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| 1 | Nanoparticles modified by polydopamine: Working as “drug” carriers显示文摘Inspired by the mechanism of mussel adhesion,polydopamine(PDA),a versatile polymer for surface modification has been discovered.Owing to its unique properties like extraordinary adhesiveness,excellent biocompatibility,mild synthesis requirements,as well as distinctive drug loading approach,strong photothermal conversion capacity and reactive oxygen species(ROS)scavenging facility,various PDA-modified nanoparticles have been desired as drug carriers.These nanoparticles with diverse nanostructures are exploited in multifunctions,consisting of targeting,imaging,chemical treatment(CT),photodynamic therapy(PDT),photothermal therapy(PTT),tissue regeneration ability,therefore have attracted great attentions in plenty biomedical applications.Herein,recent progress of PDA-modified nanoparticle drug carriers in cancer therapy,antibiosis,prevention of inflammation,theranostics,vaccine delivery and adjuvant,tissue repair and implant materials are reviewed,including preparation of PDA-modified nanoparticle drug carriers with various nanostructures and their drug loading strategies,basic roles of PDA surface modification,etc.The advantages of PDA modification in overcoming the existing limitations of cancer therapy,antibiosis,tissue repair and the developing trends in the future of PDA-modified nanoparticle drug carriers are also discussed. | Anting Jin Yitong Wang Kaili Lin Lingyong Jiang | 2020 | Bioactive Materials2020，5，3： | 13 |
| 2 | Classification of Northeast China Cold Vortex Activity Paths in Early Summer Based on K-means Clustering and Their Climate Impact显示文摘The classification of the Northeast China Cold Vortex(NCCV)activity paths is an important way to analyze its characteristics in detail.Based on the daily precipitation data of the northeastern China(NEC)region,and the atmospheric circulation field and temperature field data of ERA-Interim for every six hours,the NCCV processes during the early summer(June)seasons from 1979 to 2018 were objectively identified.Then,the NCCV processes were classified using a machine learning method(k-means)according to the characteristic parameters of the activity path information.The rationality of the classification results was verified from two aspects,as follows:(1)the atmospheric circulation configuration of the NCCV on various paths;and(2)its influences on the climate conditions in the NEC.The obtained results showed that the activity paths of the NCCV could be divided into four types according to such characteristics as the generation origin,movement direction,and movement velocity of the NCCV.These included the generation-eastward movement type in the east of the Mongolia Plateau(eastward movement type or type A);generation-southeast longdistance movement type in the upstream of the Lena River(southeast long-distance movement type or type B);generationeastward less-movement type near Lake Baikal(eastward less-movement type or type C);and the generation-southward less-movement type in eastern Siberia(southward less-movement type or type D).There were obvious differences observed in the atmospheric circulation configuration and the climate impact of the NCCV on the four above-mentioned types of paths,which indicated that the classification results were reasonable. | Yihe FANG Haishan CHEN Yi LIN Chunyu ZHAO Yitong LIN Fang ZHOU | 2021 | Advances in Atmospheric Sciences2021，38，3： | 4 |
| 3 | Improved myocardial performance in infarcted rat heart by co-injection of basic fibroblast growth factor with temperature-responsive Chitosan hydrogel显示文摘 | Haibin Wang Xuelian Zhang Yanmin Li Yitong Ma Ye Zhang Zhiqiang Liu Jin Zhou Qiuxia Lin Yanmeng Wang Cuimi Duan Changyong Wang | 2010 | Journal of Heart and Lung Transplantation2010，，8： | 1 |
| 4 | A multi-band atomic candle with microwave-dressed Rydberg atoms显示文摘Stabilizing important physical quantities to atom-based standards lies at the heart of modern atomic,molecular and optical physics,and is widely applied to the field of precision metrology.Of particular importance is the atom-based microwave field amplitude stabilizer,the so-called atomic candle.Previous atomic candles are realized with atoms in their ground state,and hence suffer from the lack of frequency band tunability and small stabilization bandwidth,severely limiting their development and potential applications.To tackle these limitations,we employ microwave-dressed Rydberg atoms to realize a novel atomic candle that features multi-band frequency tunability and large stabilization bandwidth.We demonstrate amplitude stabilization of microwave field from C-band to Ka-band,which could be extended to quasi-DC and terahertz fields by exploring abundant Rydberg levels.Our atomic candle achieves stabilization bandwidth of 100 Hz,outperforming previous ones by more than two orders of magnitude.Our simulation indicates the stabilization bandwidth can be further increased up to 100 kHz.Our work paves a route to develop novel electric field control and applications with a noise-resilient,miniaturized,sensitive and broadband atomic candle. | Yafen Cai Shuai Shi Yijia Zhou Jianhao Yu Yali Tian Yitong Li Kuan Zhang Chenhao Du Weibin Li Lin Li | 2023 | Frontiers of physics2023，18，1： | 1 |
| 5 | Antioxidant,Anti-inflammatory,and Antibacterial Activities of Different Extracts from Polygonum capitatum显示文摘[Objectives]To investigate the antioxidant,anti-inflammatory and antibacterial activities of different extracts(aqueous,ethanol,ethyl acetate and n-butanol extracts)of Miao medicine Polygonum capitatum.[Methods]Eleven batches of P.capitatum in Guizhou province were collected,and water,ethanol,ethyl acetate and n-butanol extracts were prepared by reflux extraction.Antioxidant activity was determined by radical scavenging capacity of 1,1 diphenyl-2-picyl hydrazine(DPPH),anti-inflammatory activity was screened by lipopolysaccharide(LPS)induced RAW264.7 cells to produce NO,and the minimum inhibitory concentration(MIC)was screened by broth microdilution method.[Results]When the concentration of ethyl acetate extract was 10 mg/L,the scavenging rate of DPPH ranged from 90%to 99%.The(MIC of the ethyl acetate extract against Staphylococcus aureus(SA),Pseudomonas aeruginosa(PA)and Escherichia coli(EC)was 0.18-0.65,0.13-0.82,and 0.15-0.78 g/L,respectively.In the anti-inflammatory activity,ethyl acetate extract inhibited NO production with inhibition rate of 70%.[Conclusions]The ethyl acetate extract and ethanol extract of Miao medicine P.capitatum have strong antioxidant,anti-inflammatory and antibacterial activities. | Bo TU Minghui HE Yitong SHEN Xu ZHANG Yan LIN | 2023 | Medicinal Plant2023，14，2： | 0 |
| 6 | The Coordinated Influence of Indian Ocean Sea Surface Temperature and Arctic Sea Ice on Anomalous Northeast China Cold Vortex Activities with Different Paths during Late Summer显示文摘The Northeast China cold vortex(NCCV)during late summer(from July to August)is identified and classified into three types in terms of its movement path using machine learning.The relationships of the three types of NCCV intensity with atmospheric circulations in late summer,the sea surface temperature(SST),and Arctic sea ice concentration(SIC)in the preceding months,are analyzed.The sensitivity tests by the Community Atmosphere Model version 5.3(CAM5.3)are used to verify the statistical results.The results show that the coordination pattern of East Asia-Pacific(EAP)and Lake Baikal high pressure forced by SST anomalies in the North Indian Ocean dipole mode(NIOD)during the preceding April and SIC anomalies in the Nansen Basin during the preceding June results in an intensity anomaly for the first type of NCCV.While the pattern of high pressure over the Urals and Okhotsk Sea and low pressure over Lake Baikal during late summer-which is forced by SST anomalies in the South Indian Ocean dipole mode(SIOD)in the preceding June and SIC anomalies in the Barents Sea in the preceding April-causes the intensity anomaly of the second type.The third type is atypical and is not analyzed in detail.Sensitivity tests,jointly forced by the SST and SIC in the preceding period,can well reproduce the observations.In contrast,the results forced separately by the SST and SIC are poor,indicating that the NCCV during late summer is likely influenced by the coordinated effects of both SST and SIC in the preceding months. | Yitong LIN Yihe FANG Chunyu ZHAO Zhiqiang GONG Siqi YANG Yiqiu YU | 2023 | Advances in Atmospheric Sciences2023，40，1： | 0 |
| 7 | Investigation on the Material Basis of Sijicao Granules in Treating Eczema Based on Network Pharmacology显示文摘[Objectives]To explore the pharmacodynamic material basis of Sijicao granules for the treatment of eczema through chemical composition-network pharmacology.[Methods]First of all,the chemical constituents of Polygonum capitatum and Plantago asiatica from Sijicao granules were collected,and the relevant target information of the constituents was collected by TCMSP,PubChem,DisGeNET,GeneCards and STRING databases.Furthermore,Cytoscape 3.8.2 software was used to construct the chemical compounds-target network map of Sijicao granules.Finally,STRING database was used for PPI protein network analysis,GO functional enrichment analysis and KEGG pathway enrichment analysis of core targets,and molecular docking between core constituents and protein targets was also performed.[Results]30 constituents,including quercetin,kaempferol,luteolin,ellagic acid and gallic acid,were discovered to be the key effective compounds of Sijicao granules in the treatment of eczema.And its core action protein targets were PTGS2,NOS2,AKT1,TP53,IL6,HMOX1.What s more,through GO functional enrichment analysis of biological process(BP),cell component(CC),molecular function(MF)analysis and KEGG pathway enrichment analysis,the main pathways of action of Sijicao granules for the treatment of eczema including IL-17 signaling pathway,T cell receptor signaling pathway,cancer signaling pathway,TNF signaling pathway and Relaxin signaling pathway.In addition,molecular docking results displayed that the primary active constituents quercetin,kaempferol and luteolin were well combined with the core protein targets AKT1 and IL6.[Conclusions]Sijicao granules could play an important role for the treatment of eczema through multi-component,multi-target,multi-pathway and their interaction. | Yitong SHEN Bo TU Yaru YANG Li JIANG Minghui HE Yan LIN | 2023 | Medicinal Plant2023，14，6： | 0 |
| 8 | Assessment of the Capability of ENSEMBLES Hindcasts in Predicting Spring Climate in China显示文摘Using the hindcasts provided by the Ensemble-Based Predictions of Climate Changes and Their Impacts(ENSEMBLES) project for the period of 1980–2005, the forecast capability of spring climate in China is assessed mainly from the aspects of precipitation, 2-m air temperature, and atmospheric circulations. The ENSEMBELS can reproduce the climatology and dominant empirical orthogonal function(EOF) modes of precipitation and 2-m air temperature, with some differences arising from different initialization months. The multi-model ensemble(MME) forecast of interannual variability is of good performance in some regions such as eastern China with February initialization.The spatial patterns of the MME interannual and inter-member spreads for precipitation and 2-m air temperature are consistent with those of the observed interannual spread, indicating that internal dynamic processes have major impacts on the interannual anomaly of spring climate in China. We have identified two coupled modes between intermember anomalies of the 850-hPa vorticity in spring and sea surface temperature(SST) both in spring and at a lead of 2 months, of which the first mode shows a significant impact on the spring climate in China, with an anomalous anticyclone located over Northwest Pacific and positive precipitation and southwesterly anomalies in eastern China.Our results also suggest that the SST at a lead of two months may be a predictor for the spring climate in eastern China. A better representation of the ocean–atmosphere interaction over the tropical Pacific, Northwest Pacific, and Indian Ocean can improve the forecast skill of the spring climate in eastern China. | Yitong LIN Haiming XU Jing MA Haijun LI | 2019 | Journal of Meteorological Research2019，33，2： | 0 |
| 9 | Short-term variations and influencing factors of suspended sediment concentrations at the Heisha Beach,Guangdong,China显示文摘Knowledge of sediment variation processes is essential to understand the evolution mechanism of beach morphology changes.Thus,a field measurement was conducted at the Heisha Beach,located on the west coast of the Zhujiang River(Pearl River)Estuary,to investigate the short-term variation in suspended sediment concentrations(SSCs)and the relationship between the SSC and turbulent kinetic energy,bottom shear stress(BSS),and relative wave height.Based on extreme event analysis results,extreme events have a greater influence on turbulent kinetic energy than SSC.Although a portion of the turbulent kinetic energy dissipates directly into the water column,it plays an important role in suspended sediment motion.Most of the time,the wave-current interaction is strong enough to drive sediment incipience and resuspension.When combined,the wave-current interaction and wave-induced BSSs have a greater influence on suspended sediment transport and SSC variation than current-induced BSS alone.The relative wave height also has a strong correlation with SSC,indicating that the combined effect of water depth and wave height significantly impacts SSC variation.Water depth is mainly controlled by the tide on the beaches;thus,the effects of tides and waves should be conjunctively considered when analyzing the factors influencing SSC. | Jintang Ou Haoyan Dong Liangwen Jia Xiangxin Luo Zixiao He Kanglin Chen Jing Liu Yitong Lin Mingdong Yu Mingen Liang | 2022 | Acta Oceanologica Sinica2022，41，5： | 0 |
| 10 | Purpurolide C-based microneedle promotes macrophage-mediated diabetic wound healing via inhibiting TLR4-MD2 dimerization and MYD88 phosphorylation显示文摘Delayed wound healing in diabetes is a global challenge,and the development of related drugs is a clinical problem to be solved.In this study,purpurolide C(PC),a small-molecule secondary metabolite of the endophytic fungus Penicillium purpurogenum,was found to promote diabetic wound healing.To investigate the key regulation targets of PC,in vitro RNA-seq,molecular docking calcula-tions,TLR4-MD2 dimerization SDS-PAGE detection,and surface plasmon resonance(SPR)were per-formed,indicating that PC inhibited inflammatory macrophage activation by inhibiting both TLR4-MD2 dimerization and MYD88 phosphorylation.Tlr4 knockout in vivo attenuated the promotion effect of PC on wound healing.Furthermore,a delivery system consisting of macrophage liposome and GelMA-based microneedle patches combined with PC(PC@MLIP MN)was developed,which overcame the poor water solubility and weak skin permeability of PC,so that successfully punctured the skin and delivered PC to local tissues,and accurately regulated macrophage polarization in diabetic wound management.Overall,PC is an anti-inflammatory small molecule compound with a well-defined structure and dualtarget regulation,and the PC@MLIP MN is a promising novel biomaterial for the management of diabetic wound. | Yitong Liu Guiyang Xia Yingyi Chen Huan Xia Junji Xu Lijia Guo Sheng Lin Yi Liu | 2023 | Acta Pharmaceutica Sinica B2023，13，12： | 0 |
| 11 | Single-Atom Ce-N_(4)-C-(OH)_(2)Nanozyme-Catalyzed Cascade Reaction to Alleviate Hyperglycemia显示文摘The enzyme-mimicking catalytic activity of single-atom nanozymes has been widely used in tumor treatment.However,research on alleviating metabolic diseases,such as hyperglycemia,has not been reported.Herein,we found that the single-atom Ce-N_(4)-C-(OH)_(2)(SACe-N_(4)-C-(OH)_(2))nanozyme promoted glucose absorption in lysosomes,resulting in increased reactive oxygen species production in HepG2 cells.Furthermore,the SACe-N_(4)-C-(OH)_(2)nanozyme initiated a cascade reaction involving superoxide dismutase-,oxidase-,catalase-,and peroxidase-like activity to overcome the limitations associated with the substrate and produce•OH,thus improving glucose intolerance and insulin resistance by increasing the phosphorylation of protein kinase B and glycogen synthase kinase 3β,and the expression of glycogen synthase,promoting glycogen synthesis to improve glucose intolerance and insulin resistance in high-fat diet-induced hyperglycemic mice.Altogether,these results demonstrated that the novel nanozyme SACeN_(4)-C-(OH)_(2)alleviated the effects of hyperglycemia without evident toxicity,demonstrating its excellent clinical application potential. | Guangchun Song Jia Xu Hong Zhong Qi Zhang Xin Wang Yitong Lin Scott PBeckman Yunbo Luo Xiaoyun He Jin-Cheng Li Kunlun Huang Nan Cheng | 2023 | Research2023，，4： | 0 |
| 12 | Establishment of a method for the determination of hydrogen sulfide in human serum by liquid chromatography-tandem mass spectrometry and evaluation of its clinical application显示文摘Hydrogen sulfide(H2S)is an inorganic compound.It is a colorless,water-soluble gas that results in the smell of rotten eggs.Hydrogen sulfide is the third most important endogenous gas signaling molecule after nitric oxide,NO,and carbon monoxide(CO)[1].Hydrogen sulfide is involved in many physiological and pathological processes.Relevant studies have shown that hydrogen sulfide is widely distributed in the cardiovascular,nervous,digestive,endocrine,and immune systems. | Chunyan Li Jia Chen Yu Su Wuzheng Liu Xiangyu Meng Ao Zhang Yitong Bai Yingzi Liu Ruichen Liu Lin Zhang Jun Wu | 2024 | Acta Biochimica et Biophysica Sinica2024，56，3： | 0 |
| 13 | SREBP2 inhibitor betulin sensitizes hepatocellular carcinoma to lenvatinib by inhibiting the mTOR/IL-1βpathway显示文摘Lenvatinib has become the first-line therapy in advanced hepatocellular carcinoma(HCC),but its efficacy is still limited because of the inevitable development of resistance.It has been reported that cellular cholesterol levels are associated with tyrosine kinase inhibitor(TKI)efficacy.Here,we show that betulin,a sterol regulatory elementbinding protein 2(SREBP2)inhibitor,markedly enhances the anti-tumor effect of lenvatinib in HCC both in vitro and in vivo.Our results also show that the combination treatment of lenvatinib and betulin synergistically inhibits the proliferation and clonogenicity of HCC cells.The mRNA and protein expressions of IL-1βare markedly decreased in HCC cells treated with betulin,while the sensitivity of HCC cells to lenvatinib is enhanced.Moreover,we find that the knockdown of IL-1βalso enhances the efficacy of lenvatinib,and recombinant IL-1βprotein rescues cell viability,which is reduced by lenvatinib in HCC cells.Further mechanistic studies indicate that betulin decreases the level of IL-1βin HCC cells by inhibiting the mTOR signaling pathway.Finally,the growth of the tumors in xenograft mouse models subjected to combination treatment is significantly suppressed.In summary,our study reveals that the SREBP2 inhibitor betulin sensitizes hepatocellular carcinoma to lenvatinib by inhibiting the mTOR/IL-1βpathway,which may be a promising therapeutic strategy for patients with HCC. | Minghao Fan Zhenmei Chen Weiqing Shao Yiran Chen Zhifei Lin Chenhe Yi Yitong Li Lu Lu Yu Zhou Jing Lin | 2023 | Acta Biochimica et Biophysica Sinica2023，55，9： | 0 |
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