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| 1 | Multi-functional vesicles improve Helicobacter pylori eradication by a comprehensive strategy based on complex pathological microenvironment显示文摘Helicobacter pylori(H.pylori),creating a global infection rate over 50%,presents great challenges in clinical therapies due to its complex pathological microenvironment in vivo.To improve the eradication efficacy,herein we fabricated a pharmaceutical vesicle RHL/Cl-Ch-cal where cholesterol-PEG,calcitriol and first-line antibiotic clarithromycin were co-loaded in the rhamnolipid-composed outer lipid layer.RHL/Cl-Ch-cal could quickly penetrate through gastric mucus layer to reach H.pylori infection sites,and then effectively destroyed the architecture of H.pylori biofilms,killed dispersed H.pylori and inhibited the re-adhesion of residual bacteria(called biofilms eradication tetralogy).Moreover,RHL/Cl-Ch-cal activated the host immune response to H.pylori by replenishing cholesterol to repair lipid raft on the cell membrane of host epithelial cells.Finally,RHL/Cl-Ch-cal killed the intracellular H.pylori through recovering the lysosomal acidification and assisting degradation.In experiments,RHL/Cl-Ch-cal demonstrated prominent anti-H.pylori efficacy in the classical H.pylori-infected mice model.Therefore,the study provides a“comprehensive attack”strategy for anti-H.pylori therapies including biofilms eradication tetralogy,immune activation and intracellular bacteria killing. | Xiaonan Chen Yiqing Zou Shuqi Zhang Pengchao Fang Shuxuan Li Pengyu Li Yingying Sun Gang Yuan Haiyan Hu | 2022 | Acta Pharmaceutica Sinica B2022，12，9： | 2 |
| 2 | Haplotype-resolved genome of diploid ginger (Zingiber officinale) and its unique gingerol biosynthetic pathway显示文摘Ginger(Zingiber officinale),the type species of Zingiberaceae,is one of the most widespread medicinal plants and spices.Here,we report a high-quality,chromosome-scale reference genome of ginger‘Zhugen’,a traditionally cultivated ginger in Southwest China used as a fresh vegetable,assembled from PacBio long reads,Illumina short reads,and high-throughput chromosome conformation capture(Hi-C)reads.The ginger genome was phased into two haplotypes,haplotype 1(1.53 Gb with a contig N50 of 4.68 M)and haplotype 0(1.51 Gb with a contig N50 of 5.28 M).Homologous ginger chromosomes maintained excellent gene pair collinearity.In 17,226 pairs of allelic genes,11.9%exhibited differential expression between alleles.Based on the results of ginger genome sequencing,transcriptome analysis,and metabolomic analysis,we proposed a backbone biosynthetic pathway of gingerol analogs,which consists of 12 enzymatic gene families,PAL,C4H,4CL,CST,C3’H,C3OMT,CCOMT,CSE,PKS,AOR,DHN,and DHT.These analyses also identified the likely transcription factor networks that regulate the synthesis of gingerol analogs.Overall,this study serves as an excellent resource for further research on ginger biology and breeding,lays a foundation for a better understanding of ginger evolution,and presents an intact biosynthetic pathway for species-specific gingerol biosynthesis. | Hong-Lei Li Lin Wu Zhaoming Dong Yusong Jiang Sanjie Jiang Haitao Xing Qiang Li Guocheng Liu Shuming Tian Zhangyan Wu Bin Wu Zhexin Li Ping Zhao Yan Zhang Jianmin Tang Jiabao Xu Ke Huang Xia Liu Wenlin Zhang Qinhong Liao Yun Ren Xinzheng Huang Qingzhi Li Chengyong Li Yi Wang Baskaran Xavier-Ravi Honghai Li Yang Liu Tao Wan Qinhu Liu Yong Zou Jianbo Jian Qingyou Xia Yiqing Liu | 2021 | Horticulture Research2021，8，1： | 2 |
| 3 | An improved hydrodynamic model for open wet transmission clutches 显示文摘 | Yuan Yiqing Zou Qian Liu E A | 2007 | Journal of Fluids Engineering2007，129，3： | 1 |
| 4 | Experiments and analysis of thin tungsten slice and W/Cu brazing for primary collimator scraper in CSNS/RCS显示文摘According to the requirements for the beam collimation system of the rapid cycling synchrotron(RCS)of China Spallation Neutron Source(CSNS),the main structure of a scraper of primary collimator is made by W/Cu brazing,in which the thickness of tungsten slice is 0.17 mm.In order to get the best mechanical properties,the brazing temperature is suggested to be controlled under the recrystallization temperature of tungsten,while the recrystallization temperature is affected directly by the thickness of tungsten.Because of little research and application on the brazing of thin tungsten slice of 0.17 mm and copper,tensile tests are done to get the mechanical properties of tungsten slices which experience different brazing temperatures.In keeping the inner relationships between the mechanical properties and temperature,another experiment is done by using SEM to scan the microstructures including the size and distribution of crystals.Finally we determine the recrystallization temperature of tungsten slice of 0.17 mm,and get the best parameters of W/Cu brazing for scrapers of primary collimator in CSNS/RCS. | ZOU YiQing KANG Ling YU JieBing QU HuaMin HE ZheXi | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，4： | 1 |
| 5 | Synthesis and electrochemical performance of multi-walled carbon nanotube/polyaniline/MnO 2 ternary coaxial nanostructures for supercapacitors显示文摘 | Qiang Li Jianhua Liu Jianhua Zou Anindarupa Chunder Yiqing Chen Lei Zhai | 2010 | Journal of Power Sources2010，，1： | 1 |
| 6 | Correction:Haplotype-resolved genome of diploid ginger (Zingiber officinale)and its unique gingerol biosynthetic pathway显示文摘After online publication of the article 1,the authors noticed the affiliation“College of Landscape Architecture and Life Science/Institute of Special Plants,Chongqing University of Arts and Sciences,Yongchuan,Chongqing,China”for author Yiqing Liu was missing. | Hong-Lei Li Lin Wu Zhaoming Dong Yusong Jiang Sanjie Jiang Haitao Xing Qiang Li Guocheng Liu Shuming Tian Zhangyan Wu Bin Wu Zhexin Li Ping Zhao Yan Zhang Jianmin Tang Jiabao Xu Ke Huang Xia Liu Wenlin Zhang Qinhong Liao Yun Ren Xinzheng Huang Qingzhi Li Chengyong Li Yi Wang Baskaran Xavier-Ravi Honghai Li Yang Liu Tao Wan Qinhu Liu Yong Zou Jianbo Jian Qingyou Xia Yiqing Liu | 2021 | Horticulture Research2021，8，1： | 1 |
| 7 | Heterotrophic Soil Respiration in Relation to Environmental Factors and Microbial Biomass in Two Wet Tropical Forests显示文摘 | Yiqing Li Ming Xu Xiaoming Zou | 2006 | Plant and Soil (-)2006，，1： | 1 |
| 8 | The response of major soil decomposers to landslide disturbance in a Puerto Rican rainforest 显示文摘 | Li Yiqing Ruan Honghua Zou Xiaoming | 2005 | SoilScience2005，1711，3： | 1 |
| 9 | Design and manufacturing of the antechamber for BEPCII storage rings显示文摘Antechamber which composes the arc vacuum chamber of storage rings is one of the key devices of BEPCII. It has the characteristic of various specifications, large size, complex structure, and high dimension accuracy. This paper gives a review on the structure features and the procedure of production, including the mechanical machining process, cleaning and welding process of high vacuum aluminum alloy, ultrahigh vacuum test and so on. In view of the occurrence of the concave deformation, the reasons are analyzed and the correction method developed is introduced too. | Ling Kang (1) ChunHua Li (1) KaiXi Huang (1) HuaMin Qu (1) YiQing Zou (1) Yan Zhang (1) LuXiang Han (1) LingLing Men (1) | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，S2： | 1 |
| 10 | Soil communities and plant litter decomposition as influenced by forest debris:Variation across tropical riparian and upland sites显示文摘 | Ruan Honghua Li Yiqing Zou Xiaoming | 2005 | Pedobiologia2005，49，： | 1 |
| 11 | Sequence stratigraphy and lithofacies paleogeographic evolution of Katian Stage-Aeronian Stage in southern Sichuan Basin,SW China显示文摘Based on the lithologies,sedimentary structures,graptolite zones,inorganic geochemical characteristics,electrical data of 110 shale gas wells in southern Sichuan Basin and the mineral quantitative analysis technology of scanning electron microscope,the stratigraphic sequences of the Upper Ordovician Katian Stage-Himantian Stage-Silurian Rhuddanian Stage-Aeronian Stage are divided,the sedimentary characteristics and fourth-order sequence evolution are analyzed.The target layer can be divided into two sequences,namely SQ1 and SQ2.According to Ordovician-Silurian sedimentary background,the gamma value of the target layer and U/Th,5 maximum flooding surfaces and 12 system tracts are identified.According to system tracts and their combinations,eight fourth-order sequences are identified,namely,Pss1-Pss8 from old to new.The development period and scale of dominant shale facies from Katian stage to Aeronian stage in southern Sichuan are restored.The best-quality dolomite/calcite-bearing siliceous shale facies,siliceous shale facies,clay-bearing siliceous shale facies and feldspar-bearing siliceous shale facies mainly occur in Pss3-Pss5 of Weiyuan,Western Chongqing and Luzhou,Pss6 of Western Changning-Northern Luzhou-Central Western Chongqing and Pss3-Pss4 of Changning.The siliceous clay shale facies second in quality mainly occurs in Pss6 of Southern Luzhou-Changning area(excluding Western Changning area),Pss7 of Eastern Weiyuan-Northern Western Chongqing-Southern Luzhou and Pss8 of Northern Luzhou-Weiyuan-Western Chongqing.The fourth-order sequence evolution model of Katian stage-Aeronian stage in southern Sichuan is established.During the depositional period of Pss1-Pss8,the sea level had six regressions and five transgressions,and the first transgression SQ2-MFS1 after glaciation was the largest flooding surface. | ZHU Yiqing CHEN Gengsheng LIU Yong SHI Xuewen WU Wei LUO Chao YANG Xue YANG Yu ran ZOU Yuanhong | 2021 | Petroleum Exploration and Development2021，48，5： | 0 |
| 12 | Influence of Rapid Thermal Annealing on Structural and Interfacial Properties of Lead-Zirconate-Titanate Thin Films Prepared by Excimer Laser Deposition显示文摘Lead zirconate titanate thin films were prepared by pulsed excimer laser deposition on silicon substrates.Rapid thermal annealing was used to improve its properties.Structural and interfacial characteristics of the films before and after annealing were investigated by x-ray diffraction,Rutherford backscattering spectrometry and automatic spreading resistance。 | ZHENG Lirong CHEN Yiqing LIN Chenglu ZOU Shichang | 1994 | Chinese Physics Letters1994，11，8： | 0 |
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