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| 1 | Cyanobacteria-based self-oxygenated photodynamic therapy for anaerobic infection treatment and tissue repair显示文摘Photodynamic therapy(PDT)is an important technique to deal with drug-resistant bacterial infections in the post-antibiotic era.However,the hypoxic environment in intractable infections such as refractory keratitis and periodontitis,makes PDT more difficult.In this work,spontaneous oxygen-producing cyanobacteria were used as the carrier of photosensitizer(Ce6),and ultrasmall Cu_(5.4)O nanoparticles(Cu_(5.4)O USNPs)with catalase activity for infection and inflammation elimination and rapid tissue repair(CeCycn-Cu_(5.4)O).The loading of Ce6 and Cu_(5.4)O USNPs onto cyanobacteria surface were confirmed by transmission electron microscopy,nano particle size analyzer,scanning electron microscopy.In vitro sterilization and biofilm removal experiments demonstrated that the restriction of hypoxic environment to PDT was significantly alleviated due to the oxygen production of cyanobacteria.Under laser irradiation,the close transfer of energy photons to oxygen produced by cyanobacteria reduced more than 90% of Ce6 dosages(660 nm,200 mW/cm^(2),2 min).It is worth mentioning that both rapid sterilization through PDT and long-term oxidized free radicals elimination were achieved by adjusting the ratio of Ce6 and Cu_(5.4)O USNPs.Both periodontitis and refractory keratitis animal models proved the excellent self-oxygenation enhanced antibacterial property and promotion of tissue repair. | Bailiang Wang Liyang Zhou Yishun Guo Hanwen Guo Yiming Zhong Xiaomin Huang Yifan Ge Qingying Wang Xiaoying Chu Yingying Jin Kaiyue Lan Mei Yang Jia Qu | 2022 | Bioactive Materials2022，7，6： | 3 |
| 2 | Label propagation dictionary learning based process monitoring method for industrial process with between-mode similarity显示文摘With the development of the industrial cyber-physical systems,a small amount of labeled data and a large amount of unlabeled data are collected from the industrial process.Due to the variation of internal operation conditions and external environment,there is a between-mode similarity between data samples.The scarcity of labeled data and the existence of similarity make it challenging to extract data characteristics.In addition,it creates new challenges to process monitoring.To solve these problems,this study proposes a label propagation dictionary learning method.We first establish the connection between atoms and corresponding profiles and realize the propagation of their labels through graph Laplacian regularization.Then,considering the similarity of samples in the same class,the low-rank constraint is added to sparse coding to strengthen the mutual propagation of labels.Finally,an optimization method is designed to obtain the dictionary and classifier simultaneously.When new data samples arrive,we conduct process monitoring and condition prediction based on the learned dictionary and classifier.Experiments show that the proposed method can achieve satisfactory monitoring performance when compared to several state-of-the-art methods,indicating the superiority of the proposed method. | Keke HUANG Shijun TAO Yishun LIU Chunhua YANG Weihua GUI | 2022 | Science China(Information Sciences)2022，65，1： | 2 |
| 3 | Modular design of urban traffic-light control systems based on synchronized timed Petri nets显示文摘 | Huang Yisheng Weng Yishun Zhou Mengchu | 2014 | IEEE Trans on Intelligent Transportation Systems2014，15，2： | 1 |
| 4 | Target-responsive DNAzyme hydrogel for portable colorimetric detection of lanthanide(Ⅲ)ions显示文摘Lanthanide elements(Ln)play an important role in industry and agriculture.As a result of the increasing consumption of lanthanides,environmental emission of Ln has become detrimental to the health of flora and fauna.Current methods for trace lanthanides detection mainly rely on sophisticated instruments.In this article,a Ln^(3+)dependent DNAzyme was incorporated into a hydrogel to generate Ln^(3+)sensitive DNAzyme hydrogel for portable colorimetric detection.The enzyme strand and its substrate strand act as crosslinker and functional unit of the hydrogel with polyacrylamide chains as the scaffold and gold nanoparticles(AuNPs)as the indicator of hydrogel stability.Any ions in the Ln^(3+)series can trigger the cleavage of substrate strand by activating the enzyme strand,thereby decreasing the crosslink ratio and leading to collapse of the hydrogel.The release of the encapsulated AuNPs turns the supernatant wine red.Using this colorimetric method,Ln^(3+)can be detected with high sensitivity,with a limit of detection(LOD)of 20 nM for Ce^(3+).The hydrogel responds specifically to any Ln^(3+)ion and works well with the spiked lake sample without the need of instruments and skilled operators.Our results suggest that the lanthanide responsive hydrogel can be used for portable and sensitive detection of Ln^(3+)contamination in the field. | Yishun Huang Xuemeng Wu Tian Tian Zhi Zhu Hui Lin Chaoyong Yang | 2017 | Science China Chemistry2017，60，2： | 0 |
| 5 | Molecular behavior of the aptamer HJ24 self-assembled on highly oriented pyrolytic graphite(HOPG)显示文摘Nucleic acid sensing analysis has been widely applied to the fields of food quality control, environmental monitoring, and medical diagnosis. A key step in developing effective DNA-based electrochemical biosensors is to obtain a biorecognition layer on the biosensor, which can be influenced by many factors. Hence, we constructed a series of HJ24 layers on highly oriented pyrolytic graphite to investigate the relation between the configuration of the adsorbed probe HJ24 and the redox property using atomic force microscopy and voltammetry. We used HJ24 for its diagnostic value as it specifically recognizes the SH2 domain-containing phosphatase, a critical contributor in many important signaling pathways. The results demonstrated that increasing K ions induced G-quartet oxidation peak occurrence/increase([K+]?400 mmol/L), and also resulted in the formation of more compact single strand sheets([K+]?300 mmol/L). Moreover, transitions of molecule configurations and redox currents of G-quartets were observed at low concentration [K+]=12 mmol/L, which may indicate the appearance of new configurations under this condition. Besides, by analyzing atomic force microscopy(AFM) images, it was found that the different adsorbed configurations are correlated with the HJ24 concentration, the basal configuration, and the linker group on the HJ24 sequence. This information may be useful for understanding the adsorption process of HJ24 as well as for the further development of practical applications for HJ24 films on DNA electrochemical sensors, and may ultimately help improve the diagnosis and treatment of patients with SHP2-related diseases. | Xueqin Zhao Yishun Huang Chaoyong James Yang Bingwei Mao | 2015 | Science China(Information Sciences)2015，58，12： | 0 |
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