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| 1 | miR-145 improves metabolic inflammatory disease through multiple pathways显示文摘Chronic inflammation plays a pivotal role in insulin resistance and type 2 diabetes,yet the mechanisms are not completely understood.Here,we demonstrated that serum LPS levels were significantly higher in newly diagnosed diabetic patients than in normal control.miR-145 level in peripheral blood mononuclear cells decreased in type 2 diabetics.LPS repressed the transcription of miR-143/145 cluster and decreased miR-145 levels.Attenuation of miR-145 activity by anti-miR-145 triggered liver inflammation and increased serum chemokines in C57BL/6 J mice.Conversely,lentivirus-mediated miR-145 overexpression inhibited macrophage infiltration,reduced body weight,and improved glucose metabolism in db/db mice.And miR-145 overexpression markedly reduced plaque size in the aorta in ApoE−/−mice.Both OPG and KLF5 were targets of miR-145.miR-145 repressed cell proliferation and induced apoptosis partially by targeting OPG and KLF5.miR-145 also suppressed NF-κB activation by targeting OPG and KLF5.Our findings provide an association of the environment with the progress of metabolic disorders.Increasing miR-145 may be a new potential therapeutic strategy in preventing and treating metabolic diseases such as type 2 diabetes and atherosclerosis. | Min He Nan Wu Man Cheong Leong Weiwei Zhang Zi Ye Rumei Li Jinyang Huang Zhaoyun Zhang Lianxi Li Xiao Yao Wenbai Zhou Naijia Liu Zhihong Yang Xuehong Dong Yintao Li Lili Chen Qin Li Xuanchun Wang Jie Wen Xiaolong Zhao Bin Lu Yehong Yang Qinghua Wang Renming Hu | 2020 | Journal of Molecular Cell Biology2020，12，2： | 7 |
| 2 | Research on modeling of heat source for electron beam welding fusion-solidification zone显示文摘In this paper, the common heat source model of point and linear heat source in the numerical simulation of electron beam welding (EBW) were summarized and introduced. The combined point-linear heat source model was brought forward and to simulate the welding temperature fields of EBW and predicting the weld shape. The model parameters were put forward and regulated in the combined model, which included the ratio of point heat source to linear heat source Qpr and the distribution of linear heat source Lr. Based on the combined model, the welding temperature fields of EBW were investigated. The results show that the predicted weld shapes are conformable to those of the actual, the temperature fields are reasonable and correct by simulating with combined point-linear heat source model and the typical weld shapes are gained. | Wang Yajun Fu Pengfei Guan Yongjun Lu Zhijun Wei Yintao | 2013 | Chinese Journal of Aeronautics2013，26，1： | 3 |
| 3 | Formation and evolution of the tertiary carbonate reefs in the Madura Strait Basin of Indonesia显示文摘Analysis of 2 D seismic data over 4 500 km in length from the Madura Strait Basin in the East Java Sea reveals seismic re?ection characteristics of reefs and associated sedimentary bodies, including asymmetrical or symmetrical dome re?ections, slope progradational re?ections, chaotic re?ections and discontinuous strong re?ections inside the reef, which onlap the ?ank of the reef. It is concluded that the developmental paleo-environment of most reefs is mainly conducive to shallow marine carbonate platform facies and platform margin facies, based on well core data, variations in seismic facies and strata thickness.The formation and evolution of all reefs are primarily in?uenced by the tectonic framework of the Madura Strait Basin. Platform margin reefs are principally controlled by two types of structures: one is a series of E-W trending Paleogene normal faults, and the other is an E-W trending Neogene inversion structures. In addition, wave actions, tidal currents and other ocean currents play an accelerated role in sorting, rounding and redeposition for the accumulation and evolution of reefs. Tertiary reefs in the MSB can be divided into four types: 1) an open platform coral reef of Late Oligocene to Early Miocene, 2) a platform margin coral reef controlled by normal faults in Late Oligocene to Early Miocene, 3) a platform margin Globigerina moundreef controlled by a 'hidden' inversion structure in Early Pliocene, and 4) a platform margin Globigerina mound-reef controlled by thrust faults in the early Pliocene. Patterns of the formation and evolution of reefs are also suggested. | RAN Weimin LUAN Xiwu LU Yintao LIU Hong YANG Jiajia ZHAO Yang HE Wenchang YAN Zhonghui | 2019 | Journal of Oceanology and Limnology2019，37，1： | 3 |
| 4 | Assessment of trace metal contamination in groundwater in a highly urbanizing area of Shenfu New District, Northeast China显示文摘 | Yintao LU Xinghua ZANG Hong YAO Shichao ZHANG Shaobin SUN Fang LIU | 2018 | Frontiers of Earth Science2018，12，3： | 2 |
| 5 | Impact of septic tank systems on local groundwater quality and water supply in the Pearl River Delta, China: case study 显示文摘 | LU Yintao TANG Changyuan CHEN Jianyao | 2008 | Hydrological Processes2008，22，3： | 1 |
| 6 | Large enhancement of transient photovoltage induced by the absorption of the metal Al显示文摘The transient photovoltage of ITO/CuPc/Al is studied. The transient photovoltage under the Al side illumination is much greater than that under ITO side illumination. It is not negligible while light is almost completely absorbed by the Al layer. It seems that the light absorption of the Al layer could enhance the generation of the photoinduced carriers in the organic layer, which is further shown by the transient photovoltage study of ITO/Al/NPB/Au. A possible mechanism proposed is that the holes generated in the Al are because of light absorption that is injected from the Al to organic materials. This results in further charge separation by the internal built-in electric field. | WU Bo SUN XiaoYu SUN ZhengYi YOU YinTao LU Min DING XunMin HOU XiaoYuan | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，7： | 1 |
| 7 | Assessment of major ions and heavy metals in groundwater: a case study from Guangzhou and Zhuhai of the Pearl River Delta, China显示文摘在珍珠河三角洲(PRD ) 的人为的活动由于快速的都市化和工业开发在过去的二十年引起了地下水质量的恶化。在这研究,在 PRD 的地下水的重金属的 hydrochemical 特征,质量,和来源被调查。25 件地下水样品为 pH 镇定、分析,电的电导率(EC ) ,全部的溶解固体(TDS ) , 18 O, 2 H,主要离子,和重金属。地下水是从 35.5~8,779.3 mg 的稍微酸、介绍的 TDS 价值???????彁乍???????佃呎??????????????????????????吗???????匨??桴?? | Yintao LU Changyuan TANG Jianyao CHEN Hong YAO | 2016 | Frontiers of Earth Science2016，10，2： | 1 |
| 8 | Distribution,Seismic Characteristics and Controlling Factors of Carbonate Platforms on the Northwestern Margin of the South China Sea显示文摘Newly-acquired seismic data reveal widespread carbonate deposits covering a large part of the northwestern South China Sea margin.Three carbonate platforms are identified to have developed on the topographic highs inherited from tectonic deformation and volcanic accretion.Across the carbonate platforms,the Miocene strata are characterized by high-amplitude seismic reflections and distinct platform architecture that overlaps older strata.The Guangle and Xisha carbonate platforms grew on faulted blocks due to South China Sea continental rifting,while the Zhongjian carbonate platform developed on a structural high induced by early Miocene volcanism.During the late Miocene,partial drowning resulted in the inhibition of platform growth,eventual platform drowning and termination of most carbonate deposition.The drowning of the Guangle and Zhongjian carbonate platforms is shown by the supply of siliciclastic sediments during the late Miocene and seems to be closely linked to late Neogene volcanic activity,whilst the drowning of the Xisha carbonate platform is primarily related to relative eustatic changes.Our results imply that tectonic activity,volcanism and eustasy are the dominant controls on the evolution of carbonate platforms on the northwestern margin of the South China Sea. | LI Lin WANG Bin YANG Taotao YANG Zhili LI Li LU Yintao WANG Xuefeng WU Jingwu SUN Guozhong | 2021 | Acta Geologica Sinica(English Edition)2021，95，1： | 1 |
| 9 | Carbon emissions reduction potentiality for railroad transportation based on life cycle assessment显示文摘This study addresses the comparative carbon emissions of different transportation modes within a unified evaluation framework,focusing on their carbon footprints from inception to disposal.Specifically,the entire life cycle carbon emissions of High-Speed Rail(HSR),battery electric vehicles,conventional internal combustion engine vehicles,battery electric buses,and conventional internal combustion engine buses are analyzed.The life cycle is segmented into vehicle manufacturing,fuel or electricity production,operational,and dismantlingrecycling stages.This analysis is applied to the Beijing-Tianjin intercity transportation system to explore emission reduction strategies.Results indicate that HSR demonstrates significant carbon emission reduction,with an intensity of only 24%-32% compared to private vehicles and 47%-89% compared to buses.Notably,HSR travel for Beijing-Tianjin intercity emits only 24% of private vehicle emissions,demonstrating the emission reduction benefits of transportation structure optimization.Additionally,predictive modeling reveals the potential for carbon emission reduction through energy structure optimization,providing a guideline for the development of effective transportation management systems. | Yintao Lu Tongtong Zhang Shengming Qiu Xin Liu Xiaohua Yu Hong Yao | 2023 | High-Speed Railway2023，1，3： | 0 |
| 10 | Advanced optical methods and materials for fabricating 3D tissue scaffolds显示文摘Three-dimensional(3D)printing,also known as additive manufacturing(AM),has undergone a phase of rapid development in the fabrication of customizable and high-precision parts.Thanks to the advancements in 3D printing technologies,it is now a reality to print cells,growth factors,and various biocompatible materials altogether into arbitrarily complex 3D scaffolds with high degree of structural and functional similarities to the native tissue environment.Additionally,with overpowering advantages in molding efficiency,resolution,and a wide selection of applicable materials,optical 3D printing methods have undoubtedly become the most suitable approach for scaffold fabrication in tissue engineering(TE).In this paper,we first provide a comprehensive and up-to-date review of current optical 3D printing methods for scaffold fabrication,including traditional extrusion-based processes,selective laser sintering,stereolithography,and two-photon polymerization etc.Specifically,we review the optical design,materials,and representative applications,followed by fabrication performance comparison.Important metrics include fabrication precision,rate,materials,and application scenarios.Finally,we summarize and compare the advantages and disadvantages of each technique to guide readers in the optics and TE communities to select the most fitting printing approach under different application scenarios. | Xiaobo Li Wanping Lu Xiayi Xu Yintao Wang Shih-Chi Chen | 2022 | Light(Advanced Manufacturing)2022，3，3： | 0 |
| 11 | Controls on the Gas Hydrate Occurrence in Lower Slope to Basin-Floor,Northeastern Bay of Bengal显示文摘High resolution seismic data and newly acquired logging data reveal the presence of gas hydrates in the deep-water area in the northeastern Bay of Bengal.Bottom Simulating Reflectors(BSRs)appear at 430 ms beneath the seafloor,with the features of typical gas hydrates reported elsewhere except for some discontinuity.The BSR distribution is closely related to the position of anticline structures and turbidite channels.Anticlines provide conduits for the upward migration of gases from deeper intervals,while the turbidite sands within channels act as reservoirs for gas hydrate accumulation.High sedimentation rates in the Bengal Fan were ge-nerally favorable to produce a great amount of methane gas,providing favorable preconditions for the formation of gas hydrates.The discovery of gases in adjacent area indicates the contribution of the biogenic gas to the formation of gas hydrates.Meanwhile,seismic sections provide the evidence for the potential thermogenic gas kitchen in deep intervals.The anticline structures and the associated vertical fractures may constitute vertical fluid flowing conduits,which hydraulically connect the two deeper thermogenic petroleum systems(i.e.,rifting and Eocene-Oligocene source rocks)with the turbidite reservoirs and thus facilitate the fluid migration from the sources to the reservoirs,generating favorable conditions for gas-hydrate accumulation in such foreland setting. | LU Yintao LUAN Xiwu SHI Boqing FAN Guozhang RAN Weimin XU Ning WANG Haiqiang SHAO Dali DING Liangbo WANG Xingxing | 2022 | Journal of Ocean University of China2022，21，4： | 0 |
| 12 | A buried submarine canyon in the northwest South China Sea:architecture,development processes and implications for hydrocarbon exploration显示文摘High-resolution multichannel seismic data enables the discovery of a previous,undocumented submarine canyon(Huaguang Canyon)in the Qiongdongnan Basin,northwest South China Sea.The Huaguang Canyon with a NW orientation is 140 km in length,and 2.5 km to 5 km in width in its upper reach and 4.6 km to 9.5 km in width in its lower reach.The head of the Huaguang Canyon is close to the Xisha carbonate platform and its tail is adjacent to the central canyon.This buried submarine canyon is formed by gravity flows from the Xisha carbonate platform when the sea level dropped in the early stage of the late Miocene(~10.5 Ma).The internal architecture of the Huaguang Canyon is mainly characterized by high amplitude reflections,indicating that this ancient submarine canyon was filled with coarse-grained sediments.The sediment was principally scourced from the Xisha carbonate platform.In contrast to other buried large-scale submarine canyons(central canyon and Zhongjian Canyon)in the Qiongdongnan Basin,the Huaguang Canyon displays later formation time,smaller width and length,and single sediment supply.The coarse-grained deposits within Huaguang Canyon provide a good environment for reserving oil and gas,and the muddy fillings in Huaguang Canyon have been identified as regional caps.Therefore,Huaguang Canyon is potential area for future hydrocarbon exploration in the northwest South China Sea.Our results may contribute to a better understanding of the evolution of submarine canyons formed in carbonate environment. | Bin Wang Fuliang Lyu Shuang Li Jian Li Zhili Yang Li Li Xuefeng Wang Yintao Lu Taotao Yang Jingwu Wu Guozhong Sun Hongxia Ma Xiaoyong Xu | 2021 | Acta Oceanologica Sinica2021，40，3： | 0 |
| 13 | Gas hydrate accumulation associated with fluid escape structure in the western margin of South China Sea显示文摘Gas hydrates have been found in the western continental margin of South China Sea,which are revealed by widespread bottom simulating reflectors(BSRs)imaged from a three-dimensional(3D)seismic volume near the Guangle carbonate platform in the western South China Sea.Fluid-escape structures(faults and gas chimneys)are originated below BSR were distinguished.A comprehensive model in three-level structure was proposed to depict the gas hydrate accumulation in the study area.In Level 1,regional major faults and gas chimneys provide the first pathways of upward migration of gas near basement.In Level 2,pervasive polygonal faults in carbonate layer promote the migration of gas.In Level 3,gases sourced from near-basement accumulate within shallow sediment layers and form gas hydrate above the unit with faults once appropriate temperature and pressure occur.The gas hydrates in the study area are mainly in microbial origin,and their accumulation occurs only when fluid-escape structures align in all the three levels.The proposed model of the gas hydrate accumulation in western SCS margin provides new insights for further studies in this poorly studied area. | Taotao YANG Lin LI Yintao LU Kaiqi YU Zhili YANG Xuefeng WANG Wei LI | 2023 | Journal of Oceanology and Limnology2023，41，3： | 0 |
| 14 | Key oil accumulation periods of ultra-deep fault-controlled oil reservoir in northern Tarim Basin, NW China显示文摘A giant fault-controlled oilfield has been found in the ultra-deep(greater than 6000 m) Ordovician carbonate strata in the northern Tarim Basin. It is of great significance for hydrocarbon accumulation study and oil exploitation to determine the key oil accumulation periods. Based on detailed petrographic analysis, fluid inclusion association(FIA) in calcite samples filling in fractures from 12 wells were analyzed, and key accumulation periods of the strike-slip fault-controlled oilfield was studied by combining oil generation periods of the source rocks, formation periods of the fault and traps, and the fluid inclusion data.(1) There are multiple types of FIA, among them, two types of oil inclusions, the type with yellow fluorescence from the depression area and the type with yellow-green fluorescence from the uplift area with different maturities indicate two oil charging stages.(2) The homogenization temperature of the brine inclusions in FIA is mostly affected by temperature rises, and the minimum temperature of brine inclusions symbiotic with oil inclusions is closer to the reservoir temperature during its forming period.(3) FIA with yellow fluorescence all have homogenization temperatures below 50 ℃, while the FIA with yellow-green fluorescence have homogenization temperatures of 70–90 ℃ tested, suggesting two oil accumulation stages in Middle-Late Caledonian and Late Hercynian.(4) The Middle-Late Ordovician is the key formation period of the strike-slip fault, fracture-cave reservoir and trap there.(5) The oil generation peak of the main source rock of the Lower Cambrian is in the Late Ordovician, and the oil accumulation stage is mainly the Late Ordovician in the depression area, but is mainly the Early Permian in the uplift area. The key oil accumulation period of the strike-slip fault-controlled reservoirs is the Late Caledonian, the depression area has preserved the primary oil reservoirs formed in the Caledonian, while the uplift area has secondary oil reservoirs adjusted from the depression area during the Late Hercynian. Oil reservoir preservation conditions are the key factor for oil enrichment in the strike-slip fault zone of northern Tarim, and the Aman transition zone in the depression is richer in oil and gas and has greater potential for exploration and development. | YANG Shuai WU Guanghui ZHU Yongfeng ZHANG Yintao ZHAO Xingxing LU Ziye ZHANG Baoshou | 2022 | Petroleum Exploration and Development2022，49，2： | 0 |
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