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| 1 | Ferroptosis is essential for diabetic cardiomyopathy and is prevented by sulforaphane via AMPK/NRF2 pathways显示文摘Herein,we define the role of ferroptosis in the pathogenesis of diabetic cardiomyopathy(DCM)by examining the expression of key regulators of ferroptosis in mice with DCM and a new ex vivo DCM model.Advanced glycation end-products(AGEs),an important pathogenic factor of DCM,were found to induce ferroptosis in engineered cardiac tissues(ECTs),as reflected through increased levels of Ptgs2 and lipid peroxides and decreased ferritin and SLC7 A11 levels.Typical morphological changes of ferroptosis in cardiomyocytes were observed using transmission electron microscopy.Inhibition of ferroptosis with ferrostatin-1 and deferoxamine prevented AGE-induced ECT remodeling and dysfunction.Ferroptosis was also evidenced in the heart of type 2 diabetic mice with DCM.Inhibition of ferroptosis by liproxstatin-1 prevented the development of diastolic dysfunction at 3 months after the onset of diabetes.Nuclear factor erythroid 2-related factor 2(NRF2)activated by sulforaphane inhibited cardiac cell ferroptosis in both AGE-treated ECTs and hearts of DCM mice by upregulating ferritin and SLC7 A11 levels.The protective effect of sulforaphane on ferroptosis was AMP-activated protein kinase(AMPK)-dependent.These findings suggest that ferroptosis plays an essential role in the pathogenesis of DCM;sulforaphane prevents ferroptosis and associated pathogenesis via AMPK-mediated NRF2 activation.This suggests a feasible therapeutic approach with sulforaphane to clinically prevent ferroptosis and DCM. | Xiang Wang Xinxin Chen Wenqian Zhou Hongbo Men Terigen Bao Yike Sun Quanwei Wang Yi Tan Bradley B.Keller Qian Tong Yang Zheng Lu Cai | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 20 |
| 2 | Epigenetic Modifications of mRNA and DNA in Plants显示文摘Advances in the detection and mapping of messenger RNA(mRNA)N^6-methyladenosine(m 6A)and 5-methylcytosine(m 5C),and DNA N^6-methyldeoxyadenosine(6mA)redefined our understanding of these modifications as additional tiers of epigenetic regulation.In plants,the most prevalent internal mRNA modifications,m^6A and m^5C,play crucial and dynamic roles in many processes,including embryo development,stem cell fate determination,trichome branching,leaf morphogenesis,floral transition,stress responses,fruit ripening,and root development.The newly identified and widespread epigenetic marker 6mA DNA methylation is associated with gene expression,plant development,and stress responses.Here,we review the latest research progress on mRNA and DNA epigenetic modifications,including the detection,dynamics,distribution,functions,regulatory proteins,and evolution,with a focus on m^6A,m^5C,and 6mA.We also provide some perspectives on future research of the newly identified and unknown epigenetic modifications of mRNA and DNA in plants. | Zhe Liang Adeel Riaz Sadaruddin Chachar Yike Ding Hai Du Xiaofeng Gu | 2020 | Molecular Plant2020，13，1： | 12 |
| 3 | Review of harmless treatment of municipal solid waste incineration fly ash显示文摘Incineration is widely adopted in municipal solid waste management,which produces large amounts of municipal solid waste incineration(MSWI)fly ash.The harmless treatment of MSWI fly ash requires the appropriate disposal of heavy metals and dioxins that are enriched in fly ash.This review summarizes recently developed harmless disposal methods for MSWI fly ash including solidification/stabilization,thermal treatment,and separation/extraction.In addition,we discuss heavy metal and dioxin fixation,and the removal capacity of fly ash via solidification/stabilization(including cement solidification,chemical stabilization,hydrothermal processes,and mechano-chemical methods),thermal treatment(including sintering,fuel-burning,or electric melting/vitrification),and separation/extraction(including water-washing,chemical reagent leaching,biological leaching,electrodialysis separation,chemical reagent extraction,and nanomaterials extraction).The advantages and disadvantages of different harmless treatment methods are compared and future research prospects and suggestions are summarized.This review provides general guidelines for the harmless treatment of MSWI fly ash in the future. | Yike Zhang Zengyi Ma Zhuoting Fang Yuandong Qian Pucheng Zhong Jianhua Yan | 2020 | Waste Disposal and Sustainable Energy2020，2，1： | 7 |
| 4 | Migration of multiples from the South China Sea显示文摘The South China Sea where water depth is up to 5000 m is the most promising oil and gas exploration area in China in the future.The seismic data acquired in the South China Sea contain various types of multiples that need to be removed before imaging can be developed.However,compared with the conventional reflection migration,multiples carry more information of the underground structure that helps provide better subsurface imaging.This paper presents a method to modify the conventional reverse time migration so that multiple reflections can migrate to their correct locations in the subsurface.This approach replaces the numerical impulsive source with the recorded data including primaries and multiples on the surface,and replaces the recorded primary reflection data with multiples.In the reverse time migration process,multiples recorded on the surface are extrapolated backward in time to each depth level,while primaries and multiples recorded on the surface are extrapolated forward in time to the same depth levels.By matching the difference between the primary and multiple images using an objective function,this algorithm improves the primary resultant image.Synthetic tests on Sigsbee2 B show that the proposed method can obtain a greater range and better underground illumination.Images of deep water in the South China Sea are obtained using multiples and their matching with primaries.They demonstrate that multiples can make up for the reflection illumination and the migration of multiples is an important research direction in the future. | LIU YiKe ZHU WeiLin MI LiJun ZHOU JiaXiong HAO Hu | 2015 | Science China Earth Sciences2015，58，3： | 6 |
| 5 | Novel Resonant Accelerometer with Micro Leverage Fabricated by MEMS Technology显示文摘For the purpose of improving the precision of the inertial guidance system,it is necessary to enhance the accuracy of the accelerometer.Combining the micro-fabrication processes with resonant sensor technology,a high-resolution inertial-grade novel micro resonant accelerometer is studied.Based on the detecting theory of the resonant sensors,the accelerometer is designed,fabricated,and tested.The accelerometer consists of one proofmass,two micro leverages and two double-ended-tuning-fork (DETF) resonators.The sensing principle of this accelerometer is based on that the natural frequency of the DETF resonator shifts with its axial load which is caused by inertial force.The push-pull configuration of the DETF is for temperature compensation.The two-stage micro leverage mechanisms are employed to amplify the force and increase the sensitivity of the accelerometer.The micro leverage and the resonator are modeled for static analysis and nonlinear modal analysis via theory method and finite element method (FEM),respectively.The geometrical parameters of them are optimized.The amplification factor of the leverage is 102,and the sensitivity of the resonator on theory is about 62 Hz/g.The samples of the accelerometer are fabricated with deep reactive ion etching (DRIE) technology which can get a high-aspect ratio structure for contributing a greater sensing-capacitance.The measuring results of the samples by scanning electron microscopy (SEM) show that the process is feasible,because of the complete structure,the sound combs and micro leverages,and the acceptable errors.The frequency of the resonator and the sensitivity of the accelerometer are tested via printed circuit board (PCB),respectively.The result of the test shows that the frequency of the push-resonator is about 54 530 Hz and the sensitivity of the accelerometer is about 55 Hz/g.The amplification factor of the leverage is calculated more accurately because the coupling of the two stages leverage is considered during derivation of the analysis formula.In addition,the novel differential structure of the accelerometer can greatly improve the sensitivity of the accelerometers. | HE Gaofa TANG Yike ZHOU Chuande HE Xiaoping WU Ying | 2011 | Chinese Journal of Mechanical Engineering2011，24，3： | 5 |
| 6 | Magnetic Array Assisted Triboelectric Nanogenerator Sensor for Real‑Time Gesture Interaction显示文摘In human-machine interaction,robotic hands are useful in many scenarios.To operate robotic hands via gestures instead of handles will greatly improve the convenience and intuition of human-machine interaction.Here,we present a magnetic array assisted sliding triboelectric sensor for achieving a real-time gesture interaction between a human hand and robotic hand.With a finger’s traction movement of flexion or extension,the sensor can induce positive/negative pulse signals.Through counting the pulses in unit time,the degree,speed,and direction of finger motion can be judged in realtime.The magnetic array plays an important role in generating the quantifiable pulses.The designed two parts of magnetic array can transform sliding motion into contact-separation and constrain the sliding pathway,respectively,thus improve the durability,low speed signal amplitude,and stability of the system.This direct quantization approach and optimization of wearable gesture sensor provide a new strategy for achieving a natural,intuitive,and real-time human-robotic interaction. | Ken Qin Chen Chen Xianjie Pu Qian Tang Wencong He Yike Liu Qixuan Zeng Guanlin Liu Hengyu Guo Chenguo Hu | 2021 | Nano-Micro Letters2021，13，3： | 5 |
| 7 | Targeted deletion of floral development genes in Arabidopsis with CRISPR/Cas9 using the RNA endoribonuclease Csy4 processing system显示文摘The formation of flowers in higher plants is controlled by complex gene regulatory networks.The study of floral development in Arabidopsis is promoted and maintained by transposon-tagged mutant lines.In this study,we report a CRISPR/Cas9 genome-editing system based on RNA endoribonuclease Csy4 processing to induce high-efficiency and inheritable targeted deletion of transcription factors involved in floral development in Arabidopsis.Using AP1,SVP,and TFL1 as the target genes,multisite and multiple-gene mutations were achieved with a tandemly arrayed Csy4-sgRNA architecture to express multiplexed sgRNAs from a single transcript driven by the Pol II promoter in transgenic lines.Targeted deletions of chromosomal fragments between the first exon and second exon in either one or three genes were generated by using a single binary vector.Interestingly,the efficiency of site-targeted deletion was comparable to that of indel mutation with the multiplexed sgRNAs.DNA sequencing analysis of RT-PCR products showed that targeted deletions of AP1 and TFL1 could lead to frameshift mutations and introduce premature stop codons to disrupt the open-reading frames of the target genes.In addition,no RT-PCR amplified product was acquired after SVPtargeted deletion.Furthermore,the targeted deletions resulted in abnormal floral development in the mutant lines compared to that of wild-type plants.AP1 and SVP mutations increased plant branching significantly,while TFL1 mutant plants displayed a change from indeterminate to determinate inflorescences.Thus,our results demonstrate that CRISPR/Cas9 with the RNA endoribonuclease Csy4 processing system is an efficient tool to study floral development and improve floral traits rapidly and simply. | Yingzhu Liu Yike Gao Yaohui Gao Qixiang Zhang | 2019 | Horticulture Research2019，6，1： | 4 |
| 8 | Green and Near-Infrared Dual-Mode Afterglow of Carbon Dots and Their Applications for Confidential Information Readout显示文摘Near-infrared(NIR),particularly NIR-containing dual-/multimode afterglow,is very attractive in many fields of application,but it is still a great challenge to achieve such property of materials. Herein,we report a facile method to prepare green and NIR dual-mode afterglow of carbon dots(CDs) through in situ embedding o-CDs(being prepared from o-phenylenediamine) into cyanuric acid(CA) matrix(named o-CDs@CA). Further studies reveal that the green and NIR afterglows of o-CDs@CA originate from thermal activated delayed fluorescence(TADF) and room temperature phosphorescence(RTP) of o-CDs,respectively. In addition,the formation of covalent bonds between o-CDs and CA,and the presence of multiple fixation and rigid e ects to the triplet states of o-CDs are confirmed to be critical for activating the observed dual-mode afterglow. Due to the shorter lifetime and insensitiveness to human vision of the NIR RTP of o-CDs@CA,it is completely covered by the green TADF during directly observing. The NIR RTP signal,however,can be readily captured if an optical filter(cut-o wavelength of 600 nm) being used. By utilizing these unique features,the applications of o-CDs@CA in anti-counterfeiting and information encryption have been demonstrated with great confidentiality. Finally,the as-developed method was confirmed to be applicable to many other kinds of CDs for achieving or enhancing their afterglow performances. | Yuci Wang Kai Jiang Jiaren Du Licheng Zheng Yike Li Zhongjun Li Hengwei Lin | 2021 | Nano-Micro Letters2021，13，12： | 4 |
| 9 | Language Model Score Regularization for Speech Recognition显示文摘Inspired by the fact that back-off and interpolated smoothing algorithms have significant effect on statistical language modeling, this paper proposes a sentence-level Language model(LM) score regularization algorithm to improve the fault-tolerance of LMs for recognition errors. The proposed algorithm is applicable to both count-based LMs and neural network LMs. Instead of predicting the occurrence of a sequence of words under a fixed order Markov assumption, we use a composite model consisting of different order models with either n-gram or skip-gram features to estimate the probability of the sequence of words. In order to simplify implementations,we derive a connection between bidirectional neural networks and the proposed algorithm. Experiments were carried out on the Switchboard corpus. Results on N-best lists re-scoring show that the proposed algorithm achieves consistent word error rate reduction when it is applied to count-based LMs, Feedforward neural network(FNN)LMs, and Recurrent neural network(RNN) LMs. | ZHANG Yike ZHANG Pengyuan YAN Yonghong | 2019 | Chinese Journal of Electronics2019，28，3： | 3 |
| 10 | Palcernuine, the first [5/6/6/6]-cernuane-type alkaloid from Palhinhaea cernua f.sikkimensis显示文摘One novel(named palcernuine, 1) and five known cernuane-type(2–6) alkaloids were isolated from the whole plant of Palhinhaea cernua f. sikkimensis. The structure of 1, possessing an unprecedented [5/6/6/6]-tetracyclic ring system containing two nitrogen atoms, was established on the basis of spectroscopic methods, and its absolute configuration was determined by comparison of the experimental and calculated electronic circular dichroism(ECD) spectra. A plausible biosynthetic pathway to 1 is proposed. | Yu Tang Juan Xiong Yike Zou Bastien Nay Li-Jun Wang Jin-Feng Hu | 2016 | Chinese Chemical Letters2016，27，6： | 2 |
| 11 | Effect of Preparation Method on the Structural Characteristics of NiO-ZrO2 Oxygen Carriers for Chemical-looping Combustion显示文摘Chemical-looping combustion(CLC)offers an effective approach for power generation and CO2 capture.In this work,an NiO-ZrO2 oxygen carrier prepared by three methods was subjected to an optimal reaction temperature test,an optimal flow test and a cyclic redox reaction test to explore the most suitable reaction conditions.Through comparative analysis,it is noted that the coprecipitation method is not suitable for the preparation of this NiO-ZrO2 oxygen carrier,while the oxygen carrier prepared by the mechanical mixing method and solution combustion method obtained a higher CH4 conversion rate and CO2 selectivity.In addition,these two oxygen carriers also showed high stability during successive CLC testing.Therefore,both the mechanical mixing method and the solution combustion method can be used to prepare NiO-ZrO2 oxygen carriers. | LIU Yike LONG Yanhui TANG Yaqin GU Zhenhua LI Kongzhai | 2019 | Chemical Research in Chinese Universities2019，35，6： | 2 |
| 12 | A new hybrid method—combined heat flux method with Monte-Carlo method to analyze thermal radiation显示文摘A new hybrid method, Monte-Carlo-Heat-Flux (MCHF) method, was presented to analyze the radiative heat transfer of participating medium in a three-dimensional rectangular enclosure using combined the Monte-Carlo method with the heat flux method. Its accuracy and reliability was proved by comparing the computational results with exact results from classical 'Zone Method'. | Zengwu Zhao Daqiang Cang Wenfei Wu Yike Li Baowei Li | 2006 | Journal of University of Science and Technology Beijing2006，13，1： | 2 |
| 13 | ESTIMATING OF ORDER-RESTRICTED LOCATION PARAMETERS OF TWO-EXPONENTIAL DISTRIBUTIONS UNDER MULTIPLE TYPE-Ⅱ CENSORING显示文摘§1IntroductionSupposethatXhasatwo-parameterexponentialdistributionexp(μ1,σ1)withdensityfunctionf1(x;μ1,σ1)=1σ1exp-x-μ1σ1{},x≥... | Shen Yike\ Fei Heliang | 1999 | Applied Mathematics(A Journal of Chinese Universities)1999，14，1： | 2 |
| 14 | Rock mass structure analysis based on seismic velocity and attenuation images显示文摘Seismic traveltime, amplitude and pulse-width can be used to reconstruct seismic velocity and attenuation coefficient images for a rock mass. This study discusses the appearance differences of velocity and attenuation coefficient in the ore vein and rock mass in the images. The location of the rock vein and the characteristic of the rock mass are discussed according to the difference responses of velocity and attenuation from the ore vein and mixed rock vein, fracture and rock body. The effect and limitation of the seismic tomography method for investigating ore body and rock mass is suggested on the basis of a field test result. The special observation method in this study gives a good reference for obtaining full position and directional observation in seismic tomography. | CHANG Xu LIU Yike WANG Hui GAO Xing | 2000 | Chinese Science Bulletin2000，45，13： | 2 |
| 15 | Sixteen people were killed in the major blasting accidentthat happened in Dafeng mine显示文摘 | YIKe(伊克) | 2008 | 安全与健康2008，23，： | 1 |
| 16 | Preparation and properties of ZnO-based ceramic films for low-vohage va- ristors by novel sol-gel process显示文摘 | Huang Y Q Meidong L Yike Z | 2001 | Materials Science and Engineering: B2001，86，3： | 1 |
| 17 | Capsid destabilization and epitope alterations of human papillomavirus 18 in the presence of thimerosal显示文摘Thimerosal has been widely used as a preservative in drug and vaccine products for decades.Due to the strong propensity to modify thiols in proteins,conformational changes could occur due to covalent bond formation between ethylmercury(a degradant of thimerosal)and thiols.Such a conformational change could lead to partial or even complete loss of desirable protein function.This study aims to investigate the effects of thimerosal on the capsid stability and antigenicity of recombinant human papillomavirus(HPV)18 virus-like particles(VLPs).Dramatic destabilization of the recombinant viral capsid upon thimerosal treatment was observed.Such a negative effect on the thermal stability of VLPs preserved with thimerosal was shown to be dependent on the thimerosal concentration.Two highly neutralizing antibodies,13H12 and 3C3,were found to be the most sensitive to thimerosal treatment.The kinetics of antigenicity loss,when monitored with 13H12 or 3C3 as probes,yielded two distinctly different sets of kinetic parameters,while the data from both monoclonal antibodies(mAbs)followed a biphasic exponential decay model.The potential effect of thimerosal on protein function,particularly for thiolcontaining proteinaceous active components,needs to be comprehensively characterized during formulation development when a preservative is necessary. | Xiaofen Huang Yike Li Meifeng Nie Mingxi Yue Yufang Li Zhijie Lin Huirong Pan Mujin Fang Ting Wu Shaowei Li Jun Zhang Ningshao Xia Qinjian Zhao | 2021 | Journal of Pharmaceutical Analysis2021，11，5： | 1 |
| 18 | LiFePO4 storage at room and elevated temperatures 显示文摘 | Nick Iltchev Yike Chen | 2003 | J Power Sources2003，，119121： | 1 |
| 19 | Multi-Modality Video Representation for Action Recognition显示文摘Nowadays,action recognition is widely applied in many fields.However,action is hard to define by single modality information.The difference between image recognition and action recognition is that action recognition needs more modality information to depict one action,such as the appearance,the motion and the dynamic information.Due to the state of action evolves with the change of time,motion information must be considered when representing an action.Most of current methods define an action by spatial information and motion information.There are two key elements of current action recognition methods:spatial information achieved by sampling sparsely on video frames’sequence and the motion content mostly represented by the optical flow which is calculated on consecutive video frames.However,the relevance between them in current methods is weak.Therefore,to strengthen the associativity,this paper presents a new architecture consisted of three streams to obtain multi-modality information.The advantages of our network are:(a)We propose a new sampling approach to sample evenly on the video sequence for acquiring the appearance information;(b)We utilize ResNet101 for gaining high-level and distinguished features;(c)We advance a three-stream architecture to capture temporal,spatial and dynamic information.Experimental results on UCF101 dataset illustrate that our method outperforms other previous methods. | Chao Zhu Yike Wang Dongbing Pu Miao Qi Hui Sun Lei Tan | 2020 | Journal on Big Data2020，2，3： | 1 |
| 20 | Application Strategy of Integrated Geophysical Prospecting in the Treatment of a Tunnel Disease显示文摘China is a country with complex terrain and complex geological conditions.With the development of economy and society,the demand for transportation is also increasing.There are many railways on the mountainous areas.Geological diseases severely affect the construction quality and safe operation of the tunnel,causing huge economic losses.This paper introduces the principles and application strategies of these technologies. | Yike Wei | 2020 | Journal of World Architecture2020，4，6： | 1 |
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