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| 1 | In vivo evaluation of urokinase-loaded hollow nanogels for sonothrombolysis on suture embolization-induced acute ischemic stroke rat model显示文摘The urokinase-type plasminogen activator(uPA)loaded hollow nanogels(nUK)were synthesized by a one-step reaction of glycol chitosan and aldehyde capped poly(ethylene oxide).The resultant formulation is sensitive to diagnostic ultrasound(US)of 2 MHz.Herein,we evaluated the in vivo sonothrombolysis performance of the nUK on acute ischemic stroke rat model which was established by suture embolization of middle cerebral artery(MCA).Via intravenous(i.v.)administration,the experimental data prove a controlled release of the therapeutic protein around the clots under ultrasound stimulation,leading to enhanced thrombolysis efficiency of the nUK,evidenced from smaller infarct volume and better clinical scores when compared to the i.v.dose of free uPA no matter with or without US intervention.Meanwhile,the preservation ability of the nanogels not only prolonged the circulation duration of the protein,but also resulted in the better blood-brain barrier protection of the nUK formulation,showing no increased risk on the hemorrhagic transformation than the controls.This work suggests that the nUK is a safe sonothrombolytic formulation for the treatment of acute ischemic stroke. | Yuming Teng Haiqiang Jin Ding Nan Mengnan Li Chenghe Fan Yuanyuan Liu Pu Lv Wei Cui Yongan Sun Hongjun Hao Xiaozhong Qu Zhenzhong Yang Yining Huang | 2018 | Bioactive Materials2018，3，1： | 7 |
| 2 | Characteristics of gas-solid micro fluidized beds for thermochemical reaction analysis显示文摘Fuel conversion and clean energy reaction systems involve a variety of catalytic and non-catalytic gas-solid thermochemical reactions.A good understanding of the correct reaction mechanism and kinetics,as well as the profiles of reaction products,is of great significance to the development,design,and operation of such reaction systems.The micro fluidized bed reaction analysis provides an efficient and reliable method to acquire this essential information with low capital and operating costs,low energy consumption and enhanced safety.This paper provides an overview of the system and its characteristics for the micro fluidized bed reaction analyzer that has been well proven to be a reliable new approach as well as an instrument for characterizing various gas-solid thermochemical reactions. | Zhennan Han Junrong Yue Xi Zeng Jian Yu Fang Wang Shaozeng Sun Hong Yao Guangqian Luo Xuejing Liu Yining Sun Fu Ding Liangliang Fu Lei Shi Kangjun Wang Jiebin Yang Shaonan Wang Xueqing Chen Dingrong Bai Guangwen Xu | 2020 | Carbon Resources Conversion2020，3，1： | 6 |
| 3 | Investigations into the relationship between deflection and crack mouth opening displacement of SFRC beam 显示文摘 | Ding Yining | 2011 | Construction and Building Materials2011，25，5： | 1 |
| 4 | Study on residual behavior and flexural toughness of fibre cocktail reinforced self compacting high performance concrete after exposure to high temperature 显示文摘 | DING Yining Azevedo Cecilia Aguiar J B Jalali Said | 2012 | Construction and Building Materials2012，26，1： | 1 |
| 5 | Comparative study of steel fiber-reinforced concrete and steel mesh-reinforced concrete at early ages in panel tests 显示文摘 | Ding Yining Kusterle W | 1999 | Cement and Concrete Research1999，29，11： | 1 |
| 6 | Hybrid fiber influence on strength and toughness of RC beams显示文摘 | Yining Ding Zhiguo You Said Jalali | 2009 | Composite Structures2009，，9： | 1 |
| 7 | An experimental study on the workability of self-compacting lightweight concrete显示文摘 | Zhimin Wu Yunguo Zhang Jianjun Zheng Yining Ding | 2008 | Construction and Building Materials2008，，5： | 1 |
| 8 | Comparative study of steel fibre-reinforced concrete and steel mesh-reinforced concrete at early ages in panel tests显示文摘 | Yining Ding Wolfgang Kusterle | 1999 | Cement and Concrete Research1999，29，： | 1 |
| 9 | The composite effect of steel fibers and stirrups on the shear of beams using self-consolidating concrete显示文摘 | Ding Yining You Ziguo Jalali S | 2011 | Engineering Structures2011，33，1： | 1 |
| 10 | Hybrid fiber influence on strength and toughness of RC beams 显示文摘 | Ding Yining You Zhiguo Jalali S | 2010 | Composite Structures2010，92，9： | 1 |
| 11 | The investi- gation on the workability of fibre cocktail reinforced self- compacting high performance concrete 显示文摘 | Ding Yining Liu Siguo Zhang Yulin | 2008 | Construction and Building Materials2008，22，7： | 1 |
| 12 | The composite effect of steel fibres and stirrups on the shear behaviour of beams using self-consolidating concrete显示文摘 | Ding Yining You Zhiguo Jalali S | 2011 | Engineering Struetmes2011，33，1： | 1 |
| 13 | Compressive stressstrain relationship of steel fibre-reinforced concrete at early age显示文摘 | DING Yining WOLFGANG Kusterle | 2000 | Cement and Concrete Research2000，30，： | 1 |
| 14 | Investigations into the Relationship between Deflection and Crack Mouth Opening Displacement of SFRC beam 显示文摘 | Ding Yining | 2011 | Construction and Building Materials2011，，25： | 1 |
| 15 | How does plant cell wall nanoscale architecture correlate with enzymatic digestibility 显示文摘 | Ding Shiyou Liu Yusan Zeng Yining | 2012 | Science2012，338，6110： | 1 |
| 16 | Experimen- tal investigation on the mechanical of the fibre reinforced high- performance concrete tunnel segment显示文摘 | DING Yining LIU Hekai FERNANDO T | 2011 | Composite Struc- tures2011，93，4： | 1 |
| 17 | The composite effect of steel fibers and stirrups on the shear of beams using self-con- solidating eoncrete显示文摘 | DING Yining YOU Ziguo ]ALALI S | 2011 | Engineering Structures2011，33，1： | 1 |
| 18 | Cilostazol as an alternative to aspirin after ischaemic stroke: a randomised, double-blind, pilot study显示文摘 | Yining Huang Yan Cheng Jiang Wu Yansheng Li En Xu Zhen Hong Zhengyi Li Weiwei Zhang Meiping Ding Xuguang Gao Dongsheng Fan Jinsheng Zeng Kasing Wong Chuanzhen Lu Jiangxi Xiao Chen Yao | 2008 | Lancet Neurology2008，，6： | 1 |
| 19 | Study on residual behaviour and flexural toughness of fiber cocktail reinforced self compacting high performance concrete after exposure to high temperature显示文摘 | Ding Yining | 2012 | Construction and Building Materials2012，，26： | 1 |
| 20 | Comparative study of steel fibrereinforced concrete and steel mesh-reinforced concrete at early ages in panel tests显示文摘 | Ding Yining Wolfgang Kusterle | 1999 | Cement and Concrete Research1999，，29： | 1 |
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