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| 1 | Erianin,a novel dibenzyl compound in Dendrobium extract,inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis显示文摘Ferroptosis,a novel form of programmed cell death,is characterized by iron-dependent lipid peroxidation and has been shown to be involved in multiple diseases,including cancer.Stimulating ferroptosis in cancer cells may be a potential strategy for cancer therapy.Therefore,ferroptosis-inducing drugs are attracting more attention for cancer treatment.Here,we showed that erianin,a natural product isolated from Dendrobium chrysotoxum Lindl,exerted its anticancer activity by inducing cell death and inhibiting cell migration in lung cancer cells.Subsequently,we demonstrated for the first time that erianin induced ferroptotic cell death in lung cancer cells,which was accompanied by ROS accumulation,lipid peroxidation,and GSH depletion.The ferroptosis inhibitors Fer-1 and Lip-1 but not Z-VAD-FMK,CQ,or necrostatin-1 rescued erianin-induced cell death,indicating that ferroptosis contributed to erianin-induced cell death.Furthermore,we demonstrated that Ca^(2+)/CaM signaling was a critical mediator of erianin-induced ferroptosis and that blockade of this signaling significantly rescued cell death induced by erianin treatment by suppressing ferroptosis.Taken together,our data suggest that the natural product erianin exerts its anticancer effects by inducing Ca^(2+)/CaMdependent ferroptosis and inhibiting cell migration,and erianin will hopefully serve as a prospective compound for lung cancer treatment. | Peng Chen Qibiao Wu Jiao Feng Lili Yan Yitian Sun Shuiping Liu Yu Xiang Mingming Zhang Ting Pan Xiaying Chen Ting Duan Lijuan Zhai Bingtao Zhai Wengang Wang Ruonan Zhang Bi Chen Xuemeng Han Yicong Li Liuxi Chen Ying Liu Xingxing Huang Ting Jin Wenzheng Zhang Hong Luo Xiaohui Chen Yongqiang Li Qiujie Li Guohua Li Qin Zhang Lvjia Zhuo Zuyi Yang Huifen Tang Tian Xie Xiaoping Ouyang Xinbing Sui | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 42 |
| 2 | PCDH17 increases the sensitivity of colorectal cancer to 5-fluorouracil treatment by inducing apoptosis and autophagic cell death显示文摘5-Fluorouracil(5-FU)is known as a first-line chemotherapeutic agent against colorectal cancer(CRC),but drug resistance occurs frequently and significantly limits its clinical success.Our previous study showed that the protocadherin 17(PCDH17)gene was frequently methylated and functioned as a tumor suppressor in CRC.However,the relationship between PCDH17 and 5-FU resistance in CRC remains unclear.Here,we revealed that PCDH17 was more highly expressed in 5-FU-sensitive CRC tissues than in 5-FU-resistant CRC tissues,and high expression of PCDH17 was correlated with high BECN1 expression.Moreover,this expression profile contributed to superior prognosis and increased survival in CRC patients.Restoring PCDH17 expression augmented the 5-FU sensitivity of CRC in vitro and in vivo by promoting apoptosis and autophagic cell death.Furthermore,autophagy played a dominant role in PCDH17-induced cell death,as an autophagy inhibitor blocked cell death to a greater extent than the pancaspase inhibitor Z-VAD-FMK.PCDH17 inhibition by siRNA decreased the autophagy response and 5-FU sensitivity.Mechanistically,we showed that c-Jun NH2-terminal kinase(JNK)activation was a key determinant in PCDH17-induced autophagy.The compound SP600125,an inhibitor of JNK,suppressed autophagy and 5-FU-induced cell death in PCDH17-reexpressing CRC cells.Taken together,our findings suggest for the first time that PCDH17 increases the sensitivity of CRC to 5-FU treatment by inducing apoptosis and JNK-dependent autophagic cell death.PCDH17 may be a potential prognostic marker for predicting 5-FU sensitivity in CRC patients. | Shuiping Liu Haoming Lin Da Wang Qiang Li Hong Luo Guoxiong Li Xiaohui Chen Yongqiang Li Peng Chen Bingtao Zhai Wengang Wang Ruonan Zhang Bi Chen Mingming Zhang Xuemeng Han Qiujie Li Liuxi Chen Ying Liu Xiaying Chen Guohua Li Yu Xiang Ting Duan Jiao Feng Jianshu Lou Xingxing Huang Qin Zhang Ting Pan Lili Yan Ting Jin Wenzheng Zhang Lvjia Zhuo Yitian Sun Tian Xie Xinbing Sui | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 4 |
| 3 | Fabrication and characterization of crystalline copper nanowires by electrochemical deposition inside anodic alumina template显示文摘Copper nanowires were fabricated by electrochemical deposition inside anodic alumina template anodized on aluminum substrate. The morphology, composition and structure of the copper nanowires were characterized by means of scanning electron microscopy (SEM), transmission electron microscopy (TEM), high-resolution transmission electron microscopy (HRTEM), energy-dispersive (EDS) and X-ray diffraction spectroscopy (XRD). The results revealed that copper nanowires were dense, continuous, highly-crystalline and uniform with diameters. The electrical properties of copper nanowires wrer characterized with two-terminal electrical measurements. Different current-voltage (I-V) characteristics of single copper nanowire were observed and possible conductive mechanisms were discussed. The crystalline copper nanowires are promising in application of future nanoelectronic devices and circuits. | PENG YiTian CHEN QuanFang | 2013 | Chinese Science Bulletin2013，58，27： | 2 |
| 4 | Ultrasonic-assisted fabrication of highly dispersed copper/multi-walled carbon nanotube nanowires显示文摘 | Peng Yitian Chen Quanfang | 2009 | Colloids Surf A:Physicochem Eng Aspects2009，342，： | 1 |
| 5 | A Tapped Stepped-Imped- ance Balun with Dual-Band Operations 显示文摘 | Hualiang Zhang Yitian Peng Hao Xin | 2008 | Antennas and Wire- less Propagation Letters IEEE2008，7，20： | 1 |
| 6 | Tribological behaviors of surfactant-functionalized carbon nanotubes as lubricant additive in water显示文摘 | Yitian Peng Yuanzhong Hu Hui Wang | 2006 | Tribology Letters2006，25，3： | 1 |
| 7 | Tribological behaviors of surfactant-functionalized carbon nanotubes as lubricant additive in water显示文摘 | Peng Yitian Hu Yuanzhong Wang Hui | 2007 | Tribology Letters2007，25，3： | 1 |
| 8 | Tribological Be- haviors of Surfactant - Funetionalized Carbon Nanotubesas l,ubricant Additive in Water 显示文摘 | Yitian Peng Yuanzhong Hua Hui Wang | 2007 | Tribology Letters2007，25，3： | 1 |
| 9 | Patterned deposition of multi-walled carbon nanotubes on self-assembled monolayers显示文摘Patterned chemical template consisting of both amine- and methyl-terminated self-assembled monolayers has been fabricated. The deposition of carbon nanotubes is carried out by immerging the patterned substrate into dimethylformamide (DMF) solution with suspended carbon nanotubes (CNTs). SEM images show a successful patterned deposition that carbon nanotubes selectively deposit in the area with amino-terminated SAMs due to the strong attract force between the monolayer and the suspended CNTs. This experiment provides an opportunity for manipulating individual CNTs, and represents a sig- nificant step in development of CNTs-based nanode- vices. | PENG Yitian HU Yuanzhong WANG Hui | 2006 | Chinese Science Bulletin2006，51，2： | 1 |
| 10 | Tribologieal behaviors of surfactant-funetionalized carbon nanotubes as lubricant addi- tive in water 显示文摘 | Peng Yitian Hu Yuanzhong Wang Hui | 2003 | Tribology Letters2003，25，3： | 1 |
| 11 | Nanofriction characteristics of h-BN with electric field induced electrostatic interaction显示文摘The nanofriction properties of hexagonal boron nitride(h-BN)are vital for its application as a substrate for graphene devices and solid lubricants in micro-and nano-electromechanical devices.In this work,the nanofriction characteristics of h-BN on Si/SiO_(2) substrates with a bias voltage are explored using a conductive atomic force microscopy(AFM)tip sliding on the h-BN surface under different substrate bias voltages.The results show that the nanofriction on h-BN increases with an increase in the applied bias difference(V_(t–s))between the conductive tip and the substrate.The nanofriction under negative V_(t–s) is larger than that under positive V_(t–s).The variation in nanofriction is relevant to the electrostatic interaction caused by the charging effect.The electrostatic force between opposite charges localized on the conductive tip and at the SiO2/Si interface increases with an increase in V_(t–s).Owing to the characteristics of p-type silicon,a positive V_(t–s) will first cause depletion of majority carriers,which results in a difference of nanofriction under positive and negative V_(t–s).Our findings provide an approach for manipulating the nanofriction of 2D insulating material surfaces through an applied electric field,and are helpful for designing a substrate for graphene devices. | Kemeng YU Kun ZOU Haojie LANG Yitian PENG | 2021 | Friction2021，9，6： | 0 |
| 12 | NaHCO_(3)-induced porous PbI_(2) enabling efficient and stable perovskite solar cells显示文摘Driven by their many unique features,perovskite solar cells(PSCs)have become one of the most promising candidates in the photovoltaic field.Two-step preparation of perovskite film is advantageous for its higher stability and reproducibility compared to the one-step method,which is more suitable for practical application.However,the incomplete conversion of the dense lead iodide(PbI_(2))layer during the sequential spin-coating of formamidinium/methylammonium(FA^(+)/MA^(+))organic amine salts severely affect the performance of PSCs.Herein,sodium bicarbonate(NaHCO_(3))is used to induce the formation of porous PbI_(2),which facilitates the penetration of the FA^(+)/MA^(+)ions and the formation of a perovskite film with high crystallinity and large grain microstructure.Meanwhile,the introduction of Na^(+)not only improves the energetic alignment of the PSC,but also increases the conductivity via p-doping.As a result,the optimized NaHCO_(3)-modified PSC achieves a champion power conversion efficiency of 24.0% with suppressed hysteresis.Moreover,the significant reduction in defect density and ion migration as well as a mild alkaline environment enhance the stability of device.The unencapsulated NaHCO_(3)-modified PSCs maintain over 90% of their original efficiency upon storage in ambient air(30%–40% relative humidity)for 2160 h.We have demonstrated an ingenious strategy for controlling the quality of perovskite and improving the performance of device by low-temperature foaming of simple inorganic molecules of NaHCO_(3). | Yitian Du Ying Wang Jihuai Wu Qi Chen Chunyan Deng Ran Ji Liuxue Sun Lina Tan Xia Chen Yiming Xie Yunfang Huang Yana Vaynzof Peng Gao Weihai Sun Zhang Lan | 2023 | InfoMat2023，5，6： | 0 |
| 13 | USP1-regulated reciprocal differentiation of Th17 cells and Treg cells by deubiquitinating and stabilizing TAZ显示文摘The balance between inflammatory T helper type 17(Th17)and immunosuppressive regulatory T(Treg)cells is critical for maintaining immune homeostasis in the human body and is tightly regulated under healthy conditions.An increasing number of studies have reported that deubiquitinases(DUBs)play a vital role in regulating Th17-and Treg-cell differentiation.However,the biological functions of only a small fraction of DUBs in Th17-and Treg-cell differentiation are well defined.In this study,we identified ubiquitin-specific peptidase 1(USP1)as a vital regulator of CD4+T-cell differentiation.USP1 promoted Th17-cell differentiation but attenuated Treg-cell differentiation,thereby promoting the development of inflammatory diseases.Mechanistically,USP1 in CD4+T cells enhanced the activity of RORγt but promoted the proteasomal degradation of Foxp3 through deubiquitination and stabilization of TAZ in vitro and in vivo.Notably,ML323,a specific inhibitor of the USP1/UAF1 deubiquitinase complex,inhibited Th17-cell differentiation and promoted Treg-cell differentiation in vitro and in vivo,indicating that ML323 might be a promising candidate for the treatment of diseases associated with an imbalance between Th17 and Treg cells.Our study highlights the critical role of USP1 in regulating adaptive immune responses and suggests that USP1 might be a drug target for the treatment of diseases associated with an imbalance between Th17 and Treg cells. | Xiaotong Zhu Peng Wang Xiaoxia Zhan Yuping Zhang Junli Sheng Shitong He Yitian Chen Dingnai Nie Xiaolong You Haiyan Mai Qinghong Yu Laisheng Li Ligang Jie Shengfeng Hu | 2023 | Cellular & Molecular Immunology2023，20，3： | 0 |
| 14 | Bionic immunoactivator copresenting autophagy promoting and costimulatory molecules for synergistic cancer immunotherapy显示文摘Immunotherapy has great promise in improving malignant tumor treatment.However,the efficacy of existing strategies is often limited by the immunosuppressive environment.Here,we demonstrate an in situ bionic immunoactivator,PLT-Bec1/DTA-1,with possessed natural advantages of platelets for tumor recruitment and activation,on which DTA-1(CD357 monoclonal antibody)and Bec1 were tethered as combined immune boosters.PLT-Bec1/DTA-1,as a self-triggered release repository,can deliver the pre-tethered Bec1 and DTA-1 deeply through the secretion of platelet microparticles(PMPs),thereby cooperate tacitly and exhibit superiority in immune activation of dendritic cells(DCs)and T cells via autophagy inducibility,coupled with glucocorticoid-induced tumor necrosis factor receptor(GITR)-triggered T_(Reg) suppression,remodeled the immunosuppressive network of tumor microenvironment.PLT-Bec1/DTA-1 promoted antigen presentation and T cell proliferation,and alleviated the low activity state of bone marrow-derived dendritic cells(BMDCs)in tumor suppressive environment.PLT-Bec1/DTA-1 inhibited tumor recurrence(5-and 13-fold lower of control group in tumor volume)and CD8^(+)T/T_(Reg) ratio(6.3-and 8.8-fold vs.control group)in mouse tumor model after intravenous or subcutaneous administration.Also,PLT-Bec1/DTA-1 prevented tumor colonization in lung through in situ immune activation,and was slightly superior to the combined of Bec1 and PD-L1.Our findings highlight the promise of delivering immunostimulatory payloads via bionic carriers,eliciting automatic in situ activation of effector immune cells in tumor microenvironment for tumor eradication.All these results provide promising prospects into the application of immunoactivator in improving cancer synergistic immunotherapy to overcome the bottlenecks in clinic. | Yiwei Peng Yiliang Yang Zhenzhen Yang Datong Gao Jiajia Li Qi Sun Yitian Du Meng Lin Xianrong Qi | 2024 | Nano Research2024，17，3： | 0 |
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