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| 1 | Inhibitors of 5-lipoxygenase inhibit expression of intercellular adhesion molecule-1 in human melanoma cells显示文摘AIM: To study the effect of 5-lipoxygenase inhibitors on the expression of intercellular adhesion molecule-1 (ICAM-1) inmelanoma cells. METHODS: ICAM-1 protein of human melanoma cell a375 was detected by enzyme-linkedimmunosorbent, flow cytometry and Western blot analysis. Level of ICAM-1 mRNA in a375 was evaluated byNorthern blot analysis. Adhesion of a375 to endothelial cell EC304 was analyzed by isotopic tracing. RESULTS:5-Lipoxygenase inhibitors nordihydroguaiaretic acid, AA861 and MK886, could suppress the expression of ICAM-1protein as well as of its mRNA in a375 cells and reduce the adhesion of a375 to EC304. CONCLUSION:5-Lipoxygenase inhibitors can inhibit the expression of ICAM-1 in human melanoma cells and may be valuable fortreatment of melanoma metastasis. | YinWANG BinZHOU JiLI Yong-bingCAO Xin-shengCHEN Ming-heCHENG MingYIN | 2004 | Acta Pharmacologica Sinica2004，25，5： | 12 |
| 2 | SIRT3基因与代谢综合征及心肌肥厚的相关性研究显示文摘SIRT3基因作为沉默信息调节因子2(Sirtuin)家族中的一员,主要定位于线粒体内膜,具有强大的去乙酰基作用,不仅参与调节能量代谢、细胞凋亡、肿瘤生长、抗衰老等活动,在心血管方面也发挥重要的作用。本文主要就SIRT3在代谢综合征及心肌肥厚方面的研究进展进行综述,为进一步探讨SIRT3在心血管疾病中的潜在作用提供理论依据。 | 马艳艳 巩会平 朱林 杜贻萌 Eloy Yinwang | 2017 | 中华内分泌代谢杂志2017，33，1： | 2 |
| 3 | Sirt3与心血管疾病和长寿关系的研究进展显示文摘Sirt3是一种依赖NAD+的去乙酰化酶。它与线粒体多种生物功能紧密相连,其中包括营养素氧化、ATP生成、活性氧自由基(ROS)清除及线粒体稳态等。Sirt3在心血管疾病的发生和发展中扮演重要角色,人类寿命延长与Sirt3也密切相关。 | 朱林 巩会平 马艳艳 ELOY YINWANG 杜贻萌 | 2017 | 基础医学与临床2017，37，4： | 2 |
| 4 | Pigmented pleomorphic xanthoastrocytoma: A rare variant and literature review显示文摘 | JiXiong Shu‐GuangChu YingMao YinWang | 2011 | Neuropathology2011，，1： | 1 |
| 5 | Anti- hypoxic activity of the ethanol extract from Portulaca oleracea in mice 显示文摘 | Cheng- Jie Chen Wan- YinWang Xiao- LiWang | 2009 | Journal of Ethnopharmacology2009，124，： | 1 |
| 6 | Enhancement of T cell infiltration via tumor-targeted Th9 cell delivery improves the efficacy of antitumor immunotherapy of solid tumors显示文摘Insufficient infiltration of T cells severely compromises the antitumor efficacy of adoptive cell therapy(ACT)against solid tumors.Here,we present a facile immune cell surface engineering strategy aiming to substantially enhance the anti-tumor efficacy of Th9-mediated ACT by rapidly identifying tumor-specific binding ligands and improving the infiltration of infused cells into solid tumors.Non-genetic decoration of Th9 cells with tumor-targeting peptide screened from phage display not only allowed precise targeted ACT against highly heterogeneous solid tumors but also substantially enhanced infiltration of CD8+T cells,which led to improved antitumor outcomes.Mechanistically,infusion of Th9 cells modified with tumor-specific binding ligands facilitated the enhanced distribution of tumor-killing cells and remodeled the immunosuppressive microenvironment of solid tumors via IL-9 mediated immunomodulation.Overall,we presented a simple,cost-effective,and cell-friendly strategy to enhance the efficacy of ACT against solid tumors with the potential to complement the current ACT. | Tao Chen Yucheng Xue Shengdong Wang Jinwei Lu Hao Zhou Wenkan Zhang Zhiyi Zhou Binghao Li Yong Li Zenan Wang Changwei Li Yinwang Eloy Hangxiang Sun Yihang Shen Mohamed Diaty Diarra Chang Ge Xupeng Chai Haochen Mou Peng Lin Xiaohua Yu Zhaoming Ye | 2023 | Bioactive Materials2023，，5： | 0 |
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