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您的检索式：作者名="Yijing Ling"
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| 1 | Rational Design and Development of Low-Price, Scalable, Shelf-Stable and Broadly Applicable Electrophilic Sulfonium Ylide-Based Trifluoromethylating Reagents显示文摘The development of two highly reactive electrophilic trifluoromethylating reagents(trifluoromethyl)(4-nitrophenyl)bis(carbometh-oxy)methylide(1g)and(trifluoromethyl)(3-chlorophenyl)bis(carbomethoxy)methylide(1j)through structure-activity study was described.Under mild conditions,reagent 1g reacted with β-ketoesters and silyl enol ethers to give α-trifluoromethylated-β-ketoesters or α-trifluoromethylated ketones in high yields.In addition,reagent 1g could serve as a trifluoromethyl radical for a variety of trifluo-romethylative transformations under visible light irradiation,including radical trifluoromethylation of electron-rich indoles and pyrroles and sodium aryl sulfinates as well as trifluoromethylative difunctionalization with styrene derivatives.On the other hand,as a complimentary,under reductive coupling conditions,reagent 1j reacted with a variety of(hetero)aryl iodides for the formation of tri-fluoromethylated(hetero)arenes. | Yafei Liu Yijing Ling Hangming Ge Long Lu Qilong Shen | 2021 | Chinese Journal of Chemistry2021，39，6： | 2 |
| 2 | High-density lipoprotein nitration and chlorination catalyzed by myeloperoxidase impair its effect of promoting endothelial repair显示文摘 | Bing Pan Baoqi Yu Hui Ren Belinda Willard Ling Pan Lingyun Zu Xiaoli Shen Yijing Ma Xiuli Li Chenguang Niu Jinge Kong Siyu Kang Y. Eugene Chen Subramaniam Pennathur Lemin Zheng | 2013 | Free Radical Biology and Medicine2013，，： | 1 |
| 3 | The neuroprotection of electro-acupuncture via the PGC-1α/TFAM pathway in transient focal cerebral ischemia rats显示文摘ATP depletion is one of the pathological bases in cerebral ischemia.Electro-acupuncture(EA)is widely used in clinical practice for ischemia.However,the mechanism of EA remains unclear.The purpose of this study was to investigate whether EA could activate the AMPK/PGC-1α/TFAM signaling pathway and,consequently,increase the preservation of ATP in rats with ischemia.In this study,48 rats were randomly divided into four groups as a sham-operation control group(sham group),a middle cerebral artery occlusion group(MCAO group),an EA group,and an EA group blocked by the AMPK inhibitor compound C(EA+CC group)(N=12/group).The rats of the EA group and EA+CC group received the EA treatment for 7 days.The rats that belonged in the two remaining groups were only grasped in the same condition.Then,their brain tissues were collected for further detection.When compared with other groups,EA significantly reduced neurological deficits score and increased motor function.The cerebral infarction volume was significantly reduced in the EA group according to TTC staining.With western blot,we found that EA improved the ratio of p-AMPKα/AMPKα(P<0.05),however,there is no difference between the MCAO group and sham group(P>0.05).In addition,EA also increased the expression of PGC-1αand TFAM(all P<0.05).By Elisa,we observed that EA increased the preservation of ATP(P<0.05)and mitochondrial respiratory enzymes,including Complex I(P<0.05),Complex IV(P<0.05),but not Complex III(P>0.05).In summary,we conclude that EA may protect against ischemic damage in MCAO rats,improve the preservation of ATP and mitochondrial respiratory enzymes.This effect may be positively regulated by the activation of the PGC-1α/TFAM signaling pathway. | LUPING YANG YIJING JIANG XIAOQIAN YE YONGMEI YOU LING LIN JING LIAN JUAN LI SHANLI YANG XIEHUA XUE | 2022 | BIOCELL2022，46，1： | 0 |
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