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| 1 | Incidence and mortality of laryngeal cancer in China,2008–2012显示文摘Objective:To analyze the incidence and mortality rates of laryngeal cancer in China from 2008 to 2012.Methods:Incident and death cases of laryngeal cancer were retrieved from the National Central Cancer Registry(NCCR)database collecting from 135 cancer registries in China during 2008–2012.The crude incidence and mortality rates of laryngeal cancer were calculated by area(urban/rural),region(eastern,middle,western),gender and age group(0,1–4,5–9,…,85+).China census in 2000 and Segi’s world population were applied for age standardized rates.Join Point(Version 4.5.0.1)model was used for time trend analysis.Results:The crude incidence rate of laryngeal cancer was 1.86/100,000 ranked the 21st in overall cancers.The age-standardized incidence rates by China population(ASIRC)and by World population(ASIRW)were1.22/100,000 and 1.23/100,000,respectively.The crude mortality of laryngeal cancer in China was 1.01/100,000and it was the 21st cause of cancer-related death in overall cancers.Both the age-standardized mortality rates by Chinese standard population(ASMRC)and by world standard population(ASMRW)were 0.63/100,000.Incidence and mortality rates of laryngeal cancer were higher in males than in females and higher in urban areas than in rural areas.Middle areas had the highest incidence and mortality rates followed by eastern and western areas.Incidence and mortality rates of laryngeal cancer retained low level before age of 40 years old but increased greatly after and peaked in age group of 75.Incidence showed significant down trends in recent 10 years by 1.27%annually[95%confidence interval(95%CI):–2.2%,–0.3%].Mortality declined in females sharply by 5.18%per year although stable in males and both sexes combined.Conclusions:Appropriate targeted prevention,early detection and treatment programs should be carried out to control the local burden of laryngeal cancer. | Yuqin Liu Qin Zhao Gaoheng Ding Yitong Zhu Wenying Li Wanqing Chen | 2018 | Chinese Journal of Cancer Research2018，30，3： | 29 |
| 2 | Atg5 regulates late endosome and lysosome biogenesis显示文摘Autophagy is an evolutionarily conserved lysosome-based degradation process.Atg5 plays a very important role in autophagosome formation.Here we show that Atg5 is required for biogenesis of late endosomes and lysosomes in an autophagy-independent manner.In Atg5 cells,but not in other essential autophagy genes defecting cells,recycling and retrieval of late endosomal components from hybrid organelles are impaired,causing persistent hybrid organelles and defective formation of late endosomes and lysosomes.Defective retrieval of late endosomal components from hybrid organelles resulting from impaired recruitment of a component of V1-ATPase to acidic organelles blocks the pH-dependent retrieval of late endosomal components from hybrid organelles.Lowering the intracellular pH restores late endosome/lysosome biogenesis in Atg5 cells.Our data demonstrate an unexpected role of Atg5 and shed new light on late endosome and lysosome biogenesis. | PENG JunYa ZHANG Ran CUI YiTong LIU HaoDong ZHAO XiaoXin HUANG Lei HU MingXu YUAN XiaoXi MA BenYu MA XiaoWei TAKASHI Ueno MASAAKI Komatsu LIANG XingJie YU Li | 2014 | Science China(Life Sciences)2014，57，1： | 6 |
| 3 | Networking retinomorphic sensor with memristive crossbar for brain-inspired visual perception显示文摘Compared to human vision,conventional machine vision composed of an image sensor and processor suffers from high latency and large power consumption due to physically separated image sensing and processing.A neuromorphic vision system with brain-inspired visual perception provides a promising solution to the problem.Here we propose and demonstrate a prototype neuromorphic vision system by networking a retinomorphic sensor with a memristive crossbar.We fabricate the retinomorphic sensor by using WSe_(2)/h-BN/Al_(2)O_(3)van der Waals heterostructures with gate-tunable photoresponses,to closely mimic the human retinal capabilities in simultaneously sensing and processing images.We then network the sensor with a large-scale Pt/Ta/Hf O_(2)/Ta one-transistor-one-resistor(1 T1 R)memristive crossbar,which plays a similar role to the visual cortex in the human brain.The realized neuromorphic vision system allows for fast letter recognition and object tracking,indicating the capabilities of image sensing,processing and recognition in the full analog regime.Our work suggests that such a neuromorphic vision system may open up unprecedented opportunities in future visual perception applications. | Shuang Wang Chen-Yu Wang Pengfei Wang Cong Wang Zhu-An Li Chen Pan Yitong Dai Anyuan Gao Chuan Liu Jian Liu Huafeng Yang Xiaowei Liu Bin Cheng Kunji Chen Zhenlin Wang Kenji Watanabe Takashi Taniguchi Shi-Jun Liang Feng Miao | 2021 | National Science Review2021，8，2： | 5 |
| 4 | Liensinine induces gallbladder cancer apoptosis and G2/M arrest by inhibiting ZFX-induced PI3K/AKT pathway显示文摘Gallbladder carcinoma (GBC) is the most comm on and aggressive can cer of the biliary tract. Liensinine has been proved to have hypotensive effect. However, the effect of liensinine on GBC is still unknown. The aim of this study is to investigate the effect and mechanism of liensinine in human GBC cells. Cell viability assay and colony formation assay were performed to assess cell growth and proliferation. Flow cytometry analysis was used to investigate cell cycle apoptosis in vitro. Hoechst 33342 staining was also used to evaluate cell apoptosis. Western blot analysis was used to determine the expression of proteins corresponding to the related cell cycle and apoptosis.The effect of liensinine treatment in vivo was experimented with xenografted tumors. We found that liensinine significantly inhibited the growth of GBC cells both in vivo and in vitro. In vitro, cell growth and proliferation were significantly suppressed by liensinine in a dose- and time-dependent manner. In vivo, liensinine inhibited tumor growth. Liensinine could induce GBC cells G2/M phase arrest by up-regulating the levels of Cyclin B1 and CDK1 proteins. Liensinine also affected GBC cell cycle progress!on and induced apoptosis by down-regulating phosphorylated protein kinase B (AKT), phosphorylated protein kinase B (p-AKT), phosphatidylinositol 3-kinase (PI3K), and Zinc finger X-chromosomal protein (ZFX) proteins. Liensinine induced G2/M arrest and apoptosis in gallbladder cancer, suggest!ng that liensinine might represent a novel and effective agent against gallbladder cancer. | Yitong Shen Rui Bian Yaxiong Li Yuan Gao Yingbin Liu Yuzhen Xu Xiaoling Song Yijian Zhang | 2019 | Acta Biochimica et Biophysica Sinica2019，51，6： | 4 |
| 5 | Impact of external carbon source on A2/O system and its biological phosphorus and nitrogen removal efficiency before and after restoration显示文摘以啤酒废水作为外加碳源,研究了不同浓度外加碳源对A2/O系统的冲击情况,并通过调节工艺参数对系统进行修复,对比了修复前后系统的脱氮除磷效果。结果表明,投加低浓度(COD为50mg/L)外加碳源没有影响系统的正常运行,且有助于提高系统的脱氮除磷效率;用COD为150mg/L的啤酒废水对系统进行冲击时,总氮、氨氮、总磷和COD的去除率均有所下降,依次下降了31.53、16.38、7.61、10.19百分点;经过修复后,与冲击前相比较,各分析指标的去除率略有降低。用高浓度(COD为250nag/L)的啤酒废水冲击A2/O系统,冲击期间各分析指标显著下降,且产生轻微的污泥膨胀,修复后各分析指标去除率依次降低了11.75、9.56、21.20、20.79百分点。实验表明,啤酒废水可以作为外加碳源用以调节系统的C/N,且A0/o系统对浓度变化的冲击具有一定的抵抗力。 | LIU Fangjing DUAN Yitong ZHAO Jianhui CHENG Guoling LI Yongfeng | 2014 | 环境污染与防治2014，36，4： | 4 |
| 6 | Morphology and magnetic properties of Sm_(2)Co_(7)/α-Fe nanocomposite magnets produced by high energy ball milling and spark plasma sintering显示文摘In this article,the Sm_(2)Co_(7)/α-Fe nanocomposite magnets were prepared by high energy ball milling and spark plasma sintering method.The effect of soft phase content on the magnetic properties was studied.Up to 30 wt% α-Fe was added into Sm_(2)Co_(7) matrix without the decrease of remanence.Optimal energy product(BH)max of 9.2 MGOe was obtained with 20 wt% α-Fe.TEM observation shows that the grain size of α-Fe is 20-50 nm which ensures a good coupling effect between soft and hard phase.One more thing needs to be mentioned is that there exists inter-diffusion between Sm-Co phase and α-Fe phase.Moreover,our results can also illustrate that the Sm_(2)Co_(7)/α-Fe nanocomposite magnets are able to acquire better magnetic properties than the SmCo_(5)/α-Fe magnets prepared by the same process due to the large domain width of Sm_(2)Co_(7) phase. | Yitong Zhuge Yuqing Li Xiaochang Xu Dongtao Zhang Hongguo Zhang Weiqiang Liu Ming Yue | 2021 | Journal of Rare Earths2021，39，3： | 3 |
| 7 | Empirical estimates of regional carbon budgets imply reduced global soil heterotrophic respiration显示文摘Resolving regional carbon budgets is critical for informing land-based mitigation policy.For nine regions covering nearly the whole globe,we collected inventory estimates of carbon-stock changes complemented by satellite estimates of biomass changes where inventory data are missing.The net land–atmospheric carbon exchange(NEE)was calculated by taking the sum of the carbon-stock change and lateral carbon fluxes from crop and wood trade,and riverine-carbon export to the ocean.Summing up NEE from all regions,we obtained a global‘bottom-up'NEE for net land anthropogenic CO_(2)uptake of–2.2±0.6 Pg C yr^(-1)consistent with the independent top-down NEE from the global atmospheric carbon budget during 2000–2009.This estimate is so far the most comprehensive global bottom-up carbon budget accounting,which set up an important milestone for global carbon-cycle studies.By decomposing NEE into component fluxes,we found that global soil heterotrophic respiration amounts to a source of CO_(2)of 39 Pg C yr^(-1)with an interquartile of 33–46 Pg C yr^(-1)—a much smaller portion of net primary productivity than previously reported. | Philippe Ciais Yitong Yao Thomas Gasser Alessandro Baccini Yilong Wang Ronny Lauerwald Shushi Peng Ana Bastos Wei Li Peter A.Raymond Josep G.Canadell Glen P.Peters Rob J.Andres Jinfeng Chang Chao Yue A.Johannes Dolman Vanessa Haverd Jens Hartmann Goulven Laruelle Alexandra G.Konings Anthony W.King Yi Liu Sebastiaan Luyssaert Fabienne Maignan Prabir K.Patra Anna Peregon Pierre Regnier Julia Pongratz Benjamin Poulter Anatoly Shvidenko Riccardo Valentini Rong Wang Grégoire Broquet Yi Yin Jakob Zscheischler Bertrand Guenet Daniel SGoll Ashley-P.Ballantyne Hui Yang Chunjing Qiu Dan Zhu | 2021 | National Science Review2021，8，2： | 3 |
| 8 | Preparation of CH_3NH_3PbI_3 thin films for solar cells via Vapor Transfer Method显示文摘Organometal halide perovskite based solar cells have emerged as one of the most promising candidates for low-cost and high-efficiency solar cell technologies.Here a Vapor Transfer Method(VTM)is used to fabricate high quality perovskite thin films in a balanced vacuum capsule.By adjusting the reaction temperature,CH_3NH_3I saturated vapor which then reacts with PbI_2films can be controlled and the formation process of CH_3NH_3PbI_3perovskite films can be further influenced.Prepared perovskite films which exhibit pure phase,smooth surface and high crystallinity are assembled into planar heterojunction inverted solar cells.The whole fabrication process of solar cell devices is organic solution free.Finally,the champion cell achieved power conversion efficiency(PCE)of 13.08%with negligible current–voltage hysteresis under fully open-air conditions.The photovoltaic performance could be further enhanced by optimizing perovskite composition and the device structure. | Kejie Feng Yitong Liu Yuancheng Zhang Yujie Liu Xiaoliang Mo | 2018 | Journal of Energy Chemistry2018，27，5： | 1 |
| 9 | A new method of objective speech quality assessment in communication system 显示文摘 | Zhang Weiwei Chang Yongyu Liu Yitong | 2013 | Journal of Multimedia2013，8，3： | 1 |
| 10 | A Novel Magnetic Carbon Based Catalyst Synthesized from Reed Straw and Electric Furnace Dust for Biodiesel Production显示文摘In the era of serious greenhouse gas emission and energy shortage,it is necessary to use solid waste to prepare new renewable materials.In this work,the potential application of reed straw and electric furnace dust was explored.Firstly,magnetic carbon carrier(EFD&C)was prepared by high temperature calcination,and then magnetic carbon catalyst(SM@EFD&C)was prepared by activation of sodium methoxide.The catalyst was used to prepare biodiesel by transesterification reaction to test its activity and stability.Reed biochar,EFD&C and SM@EFD&C were detected by Diffraction of X-rays(XRD),Fourier transform infrared(FT-IR),Inductively coupled plasma(ICP),Scanning electron microscope(SEM),Transmission electron microscope(TEM),Brunauer-Emmett-Teller(BET),Vibrating sample magnetometer(VSM),Temperature programmed desorption of CO_(2)(CO_(2)-TPD)and Thermogravimetric analysis(TG-DTG).The results showed that SM@EFD&C catalyst had some characteristics including porous structure,easy adsorption and better magnetism.Under the reaction conditions of 65℃for 2 h with 6 wt%catalyst and methanol/oil molar ratio of 15:1,the biodiesel yields from reed biochar and EFD&C were only 4.88 wt%and 0.03 wt%,respectively,while the yield from SM@EFD&C catalyst reached 93.14 wt%(89.84 wt%after 7 cycles)under the same conditions,which proved that it had good catalytic activity and stability when used in biodiesel production.This study is of great significance of carbon dioxide emission reduction and environmental protection. | Fuping Wang Lele Kang Rui Ji Tianji Liu Qing Yu Di Gao Xiaoman Wang Yitong Wang Jie Yang | 2022 | Journal of Renewable Materials2022，10，8： | 1 |
| 11 | Improved myocardial performance in infarcted rat heart by co-injection of basic fibroblast growth factor with temperature-responsive Chitosan hydrogel显示文摘 | Haibin Wang Xuelian Zhang Yanmin Li Yitong Ma Ye Zhang Zhiqiang Liu Jin Zhou Qiuxia Lin Yanmeng Wang Cuimi Duan Changyong Wang | 2010 | Journal of Heart and Lung Transplantation2010，，8： | 1 |
| 12 | Chiral Macrocyclic AIEgens from BINOL and Tetraphenylethene via Tailoring Chirality of Luminescent Molecular Propellers显示文摘Herein,a pair of chiral macrocyclic luminogens derived from chiral 1,1-bi(2-naphthol)(BINOL)and tetraphenylethenes(TPEs)have been prepared with high yield via intramolecular McMurry coupling,in which the preferential helicity of propeller-shaped TPE units can be tuned via choosing proper chiral BINOL tethers.The preferential chiral geometry of the macrocyclic luminogen was unambiguously confirmed by X-ray crystal crystallography and theoretical calculation,whereas the variable-temperature NMR spectra and chiral HPLC analysis further verified the intramolecular motions.These two chiral macrocyclic luminogens both exhibit obvious aggregation-induced emission behavior and mechanochromic luminescence properties.Furthermore,aggregation attenuated CD signals and circularly polarized luminescence were observed for these two chiral macrocylic luminogens in THF-water mixture and PMMA matrix.These results had paved a new approach toward constructing chiral aggregation-induced emission luminogens(AIEgens)and their structural engineering. | Yitong Wang Xiaoqing Liu Hongkun Li Xindong Liu Lei Wang Yi Liu | 2022 | Chinese Journal of Chemistry2022，40，20： | 1 |
| 13 | Oxidative demethylenation and subsequent glucuronidation are the major metabolic pathways of berberine in rats显示文摘 | Liu Yitong Hao Haiping Xie Hongguang | | 0，，11： | 1 |
| 14 | Nitrogen-doped Carbon Coated Na3V2(PO4)3 with Superior Sodium Storage Capability显示文摘Cathodes with high cycling stability and rate capability are required for ambient temperature sodium ion batteries in renewable energy storage application.Na3V2(PO4)3 is an attractive cathode material with excellent electrochemical stability and fast ion diffusion coefficient within the 3D NASICON structure.Nevertheless,the practical application of Na3V2(PO4)3 is seriously hindered by its intrinsically poor electronic conductivity.Herein,solvent evaporation method is presented to obtain the nitrogen-doped carbon coated Na3V2(PO4)3 cathode material,delivering cnhanced clectrochemical performances.N-Doped carbon layer coating servfes as a highly conducting pathway,and creates numerous extrinsic defects and active sites,which can facilitate the storage and diffusion of Na^+.Morcover,the N-doped carbon layer can provide a stable framework to accommodate the agglomeration of the electrode upon electrode cycling.N-Doped carbon coated Na3V2(PO4)3(NC-NVP)exhibits excellent long cycling life and superior rate performances than bare Na3V2(PO4)3 without carbon coating.NC-NVP delivers a stable capacity of 95.9mA·h/g after 500 cycles at 1C rate,which corresponds to high capacity retention(94.6%)with respect to the initial capacity(101.4mA·h/g).Over 91.3% of the initial capacity is retained after 500 cycles at 5C,and the capacity can reach 85mA·h/g at 30C rate. | XU Laiqiang LI Jiayang LI Yitong CAI Peng LIU Cheng ZOU Guoqiang HOU Hongshuai HUANG Lanping JI Xiaobo | 2020 | Chemical Research in Chinese Universities2020，36，3： | 1 |
| 15 | Dynamics of fipronil residue in vegetable-field ecosystem显示文摘 | Zhou Pei Lu Yitong Liu Baofeng Jay J. Gan | 2004 | Chemosphere2004，，11： | 1 |
| 16 | Artificial interphases enable dendrite-free Li-metal anodes显示文摘Li-metal is an ideal anode that can provide rechargeable batteries with high energy density,but its application in large scale is restricted by its high activity that leads to the severe decomposition of electrolyte components(solvents and salts) and the growth of Li dendrites.These parasitic reactions are responsible for the cycle life deterioration and the safety accidents of rechargeable Li-metal batteries.Correspondingly,much effort has been made to regulate Li/electrolyte interface chemistry.In this review,we summarize some strategies that have been developed recently to stabilize Li/electrolyte interface by constructing protective interphases on Li-metal anodes.Firstly,the currently available understandings on the instability of Li/electrolyte interface are outlined.Then,artificial interphases recently constructed exsitu and in-situ are illustrated in detail.Finally,possible approaches to acquire more efficiently protective interphases are prospected. | Qiankui Zhang Si Liu Yitong Lu Lidan Xing Weishan Li | 2021 | Journal of Energy Chemistry2021，30，7： | 1 |
| 17 | Specific knockout of Sox2 in astrocytes greatly reduces reactive astrocyte formation and promotes recovery after early postnatal TBI in mouse cortex显示文摘Reactive astrocytes are a double edged sword for traumatic brain injury(TBD),whether their overall effect on injury is beneficial or harmful depends on the balance between the loss and gain of function.However,the mechanism of reactive astrocytes after TBI is poorly understood.Recently more and more studies have been conducted to regulate the gene expression of astrocytes as a target to treat the disease.Here,we generated early postnatal TBI in the mouse cortex,indicating typical reactive astrocytes and glial scar were observed around damaged area;We next deleted Sox2 in astrocytes to observe its effects on reactive astrocytes and tissue repair after postnatal injury in the mouse cortex.As a result,specific deletion of Sox2 in astrocytes greatly inhibited the formation of reactive astrocytes and glial scars,and significantly promoted nerve regeneration in the damaged area and post injured repair.Together,our study indicate that Sox2 plays an important role in reactive astrocytes after early postnatal TBI in the mouse cortex.Therefore,Sox2 in astrocytes may be a putative target to develop new therapeutic tools for TBI treatment. | Liu Yitong Hong Wentong Gong Pifang Pan Xinjie Qi Guibo Qin Song | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 18 | Sequentially responsive size reduction and drug release of core-satellite nanoparticles to enhance tumor penetration and effective tumor suppression显示文摘Poor tumor accumulation remains a serious challenge for nanomedicines to achieve ideal antitumor outcomes.The different size preferences for systematic circulation,tumor retention and deep permeation have attracted great attention when designing antineoplastic nano-delivery system.Herein,we developed a nano-system which can shrink its size in tumor microenvironment to achieve better tumor retention and penetration.In this work,the cationic bovine serum albumin-protected,doxorubicin-loaded gold nanoclusters(CAuNC-DOX)and amino-functionalized mesoporous silica nanoparticles(MSN)are connected by Fe^(2+)and are further coated with hyaluronic acid(HA)to obtain a core-satellite MSN-Fe-CAuNCDOX@HA nano system(MFADH).When reaching the tumor site,the HA shell,which endows the system with both good biocompatibility and preferable tumor targeting ability,was disintegrated,followed by acid-stimulated release of small-sized pharmacological unit—CAuNC-DOX for further tumor penetration.As demonstrated in both in vitro and in vivo results,MFADH showed excellent antitumor effect,providing a proof of concept for the feasibility of shrinkable nanoplatforms in tumor treatment. | Jiayi Sun Jingyang Li Xi Li Lu Yang Yitong Liu Huile Gao Li Xiang | 2023 | Chinese Chemical Letters2023，34，5： | 0 |
| 19 | The Spatial and Electronic Effects of Substituent Groups on the Thermal Curing of Bio-Based Benzoxazines显示文摘To explore the influence of substituent groups on thermally induced curing,eight new bio-based benzoxazines containing different substituent groups with different electron negativity and volumes were synthesized.The thermal curing of these bio-based benzoxazines was studied in detail.Combined with the curing reaction kinetics,simulation and calculation of Highest Occupied Molecular and Lowest Unoccupied Molecular values,the spatial and electronic effects of different substituent groups on the curing of benzoxazine was explored.It was found that when the substituent was located at the position directly connected to the N atom,the steric hindrance effect of the group was dominant.When the substituent group was located on the benzene ring connected to the O atom,both the electronic effect and the spatial effect influenced the curing of benzoxazine.When an electron-withdrawing group was connected ortho position to the O atom,the curing reaction was promoted due to the decreased electron cloud density of O-on the oxazine ring,making the C-O bond easier to break.When an electron-donating group was connected to the meta position of the O atom it also promoted the curing reaction,possibly because it increased the electron cloud density of the+CH2 reaction site and thereby facilitated electrophilic substitution via attack of+CH2 on the cross linking reaction centre.This work provides a deeper understanding of how spatial and electronic effects of substituents affect the curing of benzoxazine. | Rumeng Li Guozhu Zhan Qi Ma Yunhe Yang Xiaoyun Liu Yitong Zhang Qixin Zhuang | 2021 | Journal of Renewable Materials2021，9，12： | 0 |
| 20 | Recent advances on catalysts for preferential oxidation of CO显示文摘The trace amount of CO in H2-rich gas poisons Pt electrode when it is adopted as feedstock for proton-exchange-membrane fuel cells.Preferential oxidation of CO(PROX)is a promising approach to selectively oxidize the trace amount of CO while keeping H2 unoxidized.Catalyst plays important roles in PROX.To date,enormous catalysts have been developed for PROX.Summarizing the catalysts developed for PROX and unveiling the reaction mechanism could definitely advance this research field.Herein,in this review,according to the nature of the active sites on the catalysts,we classify the catalysts into group VIII metal-based catalyst,group IB metal-based catalysts,group VIII-group IB bimetallic catalysts,transitional metal oxide catalysts as well as others,describe the progress of the catalysts in PROX in the latest five years,and extract the underlying reaction mechanism,with the aim to provide guidance for the rational design of efficient catalysts in the future. | Huimin Liu Dezheng Li Jiawen Guo Yuqiao Li Aidi Liu Yitong Bai Dehua He | 2023 | Nano Research2023，16，4： | 0 |
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