 1 |
| 20 | Tertiary lymphoid structure patterns predicted anti-PD1 therapeutic responses in gastric cancer显示文摘Objective:Recent studies have highlighted the distinct value of tertiary lymphoid structure(TLS)for immunotherapeutic response prediction.However,it remains unclear whether TLS could play such roles in gastric cancer(GC).Methods:In this study,tumor tissue slices from 292 GC patients from Zhongshan Hospital were firstly reviewed to explore the correlation between TLS and clinical characteristics.Subsequently,we curated 38 reported genes that may function as triggers of TLS and performed consensus molecular subtyping in public RNA-seq datasets to determine TLS patterns in GC.Based on the differentially expressed genes acquired from two TLS patterns,we quantified TLS-related genes on the principal component analysis(PCA)algorithm to develop TLS score.A Zhongshan immunotherapy cohort including 13 patients who received programmed cell death 1(PD1)blockade therapy was established to conduct RNA sequencing analysis and multiplex immunohistochemistry(mIHC)tests using formalin-fixed and paraffin-embedded(FFPE)tissues.The corresponding TLS score and immune cell counts were further compared based on therapeutic response variations.Results:Mature TLS was revealed as an independent prognostic factor in 292 GC patients.Patients with higher TLS score was characterized by prolonged survival time and superior response to immunotherapy.TLS score was correlated with immunotherapy-related characters,such as microsatellite instability(MSI)and tumor mutation burden(TMB).In addition,RNA-seq data analysis in the Zhongshan immunotherapy cohort indicated that a higher TLS score was correlated with a superior response to PD1 blockade therapy.mIHC tests also revealed that PD1+CD8+T cell counts were significantly increased in the high-TLS score group.Conclusions:This study highlighted that TLS was significantly associated with immune landscape diversity and complexity.Quantitatively evaluating TLS patterns of individual tumor will strengthen our understanding of TME characteristics and promote more effective immunotherapy strategies. | Quan Jiang Chenyu Tian Hao Wu Lingqiang Min Hao Chen Lingli Chen Fenglin Liu Yihong Sun | 2022 | Chinese Journal of Cancer Research2022，34，4： | 1 |
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