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| 1 | Reconstruction of nerve root sheaths for sacral extradural spinal meningeal cysts with spinal nerve root fibers显示文摘This study analyzed the clinical characteristics and outcomes of sacral extradural spinal meningeal cysts with spinal nerve root fibers treated by reconstruction of the nerve root sheaths.The relationships between the cysts and spinal nerve root fibers were examined microscopically,the cysts were partially excised,and the defects were oversewn to reconstruct the nerve root sheaths.The Improved Japanese Orthopedic Association(IJOA)scoring system was used to evaluate preoperative and postoperative neurological function.Thirty-eight patients were included in this study,with a mean age of 41.4±15.57 years.The mean IJOA score was 18.8±1.32 preoperatively and 19.6±0.65 postoperatively,which was a significant difference(t=–3.77,P=0.001).These results indicate a significant improvement in neurological function after surgery.The most significant improvement in neurological function was sensation(z=–2.86,P=0.004),followed by bowel/bladder function(z=–2.31,P=0.02). | SUN JianJun WANG ZhenYu LI ZhenDong WU HaiBo YEN RuYu ZHENG Mei CHANG Qing LIU Isabelle Yisha | 2013 | Science China(Life Sciences)2013，56，11： | 8 |
| 2 | Near-infrared small molecular fluorescent dyes for photothermal therapy显示文摘Near-infrared(NIR)fluorescent dyes based on small organic molecules are characterized with low cytotoxicity,good biocompatibility and minimum interference from auto-fluorescence background,which are widely used in tumor diagnosis.Intensive research on molecular properties and photothermal properties of fluorescent dyes have been explored for non-invasive photothermal treatment of cancer.In this review,we focus on the development of imaging-induced photothermal therapy of small molecules and classification according to the structures of organic molecules including cyanines,phthalocyanines,rhodamine analogues and BODIPYs. | Yisha Chen Li Li Weijie Chen Haiyan Chen Jun Yin | 2019 | Chinese Chemical Letters2019，30，7： | 3 |
| 3 | Micro RNAs Regulating Signaling Pathways:Potential Biomarkers in Systemic Sclerosis显示文摘Systemic sclerosis(SSc) is a multisystem fibrotic and autoimmune disease. Both genetic and epigenetic elements mediate SSc pathophysiology. This review summarizes the role of one epigenetic element, known as micro RNAs(mi RNAs), involved in different signaling pathways of SSc pathogenesis. The expression of key components in transforming growth factor-b(TGF-b)signaling pathway has been found to be regulated by mi RNAs both upstream and downstream of TGF-b. We are specifically interested in the pathway components upstream of TGF-b, while mi RNAs in other signaling pathways have not been extensively studied. The emerging role of mi RNAs in vasculopathy of SSc suggests a promising new direction for future investigation. Elucidation of the regulatory role of mi RNAs in the expression of signaling factors may facilitate the discovery of novel biomarkers in SSc and improve the understanding and treatment of this disease. | Yisha Li Jing Huang Muyao Guo Xiaoxia Zuo | 2015 | Genomics, Proteomics & Bioinformatics2015，13，4： | 3 |
| 4 | Photodynamic therapy based on organic small molecular fluorescent dyes显示文摘Photodynamic therapy(PDT) has shown promise as an effective treatment modality for cancer and other localized diseases due to its noninvasive properties and spatiotemporal selectivity. Near-infrared(NIR)fluorescent dyes based on organic small molecules are characterized with low cytotoxicity, good biocompatibility and excellent phototoxicity, which are widely used in PDT. In this review, we attempt to summarize the development of imaging-induced PDT based on organic small molecules and classify it according to the structures of dyes including cyanines, 4,4-difluoro-4-bora-3 a,4 a-diaza-s-indacene(BODIPY) analogues, phthalocyanine and other agents such as rhodamine analogues. | Li Li Yisha Chen Weijie Chen Ying Tan Haiyan Chen Jun Yin | 2019 | Chinese Chemical Letters2019，30，10： | 2 |
| 5 | Effective suppression of the photodarkening effect in high-power Yb-doped fiber amplifiers by H2 loading显示文摘The radical suppression of the photodarkening effect and laser performance deterioration via H2 loading were demonstrated in high-power Yb-doped fiber(YDF)amplifiers.The photodarkening loss at equilibrium was114.4 d B/m at 702 nm in the pristine fiber,while it vanished in the H2-loaded fiber.To obtain a deeper understanding of the impact of photodarkening on laser properties,the evolution of the mode instability threshold and output power in fiber amplifiers was investigated.After pumping for 300 min,the mode instability threshold of the pristine fiber dropped from 770 to 612 W,and the periodic fluctuation of the output power became intense,finally reaching 100 W.To address the detrimental effects originating from photodarkening,H2 loading was applied in contrast experiments.The output power remained stable,and no sign of mode instability was observed in the H2-loaded fiber.Moreover,the transmittance at 638 nm confirmed the absence of the photodarkening effect.The results pave the way for the further development of high-power fiber lasers. | RUITING CAO GUI CHEN YISHA CHEN ZHILUN ZHANG XIANFENG LIN BIN DAI LUYUN YANG JINYAN LI | 2020 | Photonics Research2020，8，3： | 2 |
| 6 | MicroRNA-21 in Scleroderma Fibrosis and its Function in TGF-β- Regulated Fibrosis-Related Genes Expression显示文摘 | Honglin Zhu Hui Luo Yisha Li Yaou Zhou Ying Jiang Jin Chai Xianzhong Xiao Yunhui You Xiaoxia Zuo | 2013 | Journal of Clinical Immunology2013，，6： | 1 |
| 7 | Study on Application of Conflict Analysis in Chinese Stock Market显示文摘 | Yisha Na Congdong Li | 2004 | China-USA Business Review2004，3，5： | 0 |
| 8 | ERPApplication in China.显示文摘 | Yisha Na Congdong Li | 2004 | China-USA Business Review2004，3，1： | 0 |
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