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| 1 | Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2显示文摘Emerging and re-emerging RNA viruses occasionally cause epidemics and pandemics worldwide,such as the on-going outbreak of the novel coronavirus SARS-CoV-2.Herein,we identified two potent inhibitors of human DHODH,S312 and S416,with favorable drug-likeness and pharmacokinetic profiles,which all showed broad-spectrum antiviral effects against various RNA viruses,including influenza A virus,Zika virus,Ebola virus,and particularly against SARS-CoV-2.Notably,S416 is reported to be the most potent inhibitor so far with an EC5o of 17 nmol/L and an SI value of 10,505.88 in infec-ted cells.Our results are the first to validate that DHODH is an attractive host target through high antiviral efficacy in vivo and low virus replication in DHODH knock-out cells.This work demonstrates that both S312/S416 and old drugs(Leflunomide/Teriflunomide)with dual actions of antiviral and immuno-regulation may have clinical potentials to cure SARS-CoV-2 or other RNA viruses circulating worldwide,no matter such viruses are mutated or not. | Rui Xiong Leike Zhang Shiliang Li Yuan Sun Minyi Ding Yong Wang Yongliang Zhao Yan Wu Weijuan Shang Xiaming Jiang Jiwei Shan Zihao Shen Yi Tong Liuxin Xu Yu Chen Yingle Liu Gang Zou Dimitri Lavillete Zhenjiang Zhao Rui Wang Lili Zhu Gengfu Xiao Ke Lan Honglin Li Ke Xu | 2020 | Protein & Cell2020，11，10： | 14 |
| 2 | Antibody neutralization to SARS-CoV-2 and variants after 1 year in Wuhan,China显示文摘Most COVID-19 convalescents can build effective anti-SARS-CoV-2 humoral immunity,but it remains unclear how long it can maintain and how efficiently it can prevent the reinfection of the emerging SARS-CoV-2 variants.Here,we tested the sera from 248 COVID-19 convalescents around 1 year post-infection in Wuhan,the earliest known epicenter.SARS-CoV-2 immunoglobulin G(IgG)was well maintained in most patients and potently neutralizes the infection of the original strain and the B.1.1.7 variant.However,varying degrees of immune escape was observed on the other tested variants in a patient-specific manner,with individuals showing remarkably broad neutralization potency.The immune escape can be largely attributed to several critical spike mutations.These results suggest that SARS-CoV-2 can elicit long-lasting immunity but this is escaped by the emerging variants. | Qianyun Liu Qing Xiong Fanghua Mei Chengbao Ma Zhen Zhang Bing Hu Junqiang Xu Yongzhong Jiang Faxian Zhan Suhua Zhou Li Tao Xianying Chen Ming Guo Xin Wang Yaohui Fang Shu Shen Yingle Liu Fang Liu Li Zhou Ke Xu Changwen Ke Fei Deng Kun Cai Huan Yan Yu Chen Ke Lan | 2022 | The Innovation2022，3，1： | 3 |
| 3 | Chitosansilica complex membranes from sulfonic acid functionalized silica nanoparticles for pervaporation dehydration of ethanol-water solutions显示文摘 | Liu Yingling Hsu Chihyuan Su Yuhuei | | 0，，01： | 1 |
| 4 | Functionalization of multi-walled carbon nanotubes with furan and maleimide com-pounds through diels-alder cycloaddition显示文摘 | CHANG C M LIU Yingling | 2009 | Carbon2009，47，13： | 1 |
| 5 | Electrical conductivity enhancement of polymer/multiwalled carbon nanotube (MWC-NT) composites by thermally-induced defunctionalization of MWCNTs显示文摘 | CHANG C M LIU Yingling | 2011 | ACS Appl Mater Interfaces2011，3，7： | 1 |
| 6 | Preparation and thermal properties of epoxysilica and nanocomposites from nanoscale colloidal silica显示文摘 | Liu Yingling | 2003 | Polymer2003，44，18： | 1 |
| 7 | Thermal stability of epoxy resins containing flame retardant components : an evaluation with thermogravimetric analysis 显示文摘 | Wu Chuanshao Liu Yingling Chiu Yiechan | 2002 | Polym Degrad Stab2002，78，1： | 1 |
| 8 | Role of cetyltrimethyl ammonium bromide,crystal violet and humic acid in the degradation of diclofenac under simulated sunlight irradiation显示文摘The photodegradation of diclofenac in the absence/presence of cetyltrimethyl ammonium bromide,crystal violet and humic acid under simulated sunlight has been studied.Under the study conditions,it is apparent that cetyltrimethyl ammonium bromide and crystal violet concentrations inhibit effects on the photodegradation of diclofenac.Humic acid has no distinct effect on the photodegradation of diclofenac.Crystal violet has an obvious antagonistic action for humic acid and a similar antagonistic action between cetyltrimethyl ammonium bromide and crystal violet.Cetyltrimethyl ammonium bromide and humic acid have synergistic effect.An antagonistic action is present between cetyltrimethyl ammonium bromide,crystal violet and humic acid.Moreover,a simple linear model which describes the obtained results is shown. | ZHANG Nan LIU HaiJin LIU GuoGuang WANG YingLing LI Tong WANG Gang | 2012 | Science China Chemistry2012，55，12： | 1 |
| 9 | Thermal stability of epoxy resins containing flame retardant components:an evaluation with thermogravimetric analysis显示文摘 | Wu Chuanshao Liu Yingling Chiu Yiechan | | 0，，01： | 1 |
| 10 | HIFI~ regulated expression o显示文摘 | Liu Y Bernauer AM Yingling CM | 2012 | Carcinogenesis2012，33，11： | 1 |
| 11 | The X protein of hepatitis B virus activates hepatoma cell proliferation through repressing melanoma inhibitory activity 2 gene显示文摘 | Yilin Xu Yang Yang Yanyan Cai Fang Liu Yingle Liu Ying Zhu Jianguo Wu | 2011 | Biochemical and Biophysical Research Communications2011，，3： | 1 |
| 12 | Crosslinked epoxy materials exhibiting thermal remendablility and removability from multi-functional maleimide and furan compounds显示文摘 | Liu Yingling Hsieh C Y | 2006 | Journal of Polymer Science Part A: Polymer Chemistry2006，44，2： | 1 |
| 13 | 显示文摘 | Liu Yingling Feng Dexiong Yang Peihui | 2000 | Rare Metals2000，19，4： | 1 |
| 14 | Modification of Multiwall Carbon Nanotubes with Initiators and Macroinitiators of Atom Transfer Radical Polymerization显示文摘 | Liu Yingling Chen Weihong | 2007 | Macromolecules2007，40，25： | 1 |
| 15 | One-pot synthesis of linear and branched poly(amide aspartimide)s with goodsolubility in organic solvents显示文摘 | Wu Chuanshao TSAI S H Liu Yingling | 2005 | Journal of Polymer Science: Part A Polymer Chemistry2005，43，9： | 1 |
| 16 | 显示文摘 | Liu Yingling Chiul Yiechan Chen Tsungyu | 2003 | Polym Int2003，52，： | 1 |
| 17 | Epoxy resins from novel monomers with a bis- (9,10-dihydro-9-oxa- 10-oxide- 10-phosphaphenanthrene- 10-yl-) substituent显示文摘 | Liu Yingling | 2002 | Journal of Polymer Science Part A: Polymer Chemistry2002，40，35： | 1 |
| 18 | Nogo-B mediates HeLa cell adhesion and motility through binding of Fibulin-5显示文摘 | Shumin Zhou Wei Xiao Qingwen Wan Changhua Yi Feifei Xiao Yingle Liu Yipeng Qi | 2010 | Biochemical and Biophysical Research Communications2010，，2： | 1 |
| 19 | Prepartion of silicon-/ phosphorus-containing epoxy resins from the fusion process to bring a synergistic effect on improving the resins thermal stability and flame retardancy显示文摘 | Yingling Liu Yiechan Chiu Chuanshao Wu | 2003 | Journal of Applied Polymer Science2003，87，： | 1 |
| 20 | Preparation of phosphorous-containing poly (epichlorohydrin) and polyuret hane from a novel synthesis route 显示文摘 | Chuan shao Wu Yingling Liu Yieshun Chiu | 2002 | Journal of Applied Polymer Science2002，85，： | 1 |
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