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| 1 | Hepatic stem cells: existence and origin显示文摘Stem cells are not only units of biological organization,responsible for the development and the regeneration oftissue and organ systems, but also are units in evolution bynatural selection. It is accepted that there is stem cellpotential in the liver. Like most organs in a healthy adult,the liver maintains a perfect balance between cell gain andloss. It has three levels of cells that can respond to loss ofhepatocytes: (1) Mature hepatocytes, which proliferate afternormal liver tissue renewal, less severe liver damage, etc;they are numerous, unipotent, 'committed' and respondrapidly to liver injury. (2) Oval cells, which are activated toproliferate when the liver damage is extensive and chronic,or if proliferation of hepatocytes is inhibited; they lie withinor immediately adjacent tothe canal of Hering (CoH); theyare less numerous, bipotent and respond by longer, but stilllimited proliferation. (3) Exogenous liver stem cells, whichmay derive from circulating hematopoietic stem cells (HSCs)or bone marrow stem cells; they respond to allyl alcoholinjury or hepatocarcinogenesis; they are multipotent, rare,but have a very long proliferation potential. They make amore significant contribution to regeneration, and evencompletely restore normal function in a murine model ofhereditary tyrosinaemia. How these three stem cellpopulations integrate to achieve a homeostatic balanceremains enigmatic. This review focuses on the location,activation, markers of the three candidates of liver stemcell, and the most importantly, therapeutic potential ofhepatic stem cells. | YingZhang Xue-FanBai Chang-XingHuang | 2003 | World Journal of Gastroenterology2003，9，2： | 25 |
| 2 | A novel class of tRNA-derived small RNAs extremely en- riched in mature mouse sperm显示文摘 | HongyingPeng JunchaoShi YingZhang HeZhang ShangyingLiao WeiLi LiLei ChunshengHan LinaNing YujingCao QiZhou QiChen EnkuiDuan | 2012 | Cell Research2012，22，11： | 20 |
| 3 | Evodiamine induces tumor cell death through different pathways: apoptosis and necrosis显示文摘AIM: To study the different death pathways in human cervical cancer HeLa and melanoma A375-S2 cells initiated by evodiamine. METHODS: Viability of evodiamine-induced HeLa and A375-S2 cells was measured by MTT assay. Apoptotic cells with condensed or fragmented nuclei were visualized by Hoechst 33258 staining. Nucleosomal DNA fragmentation was assayed by agarose gel electrophoresis. Proportion of cell death through apoptotic and necrotic pathways was determined by LDH activity-based cytotoxicity assays. Cell cycle distribution was observed by flow cytometry. RESULTS: Evodiamine induced HeLa and A375-S2 cell death dose- and time-dependently.Caspase-3 and -8 were activated in apoptosis induced by evodiamine 15 μmol/L. However, over 24- h incubation of A375-S2 cells, evodiamine 15 μmol/L initiated necrosis related to p38 and ERK (extracellular signal-regulated kinases)activities. Evodiamine-induced HeLa cell death was preceded by an accumulation of cells at the G2/M phase of the cell cycle, but there was no significant effect of evodiamine on A375-S2 cell cycle. CONCLUSION: Evodiamineinduces caspase-3,8-dependent apoptosis in HeLa cells which is related to G2/M arrest of the cell cycle. On the other hand, in A375-S2 cells, evodiamine initiates caspase-3,8-mediated apoptosis at early stages and the induction of MAPK-mediated necrosis at later stages of cell culture. | YingZHANG Li-junWU Shin-ichiTASHIRO SatoshiONODERA TakashiIKEJIMA | 2004 | Acta Pharmacologica Sinica2004，25，1： | 17 |
| 4 | NO and H_2O_2 induced by Verticillium dahliae toxins and its influence on the expression of GST gene in cotton suspension cells显示文摘Nitric oxide (NO) and hydrogen peroxide (H2O2) have been shown to be important signaling molecules that participate in the regulation of several physiological processes. In particular, they have significant role in plant resistance to pathogens by contributing to induction defense genes. Here, whether NO and H2O2 participate in the resistance responses against Verticillium dahliae toxins (VD-toxins) and their effects on the expression of GST gene are studied. The results reveal that NO and H2O2 are produced as part of a complex network of signals that respond to VD-toxins and may converge to function both synergistically and independently by inducing resistant responses. GST gene is potentially involved in the resistance mechanism in the cotton suspension cells. NO induces the expression of GST gene independently of H2O2. H2O2 may be a more potent signal in the resistance responses against VD-toxins. | JIA ZhiQi YUAN HaiYong Li YingZhang | 2007 | Chinese Science Bulletin2007，52，10： | 4 |
| 5 | External Approach Microsurgery of Retinal Dialysis显示文摘Purpose: To explore the effect of external approach microsurgery in retinal dialysis.Methods: Consecutive 30 eyes of 28 patients with retinal dialysis were enrolled for this study. The progresses of the external approach microsurgery were following. Under the surgical microscopy, the preplacement of mattress sutures for buckling and/or encircling following retrobulbar anesthesia and scleral exposure, draining subretinal fluid, the cryotherapy of retinal breaks, checking the position of breaks on scleral buckle and gases injection were performed in turn.Results: After drainage of subretinal fluid, with scleral depression cryotherapy reaction around breaks could be observed clearly under the microscopy. All breaks were located on anterior slope of the buckle. Intraoperative complications were mild subretinal hemorrhage at drainage site and corneal epithelium exfoliation in 3 eyes, respectively.Postoperative complications were mainly secondary glaucoma and retinal redetachment.The one-operation reattachmentl rate was 96.7% (29 eyes), and the final reattachment rate was 100% after one eye had a second external approach microsurgery. The postoperative vision acuity (VA) was significantly better than the preoperative VA (X2=9.529, P< 0.01).Conclusion: External approach microsurgery has favourable effect on the surgery of retinal dialysis. | YingZhang PiqingHu LixinShun XuechunZhu YingwuYi WenLiu | 2005 | Eye Science2005，21，1： | 3 |
| 6 | Optimization model of truck flow at open-pit mines and standards for feasibility test显示文摘In order to increase production efficiency at open-pit mines, on the basis of linear programming, a practical mathematical model for optimizing truck flow was developed, which improved the traditional fixed manual schedule method. The model has advantages from linear programming and objective programming, makes most handling points working at full capacity and keeps an optimized ratio between trucks and excavators. For ensuring feasibility of the model in practical production, four standards for feasibility test were proposed. The model satisfied all the standards. The application in a large scale open-pit iron mine indicated that the model reduced the number of required trucks by 10% compared with the fixed manual schedule method. | YingZhang YongZhao QiweiLu WenliXu | 2004 | Journal of University of Science and Technology Beijing2004，11，5： | 2 |
| 7 | AT_1 receptor in rostral ventrolateral medulla mediating blunted baroreceptor reflex in spontaneously hypertensive rats显示文摘AIM: To determine the role of AT1 receptor in the rostral ventrolateral medulla (RVLM) in mediating the blunted baroreceptor reflex in spontaneously hypertensive rats (SHR). METHODS: Intravenous injections of graded doses of phenylephrine (1, 5, 10, 20, and 40μg/kg) increased the blood pressure to elicit the baroreceptor reflex in both SHR and normotensive Wistar rats anesthetized with urethane. The baroreceptor reflex sensitivity (BRS) was determined before and after microinjection of Ang II, losartan, or AT1 receptor antisense oligodeoxynucleotides into the RVLM. AT1 receptor protein level in the RVLM was measured by Western blotting. RESULTS: The BRS was significantly decreased in SHR compared with normal rats. Bilateral microinjection of AT~ receptor antagonist losartan (250 nmol/h) into the RVLM partly reversed the blunted BRS in SHR, but had no significant effect on the BRS in normal rats. Ang II (1.5 nmol/h) significantly inhibited the BRS in normal rats, which was completely abolished by pretreatment with losartan. However, no significant change in the BRS was observed after microinjection of Ang Ⅱ into the RVLM in SHR. Bilateral microinjection of AT1 receptor antisense oligodeoxynucleotides (ASODN) into the RVLM partially recovered the blunted BRS in SHR after 3 h, but no significant change in the BRS was observed in normal rats. The AT1 receptor protein level significantly decreased after administration of ASODN. CONCLUSION: Blockage of AT1 receptor or inhibition of AT1 receptor protein synthesis in the RVLM enhanced the BRS in SHR, suggesting that the enhanced activities of AT1 receptor in the RVLM contribute to the blunted BRS in SHR. | Xin-yaGAO FengZHANG YingHAN Han-junWANG YingZHANG RuiGUO Guo-qingZHU | 2004 | Acta Pharmacologica Sinica2004，25，11： | 2 |
| 8 | Metformin improves cardiac function in rats via activation of AMP‐activated protein kinase显示文摘 | Xiao‐FangWang Jin‐YingZhang LingLi Xiao‐YanZhao Hai‐LongTao LiZhang | 2011 | Clinical and Experimental Pharmacology and Physiology2011，，2： | 2 |
| 9 | Transumbilical endoscopic surgery (TUES): another option towards scarless abdominal surgery显示文摘 | Fanzhu J Yingzhang M Jinling Y et aI | 2008 | Medigraphic2008，9，： | 1 |
| 10 | Effect of extracts of Chinese pine on its own seed germination and seedling growth显示文摘 | Zhu Meiqiu Ma Changming Wang Yingzhang | 2009 | Frontiers of Agriculture in China2009，3，3： | 1 |
| 11 | Preferential humoral immune response in prostate cancer to cellular proteins p90 and p62 in a panel of tumor‐associated antigens显示文摘 | Fu‐DongShi Jian‐YingZhang DaorongLiu AnnRearden MaxElliot DanNachtsheim TracyDaniels Carlos A.Casiano Mary JoHeeb Edward K.L.Chan Eng M.Tan | 2005 | Prostate2005，，3： | 1 |
| 12 | StudyonconstituentsofCitrusmedica显示文摘 | YingZhang LingyiKong | 2006 | ZhongguoXiandaiZhongyao2006，8，6： | 1 |
| 13 | Transumbilical endoscopic surgery: a preliminary, clinical report显示文摘 | ZHU Jiangfan HU Hai MA Yingzhang | 2009 | Surg Endosc2009，23，4： | 1 |
| 14 | Totally transumbilical endoscopic cholecystectomy without visible abdominal scar using improved instruments显示文摘 | ZHU Jiangfan HU Hai MA Yingzhang | 2009 | Surg Endosc2009，23，8： | 1 |
| 15 | Synthesis and properties of optically clear silicone resin/epoxy resin hybrids显示文摘 | YingZhang XinYang XiaojuanZhao WeiHuang | 2012 | Polym. Int2012，，2： | 1 |
| 16 | Domain 5 of high molecular weight kininogen (kininostatin) down-regulates endothelial cell proliferation and migration and inhibits angiogenesis显示文摘 | Robert WC Bradford AJ Yingzhang L | 2000 | Blood2000，95，： | 1 |
| 17 | Domain 5 of high molecular weight kininogen (kininostatin) down-regulates endothelial cell proliferation and migration and inhibits angiogenesis显示文摘 | Robert WC Bradford AJ Yingzhang L | 2000 | Blood2000，95，： | 1 |
| 18 | Developing a holistic model for digital library evaluation显示文摘 | YingZhang | 2009 | J Am Soc Inf Sci2009，，1： | 1 |
| 19 | PD‐1 negatively regulates interleukin‐12 expression by limiting STAT‐1 phosphorylation in monocytes/macrophages duringchronic hepatitis C virus infection显示文摘 | Cheng J.Ma LeiNi YingZhang C.L.Zhang Xiao Y.Wu Antwan N.Atia PennyThayer Jonathan P.Moorman Zhi Q.Yao | 2011 | Immunology2011，，3： | 1 |
| 20 | Influence of Trace Amount of Calponin on Smooth Muscle Myosin in Different States显示文摘Calponin (CaP), a thin filament-associated protein, is thought to be involved in modulating smooth muscle contractile activity, but the role and mechanism keep unknown. In this study, trace amount of calponin (TAC) was found to obviously influence myosin in different states in Ca2+-independent manner, suggesting a high efficient interaction between TAC and myosin. In this assay, the lowest ratio of CaP vs. myosin was 1:10,000, with the concentration of CaP 10,000-fold lower than that used previously. Myosin phosphorylation, myosin Mg2+-ATPase activity and protein binding activity were detected to determine the effects of TAC on the myosin in different states. The amount of precipitated myosin that bound to TAC was used as the index to determine the interaction between myosin and TAC in binding assay. Our data showed that in the absence of actin, TAC significantly increased the precipitation of unphosphorylated myosin, Ca2+- dependently or independently phosphorylated myosin by MLCK, and stimulated the Mg2+-ATPase activities of these myosins slightly but significantly. However, no obvious change of precipitation of myosin phospho- rylated by PKA was observed, indicating the relatively selective effect of TAC. In the presence of actin, the increase of myosin precipitations was abolished, and no obvious change of actin precipitations and actin- activated myosin Mg2+-ATPase activities were observed implicating the high efficiency of TAC on myosin being present in the absence of actin. Although we can not give conclusive comments to our results, we propose that the high efficiency of TAC-myosin interaction is present when actin is dissociated from myosin, even if CaP/myosin ratio is very low; this high efficient interaction can be abolished by actin. However, why and how TAC can possess such a high efficiency to influence myosin and how the physiological significance of the high efficiency of TAC is in regulating the interaction between myosin and actin remain to be investigated. | Jing-XianYANG Xiao-HuaFENG YingZHANG YuanLIN | 2004 | Acta Biochimica et Biophysica Sinica2004，36，8： | 1 |
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