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| 1 | Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2显示文摘Emerging and re-emerging RNA viruses occasionally cause epidemics and pandemics worldwide,such as the on-going outbreak of the novel coronavirus SARS-CoV-2.Herein,we identified two potent inhibitors of human DHODH,S312 and S416,with favorable drug-likeness and pharmacokinetic profiles,which all showed broad-spectrum antiviral effects against various RNA viruses,including influenza A virus,Zika virus,Ebola virus,and particularly against SARS-CoV-2.Notably,S416 is reported to be the most potent inhibitor so far with an EC5o of 17 nmol/L and an SI value of 10,505.88 in infec-ted cells.Our results are the first to validate that DHODH is an attractive host target through high antiviral efficacy in vivo and low virus replication in DHODH knock-out cells.This work demonstrates that both S312/S416 and old drugs(Leflunomide/Teriflunomide)with dual actions of antiviral and immuno-regulation may have clinical potentials to cure SARS-CoV-2 or other RNA viruses circulating worldwide,no matter such viruses are mutated or not. | Rui Xiong Leike Zhang Shiliang Li Yuan Sun Minyi Ding Yong Wang Yongliang Zhao Yan Wu Weijuan Shang Xiaming Jiang Jiwei Shan Zihao Shen Yi Tong Liuxin Xu Yu Chen Yingle Liu Gang Zou Dimitri Lavillete Zhenjiang Zhao Rui Wang Lili Zhu Gengfu Xiao Ke Lan Honglin Li Ke Xu | 2020 | Protein & Cell2020，11，10： | 14 |
| 2 | MimicCloudSim:An Environment for Modeling and Simulation of Mimic Cloud Service显示文摘In recent years,an increasing number of application services are deployed in the cloud.However,the cloud platform faces unknown security threats brought by its unknown vulnerabilities and backdoors.Many researchers have studied the Cyber Mimic Defense(CMD)technologies of the cloud services.However,there is a shortage of tools that enable researchers to evaluate their newly proposed cloud service CMD mechanisms,such as scheduling and decision mechanisms.To fill this gap,we propose MimicCloudSim as a mimic cloud service simulation system based on the basic functionalities of CloudSim.MimicCloudSim supports the simulation of dynamic heterogeneous redundancy(DHR)structure which is the core architecture of CMD technology,and provides an extensible interface to help researchers implement new scheduling and decision mechanisms.In this paper,we firstly describes the architecture and implementation of MimicCloudSim,and then discusses the simulation process.Finally,we demonstrate the capabilities of MimicCloudSim by using a decision mechanism.In addition,we tested the performance of MimicCloudSim,the conclusion shows that MimicCloudSim is highly scalable. | Liming Pu Jiangxing Wu Hailong Ma Yuhang Zhu Yingle Li | 2021 | China Communications2021，18，1： | 2 |
| 3 | Thermal stability of epoxy resins containing flame retardant components : an evaluation with thermogravimetric analysis 显示文摘 | Wu Chuanshao Liu Yingling Chiu Yiechan | 2002 | Polym Degrad Stab2002，78，1： | 1 |
| 4 | Influence of highspeed dielectric spherical particles movement on its scattering characteristics 显示文摘 | WANG Mingjun WU Zhensen LI Yingle | 2007 | Chinese Optics Letters2007，5，4： | 1 |
| 5 | Thermal stability of epoxy resins containing flame retardant components:an evaluation with thermogravimetric analysis显示文摘 | Wu Chuanshao Liu Yingling Chiu Yiechan | | 0，，01： | 1 |
| 6 | The X protein of hepatitis B virus activates hepatoma cell proliferation through repressing melanoma inhibitory activity 2 gene显示文摘 | Yilin Xu Yang Yang Yanyan Cai Fang Liu Yingle Liu Ying Zhu Jianguo Wu | 2011 | Biochemical and Biophysical Research Communications2011，，3： | 1 |
| 7 | One-pot synthesis of linear and branched poly(amide aspartimide)s with goodsolubility in organic solvents显示文摘 | Wu Chuanshao TSAI S H Liu Yingling | 2005 | Journal of Polymer Science: Part A Polymer Chemistry2005，43，9： | 1 |
| 8 | Prepartion of silicon-/ phosphorus-containing epoxy resins from the fusion process to bring a synergistic effect on improving the resins thermal stability and flame retardancy显示文摘 | Yingling Liu Yiechan Chiu Chuanshao Wu | 2003 | Journal of Applied Polymer Science2003，87，： | 1 |
| 9 | Preparation of phosphorous-containing poly (epichlorohydrin) and polyuret hane from a novel synthesis route 显示文摘 | Chuan shao Wu Yingling Liu Yieshun Chiu | 2002 | Journal of Applied Polymer Science2002，85，： | 1 |
| 10 | Flame-retardant epoxy resins from O-cresol novolae epoxy cured with a phosphorus-containing aralkyl novolac 显示文摘 | Yingling Liu Chuanshao Wu Keh Ying Hsu | 2002 | Journal of Polymer Science: Part A Polymer Chemistry2002，40，： | 1 |
| 11 | Thermal stability of epoxy resins containing flame retardant components:an evaluation with thermogravimetric analysis显示文摘 | Wu Chuanshao Liu Yingling Chiu Yiechan | | 0，，01： | 1 |
| 12 | Preparation,Thermal Properties,and Flame Retardance of Epoxy-silica Hybrid Resins显示文摘 | Liu Yingling Wu Chuanshao | | 0，，： | 1 |
| 13 | Preparation of phosphorus-containing pol(epichlorohydrin)and polyurethane显示文摘 | Wu Chuanshao liu Yingling Chiu Yieshun | 2002 | Journal of Application polymer science2002，85，10： | 1 |
| 14 | Preparation of silicon- / phosphorous-containing epoxy resins from the fusion process to bring a synergistic effect on improving the resins' thermal stability and flame retardancy显示文摘 | Liu Yingling Chiu Yiechan Wu Chuanshao | 2003 | J Appl Polym Sci2003，87，3： | 1 |
| 15 | Correction to:Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2显示文摘CORRECTION TO:PROTEIN CELL 2020,11(10):723–739 http://gffzzd3cc09b8251d45dfoxu9cnx55qq6b6co5.ffgz.tsg.suse.edu.cn/10.1007/S13238-020-00768-W In the original publication the author’s name‘Dimitri Lavillete’is published incorrectly.The correct author name should be spelt as‘Dimitri Lavillette’is provided in this correction.OPEN ACCESS This article is licensed under a Creative Commons Attribution 4.0 International License,which permits use,sharing,adaptation,distribution and reproduction in any medium or format,as long as you give appropriate credit to the original author(s)and the source,provide a link to the Creative Commons licence,and indicate if changes were made.The images or other third party material in this article are included in the article's Creative Commons licence,unless indicated otherwise in a credit line to the material.If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use,you will need to obtain permission directly from the copyright holder.To view a copy of this licence,visit http://gffzzeb6f7f563f66445dhxu9cnx55qq6b6co5.ffgz.tsg.suse.edu.cn/licenses/by/4.0/. | Rui Xiong Leike Zhang Shiliang Li Yuan Sun Minyi Ding Yong Wang Yongliang Zhao Yan Wu Weijuan Shang Xiaming Jiang Jiwei Shan Zihao Shen Yi Tong Liuxin Xu Yu Chen Yingle Liu Gang Zou Dimitri Lavillette Zhenjiang Zhao Rui Wang Lili Zhu Gengfu Xiao Ke Lan Honglin Li Ke Xu | 2022 | Protein & Cell2022，13，10： | 0 |
| 16 | Correction to: Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2显示文摘Figure 1.Discovery of novel and potent DHODHi and their anti-influenza A virus activities.(A)The discovery and design of S312 and S416.The detailed descriptions of the discovery workflow are in Method.Binding analysis of S312(B)and S416(C).Thermodynamic analysis of the binding of S312 and S416 to DHODH was carried out at 25 C on a MicroCal iTC200 instrument.Kinetic analysis of the binding of S312 and S416 to DHODH was performed with a Biacore T200 instrument. | Rui Xiong Leike Zhang Shiliang Li Yuan Sun Minyi Ding Yong Wang Yongliang Zhao Yan Wu Weijuan Shang Xiaming Jiang Jiwei Shan Zihao Shen Yi Tong Liuxin Xu Yu Chen Yingle Liu Gang Zou Dimitri Lavillete Zhenjiang Zhao Rui Wang Lili Zhu Gengfu Xiao Ke Lan Honglin Li Ke Xu | 2021 | Protein & Cell2021，12，1： | 0 |
| 17 | Camellia sinensis CsMYB4a participates in regulation of stamen growth by interaction with auxin signaling transduction repressor CsAUX/IAA4显示文摘Subgroup 4(Sg4)members of the R2R3-MYB are generally known as negative regulators of the phenylpropanoid pathway in plants.Our previous research showed that a R2R3-MYB Sg4 member from Camellia sinensis(CsMYB4a)inhibits expression of some genes in the phenylpropanoid pathway,but its physiological function in the tea plant remained unknown.Here,CsMYB4a was found to be highly expressed in anther and filaments,and participated in regulating filament growth.Transcriptome analysis and exogenous auxin treatment showed that the target of CsMYB4a might be the auxin signal pathway.Auxin/indole-3-acetic acid 4(AUX/IAA4),a repressor in auxin signal transduction,was detected from a yeast two-hybrid screen using CsMYB4a as bait.Gene silencing assays showed that both CsIAA4 and CsMYB4a regulate filament growth.Tobacco plants overexpressing CsIAA4 were insensitive to exogenous a-NAA,consistent with overexpression of CsMYB4a.Protein-protein interaction experiments revealed that CsMYB4a interacts with N-terminal of CsIAA4 to prevent CsIAA4 degradation.Knock out of the endogenous NtIAA4 gene,a CsIAA4 homolog,in tobacco alleviated filament growth inhibition and a-NAA insensitivity in plants overexpressing CsMYB4a.All results strongly suggest that CsMYB4a works synergistically with CsIAA4 and participates in regulation of the auxin pathway in stamen. | Guoliang Ma Mingzhuo Li Yingling Wu Changjuan Jiang Yifan Chen Dawei Xing Yue Zhao Yajun Liu Xiaolan Jiang Tao Xia Liping Gao | 2024 | The Crop Journal2024，12，1： | 0 |
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