3篇
您的检索式：作者名="Mingxi Yue"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | An essential role for PNLDC1 in piRNA 3' end trimming and male fertility in mice显示文摘 | Yue Zhang Rui Guo Yiqiang Cui Zhiping Zhu Yingwen Zhang Hao Wu Bo Zheng Qiuling Yue Shun Bai Wentao Zeng Xuejiang Guo Zuomin Zhou Bin Shen Ke Zheng Mingxi Liu Lan Ye Jiahao Sha | 2017 | Cell Research2017，27，11： | 2 |
| 2 | Capsid destabilization and epitope alterations of human papillomavirus 18 in the presence of thimerosal显示文摘Thimerosal has been widely used as a preservative in drug and vaccine products for decades.Due to the strong propensity to modify thiols in proteins,conformational changes could occur due to covalent bond formation between ethylmercury(a degradant of thimerosal)and thiols.Such a conformational change could lead to partial or even complete loss of desirable protein function.This study aims to investigate the effects of thimerosal on the capsid stability and antigenicity of recombinant human papillomavirus(HPV)18 virus-like particles(VLPs).Dramatic destabilization of the recombinant viral capsid upon thimerosal treatment was observed.Such a negative effect on the thermal stability of VLPs preserved with thimerosal was shown to be dependent on the thimerosal concentration.Two highly neutralizing antibodies,13H12 and 3C3,were found to be the most sensitive to thimerosal treatment.The kinetics of antigenicity loss,when monitored with 13H12 or 3C3 as probes,yielded two distinctly different sets of kinetic parameters,while the data from both monoclonal antibodies(mAbs)followed a biphasic exponential decay model.The potential effect of thimerosal on protein function,particularly for thiolcontaining proteinaceous active components,needs to be comprehensively characterized during formulation development when a preservative is necessary. | Xiaofen Huang Yike Li Meifeng Nie Mingxi Yue Yufang Li Zhijie Lin Huirong Pan Mujin Fang Ting Wu Shaowei Li Jun Zhang Ningshao Xia Qinjian Zhao | 2021 | Journal of Pharmaceutical Analysis2021，11，5： | 1 |
| 3 | Effect of heat treatment temperature on microstructure and electromagnetic shielding properties of graphene/SiBCN composites显示文摘Three-dimensional(3D) graphene/SiBCN composites(GF/SiBCN) were prepared by depositing SiBCN ceramics in 3D graphene foam via the chemical vapor infiltration technique. The effect of the heat treatment temperature on the microstructure, phase composition, and electromagnetic properties of the GF/SiBCN composite was investigated. The SiBCN ceramics maintained an amorphous structure in the composite below 1400℃ above which the crystallinity of the free carbon phase gradually increased.While the Si3N4 and B4C phases started to crystallize at 1500℃ and their crystallinity increased with temperature, SiC was observed at 1700℃. The electromagnetic shielding effectiveness of GF/SiBCN increased with the heat treatment temperature. | Wei Yue Yongsheng Liu Mingxi Zhao Fang Ye Laifei Cheng | 2019 | Journal of Materials Science & Technology2019，35，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员