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| 1 | Deep Learning and Its Applications in Biomedicine显示文摘Advances in biological and medical technologies have been providing us explosive volumes of biological and physiological data,such as medical images,electroencephalography,genomic and protein sequences.Learning from these data facilitates the understanding of human health and disease.Developed from arti?cial neural networks,deep learning-based algorithms show great promise in extracting features and learning patterns from complex data.The aim of this paper is to provide an overview of deep learning techniques and some of the state-of-the-art applications in the biomedical?eld.We?rst introduce the development of arti?cial neural network and deep learning.We then describe two main components of deep learning,i.e.,deep learning architectures and model optimization.Subsequently,some examples are demonstrated for deep learningapplications,including medical image classi?cation,genomic sequence analysis,as well as protein structure classi?cation and prediction.Finally,we offer our perspectives for the future directions in the?eld of deep learning. | Chensi Cao Feng Liu Hai Tan Deshou Song Wenjie Shu Weizhong Li Yiming Zhou Xiaochen Bo Zhi Xie | 2018 | Genomics, Proteomics & Bioinformatics2018，16，1： | 22 |
| 2 | The recommendations of Chinese Parkinson’s disease and movement disorder society consensus on therapeutic management of Parkinson’s disease显示文摘Background:Parkinson’s disease(PD)is a chronic,progressive and debilitating disease,which affects over 2.5 million people in China.PD is characterized clinically by resting tremor,muscular rigidity,bradykinesia and postural instability.As the disease progresses,additional complications can arise such as non-motor and neurobehavioral symptoms.Pharmacological treatment and surgical intervention for PD have been implemented in China.Until 10 years ago,there was lack of standardization for the management of PD in different regions and among different physicians,leading to different treatment levels in different regions and different physicians.Since then,the Chinese Parkinson’s Disease and Movement Disorder Society have published three versions of guidelines for the management of PD in China,in 2006,2009 and 2014,respectively.Correspondingly,the overall level of treatment for PD in China improved.Objectives:To update the treatment guidelines based on current foreign and domestic practice guidelines and clinical evidence,and to improve the treatment options available to physicians in the management of PD.Summary:A variety of treatment recommendations in the treatment guidelines have been proposed,including physical activity and disease-modifying medication,which should be initiated at the early-stage of the disease.The principles of dosage titration should be followed to avoid acute adverse reactions to the drugs,to achieve a satisfactory clinical effect with a low dose and to reduce the incidence of long-term motor complications.Moreover,different treatment strategies should be considered at different stages of the disease.Importantly,treatment guidelines and personalized treatments should be valued equally.A set of treatment recommendations has been developed to assist physicians to improve and optimize clinical outcomes for patients with PD in China. | Shengdi Chen Piu Chan Shenggang Sun Haibo Chen Baorong Zhang Weidong Le Chunfeng Liu Guoguang Peng Beisha Tang Lijuan Wang Yan Cheng Ming Shao Zhenguo Liu Zhenfu Wang Xiaochun Chen Mingwei Wang Xinhua Wan Huifang Shang Yiming Liu Pingyi Xu Jian Wang Tao Feng Xianwen Chen Xingyue Hu Anmu Xie Qin Xiao | 2016 | Translational Neurodegeneration2016，5，1： | 23 |
| 3 | Electronic Skin from High-Throughput Fabrication of Intrinsically Stretchable Lead Zirconate Titanate Elastomer显示文摘Electronic skin made of thin,soft,stretchable devices that can mimic the human skin and reconstruct the tactile sensation and perception offers great opportunities for prosthesis sensing,robotics controlling,and human-machine interfaces.Advanced materials and mechanics engineering of thin film devices has proven to be an efficient route to enable and enhance flexibility and stretchability of various electronic skins;however,the density of devices is still low owing to the limitation in existing fabrication techniques.Here,we report a high-throughput one-step process to fabricate large tactile sensing arrays with a sensor density of 25 sensors/cm^(2) for electronic skin,where the sensors are based on intrinsically stretchable piezoelectric lead zirconate titanate(PZT)elastomer.The PZT elastomer sensor arrays with great uniformity and passive-driven manner enable highresolution tactile sensing,simplify the data acquisition process,and lower the manufacturing cost.The high-throughput fabrication process provides a general platform for integrating intrinsically stretchable materials into large area,high device density soft electronics for the next-generation electronic skin. | Yiming Liu Huanxi Zheng Ling Zhao Shiyuan Liu Kuanming Yao Dengfeng Li Chunki Yiu Shenghan Gao Raudel Avila Pakpong Chirarattananon Lingqian Chang Zuankai Wang Xian Huang Zhaoqian Xie Zhengbao Yang Xinge Yu | 2020 | Research2020，，1： | 11 |
| 4 | Geomicrobial functional groups:A window on the interaction between life and environments显示文摘Microbes are well-known for their great diversity and abundance in modern natural environments.They also are believed to pro-vide critical links among higher organisms and their associated environments.However,the low diversity of morphological fea-tures and structures of ancient microbes preserved in sediments and rocks make them difficult to identify and classify.This diffi-culty greatly hinders the investigation of geomicrobes throughout Earth history.Thus,most previous paleontological studies have focused on faunal and floral fossils.Here,geomicrobial functional groups(GFGs),or a collection of microbes featured in specific ecological,physiological or biogeochemical functions,are suggested to provide a way to overcome the difficulties of ancient mi-crobe investigations.GFGs are known for their great diversity in ecological,physiological and biogeochemical functions.In addi-tion,GFGs may be preserved as the biogeochemical,mineralogical and sedimentological records in sediments and rocks.We reviewed the functions,origins and identification diagnostics of some important GFGs involved in the elemental cycles of carbon,sulfur,nitrogen and iron.GFGs were further discussed with respect to their significant impacts on paleoclimate,sulfur chemistry of ancient seawater,nutritional status of geological environments,and the deposition of Precambrian banded iron formations. | XIE ShuCheng YANG Huan LUO GenMing HUANG XianYu LIU Deng WANG YongBiao GONG YiMing XU Rana | 2012 | Chinese Science Bulletin2012，57，1： | 11 |
| 5 | Sequential fate-switches in stem-like cells drive the tumorigenic trajectory from human neural stem cells to malignant glioma显示文摘Glioblastoma(GBM)is an incurable and highly heterogeneous brain tumor,originating from human neural stem/progenitor cells(hNSCs/hNPCs)years ahead of diagnosis.Despite extensive efforts to characterize hNSCs and end-stage GBM at bulk and single-cell levels,the de novo gliomagenic path from hNSCs is largely unknown due to technical difficulties in early-stage sampling and preclinical modeling.Here,we established two highly penetrant hNSC-derived malignant glioma models,which resemble the histopathology and transcriptional heterogeneity of human GBM.Integrating time-series analyses of whole-exome sequencing,bulk and single-cell RNA-seq,we reconstructed gliomagenic trajectories,and identified a persistent NSC-like population at all stages of tumorigenesis.Through trajectory analyses and lineage tracing,we showed that tumor progression is primarily driven by multi-step transcriptional reprogramming and fate-switches in the NSC-like cells,which sequentially generate malignant heterogeneity and induce tumor phenotype transitions.We further uncovered stage-specific oncogenic cascades,and among the candidate genes we functionally validated C1QL1 as a new glioma-promoting factor.Importantly,the neurogenic-to-gliogenic switch in NSC-like cells marks an early stage characterized by a burst of oncogenic alterations,during which transient AP-1 inhibition is sufficient to inhibit gliomagenesis.Together,our results reveal previously undercharacterized molecular dynamics and fate choices driving de novo gliomagenesis from hNSCs,and provide a blueprint for potential early-stage treatment/diagnosis for GBM. | Xiaofei Wang Ran Zhou Yanzhen Xiong Lingling Zhou Xiang Yan Manli Wang Fan Li Chuanxing Xie Yiming Zhang Zongyao Huang Chaoqiong Ding Kaidou Shi Weida Li Yu Liu Zhongwei Cao Zhen-Ning Zhang Shengtao Zhou Chong Chen Yan Zhang Lu Chen Yuan Wang | 2021 | Cell Research2021，31，6： | 8 |
| 6 | High shear stress induces atherosclerotic vulnerable plaque formation through angiogenesis显示文摘Rupture of atherosclerotic plaques causing thrombosis is the main cause of acute coronary syndrome and ischemic strokes.Inhibition of thrombosis is one of the important tasks developing biomedical materials such as intravascular stents and vascular grafts.Shear stress(SS)influences the formation and development of atherosclerosis.The current review focuses on the vulnerable plaques observed in the high shear stress(HSS)regions,which localizes at the proximal region of the plaque intruding into the lumen.The vascular outward remodelling occurs in the HSS region for vascular compensation and that angiogenesis is a critical factor for HSS which induces atherosclerotic vulnerable plaque formation.These results greatly challenge the established belief that low shear stress is important for expansive remodelling,which provides a new perspective for preventing the transition of stable plaques to high-risk atherosclerotic lesions. | Yi Wang Juhui Qiu Shisui Luo Xiang Xie Yiming Zheng Kang Zhang Zhiyi Ye Wanqian Liu Hans Gregersen GuixueWang | 2016 | Regenerative Biomaterials2016，3，4： | 8 |
| 7 | Microbial and molecular fossils from the Permian Zoophycos in South China显示文摘The trace fossil Zoophycos was enriched in the lower part of the Guadalupian Maokou Formation of Permian in Laibin, Guangxi of South China, and characterized by observable lamellae within its spreiten. Associated with these lamellae are the prolific coccus- and spirillum-shaped microbe fossils. These microbes morphologically identified are 0.4―3.0 μm in diameter or length. Molecular fossils, including normal alkanes (dominated by C18, without an odd-over-even predominance), acyclic isoprenoids (such as pristane (Pr) and phytane (Ph)), extended tricyclic terpanes, pentacyclic triterpanes, steranes, al-kylcyclohexanes, dibenzothiophenes, benzonaphthothiophenes, benzobisbenzothiophenes, were in-strumentally identified in the wackestone characterized by the occurrence of abundant Zoophycos (composite ichnofabric indices are 4) and crowded microbial fossils. The value of the Pr/Ph ratio is less than 1, indicative of a dysoxic condition. The identification of abundant sulfur compounds (the thio-phene series) related to the contribution of reductive sulfur favors the occurrence of sulphate-reducing bacteria. The association of abundant microbial colonies with microbial molecular fossils within the spreiten suggests that trace fossils Zoophycos would be a multifunctional garden carefully constructed by the Zoophycos-producer, where different microbial colonies were orderly and carefully planted and cultured in different minor lamellae within spreiten. Hence, it is proposed that the Zoophycos-producer symbiosed with microbial colonies on the mutual basis of food supply and the redox conditions. | GONG YiMing XU Ran XIE ShuCheng HUANG XianYu HU Bin QI YongAn ZHANG GuoCheng | 2007 | Science China Earth Sciences2007，50，8： | 6 |
| 8 | Mode splitting transmission effect of surface wave excitation through a metal hole array显示文摘The resonant frequencies of the excited surface waves on a metal hole array with respect to the incident angle were studied in the terahertz region.The experimental and theoretical results demonstrate that the resonant peak of surface wave excitation splits into two when transmitted through a metal hole array off-normally.The high-order mode with resonant frequency above the cutoff frequency fc(plasma frequency effect)has a shorter attenuation length than that of the low-order mode whose resonant frequency is below fc.The reason is that the high-order mode is a coupled mode consisting of surface wave and hole modes,while the low-order mode is just an excited surface wave(which can be considered as the spoof surface plasmons).Our investigation may open a door to distinguish the spoof surface plasmons and the coupled modes of surface waves and hole modes. | Lin Chen Yiming Zhu Xiaofei Zang Bin Cai Zhou Li Le Xie Songlin Zhuang | 2013 | Light(Science & Applications)2013，2，1： | 6 |
| 9 | Phase noise filtering and phase unwrapping method based on unscented Kalman filter显示文摘This paper presents a new phase unwrapping algorithm based on the unscented Kalman filter(UKF) for synthetic aperture radar(SAR) interferometry.This method is the result of combining an UKF with path-following strategy and an omni-directional local phase slope estimator.This technique performs simultaneously noise filtering and phase unwrapping along the high-quality region to the low-quality region,which is also able to avoid going directly through the noisy regions.In addition,phase slope is estimated directly from the sample frequency spectrum of the complex interferogram,by which the underestimation of phase slope is overcome.Simulation and real data processing results validate the effectiveness of the proposed method,and show a significant improvement with respect to the extended Kalman filtering(EKF) algorithm and some conventional phase unwrapping algorithms in some situations. | Xianming Xie Yiming Pi | 2011 | Journal of Systems Engineering and Electronics2011，22，3： | 5 |
| 10 | An Approach for Network Function Combination Based on Least Busy Placement Algorithm显示文摘Recently, integrating Softwaredefined networking(SDN) and network functions virtualization(NFV) are proposed to address the issue that difficulty and cost of hardwarebased and proprietary middleboxes management. However, it lacks of a framework that orchestrates network functions to service chain in the network cooperatively. In this paper, we propose a function combination framework that can dynamically adapt the network based on the integration NFV and SDN. There are two main contributions in this paper. First, the function combination framework based on the integration of SDN and NFV is proposed to address the function combination issue, including the architecture of Service Deliver Network, the port types representing traffic directions and the explanation of terms. Second, we formulate the issue of load balance of function combination as the model minimizing the standard deviations of all servers' loads and satisfying the demand of performance and limit of resource. The least busy placement algorithm is introduced to approach optimal solution of the problem. Finally, experimental results demonstrate that the proposed method can combine functions in an efficient and scalable way and ensure the load balance of the network. | XIE Lijun JIANG Yiming WANG Binqiang XIONG Gang CHENG Guozhen | 2016 | China Communications2016，13，S1： | 3 |
| 11 | A novel cancer vaccine with the ability to simultaneously produce anti-PD-1 antibody and GM-CSF in cancer cells and enhance Th1-biased antitumor immunity显示文摘Tumor escape from immune-mediated destruction has been associated with immunosuppressive mechanisms that inhibit T-cell activation.A promising strategy for cancer immunotherapy is to disrupt key pathways regulating immune tolerance,such as program death-1(PD-1/PD-L1)pathway in the tumor environment.However,the determinants of response to anti-PD-1 monoclonal antibodies(mAbs)treatment remain incompletely understood.In murine models,PD-1 blockade alone fails to induce effective immune responses to poorly immunogenic tumors,but is successful when combined with additional interventions,such as cancer vaccines.Novel cancer vaccines combined with antibody may offer promising control of cancer development and progression.In this investigation,we generated a novel tumor cell vaccine simultaneously expressing anti-PD-1 mAbs and granulocyte-macrophage colony stimulating factor(GM-CSF)in CT26 colon cancer and B16-F10 melanoma.The antitumor effect of the vaccine was verified by therapeutic and adoptive animal experiments in vivo.The antitumor mechanism was analyzed using Flow cytometry,Elispot and in vivo intervention approaches.The results showed that tumor cell vaccine secreting PD-1 neutralizing antibodies and GM-CSF induced remarkable antitumor immune effects and prolonged the survival of tumor-bearing animals compared with animals treated with either PD-1 mAbs or GM-CSF alone.Antitumor effects and prolonged survival correlated with strong antigen-specific T-cell responses by analyzing CD11c^(+)CD86^(+)DC,CD11b^(+)F4/80^(+)MΦcells,increased ratio of Teff/Treg in the tumor microenvironment,and higher secretion levels of Th1 proinflammatory cytokines in serum.Furthermore,the results of ELISPOT and in vivo blocking strategies further confirmed that the antitumor immune response is acquired by CD4 and CD8 T immune responses,primarily dependent on CD4 Th1 immune response,not NK innate immune response.The combination of PD-1 blockade with GM-CSF secretion potency creates a novel tumor cell vaccine immunotherapy,affording significantly improved antitumor responses by releasing the state of immunosuppressive microenvironment and augmenting the tumor-reactive T-cell responses. | Hongwei Tian Gang Shi Qin Wang Yiming Li Qianmei Yang Chunlei Li Guoyou Yang Min Wu Qian Xie Shuang Zhang Yang Yang Rong Xiang Dechao Yu Yuquan Wei Hongxin Deng | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 12 | Dual-layered metasurfaces for asymmetric focusing显示文摘Asymmetric transmission,defined as the difference between the forward and backward transmission,enables a plethora of applications for on-chip integration and telecommunications.However,the traditional method for asymmetric transmission is to control the propagation direction of the waves,hindering further applications.Metasurfaces,a kind of two-dimensional metamaterials,have shown an unprecedented ability to manipulate the propagation direction,phase,and polarization of electromagnetic waves.Here we propose and experimentally demonstrate a metasurface-based directional device consisting of a geometric metasurface with spatially rotated microrods and metallic gratings,which can simultaneously control the phase,polarization,and propagation direction of waves,resulting in asymmetric focusing in the terahertz region.These dual-layered metasurfaces for asymmetric focusing can work in a wide bandwidth ranging from 0.6 to 1.1 THz.The flexible and robust approach for designing broadband asymmetric focusing may open a new avenue for compact devices with potential applications in encryption,information processing,and communication. | BINGSHUANG YAO XIAOFEI ZANG ZHEN L LIN CHEN JINGYA XIE YIMING ZHU SONGLIN ZHUANG | 2020 | Photonics Research2020，8，6： | 2 |
| 13 | Qualitative and quantitative analysis of glucosinolates and nucleosides in Radix Isatidis by HPLC and liquid chromatography tandem mass spectrometry显示文摘Multi-component fingerprinting and quantitation of the glucosinolates and nucleosides in samples of Radix Isatidis have been carried out using high-performance liquid chromatography with diode-array detection and electrospray ionization tandem mass spectrometry(HPLC–DAD–ESI/MS).Five nucleosides together with one glucosinolate were identified by comparing retention times,ultraviolet spectra,mass spectra and/or empirical molecular formulae of reference compounds.Quantitation of these six compounds was carried out simultaneously by HPLC on a Phenomenex Luna C18 column using gradient elution with methanol and water and detection at 254 nm.All calibration curves were linear(r40.9994)within test ranges.Limits of detection and quantitation were 0.33 ng and 2.50 ng on column,respectively.Intra-and inter-day precision(as relative standard deviation)for all analytes was o2.19%with recoveries in the range 99.6%–101.8%at three concentration levels.The validated method was successfully applied to fingerprinting and assay of 25 batches of Radix Isatidis sourced from different geographical regions of China.The method is simple and reliable and has potential value in the quality control of Radix Isatidis. | Xiuming Wang Yuanyuan Xie Xiaomei Hu Youkang Li Ping Hu Yiming Wang Qionglin Liang Guoan Luo | 2013 | Acta Pharmaceutica Sinica B2013，3，5： | 2 |
| 14 | A NEW UNSUPERVISED CLASSIFICATION ALGORITHM FOR POLARIMETRIC SAR IMAGES BASED ON FUZZY SET THEORY显示文摘In this letter, a new method is proposed for unsupervised classification of terrain types and man-made objects using POLarimetric Synthetic Aperture Radar (POLSAR) data. This technique is a combi-nation of the usage of polarimetric information of SAR images and the unsupervised classification method based on fuzzy set theory. Image quantization and image enhancement are used to preprocess the POLSAR data. Then the polarimetric information and Fuzzy C-Means (FCM) clustering algorithm are used to classify the preprocessed images. The advantages of this algorithm are the automated classification, its high classifica-tion accuracy, fast convergence and high stability. The effectiveness of this algorithm is demonstrated by ex-periments using SIR-C/X-SAR (Spaceborne Imaging Radar-C/X-band Synthetic Aperture Radar) data. | Fu Yusheng Xie Yan Pi Yiming Hou Yinming | 2006 | Journal of Electronics(China)2006，23，4： | 2 |
| 15 | A metal-electrode-free, fully integrated, soft triboelectric sensor array for self-powered tactile sensing显示文摘The dramatic advances in flexible/wearable electronics have garnered great attention for touch sensors for practical applications in human health monitoring and human–machine interfaces.Self-powered triboelectric tactile sensors with high sensitivity,reduced crosstalk,and simple processing routes are highly desirable.Herein,we introduce a facile and low-cost fabrication approach for a metal-electrode free,fully integrated,flexible,and self-powered triboelectric tactile sensor array with 8-by-8 sensor units.Through the height difference between the sensor units and interconnect electrodes,the crosstalk derived from the electrodes has been successfully suppressed with no additional shielding layers.The tactile sensor array shows a remarkable sensitivity of 0.063VkPa^(–1) with a linear range from 5 to 50kPa,which covers a broad range of testing objects.Furthermore,due to the advanced mechanical design,the flexible sensor array exhibits great capability of pressure sensing even under a curved state.The voltage responses from the pattern mapping by finger touching demonstrate the uniformity of the sensor array.Finally,real-time tactile sensing associated with light-emitting diode(LED)array lighting demonstrates the potential application of the sensor array in position tracking,self-powered touch screens,human–machine interfaces and many others. | Lingyun Wang Yiming Liu Qing Liu Yuyan Zhu Haoyu Wang Zhaoqian Xie Xinge Yu Yunlong Zi | 2020 | Microsystems & Nanoengineering2020，6，1： | 2 |
| 16 | Metal Free Mono- and 2,3-Bis-sulfenylation of Indoles in Water with Sodium Sulfinates as a Sulfur Source显示文摘 | Changqing Liu Jian Fan Manyi Wu Jiahui Chen Yiming Zhao Meihua Xie | 2018 | Chinese Journal of Chemistry2018，36，9： | 2 |
| 17 | Surface passivation and band engineering: a way toward high ef- ficiency graphene-planar Si solar cells显示文摘 | Xie Chao Zhang Xiaozhen Wu Yiming | 2013 | J Mater Chern A2013，，1： | 1 |
| 18 | Multi-baseline Phase Unwrapping Algorithm Based on the Unscented Kalman Filter显示文摘 | XIE XIANMING PI YIMING | 2011 | IET Radar Sonar & Navigation2011，5，3： | 1 |
| 19 | PBKα inhibitor impairs AKT phosphorylation and synergizes with novel angiogenesis inhibitor AL3810 in human hepatocellular carcinoma显示文摘Dear Editor,Hepatocellular carcinoma(HCC)is the second leading cause of cancer-related death worldwide with a 5-year survival rate-50-80% after curative treatment,like surgery,targeted therapy plus TACE or RFA or local treatments,immunotherapy,and so on.1 The approval of several angiogenesis inhibitors,such as sorafenib,regorafenib,lenvatinib,and cabozantinib,have shown therapeutic potential for HCC treatment.However,the improvement of overall survival or progression-free survival is still limited based on angiogenesis inhibitor monotherapy at present. | Qin Xie Shuaishuai Chi Yanfen Fanq Yiming Sun Linghua Meng Jian Ding Yi Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 1 |
| 20 | Antiretroviral therapy to prevent HIV transmission in serodiscordant couples in China (2003–11): a national observational cohort study显示文摘 | Zhongwei Jia Yuhua Ruan Qianqian Li Peiyan Xie Ping Li Xia Wang Ray Y Chen Yiming Shao | 2012 | The Lancet2012，，： | 1 |
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