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| 1 | On the origin and continuing evolution of SARS-CoV-2显示文摘The SARS-Co V-2 epidemic started in late December 2019 in Wuhan, China, and has since impacted a large portion of China and raised major global concern. Herein, we investigated the extent of molecular divergence between SARS-CoV-2 and other related coronaviruses. Although we found only 4% variability in genomic nucleotides between SARS-CoV-2 and a bat SARS-related coronavirus(SARSr-CoV;Ra TG13), the difference at neutral sites was 17%, suggesting the divergence between the two viruses is much larger than previously estimated. Our results suggest that the development of new variations in functional sites in the receptor-binding domain(RBD) of the spike seen in SARS-Co V-2 and viruses from pangolin SARSr-Co Vs are likely caused by natural selection besides recombination. Population genetic analyses of 103 SARS-CoV-2 genomes indicated that these viruses had two major lineages(designated L and S), that are well defined by two different SNPs that show nearly complete linkage across the viral strains sequenced to date. We found that L lineage was more prevalent than the S lineage within the limited patient samples we examined. The implication of these evolutionary changes on disease etiology remains unclear.These findings strongly underscores the urgent need for further comprehensive studies that combine viral genomic data, with epidemiological studies of coronavirus disease 2019(COVID-19). | Xiaolu Tang Changcheng Wu Xiang Li Yuhe Song Xinmin Yao Xinkai Wu Yuange Duan Hong Zhang Yirong Wang Zhaohui Qian Jie Cui Jian Lu | 2020 | National Science Review2020，7，6： | 67 |
| 2 | An updated estimation of the risk of transmission of the novel coronavirus(2019-nCov)显示文摘The basic reproduction number of an infectious agent is the average number of infections one case can generate over the course of the infectious period,in a naïve,uninfected population.It is well-known that the estimation of this number may vary due to several methodological issues,including different assumptions and choice of parameters,utilized models,used datasets and estimation period.With the spreading of the novel coronavirus(2019-nCoV)infection,the reproduction number has been found to vary,reflecting the dynamics of transmission of the coronavirus outbreak as well as the case reporting rate.Due to significant variations in the control strategies,which have been changing over time,and thanks to the introduction of detection technologies that have been rapidly improved,enabling to shorten the time from infection/symptoms onset to diagnosis,leading to faster confirmation of the new coronavirus cases,our previous estimations on the transmission risk of the 2019-nCoV need to be revised.By using time-dependent contact and diagnose rates,we refit our previously proposed dynamics transmission model to the data available until January 29th,2020 and re-estimated the effective daily reproduction ratio that better quantifies the evolution of the interventions.We estimated when the effective daily reproduction ratio has fallen below 1 and when the epidemics will peak.Our updated findings suggest that the best measure is persistent and strict self-isolation.The epidemics will continue to grow,and can peak soon with the peak time depending highly on the public health interventions practically implemented. | Biao Tang Nicola Luigi Bragazzi Qian Li Sanyi Tang Yanni Xiao Jianhong Wu | 2020 | Infectious Disease Modelling2020，5，1： | 54 |
| 3 | The Genome of Artemisia annua Provides Insight into the Evolution of Asteraceae Family and Artemisinin Biosynthesis显示文摘Artemisia annua,通常已知的同样香甜的苦恼或 Qinghao,是到中国的一个灌木土著人并且长被用于药用的目的。A。annua 现在作为有势力抗疟药混合物的唯一的生来的来源全球性被栽培, artemisinin。这里,我们报导 A 的 1.74-gigabase 染色体的一个高质量的草稿集会。annua,高度异质接合,富于重复定序,并且包含 63 ? 226 编码蛋白质的基因,在定序的植物种类之中的最大的数字之一。我们发现了那,作为在 Asteraceae 的一些定序的染色体之一, A。annua 染色体包含对这大被子植物 clade 特定的很多基因。尤其是,扩大和编码涉及萜烯生合成的酶的基因的功能的多样化与 artemisinin biosynthetic 小径的进化一致。我们进一步由介绍那 A 的 transcriptome 揭示了。annua 发展了复杂 transcriptional 规章的网络位于 \O 下面 artemisinin 生合成。把转基因的 A 基于我们产生了的全面 genomic 和 transcriptomic 分析。artemisinin 高级的生产的 annua 线,它现在为大规模生产准备好了并且将从而帮助遇见增加 artemisinin 的全球需求的挑战。 | Qian Shen Lida Zhang Zhihua Liao Shengyue Wang Tingxiang Yan Pu Shi Meng Liu Xueqing Fu Qifang Pan Yuliang Wang Zongyou Lv Xu Lu Fangyuan Zhang Weimin Jiang Yanan Ma Minghui Chen Xiaolong Hao Ling Li Yueli Tang Gang Lv Yan Zhou Xiaofen Sun Peter E. Brodelius Jocelyn K.C. Rose Kexuan Tang | 2018 | Molecular Plant2018，11，6： | 47 |
| 4 | Reduction of tumorigenicity of SMMC-7721 hepatoma cells by vascular endothelial growth factor antisense gene therapy显示文摘AIM To test the hypothesis to block VEGFexpression of SMMC-7721 hepatoma cells mayinhibit tumor growth using the rat hepatomamodel.METHODS Amplifiy the 200 VEGF cDNAfragment and insert it into human U6 genecassette in the reverse orientation transcribingsmall antisense RNA which could specificallyinteract with VEGF165, and VEGF121 mRNA.Construct the retroviral vector containing thisantisense VEGF U6 cassette and package thereplication-deficient recombinant retrovirus.SMMC-7721 cells were transduced with thesevirus and positive clones were selected withG418. PCR and Southern blot analysis wereperformed to determine if U6 cassette integratedinto the genomic DNA of positive clone.Transfected tumor cells were evaluated for RNAexpression by ribonuclease protection assays.The VEGF protein in the supernatant of parentaltumor cells and genetically modified tumor cellswas determined with ELISA. In vitro and in vivogrowth properties of antisense VEGF cell clonein nude mice were analyzed.RESULTS Restriction enzyme digestion andPCR sequencing verified that the antisense VEGFRNA retroviral vector was successfullyconstructed. After G418 selection, resistantSMMC-7721 cell clone was picked up. PCR andSouthern blot analysis suggested that U6cassette was integrated into the cell genomicDNA. Stable SMMC-7721 cell clone transducedwith U6 antisense RNA cassette could express200bp small antisense VEGF RNA and secretereduced levels of VEGF in culture condition.Production of VEGF by antisense transgeneexpressing cells was 65 ± 10 ng / L per 106 cells,420 ± 45 ng/L per 106 cells in sense group and 485± 30 ng/L per 106 cells in the negative control group, (P<0.05). The antisense-VEGF cell clone appeared phenotypically indistinguishable from SMMC-7721 cells and SMMC-7721 cells transfected sense VEGF. The growth rate of the antisense-VEGF cell clone was the same as the control cells. When S. C. was implanted into nude mice, growth of antisense-VEGF cell lines was greatly inhibited compared with control cells.CONCLUSION Expression of antisense VEGFRNA in SMMC-7721 cells could decrease thetumorigenicity, and antisense-VEGF genetherapy may be an adjuvant treatment forhepatoma. | Yu Cheng Tang Yu Li Guan Xiang Qian Department of Biochemistry, Shanghai Second Medical University, Shanghai 200025, China | 2001 | World Journal of Gastroenterology2001，7，1： | 33 |
| 5 | Genome-wide Targeted Mutagenesis in Rice Using the CRISPR/Cas9 System显示文摘 | Lu, Yuming Ye, Xiao Guo, Renming Huang, Jing Wang, Wei Tang, Jiuyou Tan, Longtao Zhu, Jian-kang Chu, Chengcai Qian, Yangwen | 2017 | Molecular Plant2017，10，9： | 28 |
| 6 | Role of oxidative stress in the apoptosis of hepatocellular carcinoma induced by combination of arsenic trioxide and ascorbic acid显示文摘瞄准:现在的学习被设计决定位于三氧化二砷的联合使用导致的 apoptosis 的改进下面的可能的小径(作为(2 ) O (3 )) 并且抗坏血酸(AA ) 。方法:细胞内部的反应的氧种类(ROS ) 的水平与上载的一根氧化敏感的荧光灯的探针(6-carboxy-2',7' dichlorodihydrofluorescein 乙酰乙酸盐) 借助于流动血细胞计数分析被检测。谷胱甘肽(GSH ) 的活动,谷胱甘肽过氧化物酶(GPx ) ,和超级氧化物歧化酶(草皮) 被生物化学的方法检测。mitochondrial 膜电位被流动血细胞计数分析与玫瑰精 123 测量染色。caspase-3 的 Bcl-2, Bax,和 p17 子单元用西方的污点方法被分析。apoptosis 率被流动血细胞计数与 annexin-V/propidium 碘化物染色决定。结果:与相比当( 2 ) O ( 3 )( 2.0 micromol/L )独自对待,( 2 )在有 AA ( 100 micromol/L )的联合的 O ( 3 )( 2.0 micromol/L )减少了从 101.30+/-5.76 的细胞内部的 GSH 内容到 81.91+/-3.12 mg/g 蛋白质,并且增加了 ROS 从 127.61+/-5.12 铺平到 152.60+/-5.88 ,它被代表由 2 , 7-dichlorofluorescein 紧张。线粒体膜电位的损失从 1269.97+/-36.11 被增加到 1540.52+/-52.63,它被荧光紧张介绍。caspase-3 表示的 p17 子单元被增加近似 2 褶层。然而,草皮和 GPx 弄空和到 Bax 的 Bcl-2 的比率等于独自对待的 As2O3 (P>0.05 ) 的。什么时候 ROS 清道工人, N-acetyl-L-cysteine,被加到当(2 ) O (3 ) 和 AA 联合了处理组, apoptosis 率从 15.60 %+/-1.14% 减少了到 9.48%+/-0.67% ,和 ROS 水平从 152.60+/-5.88 减少了到 102.77+/-10.25。结论:当(2 ) O (3 ) 由增加 ROS 水平通过氧化小径导致了 apoptosis, AA 加强了。这可以是弄空的结果细胞内部的 GSH。它可以影响下游的串联追随者 ROS,包括线粒体去极和 caspase-3 激活。然而,草皮和 GPx 弄空和到 Bax 的 Bcl-2 的比率影响了由因为(2 ) O (3 ) 是,别发现被 AA 加强。 | Jing-jing LI Qiang TANG Yuan LI Ben-rong HU Zhang-yin MING Qin FU Jia-qing QIAN Ji-zhou XIANG | 2006 | Acta Pharmacologica Sinica2006，27，8： | 25 |
| 7 | Roles of nitric oxide in protective effect of berberine in ethanol-induced gastric ulcer mice显示文摘瞄准:在老鼠在导致乙醇的胃溃疡上调查小檗硷的保护的效果。方法:胃溃疡被乙醇的口头的摄取导致。氮的氧化物(没有) 内容被测量,并且内皮的氮的氧化物 synthase (eNOS ) 的 mRNA 表示和可诱导的氮的氧化物 synthase (i NOS ) 被反向的抄写聚合酶链反应(RT-PCR ) 分析。结果:在在乙醇的口服以后的 1 h, 2 h, 3 h 和 6 h 的溃疡索引(UI ) 分别地是 23.8+/-1.4, 23.3+/-2.2, 22.3+/-1.2 和 20.8+/-1.1。在对待 berberine 的组(5 mg/kg 和 50 mg/kg ) 的 UI 是不到控制组。内容不在控制组是在胃的果汁和 5.8+/-1.1 micromol/g 的 73.3+/-7.3 microL/L , 94.0+/-9.2 microL/L , 109.6+/-6.4 microL/L 和 138.2+/-10.2 microL/L 在在 1 h , 2 h , 3 h 和 6 h 的胃的织物的蛋白质, 8.3+/-1.1 micromol/g 蛋白质, 9.8+/-1.1 micromol/g 蛋白质和 11.9+/-1.2 micromol/g 蛋白质,分别地,在乙醇的口服以后。内容不在对待 berberine 的组(5 mg/kg 和 50 mg/kg ) 比在在乙醇的口服以后的 1 h | Long-rui PAN Qiang TANG Qin FU Ben-rong HU Ji-zhou XIANG Jia-qing QIAN | 2005 | Acta Pharmacologica Sinica2005，26，11： | 23 |
| 8 | Extracellular vesicle activities regulating macrophage- and tissue-mediated injury and repair responses显示文摘Macrophages are typically identified as classically activated(M1) macrophages and alternatively activated(M2) macrophages,which respectively exhibit pro-and anti-inflammatory phenotypes,and the balance between these two subtypes plays a critical role in the regulation of tissue inflammation,injury,and repair processes.Recent studies indicate that tissue cells and macrophages interact via the release of small extracellular vesicles(EVs) in processes where EVs released by stressed tissue cells can promote the activation and polarization of adjacent macrophages which can in turn release EVs and factors that can promote cell stress and tissue inflammation and injury and vice versa.This review discusses the roles of such EVs in resulating such interactions to influence tissue inflammation and injury in a number of acute and chronic inflammatory disease conditions,and the potential applications,advantage and concerns for using EV-based therapeutic approaches to treat such conditions,including their potential role of drug carriers for the treatment of infectious diseases. | Qian Hu Christopher J.Lyon Jesse K.Fletcher Wenfu Tang Meihua Wan Tony Y.Hu | 2021 | Acta Pharmaceutica Sinica B2021，11，6： | 22 |
| 9 | Free triiodothyronine level indicates the degree of myocardial injury in patients with acute ST-elevation myocardial infarction显示文摘 | Wang Wen-yao Tang Yi-da Yang Min Cui Cheng Mu Mu Qian Jie Yang Yue-jin | 2013 | Chinese Medical Journal2013，，20： | 21 |
| 10 | Angiopoiesis and bone regeneration via co expression of the hVEGF and hBMP genes from an adeno-associated viral vector in vitro and in vivo显示文摘 | Chen ZHANG Kun-zheng WANG Hui QIANG Yi-lun TANG Qian LI Miao LI Xiao-qian DANG | 2010 | Acta Pharmacologica Sinica2010，31，7： | 20 |
| 11 | Lunar topographic model CLTM-s01 from Chang’E-1 laser altimeter显示文摘More than 3 million range measurements from the Chang’E-1 Laser Altimeter have been used to produce a global topographic model of the Moon with improved accuracy. Our topographic model, a 360th degree and order spherical harmonic expansion of the lunar radii, is designated as Chang’E-1 Lunar Topography Model s01 (CLTM-s01). This topographic field, referenced to a mean radius of 1738 km, has an absolute vertical accuracy of approximately 31 m and a spatial resolution of 0.25o (~7.5 km). This new lunar topographic model has greatly improved previous models in spatial coverage, accuracy and spatial resolution, and also shows the polar regions with the altimeter results for the first time. From CLTM-s01, the mean, equatorial, and polar radii of the Moon are 1737103, 1737646, and 1735843 m, respectively. In the lunar-fixed coordinate system, this model shows a COM/COF offset to be (-1.777, -0.730, 0.237) km along the x, y, and z directions, respectively. All the basic lunar shape parameters derived from CLTM-s01 are in agreement with the results of Clementine GLTM2, but CLTM-s01 offers higher accuracy and reliability due to its better global samplings. | PING JinSong HUANG Qian YAN JianGuo CAO JianFeng TANG GeShi SHU Rong | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，7： | 19 |
| 12 | The mechanisms of sorafenib resistance in hepatocellular carcinoma:theoretical basis and therapeutic aspects显示文摘Sorafenib is a multikinase inhibitor capable of facilitating apoptosis,mitigating angiogenesis and suppressing tumor cell proliferation.In late-stage hepatocellular carcinoma(HCC),sorafenib is currently an effective first-line therapy.Unfortunately,the development of drug resistance to sorafenib is becoming increasingly common.This study aims to identify factors contributing to resistance and ways to mitigate resistance.Recent studies have shown that epigenetics,transport processes,regulated cell death,and the tumor microenvironment are involved in the development of sorafenib resistance in HCC and subsequent HCC progression.This study summarizes discoveries achieved recently in terms of the principles of sorafenib resistance and outlines approaches suitable for improving therapeutic outcomes for HCC patients. | Weiwei Tang Ziyi Chen Wenling Zhang Ye Cheng Betty Zhang Fan Wu Qian Wang Shouju Wang Dawei Rong F.P.Reiter E.N.De Toni Xuehao Wang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 19 |
| 13 | Combined subfascial endoscopic perforator surgery and endovenous laser treatment without impact on the great saphenous vein for management of lower-extremity varicose veins显示文摘 | GAN Shu-jie QIAN Shui-xian ZHANG Ci MAO Jie-qi LI Ke TANG Jing-dong | 2013 | Chinese Medical Journal2013，，3： | 18 |
| 14 | Identifying Global Monsoon Troughs and Global Atmospheric Centers of Action on a Pentad Scale显示文摘Using two datasets of global pentad grid precipitation and global 850 hPa geopotential height during 1979-2007,this study identified global monsoon troughs and global atmospheric centers of action (ACAs) on a pentad scale.The global monsoon troughs consist of planetary-scale monsoon troughs and peninsula-scale monsoon troughs.Forced by seasonal variations in solar radiation,the inter-tropical convergence zones (ITCZs) represent the planetary-scale monsoon troughs,which are active and shift over the tropical North Pacific,the tropical North Atlantic,and the tropical South Indian oceans.The peninsula-scale monsoon troughs are originated from regional land-sea topography and varied with contrasts in seasonal land-sea surface temperatures and precipitation.During the boreal summer,five peninsula-scale troughs and one planetary-scale trough are distributed in the Asia-Northwest Pacific (NWP) region.In total,22 troughs,nine monsoon troughs,and 19 ACAs in the lower troposphere were identified.Relevant ACAs may be useful in constructing regional monsoon and circulation indices. | QIAN Wei-Hong TANG Shuai-Qi | 2010 | Atmospheric and Oceanic Science Letters2010，3，1： | 18 |
| 15 | Three-dimensional human facial morphologies as robust aging markers显示文摘老化与许多复杂疾病被联系。变老的过程的可靠预言为估计联系老化的疾病的风险是重要的。然而尽管有强烈研究,到目前为止没有可靠老化标记。这里,我们由检验人的 3D 美容成像特征是否能被用作可靠老化标记处理了这个问题。我们收集了 >300 幅 3D 人美容图象和越过 17 ~ 77 年的年龄散布得好的血侧面。由分析词法侧面,我们产生了变老的人的面部 phenome 的第一张全面地图。我们鉴别量的面部特征例如眼睛斜坡,高度与年龄联系了。我们构造了一个柔韧的年龄预言者并且发现平均,一样的按年代先后的年龄的人由 ± 不同;在美容的 6 年变老,与在年龄 40 以后增加的偏差。用这个预言者,我们识别了被健康指示物的层次显著地支持的慢、快的蒸化机。尽管有在在血的面部词法特征和健康指示物之间的一种靠近的关系,面部特征比血侧面是更可靠的老化 biomarkers 并且能更好比按年代先后的年龄反映一般健康地位。 | Weiyang Chen Wei Qian Gang Wu Weizhong Chen Bo Xian Xingwei Chen Yaqiang Cao Christopher D Green Fanghong Zhao Kun Tang Jing-Dong J Han | 2015 | Cell Research2015，25，5： | 17 |
| 16 | Human monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptor显示文摘According to the World Health Organization(WHO)newly updated situation report on March 18th,2020,the coronavirus disease 2019(COVID-19)pandemic has confirmed 191,127 cases and claimed 7807 deaths worldwide.1 The etiological agent of COVID-19 has been identified as a novel coronavirus,the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),belonging to Sarbecovirus subgenus(genus Betacoronavirus,family Coronaviridae)and showing 79.6 and 96.2%sequence identity in nucleotide to SARS-CoV and a bat coronavirus(BatCoV RaTG13),respectively.2–4 Like SARS-CoV infection,a substantial fraction of COVID-19 patients exhibits severe respiratory symptoms and has to be hospitalized in intensive care unit.5–8 Although the mortality rate of COVID-19 is significantly lower than that of SARS-CoV infection,SARS-CoV-2 shows much higher human-to-human transmission rate,rapidly leading to a global pandemic declared by WHO on March 11th,2020. | Xiangyu Chen Ren Li Zhiwei Pan Chunfang Qian Yang Yang Renrong You Jing Zhao Pinghuang Liu Leiqiong Gao Zhirong Li Qizhao Huang Lifan Xu Jianfang Tang Qin Tian Wei Yao Li Hu Xiaofeng Yan Xinyuan Zhou Yuzhang Wu Kai Deng Zheng Zhang Zhaohui Qian Yaokai Chen Lilin Ye | 2020 | Cellular & Molecular Immunology2020，17，6： | 17 |
| 17 | Aminoglycoside-induced and non-syndromic hearing loss is associated with the G7444A mutation in the mitochondrial COI/tRNA (Ser(UCN)) genes in two Chinese families显示文摘 | Zhu Y Qian YP Tang XW Wang JD Yang L Liao ZS Li RH Ji JZ Li ZY Chen JF Choo DI Lu JX Guan MX | 2006 | 中国生物学文摘2006，20，4： | 16 |
| 18 | Epigastric pain syndrome: What can traditional Chinese medicine do? A randomized controlled trial of Biling Weitong Granules显示文摘BACKGROUND Recent research suggests that although prokinetic agents,acid suppressors,and radical treatment for Helicobacter pylori infection may be effective in patients with functional dyspepsia(FD),a large proportion of patients still fail to respond to these treatments or may suffer from severe adverse reactions.Many traditional Chinese medicinal herbs can regulate the status of the entire body and have special advantages in the treatment of functional diseases.The present study was designed to verify the efficacy of Biling Weitong Granules(BLWTG),a traditional Chinese medicinal herbal compound formula,in alleviating epigastric pain syndrome(EPS)in FD patients,in an attempt to provide an effective prescription for the clinical treatment of this disease.AIM To evaluate the clinical efficacy and safety of BLWTG in treating EPS in patients with FD.METHODS In this multicenter,stratified,randomized,double-blind,placebo-controlled,parallel group clinical trial,eligible patients were randomized into the BLWTG and placebo groups who were treated for 6 wk.Efficacy indicators including the severity and frequency of EPS and the time to pain resolution and safety indicators including adverse events were observed and compared.RESULTS The baseline demographic data and clinical characteristics,such as epigastric pain symptoms,pain intensity,and frequency of attacks,were matched between the two groups before randomization.After 6 wk of treatment and after the center effect was eliminated,the epigastric pain was significantly improved in 28.33%and 85.59%of the patients in the placebo and BLWTG groups,respectively(P<0.05).At 6 wk,the resolution rate of epigastric pain was 15%and 69.49%in the placebo and BLWTG groups,respectively(P<0.05).The differences of total FD clinical score between these two groups were significant(P<0.05)at 2,4,and 6 wk(P<0.05).The scores of each item and the total score in the Functional Digestive Disorders Quality of Life Questionnaire showed significant differences between the two groups at 6 wk after both the center and interaction effects were eliminated(P<0.05).There was no significant difference in the incidence of adverse events between the two groups,and no serious adverse event was noted during the observation.CONCLUSION Compared with placebo,BLWTG markedly improved EPS in FD patients without causing serious adverse reactions. | Yan-Dong Wen Fang Lu Ying-Pan Zhao Ping Wang Qian Yang Jun-Xiang Li Hui-Zhen Li Li-Li Chi Zheng-Hua Zhou Yan-Ping Tang Jin-Kang Xu Yang Zhao Xu-Dong Tang | 2020 | World Journal of Gastroenterology2020，26，28： | 16 |
| 19 | Single-cell transcriptomic analysis defines the interplay between tumor cells,viral infection,and the microenvironment in nasopharyngeal carcinoma显示文摘Nasopharyngeal carcinoma(NPC)is an Epstein-Barr virus(EBV)-associated malignancy with a complex tumor ecosystem.How the interplay between tumor cells,EBV,and the microenvironment contributes to NPC progression and immune evasion remains unclear.Here we performed single-cell RNA sequencing on^104,000 cells from 19 EBV^+NPCs and 7 nonmalignant nasopharyngeal biopsies,simultaneously profiling the transcriptomes of malignant cells,EBV,stromal and immune cells.Overall,we identified global upregulation of interferon responses in the multicellular ecosystem of NPC.Notably,an epithelial–immune dual feature of malignant cells was discovered and associated with poor prognosis.Functional experiments revealed that tumor cells with this dual feature exhibited a higher capacity for tumorigenesis.Further characterization of the cellular components of the tumor microenvironment(TME)and their interactions with tumor cells revealed that the dual feature of tumor cells was positively correlated with the expression of co-inhibitory receptors on CD8^+tumor-infiltrating T cells.In addition,tumor cells with the dual feature were found to repress IFN-γproduction by T cells,demonstrating their capacity for immune suppression.Our results provide new insights into the multicellular ecosystem of NPC and offer important clinical implications. | Shanzhao Jin Ruoyan Li Ming-Yuan Chen Chao Yu Lin-Quan Tang Yan-Min Liu Jiang-Ping Li Yi-Na Liu Yi-Ling Luo Yifan Zhao Yu Zhang Tian-Liang Xia Shang-Xin Liu Qi Liu Guan-Nan Wang Rui You Jing-Yun Peng Jiang Li Feng Han Jianwei Wang Qiu-Yan Chen Li Zhang Hai-Qiang Mai Benjamin E.Gewurz Bo Zhao Lawrence S.Young Qian Zhong Fan Bai Mu-Sheng Zeng | 2020 | Cell Research2020，30，11： | 16 |
| 20 | Extraction and Analysis of Gully Head of Loess Plateau in China Based on Digital Elevation Model显示文摘In China′s Loess Plateau area, gully head is the most active zone of a drainage system in gully areas. The differentiation of loess gully head follows geospatial patterns and reflects the process of the loess landform development and evolution of its drainage system to some extent. In this study, the geomorphic meaning, basic characteristics, morphological structure and the basic types of loess gully heads were systematically analysed. Then, the loess gully head′s conceptual model was established, and an extraction method based on Digital Elevation Model(DEM) for loess gully head features and elements was proposed. Through analysing the achieved statistics of loess gully head features, loess gully heads have apparently similar and different characteristics depending on the different loess landforms where they are found. The loess head characteristics reflect their growth period and evolution tendency to a certain degree, and they indirectly represent evolutionary mechanisms. In addition, the loess gully developmental stages and the evolutionary processes can be deduced by using loess gully head characteristics. This study is of great significance for development and improvement of the theoretical system for describing loess gully landforms. | ZHU Hongchun TANG Guoan QIAN Kejian LIU Haiying | 2014 | Chinese Geographical Science2014，24，3： | 16 |
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