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| 1 | Structural design and parameter determination for fluted-roller fertilizer applicator显示文摘The instability of the motion layer of fertilizer particle influences the precision and the accuracy of the amount of fertilizer application in the working process of fluted-roller fertilizer applicator.The characteristics of the motion layer were investigated,and a systematic scheme was proposed for designing the structures of fertilizer-filling cavity,fertilizer-filling surface and fertilizer-delivery cavity.The key parameters of the structure were studied by discrete element method.It was figured out that to ensure the smooth operation of fertilizer applicator,the fertilizer-filling angle was 105°,fertilizer-contact angle should be large than 100°,and the fertilizer-resistance angle should be smaller than 35°.Moreover,the stability of fertilizer motion morphology was investigated to verify the design.The results showed that when the roll rotational speed was larger than 120 deg/s,compared with the conventional design the CV of the amount of fertilizer application was reduced from 1.5%-3.5%to 0.5%-1.0%,and the accuracy of the fertilizer discharge was improved with the square of the correlation coefficient between the amount of fertilizer application and the roll rotational speed was larger than 0.999.It was deduced from the results that the precision and accuracy of the amount of fertilizer application are improved via eliminating the driving layer and enhancing the stable filling and conveying of the forced layer. | Shan Zeng Yipeng Tan Yu Wang Xiwen Luo Lamei Yao Dengpan Huang Zewen Mo | 2020 | International Journal of Agricultural and Biological Engineering2020，13，2： | 4 |
| 2 | Gd_(2)O_(3) nanoparticles modified g-C_(3)N_(4) with enhanced photocatalysis activity for degradation of organic pollutants显示文摘Gd_(2) O_(3) nanoparticles modified g-C_(3) N_(4) photocatalytic composites were synthesized by a simple one-step hydrothermal method.The structure,morphology,optical properties of the prepared photocatalyst were characterized by X-ray diffraction(XRD),field emission scanning electron microscopy(FESEM),field emission transmission electron microscopy(FETEM) and X-ray photoelectron spectroscopy(XPS).The result demonstrates that gadolinium is mainly dispersed on the surface of g-C_(3) N_(4) in the form of Gd_(2) O_(3),and does not destroy the lattice structure of g-C_(3) N_(4).Besides,the gadolinium can cause the red shift of the absorption edge of light,narrow the band gap,and increase the separation efficiency of the photogenerated electron and hole of g-C_(3) N_(4).Especially,the specific surface area of g-C_(3) N_(4) can be significantly increased.Furthermore,g-C_(3) N_(4)/Gd-0.05 displays the highest photodegradation performance when it is used for degradation of methyl orange(MO),methylene blue(MB) and Rhodamine B(RhB).The photodegradation rate of g-C_(3) N_(4)/Gd-0.05 composites is 72.4% for MO,95.5% for RhB,100% for MB after120 min under visible light(λ> 420 nm) irradiation.Narrow band gap promotes the separation of photogenerated electron and hole,which enhances the photocatalytic activity of g-C_(3) N_(4).It is noted that g-C_(3) N_(4)/Gd-0.05 exhibits excellent photocatalytic stability by the photocurrent and the cyclic photodegradation of MO. | Yipeng Zhou Fanshan Zeng Chaoyang Sun Jun Wu Yu Xie Fayun Zhang Senlin Rao Fahui Wang Jinbing Zhang Jinsheng Zhao Shiqian Li | 2021 | Journal of Rare Earths2021，39，11： | 1 |
| 3 | Super enhancers targeting ZBTB16 in osteogenesis protect against osteoporosis显示文摘As the major cell precursors in osteogenesis, mesenchymal stem cells(MSCs) are indispensable for bone homeostasis and development. However, the primary mechanisms regulating osteogenic differentiation are controversial. Composed of multiple constituent enhancers, super enhancers(SEs) are powerful cis-regulatory elements that identify genes that ensure sequential differentiation. The present study demonstrated that SEs were indispensable for MSC osteogenesis and involved in osteoporosis development. Through integrated analysis, we identified the most common SE-targeted and osteoporosis-related osteogenic gene,ZBTB16. ZBTB16, positively regulated by SEs, promoted MSC osteogenesis but was expressed at lower levels in osteoporosis.Mechanistically, SEs recruited bromodomain containing 4(BRD4) at the site of ZBTB16, which then bound to RNA polymerase IIassociated protein 2(RPAP2) that transported RNA polymerase Ⅱ(POL Ⅱ) into the nucleus. The subsequent synergistic regulation of POL Ⅱ carboxyterminal domain(CTD) phosphorylation by BRD4 and RPAP2 initiated ZBTB16 transcriptional elongation, which facilitated MSC osteogenesis via the key osteogenic transcription factor SP7. Bone-targeting ZBTB16 overexpression had a therapeutic effect on the decreased bone density and remodeling capacity of Brd4^(fl/fl)Prx1-cre mice and osteoporosis(OP) models.Therefore, our study shows that SEs orchestrate the osteogenesis of MSCs by targeting ZBTB16 expression, which provides an attractive focus and therapeutic target for osteoporosis. | Wenhui Yu Zhongyu Xie Jinteng Li Jiajie Lin Zepeng Su Yunshu Che Feng Ye Zhaoqiang Zhang Peitao Xu Yipeng Zeng Xiaojun Xu Zhikun Li Pei Feng Rujia Mi Yanfeng Wu Huiyong Shen | 2023 | Bone Research2023，11，3： | 1 |
| 4 | Design and experimental study of the fertilizer applicator with vertical spiral fluted rollers显示文摘To improve the uniformity and accuracy of fertilizing amount for fertilizer applicators with spiral fluted roller,this paper experimentally studied the influence of major structural parameters on the fertilizing performance.Through two sets of orthogonal tests,it is found that the helix angle and installation angle of spiral fluted rollers are the main factors,which affect the uniformity of fertilizer discharge and the linear relationship between fertilizing amount and opening,respectively.Based on these findings,the experiment and analysis were carried out to determine the optimal helix angle and installation angle for the spiral fluted roller The experimental results of fertilizing performance show that:when the helix angle is 45°,it able to achieve satisfactory uniformity of fertilizer discharge and linear relationship between fertilizing amount and rotational speed;when the installation angle is 40°,it enhances the accuracy of fertilizer discharge with good linear relationship between fertilizing amount and opening.Compared with the fertilizing performance of traditional fertilizer applicators with horizontally installed straight fluted roller,in the aspect of uniformity,the optimized fertilizer applicators reduce the variation coefficient of fertilizing amount within 0.2 s at low speed(10-30 r/min)from 5.1%-52.5%to 4.2%-14.7%;in the aspect of accuracy;and increase the correlation coefficient square R2 between fertilizing amount and opening from 0.93-0.97 to no less than 0.996,and the regression intercept in the fitting equation is reduced from larger than 10.0 to less than 1.0. | Yu Wang Yipeng Tan Silong Wei Mingming Liao Ying Zang Shan Zeng | 2023 | International Journal of Agricultural and Biological Engineering2023，16，5： | 0 |
| 5 | A novel mutation in ROR2 led to the loss of function of ROR2 and inhibited the osteogenic differentiation capability of bone marrow mesenchymal stem cells(BMSCs)显示文摘Receptor tyrosine kinase-like orphan receptor 2(ROR2)has a vital role in osteogenesis.However,the mechanism underlying the regulation of ROR2 in osteogenic differentiation is still poorly comprehended.A previous study by our research group showed that a novel compound heterozygous ROR2 variation accounted for the autosomal recessive Robinow syndrome(ARRS).This study attempted to explore the impact of the ROR2:c.904C>T variant specifically on the osteogenic differentiation of BMSCs.Methods:Coimmunoprecipitation(CoIP)-western blotting was carried out to identify the interaction between ROR2 and Wnt5a.Double-immunofluorescence staining was used for determining the expressions and co-localization of ROR2 and Wnt5a in bone marrow mesenchymal stem cells(BMSCs).Western blot(WB)analysis and quantitative reverse transcription polymerase chain reaction(RT-qPCR)were conducted to identify the expression levels of ROR2 in the BMSCs transfected with LV-shROR2 or LV-ROR2-c.904C>T.The alkaline phosphatase(ALP)activity was detected,and Alizarin Red S staining was done for evaluating the osteogenic differentiation of BMSCs.RT-qPCR was employed to identify the expression of the sphingomyelin synthase 1(SMS1)mRNA in the BMSCs transfected with LV-shROR2 or LV-ROR2-c.904C>T and the mRNA expression levels of Runt-related transcription factor 2(RUNX2),osteocalcin(OCN),and osteopontin(OPN).WB was performed to confirm the protein expressions of extracellular regulated protein kinases1(ERK),P-ERK,Smad family member1/5/8(Smad1/5/8),P-Smad1/5/8,P-P38,P38,RUNX2,OCN,and OPN in the BMSCs transfected with LV-shROR2/LV-ROR2-c.904C>T and sphingomyelin(SM).Results:The ROR2:c.904C>T mutant altered the subcellular localization of the ROR2 protein,which caused an impaired interaction between ROR2 and Wnt5a.The depletion of ROR2 restricted the osteogenic differentiation capability of BMSCs and downregulated the expression of SMS1.SM treatment could reverse the inhibition of osteoblastic differentiation in ROR2-depleted BMSCs.Conclusion:The findings of this work revealed that the ROR2:c.904C>T variant led to the loss of function of ROR2,which impaired the interaction between ROR2 and Wnt5a and also controlled the osteogenic differentiation capability of BMSCs.Furthermore,SM was revealed to be engaged in the osteoblastic differentiation of BMSCs regulated by ROR2,which renders SM a potential target in the therapy for ARRS. | WENQI CHEN XIAOYANG CHU YANG ZENG YOUSHENG YAN YIPENG WANG DONGLAN SUN DONGLIANG ZHANG JING ZHANG KAI YANG | 2023 | BIOCELL2023，47，7： | 0 |
| 6 | Smartphone-based bridge frequency identification using vehicle contact-point response显示文摘Bridge frequency(BF)identification using the vehicle scanning method has attracted considerable attention during the last two decades.However,most previous studies have adopted unrealistic vehicle models,thus finding limited practical applications.This study proposes a smartphone-based BF identification method that uses the contact-point acceleration response of a four degree-of-freedom vehicle model.The said response can be inferred from the vehicle body response measured by a smartphone.For realizing practical applications,this method is incorporated into a self-developed smartphone app to obtain data smoothly and identify BFs in a timely manner.Numerical and experimental investigations are performed to verify the effectiveness of the proposed method.In particular,the robustness of this method is investigated numerically against various factors,including the vehicle speed,bridge span,road roughness,and bridge type.Furthermore,laboratory calibration tests are performed to investigate the accuracy of the smartphone gyroscope in measuring the angular velocity,where anomalous data are detected and eliminated.Laboratory experiment results for a simply supported bridge indicate that the proposed method can be used to identify the first two BFs with acceptable accuracy. | Liu Chengyin Zhu Yipeng Zeng Qing Wu Xiaodong | 2023 | Earthquake Engineering and Engineering Vibration2023，22，4： | 0 |
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