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| 1 | CPSF30-L-mediated recognition of mRNA m^(6)A modification controls alternative polyadenylation of nitrate signaling-related gene transcripts in Arabidopsis显示文摘N6-methyladenosine(m^(6)A),a ubiquitous internal modification of eukaryotic mRNAs,plays a vital role in almost every aspect of mRNA metabolism.However,there is little evidence documenting the role of m^(6)A in regulating alternative polyadenylation(APA)in plants.APA is controlled by a large protein-RNA complex with many components,including CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR30(CPSF30).In Arabidopsis,CPSF30 has two isoforms and the longer isoform(CPSF30-L)contains a YT512-B Homology(YTH)domain,which is unique to plants.In this study,we showed that CPSF30-L YTH domain binds to m^(6)A in v itro.In the cpsf30-2 mutant,the transcripts of many genes including several important nitrate signaling-related genes had shifts in polyadenylation sites that were correlated with m^(6)A peaks,indicating that these gene transcripts carrying m^(6)A tend to be regulated by APA.Wild-type CPSF30-L could rescue the defects in APA and nitrate metabolism in cpsf30-2,but m^(6)A-binding-defective mutants of CPSF30-L could not.Taken together,our results demonstrated that m^(6)A modification regulates APA in Arabidops is and revealed that the m^(6)A reader CPSF30-L affects nitrate signaling by controlling APA,shedding new light on the roles of the m^(6)A modification during RNA 3-end processing in nitrate metabolism. | Yiteng Hou Jing Sun Baixing Wu Yangyang Gao Hongbo Nie Zhentian Nie Shuxuan Quan Yong Wang Xiaofeng Cao Sisi Li | 2021 | Molecular Plant2021，14，4： | 12 |
| 2 | Primary structure of helix C to helix G of a new retinal protein in H.sp.xz515显示文摘The gene fragment encoding the retinal protein from helix C to helix G in a new strain of halobacteria, H.sp.xz515 has been amplified by PCR method. The nucleotide sequence of this fragment has been determined. The deduced amino acid sequence has been compared with halobium br and other two br-like proteins, ar-1 and ar-2. Results show that those amino acid residues in br, essential for proton pumping and binding to retinal, are conserved. The residue M145 in br may be important for isomerization reaction of retinal. | Hui Wang Shuxuan Zhan Qingan Sun Deqiang Xu Wei Zhao Weida Huang Qingguo Li | 2000 | Chinese Science Bulletin2000，45，12： | 5 |
| 3 | Peripheral Lymphocyte Subsets as a Marker of Parkinson's Disease in a Chinese Population显示文摘In this study, we conducted a clinical analysis of lymphocyte subtypes in 268 patients with Parkinson's disease(PD) to assess their clinical impact as a potential marker of advanced PD in Chinese patients. The participants comprised 268 sporadic PD patients and 268 healthy controls. The numbers of natural killer(NK) cells and CD3+, CD3+CD4+, CD3+CD8+, and CD19+ lymphocytes from peripheral blood were determined by immunostaining and flow cytometric analysis and the percentages of these CD+ T cells were calculated. The ratio of regulatory T(Treg)/helper T 17(Th17) lymphocytes from 64 PD patients and 46 controls was determined by flow cytometric analysis.The results showed that the percentage of NK cells was higher in advanced PD patients than in controls(22.92% ±10.08% versus 19.76% ± 10.09%, P = 0.006), while CD3+ T cells are decreased(62.93% ± 9.27% versus65.75% ± 9.13%, P = 0.005). The percentage of CD19+B cells in male patients was lower(P = 0.021) than in female patients, whereas NK cells were increased(P \ 0.0001). The scores on the Unified Parkinson's Disease Rating Scale(UPDRS) and the Non-Motor Symptoms Scale in late-onset PD patients were significantly higher than those in earlyonset patients(P = 0.024 and P = 0.007, respectively). The percentage of CD19+ B cells in patients with UPDRS scores[24 was lower than in those with scores \24(10.17% ±4.19% versus 12.22% ± 5.39%, P = 0.009). In addition, the Treg/Th17 ratio in female patients was higher than that in female controls(13.88 ± 6.32 versus 9.94 ± 4.06, P =0.042). These results suggest that the percentages of NK cells,CD3+ T cells, and CD19+ B cells along with the Treg/Th17 ratio in peripheral blood may be used to predict the risk of PD in Chinese individuals and provide fresh avenues for novel diagnostic biomarkers and therapeutic designs. | Luan Cen Chaohao Yang Shuxuan Huang Miaomiao Zhou Xiaolu Tang Kaiping Li Wenyuan Guo Zhuohua Wu Mingshu Mo Yousheng Xiao Xiang Chen Xinling Yang Qinhui Huang Chaojun Chen Shaogang Qu Pingyi Xu | 2017 | Neuroscience Bulletin2017，33，5： | 5 |
| 4 | Multi-functional vesicles improve Helicobacter pylori eradication by a comprehensive strategy based on complex pathological microenvironment显示文摘Helicobacter pylori(H.pylori),creating a global infection rate over 50%,presents great challenges in clinical therapies due to its complex pathological microenvironment in vivo.To improve the eradication efficacy,herein we fabricated a pharmaceutical vesicle RHL/Cl-Ch-cal where cholesterol-PEG,calcitriol and first-line antibiotic clarithromycin were co-loaded in the rhamnolipid-composed outer lipid layer.RHL/Cl-Ch-cal could quickly penetrate through gastric mucus layer to reach H.pylori infection sites,and then effectively destroyed the architecture of H.pylori biofilms,killed dispersed H.pylori and inhibited the re-adhesion of residual bacteria(called biofilms eradication tetralogy).Moreover,RHL/Cl-Ch-cal activated the host immune response to H.pylori by replenishing cholesterol to repair lipid raft on the cell membrane of host epithelial cells.Finally,RHL/Cl-Ch-cal killed the intracellular H.pylori through recovering the lysosomal acidification and assisting degradation.In experiments,RHL/Cl-Ch-cal demonstrated prominent anti-H.pylori efficacy in the classical H.pylori-infected mice model.Therefore,the study provides a“comprehensive attack”strategy for anti-H.pylori therapies including biofilms eradication tetralogy,immune activation and intracellular bacteria killing. | Xiaonan Chen Yiqing Zou Shuqi Zhang Pengchao Fang Shuxuan Li Pengyu Li Yingying Sun Gang Yuan Haiyan Hu | 2022 | Acta Pharmaceutica Sinica B2022，12，9： | 2 |
| 5 | Multi-scale variation characteristics of polar vortex at 10 hPa in the Southern Hemisphere显示文摘By use of 1948-2007 NCEP/NCAR reanalysis monthly geopotential data, a set of circulation indices are defined to characterize the polar vortex at 10 hPa in the Southern Hemisphere, including area-(S), intensity-(P) and centre position-(λc , φc) indices. Sea-sonal variation, interannual anomalies and their possible causes of 10 hPa polar vortex in the Southern Hemisphere are analyzed by using these indices, the relationship between 10 hPa polar vortex strength and the Antarctic Oscillation are analyzed as well. The results show that: (1) the polar region at 10 hPa in the Southern Hemisphere is controlled by anticyclone (cyclone) from Dec. to Jan. (from Mar. to Oct.), Feb. and Nov. are circulation transition seasons. (2) Intensity index (P) and area index (S) of anticy-clone (cyclone) in Jan. (Jul.) show a significant spike in the late 1970s, the anticyclone (cyclone) enhances (weakens) from ex-tremely weak (strong) oscillation to near the climatic mean before a spike, anticyclone tends to the mean state from very strong oscillation and cyclone oscillates in the weaker state after the spike. (3) There is significant interdecadal change for the anticyclone center in Jan., while markedly interannual variation for cyclone center in July. (4) The ozone anomalies can cause the interannual anomaly of the polar anticyclone at 10 hPa in the Southern Hemisphere in Jan. (positive correlation between them), but it is not related to the polar cyclone anomalies. (5) There is notable negative correlation between the polar vortex intensity index P and the Antarctic Oscillation index (AAOI), thus AAOI can be represented by P. | LiPing Li JuHui Ma PanXing Wang Dong Guo MingKen Duan ShuXuan Guan | 2010 | Research in Cold and Arid Regions2010，2，1： | 1 |
| 6 | Definition and analysis of the circulation indices of polar vortex at 10 hPa in the Northern Hemisphere显示文摘A set of circulation indices are defined and calculated to characterize monthly mean polar vortex at 10 hPa geopotential height chart in the Northern Hemisphere,including area-(S),intensity-(P) and center position (λc,φc)-indices by use of 1948-2007 NCEP/NCAR 10 hPa monthly height data.These indices series are used to investigate the seasonal variation and interannual anomaly of polar vortex,along with the relations with global warming,ozone anomaly and Arctic Oscillation (AO).The results show that (1) there is anticyclonic (cyclonic) from Jun.to Aug.(from Sep.to Mar.).The change of spring circulation pattern is slower than that of autumn.(2) S can be replaced by P due to the interannual synchronal variations of the intensity and area for polar vortex.The interannual (interdecadal) variations of P are significant in Jan.(Jul.).(3) The anomalies of system center position in Jan.are more evident than that in Jul.(4) The variations of mean temperature at mid-stratosphere in the vicinity of pole zone in Jan.are different from that in Jul.,but they are synchronal with the corresponding P and not significant correlation with the trend of global warming.However,the relationship between P and total O3 in Jul.are obvious.(5) There is so notable correlation between P and AO that P can represent AO. | LiPing Li ShuXuan Guan PanXing Wang JuHui Ma | 2009 | Research in Cold and Arid Regions2009，1，6： | 1 |
| 7 | Building the metaverse using digital twins at all scales,states,and relations显示文摘Developments in new-generation information technology have enabled Digital Twins to reshape the physical world into a virtual digital space and provide technical support for constructing the Metaverse.Metaverse objects can be at the micro-,meso-,or macroscale.The Metaverse is a complex collection of solid,liquid,gaseous,plasma,and other uncertain states.Additionally,the Metaverse integrates tangibles with social relations,such as interpersonal(friends,partners,and family)and social relations(ethics,morality,and law).This review introduces some principles and laws,such as broken windows theory,small-world phenomenon,survivor bias,and herd behavior,for constructing a Digital Twins model for social relations.Therefore,from multiple perspectives,this article reviews mappings of tangible and intangible real-world objects to the Metaverse using the Digital Twins model. | Zhihan LV Shuxuan XIE Yuxi LI M.Shamim HOSSAIN Abdulmotaleb El SADDIK | 2022 | Virtual Reality & Intelligent Hardware2022，4，6： | 1 |
| 8 | Regulating ethane and ethylene synthesis by proton corridor microenvironment for CO_(2) electrolysis显示文摘Electrocatalytic reduction of carbon dioxide is one of the most effective strategies to achieve carbon neutrality and energy sustainability.Although high-value multi-carbon products have been widely studied,limited electrocatalysts have been reported for the selective conversion of ethane.More importantly,the factors tuning the selectivity between ethane and ethylene have not been clarified.Here,Zn@Cu nanowire arrays(Zn@Cu-NWAs) catalyst is proposed to stimulate the maintenance of efficient CO_(2)-to-C_(2)H_(6) conversion at high current densities.Meanwhile,in order to investigate the factors affecting the interconversion between ethane and ethylene,the counterpart catalyst that facilitates C–C coupling to ethylene was also synthesized.Time-of-flight secondary-ion mass spectroscopy(TOF-SIMS),in-situ Raman spectroscopy,and simulation results show that Zn@Cu-NWAs can provide a localized proton corridor environment for the formation of ethane,accelerating the further proton-coupled CO_(2) reduction reaction(CO_(2)RR)kinetics.Hence,this catalyst delivered an ethane Faraday efficiency of over 65% at-1.14 V vs.RHE with a total current density of 142.3 mA/cm^(2).This work provides a new perspective on regulating the local microenvironment to modify the selectivity of multi-carbon products. | Xiaowen Zhang Bohua Ren Hao Li Shuxuan Liu Haoyang Xiong Silong Dong Yifan Li Dan Luo Yi Cui Guobin Wen Xin Wang | 2023 | Journal of Energy Chemistry2023，，12： | 0 |
| 9 | Phosphorus Fractions in Water and Sediment and Their Correlations in Hengshui Lake, China显示文摘 | Zhanchen Li Fang Liu Zhe Qin Shuxuan Liang | 2016 | Journal of Environmental Science and Engineering(A)2016，5，7： | 0 |
| 10 | π-Pimer,π-Dimer,π-Trimer,and 1Dπ-Stacks in a Series of Benzene Triimide Radical Anions:Substituent-Modulated π Interactions and Physical Properties in Crystalline State显示文摘We herein present the efficient syntheses,crystal structures,and physical properties of a series of novel benzene triimide(BTI)radical anions,emphasizing the relationship between molecular structure with spin–spin intermolecular interactions and physical properties in the crystalline state.BTI radical crystals were preparedby reducingvarious substitutedBTIs(1)with cobaltocene(CoCp2),followed by sequential crystallization processes.Two isolable radical species,that is,neutral molecule-radical anion pair(2)and monoradical species(3),were obtained from BTIs bearing small substituents(ethyl and propyl),while for those bearing larger substituents(butyl,hexyl,and benzyl)sole monoradicals(3)were produced.The radical species showed diverse intermolecular stackings in the crystalline state referred to asπ-pimer,π-dimer,alternatingπ-trimer,and one-dimensional(1D)slippedπ-stacks depending on the length and size of the substituents.Different spin–spin interactions arising from the substituent-tuned radical packings were demonstrated by electron spin resonance(ESR)spectra.The structure–property relationshipwas studied in terms of magnetism and conductivity.The radicalπ-pimers andπ-stacks with effective charge transport exhibited paramagnetic property and conductivity feasibly at room temperature,whileπ-dimers andπ-trimers featuring thermally populated spin-triplet stateswere antiferromagnetic and nonconductive due to their strong radical–radical pairing effect. | De-Hui Tuo Shuxuan Tang Pengfei Jin Jikun Li Xinping Wang Chuang Zhang Yu-Fei Ao Qi-Qiang Wang De-Xian Wang | 2023 | CCS Chemistry2023，5，6： | 0 |
| 11 | A multifunctional cholesterol-free liposomal platform based on protopanaxadiol for alopecia therapy显示文摘Liposome could form a long-term drug reservoir in the skin for sustained drug release,which is beneficial to improving efficacy and alleviating adverse effects.Thus,it has become a better option for anti-alopecia drugs delivery.However,cholesterol used as the fluidity buffer in conventional liposomes is a precursor for testosterone biosynthesis,which could convert to dihydrotestosterone,resulting in hair follicle damage and potentiating hair loss.To overcome the limitations,in this study we prepared a cholesterol-free liposome(PPD-Lip)using protopanaxadiol(PPD)instead of cholesterol to avoid the biosynthesis of testosterone which is adverse to alopecia therapy.PPD-Lip also worked as an active ingredient to facilitate hair growth by promoting dermal papilla cells proliferation and migration,upregulating mRNA levels of hair growth-related positive regulators,and accelerating angiogenesis in vitro.Meanwhile,it promoted hair regrowth in telogen and androgenetic alopecia mice models in vivo.In addition,our study showed that as the liposomal vehicle,PPD-Lip loaded with dutasteride exerted a stronger efficacy in the treatment of androgenetic alopecia and such a strategy could extend to other anti-alopecia agents.To the best of our knowledge,being easy for clinical transformation,the PPD-based liposomal delivery system provides a promising and multifunctional alternative platform for the delivery of alopecia treatment agents. | Xuefei Zhang Shuxuan Li Yating Dong Hehui Rong Junke Zhao Haiyan Hu | 2022 | Nano Research2022，15，10： | 0 |
| 12 | Design and Realization of Baiyangdian Water Environment Information System Based on ArcGIS Engine显示文摘 | Fan Li Xiaoyan Li Hao Xu Shuxuan Liang | 2013 | Journal of Environmental Science and Engineering(A)2013，2，1： | 0 |
| 13 | In situ magnetometry study on the origin of anomalously capacity in transition metal sulfides显示文摘Cobalt sulfides are considered as promising candidates for lithium-ion battery(LIB)anode materials with high energy densities.Their energy storage mechanism is widely understood to involve the traditional intercalation and conversion reaction.However,these conventional mechanisms are unable to explain the storage capacities of certain materials which exceed the theoretical limit.Here,utilizing advanced in situ magnetometry to detect the magnetization evolution of Co_(1-x) S LIBs in real time,it is demonstrated that the Co-catalytic lithium storage process and interfacial space charge storage mechanism are strongly related to the additional capacity of cobalt sulfides.During discharge,a Co/Li_(2) S interface is formed,wherein the Co nanoparticles and Li_(2) S could store a large amount of polarized electrons Li^(+),respectively.Subsequently,the electrons stored in Co are transferred to the polymeric film,forming radical anions and contributing extra capacity.These findings reveal the charge storage mechanisms of transition metal sulfides and highlight the critical role of magnetic testing in the investigation of energy storage mechanisms. | Yan Liu Yuanyuan Han Shuxuan Liao Fangchao Gu Hengjun Liu Xixiang Xu Zhiqiang Zhao Xiancheng Sang Qinghao Li Weijin Kong Qiang Li | 2023 | ChemPhysMater2023，2，3： | 0 |
| 14 | Expression and analysis of zinc fi nger family gene in Lenzites gibbosa显示文摘Zinc finger transcription factors play significant roles in the growth and development of plant and animal,but their function remains obscure in fungi.Lenzites gibbosa mycelia were extracted and sequenced by transcriptome analysis after growing on sawdust at different times to support mycelial growth of L.gibbosa in a nutrient matrix.Data bases used for analysis were the Kyoto encyclopedia of genes and genomes(KEGG)annotation,the cluster of orthologous groups of proteins(COG)and gene ontology(GO)annotation.Zinc finger class genes related to the growth and development of L.gibbosa were screened.GO annotation and enrichment analysis of diff erentially expressed genes were carried out.A total of 114.55 Gb Clean Data were obtained from the L.gibbosa transcriptome.The average Clean Data in each sample was 6.16 Gb.The relative efficiency of reads between each sample and the reference genome was 88.5%to 91.4%.The COG analysis showed that most zinc finger protein genes were related to replication,recombination and repair function.GO enrichment analysis showed that the expressed genes involved in cellular process,cell part and binding.We identifi ed seventy-two expressed genes including seven up-regulated genes and sixty-five down-regulated genes by applying DESeq2 data analysis software.By comparing the significantly expressed genes with KEGG database,66 annotated sequences were obtained,and 35 primary metabolic pathways were annotated.Pathway enrichment analysis showed that differentially expressed genes were signifi cantly enriched in protein processing in endoplasmic reticulum and ubiquitin-mediated proteolysis pathways.Gene_11750 and gene_5266 are highly correlated with the growth and development of L.gibbosa and are closely related to protein processing in endoplasmic reticulum and ubiquitin-mediated proteolysis pathway.According to gene functional analysis,seven important differentially expressed genes related to the growth and development of L.gibbosa were identified. | Jun Zhang Yujie Chi Shuxuan Li Jian Zhang Jie Chen | 2020 | Journal of Forestry Research2020，31，5： | 0 |
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