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| 1 | 对建筑遗产基本问题的认知显示文摘作者基于理论与实践的思考,从基本概念范畴与问题的阐释出发,对建筑遗产保护与再生这一专业领域的发展主线、前沿及其中西语境差异,做了系统的梳理和整合。特别侧重对基本概念的歧义性,价值判定的多元性,保存与修复的矛盾性,以及中国建筑遗产的特征及保存与修复传统等,做了多向度的反思和论辩。此外,文章还从中西比较的视角,讨论了城市更新中的历史空间转化与再生问题。 | 常青 Jiang Tianyi Chen Chenand Li Yingchun | 2016 | 建筑遗产2016，0，1： | 88 |
| 2 | Aerodynamic Design Methodology for Blended Wing Body Transport显示文摘This paper puts forward a design idea for blended wing body(BWB).The idea is described as that cruise point,maximum lift to drag point and pitch trim point are in the same flight attitude.According to this design idea,design objectives and constraints are defined.By applying low and high fidelity aerodynamic analysis tools,BWB aerodynamic design methodology is established by the combination of optimization design and inverse design methods.High lift to drag ratio,pitch trim and acceptable buffet margin can be achieved by this design methodology.For 300-passenger BWB configuration based on static stability design,as compared with initial configuration,the maximum lift to drag ratio and pitch trim are achieved at cruise condition,zero lift pitching moment is positive,and buffet characteristics is well.Fuel burn of 300-passenger BWB configuration is also significantly reduced as compared with conventional civil transports.Because aerodynamic design is carried out under the constraints of BWB design requirements,the design configuration fulfills the demands for interior layout and provides a solid foundation for continuous work. | LI Peifeng ZHANG Binqian CHEN Yingchun YUAN Changsheng LIN Yu | 2012 | Chinese Journal of Aeronautics2012，25，4： | 29 |
| 3 | Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a poor-prognosis cancer type with limited understanding of its molecular etiology.Using 508 ESCC genomes,we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’outcomes.Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function,or even conferred oncogenic activities.Additionally,we found that the NFE2L2 mutations were significantly associated with worse prognosis of ESCC.We also identified potential noncoding driver mutations including hotspot mutations in the promoter region of SLC35E2 that were correlated with worse survival.Approximately 5.9%and 15.2%of patients had high tumor mutation burden or actionable mutations,respectively,and may benefit from immunotherapy or targeted therapies.We found clinically relevant coding and noncoding genomic alterations and revealed three major subtypes that robustly predicted patients’outcomes.Collectively,we report the largest dataset of genomic profiling of ESCC useful for developing ESCC-specific biomarkers for diagnosis and treatment. | Yongping Cui Hongyan Chen Ruibin Xi Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qimin Zhan Yanhong Li Zhihua Liu-Show | 2020 | Cell Research2020，30，10： | 19 |
| 4 | Impact of urbanization on changes in temperature extremes in Beijing during 1978–2008显示文摘To quantify the impact of urbanization on changes in observed surface air temperature and extremes,a homogenized dataset of daily mean,maximum and minimum temperature(Tm,Tmax and Tmin)observations at 20 stations in Greater Beijing(GBJ)from1978 to 2008 is analyzed.In contrast with previous studies,a cluster analysis is done to objectively classify observing stations into four categories(urbanized,suburban,rural and mountain),which is checked with remote-sensing night-light images since the1990s.At urbanized sites,there is an added warming trend in annual mean Tm representing an average of 10.9%(up to 18.4%or0.12°C/decade at the most strongly influenced site)of overall warming.Corresponding contributions for Tmin are 12.7%(up to20.8%or 0.19°C/decade)and 24%for diurnal temperature range DTR(up to 37.4%or 0.149°C/decade)over the last three decades.Although it has not had a significant impact on daytime records(Tmax),urbanization has enhanced the increasing(decreasing)trend of extremely warm(cold)nights by an average of 12.7%or 2.07 d/decade(29.0%or 5.06 d/decade)at the urbanized sites since the 1970s. | WANG Jun YAN ZhongWei LI Zhen LIU WeiDong WANG YingChun | 2013 | Chinese Science Bulletin2013，58，36： | 18 |
| 5 | Geochronologic constraints on magmatic intrusions and mineralization of the Zhunuo porphyry copper deposit in Gangdese,Tibet显示文摘In situ zircon U-Pb ages for the recently discovered Zhunuo porphyry copper deposit in the western part of the Gangdese metallogenic belt in Tibet were determined by sensitive high-resolution ion mi-croprobe(SHRIMP) . The ages can be divided into two separate groups,reflecting more than four major tectono-magmatic events in the area. The 62.5±2.5 Ma age of inherited zircons may be related to the volcanic eruption of the Linzizong Group formed shortly after the India-Asia continental collision. The 50.1±3.6 Ma age most likely corresponds to the time of underplating of mantle-derived mafic magma in Gangdese. The 15.6±0.6 Ma age obtained from magmatic zircons is interpreted as the age of crystalli-zation of the Zhunuo ore-forming porphyry. Finally,a molybdenite Re-Os isochron age of 13.72±0.62 Ma is consistent with another zircon U-Pb age of 13.3 ±0.2 Ma,representing the time of copper mineraliza-tion. These ages,in combination with available literature data,indicate that magmatic crystallization and copper mineralization in the Gangdese metallogenic belt became gradually younger westward,and further suggest that the Zhunuo porphyry copper deposit was formed in the same tectonic stage as other porphyry copper deposits in the eastern and central Gangdese belt. This conclusion provides critical information for future exploration of porphyry copper deposits in western Gangdese. | ZHENG YouYe ZHANG GangYang XU RongKe GAO ShunBao PANG YingChun CAO Liang DU AnDao SHI YuRuo | 2007 | Chinese Science Bulletin2007，52，22： | 17 |
| 6 | Geothermal data analysis at the high-temperature hydrothermal area in Western Sichuan显示文摘The western Sichuan hydrothermal area is located at the northeastern margin of the eastern syntaxis of the Qinghai-Tibet Plateau, which is also the eastern end of the Mediterranean-Himalayan geothermal activity zone. There are 248 warm or hot springs in this area, and 11 have temperatures beyond the local boiling temperature. Most of these hot springs are distributed along the Jinshajiang, Dege-Xiangcheng, Ganzi-Litang, and Xianshuihe faults, forming a NW-SE hydrothermal belt. A geothermal analysis of this high-temperature hydrothermal area is an important basis for understanding the deep geodynamic process of the eastern syntaxis of the Qinghai-Tibet Plateau. In addition, this study offers an a priori view to utilize geothermal resources, which is important in both scientific research and application. We use gravity, magnetic, seismic, and helium isotope data to analyze the crust-mantle heat flow ratio and deep geothermal structure. The results show that the background terrestrial heat flow descends from southwest to northeast. The crustal heat ratio is not more than 60%. The high temperature hydrothermal active is related to crustal dynamics processes. Along the Batang-Litang-Kangding line, the Moho depth increases eastward, which is consistent with the changing Qc/Qm(crustal/mantle heat flow) ratio trend. The geoid in the hydrothermal zone is 4–6 km higher than the surroundings, forming a local 'platform'. The NW-SE striking local tensile stress zone and uplift structure in the upper and middle crust corresponds with the surface hydrothermal active zone. There is an average Curie Point Depth(CPD) of 19.5–22.5 km in Batang, Litang, and Kangding. The local shear-wave(S-wave) velocity is relatively low in the middle and lower crust. The S-wave shows a low velocity trap(Vs<3.2 km s.1) at 15–30 km, which is considered a high-temperature partial melting magma, the crustal source of the hydrothermal active zone. We conclude that the hydrothermal system in this area can be divided into Batang-type and Kangding-type, both of which rely on a crustal heating cycle of atmospheric precipitation and surface water along the fracture zone. The heat is derived from the middle and lower crust: groundwater penetrates the deep faults bringing geothermal energy back to the surface and forming high-temperature springs. | ZHANG Jian LI WuYang TANG XianChun TIAN Jiao WANG YingChun GUO Qi PANG ZhongHe | 2017 | Science China Earth Sciences2017，60，8： | 17 |
| 7 | Constrained large-eddy simulation and detached eddy simulation of flow past a commercial aircraft at 14 degrees angle of attack显示文摘With the development of computational power and numerical algorithms,computational fluid dynamics(CFD) has become an important strategy for the design of aircraft,which significantly reduces the reliance on wind-tunnel and flight tests.In this paper,we conducted a numerical investigation on the flow past a full commercial aircraft at Mach number 0.2 and 14 degrees angle of attack by means of Reynolds-averaged Navier-Stokes(RANS),detached-eddy simulation(DES) and our newly developed constrained large-eddy simulation(CLES).The objective of this paper is to study the capability of these models in simulating turbulent flows.To our knowledge,this is the first large-eddy simulation method for full commercial aircraft simulation.The results show that the CLES can predict the mean statistical quantities well,qualitatively consistent with traditional methods,and can capture more small-scale structures near the surface of the aircraft with massive separations.Our study demonstrates that CLES is a promising alternative for simulating real engineering turbulent flows. | CHEN ShiYi CHEN YingChun XIA ZhenHua QU Kun SHI YiPeng XIAO ZuoLi LIU QiuHong CAI QingDong LIU Feng LEE Cunbiao ZHANG RiKui CAI JinSheng | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，2： | 14 |
| 8 | 清代样式雷建筑图档中的平格研究--中国传统建筑设计理念与方法的经典范例显示文摘文章从清代样式雷建筑图档中的平格入手,将其放在清代皇家建筑从选址、规划设计到施工的全过程中予以考察,进而揭示中国传统建筑设计过程、设计方法及其理念的关键所在。并在此基础上向前回溯,探讨平格方法在中国传统文化中的历史渊源和流变。 | 王其亨 Li Yingchun | 2016 | 建筑遗产2016，0，1： | 13 |
| 9 | Aquaporin JcPIP2 is Involved in Drought Responses in Jatropha curcas显示文摘水隧道蛋白质, aquaporins,在在植物的 transmembranewater 运动的戏基础角色。编码 aquaporin 的新全身的 cDNA 从 Jatropha curcas 的幼苗被孤立。质膜的基因从 J 的内在的蛋白质(果仁) 。curcas (JcPIP2 ) 包含了 843 bp 编码 280 氨基酸的蛋白质的开的读框架。氨基酸顺序与 Ricinus communis 果仁显示出 94% 身份。JcPIP2 互补 RNA intoXenopus 卵母细胞的注射增加了 10 褶层卵母细胞的渗透的水渗透。有 anti-JcPIP2 抗体的 Immunodetection ofJcPIP2 显示这蛋白质无所不在地位于植物的所有测试纸巾。调查在 aquaporins 和干旱抵抗 inJ 之间的关系。curcas,许多 JcPIP2 在二 J 的幼苗被检验。curcas 人口, GaoYouCSC63 和 YanBian S1,在有 PEG6000 的水赤字下面。在地条件下面,那些二张人口, GaoYou CSC63 是抵抗的浇赤字,而是 YanBian S1 是敏感的浇剥夺。与干旱应力的增加的度, JcPIP2 水平在幼苗 ofGaoYou CSC63 增加了,而在 YanBian S1 的幼苗没有重要变化。比较 withYanBian S1, GaoYou CSC63 也显示出更高的根在在水赤字下面的幼苗的水力的电导率和更低的减少趋势。这些结果显示 JcPIP2 可能在 J 在干旱抵抗起了一个作用。curcas。 | Ying ZHANG Yunxiao WANG Luding JIANG Ying XU Yingchun WANG Daihua LU Fang CHEN | 2007 | Acta Biochimica et Biophysica Sinica2007，39，10： | 13 |
| 10 | Statistic characteristics and weather significance of infrared TBB during May―August in Beijing and its vicinity显示文摘In order to meet the demand of nowcasting convective storms in Beijing, the climatological characteristics of convective storms in Beijing and its vicinity were analyzed based on the infrared (IR) temperature of black body (TBB) data during May―August of 1997―2004. The climatological probabilities, the diurnal cycle and the spatial distribution of convective storms are given respectively in this paper. The results show that the climatological characteristics of convective storms denoted by TBB≤-52℃ are consistent with those statistic studies based on the surface and lightning observations. Furthermore, the climatological characteristics of May and June are very different from those of July and August, showing that there are two types of convective storms in this region. One occurs in the transient polar air mass on the midlatitude continent during the late spring and early summer. This type of convection arises with thunder, strong wind gust and hail over the mountainous area in the northern part of this region from afternoon to nightfall, the other occurs with heavy rainfall in the warm and moist air mass over the North China Plain and vicinity of Bohai Sea. This study also shows that the long-term data of IR TBB observed by geostationary satellite can complement the temporal and spatial limitation of the weather radar and surface observations. | ZHENG YongGuang CHEN Jiong CHEN MingXuan WANG YingChun DING QingLan | 2007 | Chinese Science Bulletin2007，52，24： | 12 |
| 11 | Existence of Qiongnan suture zone on the north margin of South China Sea显示文摘This paper aims to explore whether paleo-suture zone exists in the pre-Cenozoic basement of South China Sea (SCS). By taking advantage of integrated geophysical surveying data, including multi-channel reflection seismicity, oceanic bottom seismicity, gravity and magnetic data as well as paleomagnetism and drilling information, a comprehensive analysis on sedimentary stratigraphy, seismic stratigraphy, magmatic and metamorphic petrology, geochemistry, gravity study, magnetics, paleogeomagnetics as well as geotectonics was carried out, and the results clearly indicate that a pre-Cenozoic suture zone, i.e. “Qiongnan (south Hainan Island) suture zone”, does exist on the north margin of SCS. This suture zone starts in the west from the Jiusuo-Lingshui fault zone in the south of Hainan Island, extends eastward across the continental slope to the north of SCS, and links with Shoufeng fault in Taiwan. It is inferred that the Qiongnan suture zone was sutured approximately in Indosinian (Triassic) Epoch and is actually the vestige of “Qiongnan ocean basin”, the extension of the main paleo-Tethys ocean basin in SCS. The formation of Qiongnan suture zone marked the collision-accretion of the Qiongnan Block toward the Qiongzhong Block. The Qiongnan suture zone is linked to the west with the southward extension of the principal suture zone of the Paleo-Tethys at Bitu-Changning-Menglian-Bentong-Raub, across the southern segment of the Red River-East Vietnam-Wanna strike-slip fault zone, and connected to the east with the suture zone emplaced into the south margin of the Oki-Hida Pre-Jurassic terranes in southwest Japan, across the northerni2 e segment of the Manila trench fault zone in the northeast side of Taiwan Island. The discovery of this suture zone is believed to be potentially significant toward study of the pre-Cenozoic geotectonic pattern of SCS, the temporal and spatial distribution of the east paleo-Tethys structural domain in SCS and the relationship of recombination and superimposition between the east paleo-Tethys structural domain and the west Pacific structural domain, in addition to the oil/gas geological potentials in the pre-Cenozoic marine vestige-superimposed basin in the study area. | LIU Hailing YAN Pin LIU Yingchun DENG Hui | 2006 | Chinese Science Bulletin2006，51，B12： | 12 |
| 12 | New Progress on the Coal Fines Affecting the Development of Coalbed Methane显示文摘Objective The production of coal fines is very common in the development of coalbed methane(CBM)in the eastern margin of the Ordos Basin,China.A large amount of produced coal fines seriously affect the productivity of CBM wells(Wei Yingchun et al.,2013).Therefore,the production problems of CBM wells caused by coal fines have attracted extensive attention.The destruction | WEI Yingchun LI Chao CAO Daiyong ZHANG Aoxiang WANG Anmin XIANG Xinxuan | 2018 | Acta Geologica Sinica(English Edition)2018，92，5： | 11 |
| 13 | Hypoxia-induced factor-1 alpha upregulates vascular endothelial growth factor C to promote lymphangiogenesis and angiogenesis in breast cancer patients显示文摘Hypoxia-induced factor-1 alpha(HIF-1α)affects many effector molecules and regulates tumor lymphangiogenesis and angiogenesis during hypoxia.The aim of this study was to investigate the role of HIF-1αin the regulation of vascular endothelial growth factor C(VEGF-C)expression and its effect on lymphangiogenesis and angiogenesis in breast cancer.Lymphatic vessel density(LVD),microvessel density(MVD)and the expressions of HIF-1αand VEGF-C proteins were evaluated by immunohistochemistry in 75 breast cancer samples.There was a significant correlation between HIF-1αand VEGF-C(P=0.014,r=0.273,Spearman's coefficient of correlation).HIF-1αand VEGF-C overexpression was significantly correlated with higher LVD(P=0.003 and P=0.017,respectively),regional lymph nodal involvement(P=0.002 and P=0.004,respectively)and advanced tumor,node,metastasis(TNM)classification(P=0.001 and P=0.01,respectively).Higher MVD was observed in the group expressing higher levels of HIF-1αand VEGF-C(P=0.033 and P=0.037,respectively).Univariate analysis showed shorter survival time in patients expressing higher levels of HIF-1αand VEGF-C.HIF-1αwas also found to be an independent prognostic factor of overall survival in multivariate analysis.The results suggest that HIF-1αmay affect VEGF-C expression,thus acting as a crucial regulator of lymphangiogenesis and angiogenesis in breast cancer.This study highlights promising potential of HIF-1αas a therapeutic target against tumor lymph node metastasis. | Xiaojian Ni Yingchun Zhao Jingjing Ma Tiansong Xia Xiaoan Liu Qiang Ding Xiaoming Zha Shui Wang | 2013 | The Journal of Biomedical Research2013，27，6： | 10 |
| 14 | Antimicrobial susceptibility of Gram-negative bacteria causing intra-abdominal infections in China: SMART China 2011显示文摘 | Zhang Hui Yang Qiwen Xiao Meng Chen Minjun Robert E. Badal Xu Yingchun | 2014 | Chinese Medical Journal2014，，13： | 10 |
| 15 | Roof pre-blasting to prevent support crushing and water inrush accidents显示文摘Support crushing and water inrush when mining under an unconsolidated confined aquifer in the Qidong Coal Mine was prevented by roof pre-blasting. The mechanism and applicable conditions for this method have been studied. The results show that when an overburden structure that may cause support crushing and a water inrush accident exists the weakening of the primary key stratum, which thereby reduces its weighting step, roof pre-blasting is both feasible and effective. If the position of the primary key stratum can be moved upward to exceed 10 times the mining height the possibility of support crushing and water inrush disaster caused by key stratum compound breakage will be lowered. The overburden structure of the number 7121 working face was considered during the design of a technical proposal involving roof pre-blasting. After comprehensively analyzing the applicability of roof pre-blasting the resulting design prevented support crushing and water inrush disasters from happening at the number 7121 working face and laid a solid foundation for mining safely. | Wang Xiaozhen | 2012 | International Journal of Mining Science and Technology2012，22，3： | 10 |
| 16 | Progress in modifications and applications of fluorescent dye probe显示文摘This review summarizes the labeling technology and applications of fluorescent dye probe in biology,especially the characteristics,modification and applications of cyanine dyes.Based on the currently available modification methods of fluorescent dye probe,we discuss the studies of enhancing the water-solubility,improving the degree of biocompatibility and target-labeling,increasing the sensitivity and decreasing the toxicity of fluorescent dye.We also give a brief introduction on the modification method,that the fluorescent dye is directly introduced onto the cell surfaces by amine derivatives or azides to intensify the transferring information of aberrant cells.We suggest that fluorescent dye modified with chitosan oligosaccharide can obviously increase the degree of biocompatibility and target-labeling,and decrease the degree of toxicity. | Xuening Fei,Yingchun Gu Department of Material Science and Engineering,Tianjin Institute of Urban Construction,Tianjin 300384,China | 2009 | Progress in Natural Science:Materials International2009，19，1： | 9 |
| 17 | Hybrid electromagnetic-triboelectric nanogenerator for harvesting vibration energy显示文摘 | Ting Quan Yingchun Wu Ya Yang | 2015 | Nano Research2015，8，10： | 9 |
| 18 | A Model Output Machine Learning Method for Grid Temperature Forecasts in the Beijing Area显示文摘In this paper, the model output machine learning (MOML) method is proposed for simulating weather consultation, which can improve the forecast results of numerical weather prediction (NWP). During weather consultation, the forecasters obtain the final results by combining the observations with the NWP results and giving opinions based on their experience. It is obvious that using a suitable post-processing algorithm for simulating weather consultation is an interesting and important topic. MOML is a post-processing method based on machine learning, which matches NWP forecasts against observations through a regression function. By adopting different feature engineering of datasets and training periods, the observational and model data can be processed into the corresponding training set and test set. The MOML regression function uses an existing machine learning algorithm with the processed dataset to revise the output of NWP models combined with the observations, so as to improve the results of weather forecasts. To test the new approach for grid temperature forecasts, the 2-m surface air temperature in the Beijing area from the ECMWF model is used. MOML with different feature engineering is compared against the ECMWF model and modified model output statistics (MOS) method. MOML shows a better numerical performance than the ECMWF model and MOS, especially for winter. The results of MOML with a linear algorithm, running training period, and dataset using spatial interpolation ideas, are better than others when the forecast time is within a few days. The results of MOML with the Random Forest algorithm, year-round training period, and dataset containing surrounding gridpoint information, are better when the forecast time is longer. | Haochen LI Chen YU Jiangjiang XIA Yingchun WANG Jiang ZHU Pingwen ZHANG | 2019 | Advances in Atmospheric Sciences2019，36，10： | 9 |
| 19 | Downward continuation of airborne geomagnetic data based on two iterative regularization methods in the frequency domain显示文摘Downward continuation is a key step in processing airborne geomagnetic data. However,downward continuation is a typically ill-posed problem because its computation is unstable; thus, regularization methods are needed to realize effective continuation. According to the Poisson integral plane approximate relationship between observation and continuation data, the computation formulae combined with the fast Fourier transform(FFT)algorithm are transformed to a frequency domain for accelerating the computational speed. The iterative Tikhonov regularization method and the iterative Landweber regularization method are used in this paper to overcome instability and improve the precision of the results. The availability of these two iterative regularization methods in the frequency domain is validated by simulated geomagnetic data, and the continuation results show good precision. | Liu Xiaogang Li Yingchun Xiao Yun Guan Bin | 2015 | Geodesy and Geodynamics2015，6，1： | 8 |
| 20 | The effect of cdk-5 overexpression on tau phosphorylation and spatial memory of rat显示文摘In Alzheimer抯 disease (AD), hyperphosphorylation of tau may be the underlying mechanism for the cytoskeletal abnormalities and neuronal death. It was reported that cy-clin-dependent kinase5 (cdk-5) could phosphorylate tau at most AD-related epitopes in vitro. In this study, we investigated the effect of cdk-5 overexpression on tau phosphorylation and spatial memory in rat. We demonstrated that 24 h after transfection into rat hippocampus, cdk-5 was overexpressed and induced a reduced staining with antibody tau-1 and an enhanced staining with antibodies 12e8 and PHF-1, suggesting hyperphosphorylation of tau at Ser199/202, Ser262/356 and Ser396/404 sites. Additionally, the cdk-5 transfected rats showed long latency to find the hidden platform in Morris water maze compared to the control rat. 48 h after transfection, the level of cdk-5 was decreased significantly, and the latency of rats to find the hidden platform was prolonged. It implies that in vivo overexpression of cdk-5 leads to impairment of spatial memory in rat and tau hyperphosphorylation may be the underlying mechanism. | LIAO Xiaomei ZHANG Yingchun WANG Yipeng WANG Jianzhi | 2004 | Science China(Life Sciences)2004，47，3： | 8 |
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